Hypoalbuminemia and lymphocytopenia are predictive risk factors for in-hospital mortality in patients with tuberculosis

Internal Medicine

Volumn 52, Issue 4, 2013, Pages 439-444

  Okamura, Kyoko ^a,d   Nagata, Nobuhiko ^b   Wakamatsu, Kentaro ^a   Yonemoto, Koji ^c   Ikegame, Satoshi ^a   Kajiki, Akira ^a   Takayama, Koichi ^d   Nakanishi, Yoichi ^d  

^a Omuta National Hospital   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

^c KURUME UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

Author keywords

Malnutrition; Prognosis; Tuberculosis

Indexed keywords

ALBUMIN; ETHAMBUTOL; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN; STREPTOMYCIN;

AGED; ARTICLE; COHORT ANALYSIS; COMORBIDITY; DEATH; FEMALE; GRANULOMATOUS INFLAMMATION; HISTOPATHOLOGY; HOSPITAL ADMISSION; HUMAN; HUMAN TISSUE; HYPOALBUMINEMIA; LYMPHOCYTE COUNT; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; MORTALITY; MYCOBACTERIUM TUBERCULOSIS; NECROSIS; NUTRITIONAL STATUS; PLEURA EFFUSION; POLYMERASE CHAIN REACTION; PROGNOSIS; RADIOGRAPHY; RETROSPECTIVE STUDY; RISK FACTOR; SPUTUM SMEAR; TUBERCULOSIS;

AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; HOSPITAL MORTALITY; HUMANS; HYPOALBUMINEMIA; LYMPHOPENIA; MALE; MULTIVARIATE ANALYSIS; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; TUBERCULOSIS;

EID: 84873973811     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.52.8158     Document Type: Article

References (21)

1. Mitchson DA. The diagnosis and therapy of tuberculosis during the past 100 years. Am J Respir Crit Care Med 171: 699-706, 2005.
2. Mazurek GH, Jereb J, Lobue P, et al. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tubercu-losis infection, United States. MMWR Recomm Rep 54 (RR-15): 49-55, 2005.
3. Yew WW, Leung CC. Update in tuberculousis 2008. Am J Respir Crit Care Med 179: 337-343, 2009.
4. World Health Organization. Global tuberculosis control: WHO re-port 2011.
5. Aoki M. Tuberculosis in the world, and in Japan. Kekkaku 81: 623-629, 2006 (in Japanese, Abstract in English).
6. Japan Anti-Tuberculosis Association. Statistics of TB 2012 (in Japanese).
7. Gupta KB, Gupta R, Atreja A, Verma M, Vishvkarma S. Tubercu-losis and nutrition. Lung India 26: 9-16, 2009.
8. Onwubalili JK. Malnutrition among tuberculosis patients in Har-row, England. Eur J Clin Nutr 42: 363-366, 1988.
9. Harries AD, Nkhoma WA, Thompson PJ, Nyangulu DS, Wirima JJ. Nutritional status in Malawian patients with pulmonary tuber-culosis and response to chemotherapy. Eur J Clin Nutr 42: 445-450, 1988.
10. Karyadi E, Schultink W, Nelwan RH, et al. Poor micronutrient status of active pulmonary tuberculosis patients in Indonesia. J Nutr 130: 2953-2958, 2000.
11. Cegielski JP, McMurray DN. The relationship between malnutri-tion and tuberculosis: evidence from studies in humans and ex-perimental animals. Int J Tuberc Lung Dis 8: 286-298, 2004.
12. Okamura K, Nagata N, Kumazoe H, et al. Relationship between computed tomography findings and nutritional status in elderly pa-tients with pulmonary tuberculosis. Intern Med 50: 1809-1814, 2011.
13. Matos ED, Moreira Lemos AC. Association between serum albu-min levels and in-hospital deaths due to tuberculosis. Int J Tuberc Lung Dis 10: 1360-1366, 2006.
14. Kim HJ, Lee CH, Shin S, et al. The impact of nutritional deficit on mortality of in-patients with pulmonary tuberculosis. Int J Tu-berc Lung Dis 14: 79-85, 2010.
15. Kim DK, Kim HJ, Kwon SY, et al. Nutritional deficit as a nega-tive prognostic factor in patients with miliary tuberculosis. Eur Respir J 32: 1031-1036, 2008.
16. Rao VK, Iademarco EP, Fraser VJ, Kollef MH. The impact of comorbidity on mortality following in hospital diagnosis of tuber-culosis. Chest 114: 1244-1252, 1998.
17. Kawasaki T, Sasaki Y, Nishimura H, et al. A hospital based study on evaluation of causes of death in 52 patients with pulmonary tu-berculosis. Kekkaku 84: 667-673, 2009 (in Japanese, Abstract in English).
18. Zahar JR, Azoulary E, Klement E, et al. Delayed treatment con-tributes to mortality in ICU patients with severe active pulmonary tuberculosis and acute respiratory failure. Intensive Care Med 27: 513-520, 2001.
19. Baby GC Jr. Leukopenia and leukocytosis. In: Cecil Textbook of Medicine. 22nd ed. Goldman L, Ausiello D, Eds. Saunders, Phila-delphia, 2004: 979-990.
20. Light RW. Pleural diseases. In: Clinical Menifestations and Useful Tests. 5th ed. Lippincott, Williams & Wilkins, Philadelphia, 2007: 93-96.
21. Dye C, Bourdin Trunz B, Lonnroth K, Roglic G, Williams BG. Nutrition, diabetes and tuberculosis in the epidemiological transi-tion. PLoS One 6: e21161, 2011.