The Role of the acidity of N-heteroaryl sulfonamides as inhibitors of Bcl-2 family protein-protein interactions

ACS Medicinal Chemistry Letters

Volumn 4, Issue 2, 2013, Pages 186-190

  Touré, B Barry ^a   Miller Moslin, Karen ^a   Yusuff, Naeem ^a   Perez, Lawrence ^a   Doré, Michael ^a   Joud, Carol ^a   Michael, Walter ^a   Dipietro, Lucian ^a   Van Der Plas, Simon ^a   McEwan, Michael ^a   Lenoir, Francois ^a   Hoe, Madelene ^a   Karki, Rajesh ^a   Springer, Clayton ^a   Sullivan, John ^a   Levine, Kymberly ^a   Fiorilla, Catherine ^a   Xie, Xiaoling ^a   Kulathila, Raviraj ^a   Herlihy, Kara ^a   Porter, Dale ^a   Visser, Michael ^a   more..

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

apoptosis; B cell lymphoma; Bcl 2 family; cancer; protein protein interaction

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; NAVITOCLAX; PROTEIN BCL 2; SULFONAMIDE;

ACIDITY; ANIMAL EXPERIMENT; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; B CELL LYMPHOMA; BINDING AFFINITY; CELL SURVIVAL; CRYSTAL STRUCTURE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG POTENCY; DRUG SOLUBILITY; HYDROGEN BOND; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; STATIC ELECTRICITY;

EID: 84873946681     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml300321d     Document Type: Article

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