Cervical lymph node metastases from thyroid cancer: Does thyroglobulin and calcitonin measurement in fine needle aspirates improve the diagnostic value of cytology?

BMC Clinical Pathology

Volumn 13, Issue 1, 2013, Pages

  Baldini, Enke ^a   Sorrenti, Salvatore ^b   Di Gioia, Cira ^b   De Vito, Corrado ^c   Antonelli, Alessandro ^d   Gnessi, Lucio ^a   Carbotta, Giovanni ^a   D'Armiento, Eleonora ^a   Miccoli, Paolo ^d   De Antoni, Enrico ^b   Ulisse, Salvatore ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

Calcitonin; Diagnosis; Fine needle aspiration cytology; Follow up; Lymph node metastasis; Thyroglobulin; Thyroid cancer

Indexed keywords

CALCITONIN; MESSENGER RNA; THYROGLOBULIN;

ADULT; AGED; ARTICLE; CERVICAL LYMPH NODE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOPATHOLOGY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; EXON; FEMALE; FINE NEEDLE ASPIRATION BIOPSY; HISTOPATHOLOGY; HUMAN; LYMPH NODE METASTASIS; MALE; PREDICTIVE VALUE; PROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; THYROID CANCER; THYROID MEDULLARY CARCINOMA; THYROIDECTOMY;

EID: 84873947161     PISSN: None     EISSN: 14726890     Source Type: Journal    
DOI: 10.1186/1472-6890-13-7     Document Type: Article

References (33)

1. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM, Int J Cancer 2010 127 2893 2917 10.1002/ijc.25516 21351269
2. Trend in thyroid carcinoma size, age at diagnosis and histology in a retrospective study of 500 cases diagnosed over 20 years. Trimboli P, Ulisse S, Graziano FM, Marzullo A, Ruggieri M, Calvanese A, Piccirilli F, Cavaliere R, Fumarola A, D'Armiento M, Thyroid 2006 16 1151 1155 10.1089/thy.2006.16.1151 17123342
3. Thyroid carcinoma. Sherman SI, Lancet 2003 36 501 511
4. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Kloos RT, Eng C, Evans DB, Francis GL, Gagel RF, Gharib H, Moley JF, Pacini F, Ringel MD, Schlumberger M, Wells SA Jr, American Thyroid Association Guidelines Task Force, Thyroid 2009 19 565 612 10.1089/thy.2008.0403 19469690
5. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, Mclver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM, American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Thyroid 2009 19 1167 1214 10.1089/thy.2009.0110 19860577
6. Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective. Schlumberger M, Berg G, Cohen O, Duntas L, Jamar F, Jarzab B, Limbert E, Lind P, Pacini F, Reiners C, Sánchez Franco F, Toft A, Wiersinga WM, Eur J Endocrinol 2004 150 105 112 10.1530/eje.0.1500105 14763906
7. European Thyroid Cancer Taskforce: European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W, Eur J Endocrinol 2006 154 787 803 10.1530/eje.1.02158 16728537
8. Virchow's node revisited. Analysis with clinicopathologic correlation of 152 fine-needle aspiration biopsies of supraclavicular lymph nodes. Cervin JR, Silverman JF, Loggie BW, Geisinger KR, Arch Pathol Lab Med 1995 8 727 730
9. American Thyroid Association Surgical Affairs Committee: American thyroid association consensus review and statement regarding the anatomy, terminology, and rationale for lateral neck dissection in differentiated thyroid cancer. Stack BC Jr, Ferris RL, Goldenberg D, Haymart M, Shaha A, Sheth S, Sosa JA, Tufano RP, Thyroid 2012 22 501 508 10.1089/thy.2011.0312 22435914
10. Cancer Committee of the Henry Mayo Newhall Memorial Hospital: The reliability of fine-needle aspiration biopsy as the initial diagnostic procedure for palpable masses: a 4-year experience of 730 patients from a community hospital-based outpatient aspiration biopsy clinic. Florentine BD, Staymates B, Rabadi M, Barstis J, Black A, Cancer 2006 107 406 416 10.1002/cncr.21976 16773630
11. High frequency of incidental diagnosis of extrathyroidal neoplastic diseases at the fine-needle aspiration biopsy of laterocervical lymph nodes in patients with thyroid nodules. Cignarelli M, Triggiani V, Ciampolillo A, Ambrosi A, Giorgino F, Liso V, Giorgino R, Thyroid 2001 11 65 71 10.1089/ 10507250150500685 11272099
12. Cystic change in metastatic lymph nodes: A common diagnostic pitfall in fine-needle aspiration cytology. Ustün M, Risberg B, Davidson B, Berner A, Diagn Cytopathol 2002 27 387 392 10.1002/dc.10201 12451573
13. Cystic appearance of cervical lymph nodes is characteristic of metastatic papillary thyroid carcinoma. Kessler A, Rappaport Y, Blank A, Marmor S, Weiss J, Graif M, J Clin Ultrasound 2003 1 21 25
14. Diagnostic utility of thyroglobulin detection in fine-needle aspiration of cervical cystic metastatic lymph nodes from papillary thyroid cancer with negative cytology. Cignarelli M, Ambrosi A, Marino A, Lamacchia O, Campo M, Picca G, Giorgino F, Thyroid 2003 13 1163 1167 10.1089/10507250360731578 14751038
15. Significance of low levels of thyroglobulin in fine needle aspirates from cervical lymph nodes of patients with a history of differentiated thyroid cancer. Borel AL, Boizel R, Faure P, Barbe G, Boutonnat J, Sturm N, Seigneurin D, Bricault I, Caravel JP, Chaffanjon P, Chabre O, Eur J Endocrinol 2008 158 691 698 10.1530/EJE-07-0749 18426828
16. Serum thyroglobulin, high-resolution ultrasound, and lymph node thyroglobulin in diagnosis of differentiated thyroid carcinoma nodal metastases. Snozek CL, Chambers EP, Reading CC, Sebo TJ, Sistrunk JW, Singh RJ, Grebe SK, J Clin Endocrinol Metab 2007 92 4278 4281 10.1210/jc.2007-1075 17684045
17. Diagnostic value of thyroglobulin measurement in fine-needle aspiration biopsy for detecting metastatic lymph nodes in patients with papillary thyroid carcinoma. Salmaslioǧlu A, Erbil Y, Citlak G, Ersöz F, Sari S, Olmez A, Tunaci M, Yilmazbayhan D, Colak N, Ozarmaǧan S, Langenbecks Arch Surg 2011 396 77 81 10.1007/s00423-010-0723-1 21052711
18. Thyroglobulin measurement in fine-needle aspirate washout: the criteria for neck node dissection for patients with thyroid cancer. Kim MJ, Kim EK, Kim BM, Kwak JY, Lee EJ, Park CS, Cheong WY, Nam KH, Clin Endocrinol 2009 70 145 151 10.1111/j.1365-2265.2008.03297.x
19. Detection of thyroglobulin in fine needle aspirates of nonthyroidal neck masses: a clue to the diagnosis of metastatic differentiated thyroid cancer. Pacini F, Fugazzola L, Lippi F, Ceccarelli C, Centoni R, Miccoli P, Elisei R, Pinchera A, J Clin Endocrinol Metab 1992 74 1401 1404 10.1210/jc.74.6.1401 1592886
20. Detection of recurrent papillary thyroid carcinoma by thyroglobulin assessment in the needle washout after fine-needle aspiration of suspicious lymph nodes. Baskin HJ, Thyroid 2004 14 959 963 10.1089/thy.2004.14.959 15671775
21. Thyroglobulin detection in fine-needle aspirates of cervical lymph node: a technique for the diagnosis of metastatic differentiated thyroid cancer. Cunha N, Rodrigues F, Curado F, Ilhéu O, Cruz C, Naidenov P, Rascão MJ, Ganho J, Gomes I, Pereira H, Real O, Figueiredo P, Campos B, Valido F, Eur J Endocrinol 2007 157 101 107 10.1530/EJE-07-0088 17609408
22. Thyroglobulin measurement in fine-needle aspirates of lymph nodes in patients with differentiated thyroid cancer: a simple definition of the threshold value, with emphasis on potential pitfalls of the method. Bournaud C, Charrié A, Nozières C, Chikh K, Lapras V, Denier ML, Paulin C, Decaussin-Petrucci M, Peix JL, Lifante JC, Cornu C, Giraud C, Orgiazzi J, Borson-Chazot F, Clin Chem Lab Med 2010 48 1171 1177 20441483
23. Cut-off value for needle washout thyroglobulin in athyrotropic patients. Lee YH, Seo HS, Suh SI, Lee NJ, Kim JH, Seol HY, Lee JH, Kwon SY, Kim NH, Seo JA, Yang KS, Laryngoscope 2010 120 1120 1124 20513027
24. Role of thyroglobulin measurement in fine-needle aspiration biopsies of cervical lymph nodes in patients with differentiated thyroid cancer. Frasoldati A, Toschi E, Zini M, Flora M, Caroggio A, Dotti C, Valcavi R, Thyroid 1999 9 105 111 10.1089/thy.1999.9.105 10090308
25. Diagnostic performance of thyroglobulin value in indeterminate range in fine needle aspiration washout fluid from lymph nodes of thyroid cancer. Sohn YM, Kim MJ, Kim EK, Kwak JY, Yonsei Med J 2012 53 126 131 10.3349/ymj.2012.53.1. 126 22187242
26. Thyroglobulin measurement on fine-needle washout fluids: influence of sample collection methods. Giovanella L, Cerlani L, Suriano S, Crippa S, Diagn Cytopathol 2009 37 42 44 10.1002/dc.20964 18973125
27. Usefulness of thyroglobulin measurement in needle-washout of fine-needle aspiration biopsy for the diagnosis of cervical lymph node metastases from papillary thyroid cancer before thyroidectomy. Kim DW, Jeon SJ, Kim CG, Endocrine 2012 42 399 403 10.1007/s12020-012-9636-9 22350587
28. Detection of lymph node metastases of papillary thyroid cancer-comparison of the results of histopathology, immunohistochemistry and reverse transcription-polymerase chain reaction-a preliminary report. Pomorski L, Kaczka K, Piaskowski S, Wójcik I, Rieske P, Matejkowska M, Kuzdak K, Langenbecks Arch Surg 2005 390 209 215 10.1007/s00423-004-0528-1 15645281
29. Hypogonadism in a patient with two novel mutations of the luteinizing hormone beta-subunit gene expressed in a compound heterozygous form. Basciani S, Watanabe M, Mariani S, Passeri M, Persichetti A, Fiore D, Scotto D'Abusco A, Caprio M, Lenzi A, Fabbri A, Gnessi L, J Clin Endocrinol Metab 2012 97 3031 3038 10.1210/jc.2012-1986 22723313
30. Techincal evaluation of a new immunoradiometric and a new immunoluminometric assay for thyroglobulin. Morgenthaler NG, Froehlich J, Rendl J, Willnich M, Alonso C, Bergmann A, Reiners C, Clin Chem 2002 48 1077 1083 12089177
31. The diagnostic value for differentiated thyroid carcinoma metastases of thyroglobulin (Tg) measurement in washout fluid from fine-needle aspiration biopsy of neck lymph node is maintained in presence of circulating anti-Tg antibodies. Boi F, Baghino G, Atzeni F, Lai ML, Faa G, Mariotti S, J Clin Endocrinol Metab 2006 91 1364 1369 10.1210/jc.2005-1705 16434461
32. TSH receptor and thyroid specific genes expression in human skin. Cianfarani F, Baldini E, Cavalli A, Marchioni E, Lembo L, Teson M, Persechino S, Zambruno G, Ulisse S, Odorisio T, D'Armiento M, J Invest Dermatol 2010 130 93 101 10.1038/jid.2009.180 19641516
33. Diagnostic utility of thyroglobulin measurement in the fine needle aspirates from cervical lymph nodes: a case report. Baldini E, Sorrenti S, Catania A, Guaitoli E, Prinzi N, Mocini R, Nardi F, D'Armiento E, Bianchini M, Favoriti P, Di Matteo FM, Ruggieri M, De Antoni E, Ulisse S, G Chir 2012 33 387 391 23140922