메뉴 건너뛰기




Volumn 22, Issue 2, 2013, Pages 558-572

Discovery of novel DPP IV inhibitors: Application of pharmacophore-based virtual screening

Author keywords

3D quantitative structure activity relationship; Dipeptidyl peptidase IV (DPP IV); Glucagon like peptide; National Cancer Institute (NCI)

Indexed keywords

AW 01077; CD 01797; CD 02493; CD 06202; DIPEPTIDYL PEPTIDASE IV; DIPEPTIDYL PEPTIDASE IV INHIBITOR; NSC 2450; NSC 5815; NSC 997; UNCLASSIFIED DRUG;

EID: 84874000349     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-012-0044-8     Document Type: Article
Times cited : (5)

References (16)
  • 1
    • 0034666562 scopus 로고    scopus 로고
    • Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV
    • 10980284 10.1016/S0014-2999(00)00600-2 1:CAS:528:DC%2BD3cXmt1aisL0%3D
    • Ahren B, Holst JJ, Martensson H, Balkan B (2000) Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV. Eur J Pharmacol 404:239-245
    • (2000) Eur J Pharmacol , vol.404 , pp. 239-245
    • Ahren, B.1    Holst, J.J.2    Martensson, H.3    Balkan, B.4
  • 2
    • 0000135759 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats
    • 10550416 10.1007/s001250051445 1:CAS:528:DyaK1MXmvF2ms7k%3D
    • Balkan B, Kwasnik L, Miserendino R, Holst JJ, Li X (1999) Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia 42:1324-1331
    • (1999) Diabetologia , vol.42 , pp. 1324-1331
    • Balkan, B.1    Kwasnik, L.2    Miserendino, R.3    Holst, J.J.4    Li, X.5
  • 3
    • 84986512474 scopus 로고
    • CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
    • 10.1002/jcc.540040211 1:CAS:528:DyaL3sXit1aiu7w%3D
    • Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (1983) CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J Comput Chem 4:187-217
    • (1983) J Comput Chem , vol.4 , pp. 187-217
    • Brooks, B.R.1    Bruccoleri, R.E.2    Olafson, B.D.3    States, D.J.4    Swaminathan, S.5    Karplus, M.6
  • 4
    • 0031916924 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon like peptide 1 in the anesthetized pig
    • 9588448 10.2337/diabetes.47.5.764 1:CAS:528:DyaK1cXjs1SgsLc%3D
    • Deacon CF, Hughes TE, Holst JJ (1998) Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon like peptide 1 in the anesthetized pig. Diabetes 47:764-769
    • (1998) Diabetes , vol.47 , pp. 764-769
    • Deacon, C.F.1    Hughes, T.E.2    Holst, J.J.3
  • 5
    • 0009307846 scopus 로고
    • Glucagon-like peptide-1 (GLP-1) a newly discovered GI hormone
    • Holst JJ (1994) Glucagon-like peptide-1 (GLP-1) a newly discovered GI hormone. Gastroenterology 107:1048-1055
    • (1994) Gastroenterology , vol.107 , pp. 1048-1055
    • Holst, J.J.1
  • 6
    • 0031690479 scopus 로고    scopus 로고
    • Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes
    • 9792533 10.2337/diabetes.47.11.1663 1:CAS:528:DyaK1cXmvF2qu7c%3D
    • Holst JJ, Deacon CF (1998) Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes. Diabetes 47:1663-1670
    • (1998) Diabetes , vol.47 , pp. 1663-1670
    • Holst, J.J.1    Deacon, C.F.2
  • 7
    • 0030037462 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV-B, a novel form of cell-surface-expressed protein with dipeptidyl-peptidase IV activity
    • 8706727 10.1111/j.1432-1033.1996.0248u.x 1:CAS:528:DyaK28Xks1ersLw%3D
    • Jacotot E, Callebaut C, Blanco J, Krust B, Neubert K, Barth A, Hovanessian AG (1996) Dipeptidyl-peptidase IV-B, a novel form of cell-surface-expressed protein with dipeptidyl-peptidase IV activity. Eur J Biochem 239:248-258
    • (1996) Eur J Biochem , vol.239 , pp. 248-258
    • Jacotot, E.1    Callebaut, C.2    Blanco, J.3    Krust, B.4    Neubert, K.5    Barth, A.6    Hovanessian, A.G.7
  • 9
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • 10588446 10.1016/S0167-0115(99)00089-0 1:CAS:528:DyaK1MXntVCitLs%3D
    • Mentlein R (1999) Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 85:9-24
    • (1999) Regul Pept , vol.85 , pp. 9-24
    • Mentlein, R.1
  • 10
    • 0027215348 scopus 로고
    • Dipeptidylpeptidase IV hydrolyzes gastric inhibitory polypeptide, glucagon like peptide-1 (7-36), peptide histidine methionine and is responsible for their degradation in human serum
    • 8100523 10.1111/j.1432-1033.1993.tb17986.x 1:CAS:528:DyaK3sXks1elsLs%3D
    • Mentlein R, Gallwitz B, Schmidt WE (1993) Dipeptidylpeptidase IV hydrolyzes gastric inhibitory polypeptide, glucagon like peptide-1 (7-36), peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 214:829-835
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 12
    • 0031870418 scopus 로고    scopus 로고
    • Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide
    • 9703325 10.2337/diabetes.47.8.1253 1:CAS:528:DyaK1cXltFyrt78%3D
    • Pederson RP, White HA, Schlenzig D, Pauly RP, McIntosh CRP, Demuth HU (1998) Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide. Diabetes 47:1253-1258
    • (1998) Diabetes , vol.47 , pp. 1253-1258
    • Pederson, R.P.1    White, H.A.2    Schlenzig, D.3    Pauly, R.P.4    McIntosh, C.R.P.5    Demuth, H.U.6
  • 13
    • 0031033531 scopus 로고    scopus 로고
    • Near normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide 1 (GLP-1) in subjects with NIDDM
    • 9049482 10.1007/s001250050664 1:STN:280:DyaK2s3gtF2nuw%3D%3D
    • Rachman J, Borrow BA, Levy JC, Turner RC (1997) Near normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide 1 (GLP-1) in subjects with NIDDM. Diabetologia 40:205-211
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Borrow, B.A.2    Levy, J.C.3    Turner, R.C.4
  • 14
    • 0027533758 scopus 로고
    • Truncated GLP-1 (proglucagon 72-107 amide) inhibits gastric and pancreatic functions in man
    • 8462365 10.1007/BF01316798 1:CAS:528:DyaK3sXltlWqtbs%3D
    • Wettergren A, Schjoldager B, Martensen PE, Myhre J, Christiansen J, Holst JJ (1993) Truncated GLP-1 (proglucagon 72-107 amide) inhibits gastric and pancreatic functions in man. Dig Dis Sci 38:665-673
    • (1993) Dig Dis Sci , vol.38 , pp. 665-673
    • Wettergren, A.1    Schjoldager, B.2    Martensen, P.E.3    Myhre, J.4    Christiansen, J.5    Holst, J.J.6
  • 15
    • 0027439867 scopus 로고
    • Proline-dependent structural and biological properties of peptides and proteins
    • 8444042 10.3109/10409239309082572 1:CAS:528:DyaK3sXit1ylu70%3D
    • Yaron A, Nadier F (1993) Proline-dependent structural and biological properties of peptides and proteins. Crit Rev Biochem Mol Biol 28:31-81
    • (1993) Crit Rev Biochem Mol Biol , vol.28 , pp. 31-81
    • Yaron, A.1    Nadier, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.