Efficient biological process characterization by definitive-screening designs: The formaldehyde treatment of a therapeutic protein as a case study

Biotechnology Letters

Volumn 35, Issue 3, 2013, Pages 323-329

  Erler, Axel ^a   de Mas, Nuria ^a,c   Ramsey, Philip ^b   Henderson, Grant ^a  

^a LONZA AG   (Switzerland)

^b University of New Hampshire   (United States)

^c Bristol Myers Squibb Company   (United States)

Author keywords

Definitive screening; Formylation; Process characterization; Process model; Process simulation; Vaccine

Indexed keywords

AMINO ACIDS; CROSSLINKING; FORMALDEHYDE; MANUFACTURE; VACCINES;

FORMALDEHYDE TREATMENT; FORMYLATION; PROCESS CHARACTERIZATION; PROCESS MODELING; PROCESS SIMULATIONS; PROTEIN CONCENTRATIONS; PROTEIN CROSSLINKING; REACTION TEMPERATURE;

PROTEINS;

EID: 84873987030     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-012-1089-y     Document Type: Article

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