Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1

Translational Psychiatry

Volumn 2, Issue , 2012, Pages

  Meier, S ^a   Mattheisen, M ^b,c   Vassos, E ^d   Strohmaier, J ^a   Treutlein, J ^a   Josef, F ^a   Breuer, R ^a   Degenhardt, F ^b   Muhleisen T W ^b   Muller Myhsok B ^e   Steffens, M ^b   Schmael, C ^a   McMahon, F J ^f   Nothen M M ^b,g   Cichon, S ^b,h   Schulze, T G ⁱ   Rietschel, M ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^f NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^g GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^h FORSCHUNGSZENTRUM JÜLICH   (Germany)

ⁱ UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

bipolar disorder; delusions; factor dimensions; genome wide; SLC2A2; subphenotype

Indexed keywords

SPACER DNA; GLUCOSE TRANSPORTER 2; SLC2A2 PROTEIN, HUMAN;

ADULT; ARTICLE; BIPOLAR DISORDER; CASE CONTROL STUDY; CHROMOSOME 3Q; CONTROLLED STUDY; DELUSION; EUROPEAN AMERICAN; FEMALE; FOLLOW UP; GENE LOCATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; NEGATIVE MOOD DELUSION; NEGATIVE SYNDROME; ALLELE; FACTORIAL ANALYSIS; GENETICS; MIDDLE AGED; PSYCHOLOGICAL ASPECT;

ADULT; ALLELES; BIPOLAR DISORDER; CASE-CONTROL STUDIES; DELUSIONS; FACTOR ANALYSIS, STATISTICAL; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GLUCOSE TRANSPORTER TYPE 2; HUMANS; MALE; MIDDLE AGED;

EID: 84873971894     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2012.81     Document Type: Article

References (37)

1. Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a populationbased study. Lancet 2009; 373: 234-239.
2. Kieseppä T, Partonen T, Haukka J, Kaprio J, Lönnqvist J. High concordance of bipolar I disorder in a nationwide sample of twins. Am J Psychiatry 2004; 161: 1814-1821.
3. McGuffin P, Rijsdijk F, Andrew M, Sham P, Katz R, Cardno A. The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Arch Gen Psychiatry 2003; 60: 497-502.
4. Chen DT, Jiang X, Akula N, Shugart YY, Wendland JR, Steele CJ et al. Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder. Mol Psychiatry advance online publication, 20 December 2011; doi:10.1038/mp.2011.157.
5. Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet 2011; 43: 977-983.
6. Baum AE, Hamshere M, Green E, Cichon S, Rietschel M, Noethen MM et al. Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement. Mol Psychiatry 2008; 13: 466-467.
7. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet 2008; 40: 1056-1058.
8. Cichon S, Mü hleisen TW, Degenhardt FA, Mattheisen M, Miro X, Strohmaier J et al. Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder. Am J Hum Genet 2011; 88: 372-381.
9. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748-752.
10. Zandi PP, Badner JA, Steele J, Willour VL, Miao K, MacKinnon DF et al. Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates. Mol Psychiatry 2007; 12: 630-639.
11. Park N, Juo SH, Cheng R, Liu J, Loth JE, Lilliston B et al. Linkage analysis of psychosis in bipolar pedigrees suggests novel putative loci for bipolar disorder and shared susceptibility with schizophrenia. Mol Psychiatry 2004; 9: 1091-1099.
12. Potash JB, Zandi PP, Willour VL, Lan TH, Huo Y, Avramopoulos D et al. Suggestive linkage to chromosomal regions 13q31 and 22q12 in families with psychotic bipolar disorder. Am J Psychiatry 2003; 160: 680-686.
13. Kerner B, Brugman DL, Freimer NB. Evidence of linkage to psychosis on chromosome 5q33-34 in pedigrees ascertained for bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2007; 144: 74-78.
14. Joo EJ, Greenwood TA, Schork N, McKinney RA, Sadovnick AD, Remick RA et al. Suggestive evidence for linkage of ADHD features in bipolar disorder to chromosome 10p14. Am J Med Genet B Neuropsychiatr Genet 2010; 153: 260-268.
15. Green EK, Raybould R, Macgregor S, Gordon-Smith K, Heron J, Hyde S et al. Operation of the schizophrenia susceptibility gene, neuregulin 1, across traditional diagnostic boundaries to increase risk for bipolar disorder. Arch Gen Psychiatry 2005; 62: 642-648.
16. De Pradier M, Gorwood P, Beaufils B, Ades J, Dubertret C. Influence of the serotonin transporter gene polymorphism, cannabis and childhood sexual abuse on phenotype of bipolar disorder: a preliminary study. Eur Psychiatry 2010; 25: 323-327.
17. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. J Affect Disord 2010; 125: 341-344.
18. Schulze TG, Ohlraun S, Czerski PM, Schumacher J, Kassem L, Deschner M et al. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. Am J Psychiatry 2005; 162: 2101-2108.
19. Priebe L, Degenhardt FA, Herms S, Haenisch B, Mattheisen M, Nieratschker V et al. Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder. Mol Psychiatry 2012; 17: 421-432.
20. First MB, Spitzer RL, Gibbon M, JBW Williams. Structured Clinical Interview for DSM-IV Disorders. American Psychiatric Publishing: Arlington, USA, 1998.
21. McGuffin P, Farmer A, Harvey I. A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 1991; 48: 764-770.
22. Smith EN, Bloss CS, Badner JA, Barrett T, Belmonte PL, Berrettini W et al. Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry 2009; 14: 755-763.
23. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J et al. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch Gen Psychiatry 1994; 51: 849-859.
24. Dziuban CD, Shirkey EC. When is a correlation matrix appropriate for factor analysis? Some decision rules. Psychol Bull 1974; 81: 358-361.
25. Yeomans KA, Golder PA. The Guttman-Kaiser criterion as a predictor of the number of common factors. J R Stat Soc Ser D 1982; 31: 221-229.
26. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575.
27. Wellcome Trust Case Control Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661-678.
28. International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 43: 71299-71320.
29. Tabachnick B, Fidell L. Using Multivariate Statistics. HarperCollins College Publishers: New York, USA, 1996.
30. Roncero I, Alvarez E, Chowen JA, Sanz C, Rabano A, Vazquez P et al. Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain. J Neurochem 2004; 88: 1203-1210.
31. Brandish PE, Su M, Holder DJ, Hodor P, Szumiloski J, Kleinhanz RR et al. Regulation of gene expression by lithium and depletion of inositol in slices of adult rat cortex. Neuron 2005; 45: 861-872.
32. Boudry G, Cheeseman CI, Perdue MH. Psychological stress impairs Na\+-dependent glucose absorption and increases GLUT2 expression in the rat jejunal brush-border membrane. Am J Physiol Regul Integr Comp Physiol 2007; 292: 862-867.
33. Potkin SG, Turner JA, Guffanti G, Lakatos A, Fallon JH, Nguyen DD et al. A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype. Schizophr Bull 2009; 35: 96-108.
34. Davidson RJ, Irwin W. The functional neuroanatomy of emotion and affective style. Trends Cogn Sci 1999; 3: 11-21.
35. Ritchey M, Dolcos F, Eddington KM, Strauman TJ, Cabeza R. Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response. J Psychiatr Res 2011; 45: 577-587.
36. Hamilton JP, Etkin A, Furman DJ, Lemus MG, Johnson RF, Gotlib IH. Functional neuroimaging of major depressive disorder: a meta-analysis and new integration of baseline activation and neural response data. Am J Psychiatry 2012; doi:10.1176/appi.ajp.2012.11071105.
37. Hulvershorn LA, Karne H, Gunn AD, Hartwick SL, Wang Y, Hummer TA et al. Neural activation during facial emotion processing in unmedicated bipolar depression, euthymia, and mania. Biol Psychiatry 2012; 71: 603-610.