Assessing myocardial recovery following ST-segment elevation myocardial infarction: Short-and long-term perspectives using cardiovascular magnetic resonance

Expert Review of Cardiovascular Therapy

Volumn 11, Issue 2, 2013, Pages 203-219

  Klug, Gert ^a   Metzler, Bernhard ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

cine; CMR; first pass perfusion; late enhancement; STEMI; T2 weighted imaging

Indexed keywords

BLOOD VESSEL OCCLUSION; CARDIOVASCULAR MAGNETIC RESONANCE; CLINICAL ASSESSMENT; DIAGNOSTIC IMAGING; HEART INFARCTION SIZE; HEART LEFT ATRIUM; HEART LEFT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE; HUMAN; PATIENT CARE; REVIEW; SCINTIGRAPHY; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION;

ANIMALS; CONTRAST MEDIA; CORONARY CIRCULATION; HEART; HUMANS; MAGNETIC RESONANCE IMAGING; MICROVESSELS; MYOCARDIAL INFARCTION; MYOCARDIUM; PROGNOSIS; VENTRICULAR DYSFUNCTION; VENTRICULAR REMODELING;

EID: 84873916496     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.12.173     Document Type: Review

References (155)

1. Muller JE. Diagnosis of myocardial infarction: historical notes from the Soviet Union and the United States. Am. J. Cardiol. 40(2), 269-271 (1977).
2. Norris RM, Clarke ED, Sammel NL, Smith WM, Williams B. Protective effect of propranolol in threatened myocardial infarction. Lancet 2(8096), 907-909 (1978).
3. Chazov EI, Matveeva LS, Mazaev AV, Sargin KE, Sadovskaia GV, Ruda MI. [Intracoronary administration of fibrinolysin in acute myocardial infarct]. Ter. Arkh. 48(4), 8-19 (1976).
4. Rentrop KP, Blanke H, Karsch KR, Kreuzer H. Initial experience with transluminal recanalization of the recently occluded infarct-related coronary artery in acute myocardial infarction -comparison with conventionally treated patients. Clin. Cardiol. 2(2), 92-105 (1979).
5. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet 361(9351), 13-20 (2003).
6. Van de Werf F, Bax J, Betriu A et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur. Heart J. 29(23), 2909-2945 (2008).
7. Klug G, Trieb T, Schocke M et al. Quantification of regional functional improvement of infarcted myocardium after primary PTCA by contrast-enhanced magnetic resonance imaging. J. Magn. Reson. Imaging 29(2), 298-304 (2009).
8. Buller CE, Fu Y, Mahaffey KW et al. ST-segment recovery and outcome after primary percutaneous coronary intervention for ST-elevation myocardial infarction: insights from the Assessment of Pexelizumab in Acute Myocardial Infarction (APEX-AMI) trial. Circulation 118(13), 1335-1346 (2008).
9. Klug G, Mayr A, Schenk S et al. Prognostic value at 5 years of microvascular obstruction after acute myocardial infarction assessed by cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 14, 46 (2012).
10. de Waha S, Desch S, Eitel I et al. Impact of early vs. late microvascular obstruction assessed by magnetic resonance imaging on long-term outcome after ST-elevation myocardial infarction: a comparison with traditional prognostic markers. Eur. Heart J. 31(21), 2660-2668 (2010).
11. Haase A, Frahm J, Matthaei D et al. FLASH imaging: rapid NMR imaging using low flip-angle pulses. 1986. JMRI 67(2), 258-266 (1986).
12. Lackner K, Krahe T, Neubauer S, Ertl G. [Computed tomography and magnetic resonance tomography in cases of coronary heart disease]. Rontgenblatter 43(9), 391-397 (1990).
13. Abdel-Aty H, Zagrosek A, Schulz-Menger J et al. Delayed enhancement and T2-weighted cardiovascular magnetic resonance imaging differentiate acute from chronic myocardial infarction. Circulation 109(20), 2411-2416 (2004).
14. Ubachs JF, Engblom H, Erlinge D et al. Cardiovascular magnetic resonance of the myocardium at risk in acute reperfused myocardial infarction: comparison of T2-weighted imaging versus the circumferential endocardial extent of late gadolinium enhancement with transmural projection. J. Cardiovasc. Magn. Reson. 12, 18 (2010).
15. Carlsson M, Ubachs JF, Hedström E, Heiberg E, Jovinge S, Arheden H. Myocardium at risk after acute infarction in humans on cardiac magnetic resonance: quantitative assessment during follow-up and validation with single-photon emission computed tomography. JACC Cardiovasc. Imaging 2(5), 569-576 (2009).
16. O'Regan DP, Ahmed R, Karunanithy N et al. Reperfusion hemorrhage following acute myocardial infarction: assessment with T2, mapping and effect on measuring the area at risk. Radiology 250(3), 916-922 (2009).
17. Kumar A, Green JD, Sykes JM et al. Detection and quantification of myocardial reperfusion hemorrhage using T2, -weighted CMR. JACC. Cardiovasc. Imaging 4(12), 1274-1283 (2011).
18. Kim RJ, Wu E, Rafael A et al. The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N. Engl. J. Med. 343(20), 1445-1453 (2000).
19. Trieb T, Mayr A, Klug G et al. Patterns of myocardial perfusion in the acute and chronic stage after myocardial infarction: a cardiac magnetic resonance study. Eur. J. Radiol. 81(4), 767-772 (2012).
20. Syed MA, Carlson K, Murphy M, Ingkanisorn WP, Rhoads KL, Arai AE. Long-term safety of cardiac magnetic resonance imaging performed in the first few days after bare-metal stent implantation. J. Magn. Reson. Imaging 24(5), 1056-1061 (2006).
21. Ibrahim el-SH, Stuber M, Fahmy AS et al. Real-time MR imaging of myocardial regional function using strain-encoding (SENC) with tissue through-plane motion tracking. J. Magn. Reson. Imaging 26(6), 1461-1470 (2007).
22. Hedström E, Bloch KM, Bergvall E, Ståhlberg F, Arheden H. Effects of gadolinium contrast agent on aortic blood flow and myocardial strain measurements by phase-contrast cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 12, 70 (2010).
23. Bergvall E, Hedstrom E, Bloch KM, Arheden H, Sparr G. Spline-based cardiac motion tracking using velocity-encoded magnetic resonance imaging. IEEE Trans. Med. Imaging 27(8), 1045-1053 (2008).
24. Neizel M, Lossnitzer D, Korosoglou G et al. Strain-encoded (SENC) magnetic resonance imaging to evaluate regional heterogeneity of myocardial strain in healthy volunteers: comparison with conventional tagging. J. Magn. Reson. Imaging 29(1), 99-105 (2009).
25. Chang SA, Chang HJ, Choi SI et al. Usefulness of left ventricular dyssynchrony after acute myocardial infarction, assessed by a tagging magnetic resonance image derived metric, as a determinant of ventricular remodeling. Am. J. Cardiol. 104(1), 19-23 (2009).
26. Paelinck BP, Vrints CJ, Bax JJ et al. Relation of B-type natriuretic peptide early after acute myocardial infarction to left ventricular diastolic function and extent of myocardial damage determined by magnetic resonance imaging. Am. J. Cardiol. 97(8), 1146-1150 (2006).
27. Klug G, Wolf C, Trieb T et al. Evaluation of transient apical ballooning with cardiac magnetic resonance imaging and 31-phosphorous magnetic resonance spectroscopy. Int. J. Cardiol. 118(2), 249-252 (2007).
28. Weir RA, Martin TN, Petrie CJ et al. Cardiac and extracardiac abnormalities detected by cardiac magnetic resonance in a post-myocardial infarction cohort. Cardiology 113(1), 1-8 (2009).
29. Beek AM, Kühl HP, Bondarenko O et al. Delayed contrast-enhanced magnetic resonance imaging for the prediction of regional functional improvement after acute myocardial infarction. J. Am. Coll. Cardiol. 42(5), 895-901 (2003).
30. Geiser EA, Bove KE. Calculation of left ventricular mass and relative wall thickness. Arch. Pathol. 97(1), 13-21 (1974).
31. Cerqueira MD, Weissman NJ, Dilsizian V et al.; American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int. J. Cardiovasc. Imaging 18(1), 539-542 (2002).
32. Volpi A, De Vita C, Franzosi MG et al. Determinants of 6-month mortality in survivors of myocardial infarction after thrombolysis. Results of the GISSI-2 data base. The ad hoc Working Group of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-2 Data Base. Circulation 88(2), 416-429 (1993).
33. Pfeffer MA, Braunwald E, Moyé LA et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. N. Engl. J. Med. 327(10), 669-677 (1992).
34. Ingkanisorn WP, Rhoads KL, Aletras AH, Kellman P, Arai AE. Gadolinium delayed enhancement cardiovascular magnetic resonance correlates with clinical measures of myocardial infarction. J. Am. Coll. Cardiol. 43(12), 2253-2259 (2004).
35. Klug G, Mayr A, Mair J et al. Role of biomarkers in assessment of early infarct size after successful p-PCI for STEMI. Clin. Res. Cardiol. 100(6), 501-510 (2011).
36. Mayr A, Mair J, Schocke M et al. Predictive value of NT-pro BNP after acute myocardial infarction: relation with acute and chronic infarct size and myocardial function. Int. J. Cardiol. 147(1), 118-123 (2011).
37. Mayr A, Pedarnig K, Klug G et al. Regional functional recovery after acute myocardial infarction: a cardiac magnetic resonance long-term study. Int. J. Cardiovasc. Imaging 28(6), 1445-1453 (2012).
38. Nijveldt R, Beek AM, Hofman MB et al. Late gadolinium-enhanced cardiovascular magnetic resonance evaluation of infarct size and microvascular obstruction in optimally treated patients after acute myocardial infarction. J. Cardiovasc. Magn. Reson. 9(5), 765-770 (2007).
39. Mayr A, Mair J, Klug G et al. Cardiac troponin T and creatine kinase predict mid-term infarct size and left ventricular function after acute myocardial infarction: a cardiac MR study. J. Magn. Reson. Imaging 33(4), 847-854 (2011).
40. Baks T, van Geuns RJ, Biagini E et al. Recovery of left ventricular function after primary angioplasty for acute myocardial infarction. Eur. Heart J. 26(11), 1070-1077 (2005).
41. Nowosielski M, Schocke M, Mayr A et al. Comparison of wall thickening and ejection fraction by cardiovascular magnetic resonance and echocardiography in acute myocardial infarction. J. Cardiovasc. Magn. Reson. 11, 22 (2009).
42. McClements BM, Weyman AE, Newell JB, Picard MH. Echocardiographic determinants of left ventricular ejection fraction after acute myocardial infarction. Am. Heart J. 140(2), 284-289 (2000).
43. Ureña PE, Lamas GA, Mitchell G et al. Ejection fraction by radionuclide ventriculography and contrast left ventriculogram. A tale of two techniques. SAVE Investigators. Survival and Ventricular Enlargement. J. Am. Coll. Cardiol. 33(1), 180-185 (1999).
44. Rashid H, Exner DV, Mirsky I, Cooper HA, Waclawiw MA, Domanski MJ. Comparison of echocardiography and radionuclide angiography as predictors of mortality in patients with left ventricular dysfunction (studies of left ventricular dysfunction). Am. J. Cardiol. 84(3), 299-303 (1999).
45. Grothues F, Smith GC, Moon JC et al. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am. J. Cardiol. 90(1), 29-34 (2002).
46. Patel MR, Worthley SG, Stebbins A et al. Pexelizumab and infarct size in patients with acute myocardial infarction underAssessing going primary percutaneous coronary intervention: a delayed enhancement cardiac magnetic resonance substudy from the APEX-AMI trial. JACC Cardiovasc. Imaging 3(1), 52-60 (2010).
47. Traverse JH, Henry TD, Moye' LA. Is the measurement of left ventricular ejection fraction the proper end point for cell therapy trials? An analysis of the effect of bone marrow mononuclear stem cell administration on left ventricular ejection fraction after ST-segment elevation myocardial infarction when evaluated by cardiac magnetic resonance imaging. Am. Heart J. 162(4), 671-677 (2011).
48. Desch S, Eitel I, de Waha S et al. Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction. Trials 12, 204 (2011).
49. Bellenger NG, Burgess MI, Ray SG et al. Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable? Eur. Heart J. 21(16), 1387-1396 (2000).
50. Ganame J, Messalli G, Dymarkowski S et al. Impact of myocardial haemorrhage on left ventricular function and remodelling in patients with reperfused acute myocardial infarction. Eur. Heart J. 30(12), 1440-1449 (2009).
51. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling -concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling. Behalf of an International Forum on Cardiac Remodeling. J. Am. Coll. Cardiol. 35(3), 569-582 (2000).
52. Tarantini G, Razzolini R, Cacciavillani L et al. Influence of transmurality, infarct size, and severe microvascular obstruction on left ventricular remodeling and function after primary coronary angioplasty. Am. J. Cardiol. 98(8), 1033-1040 (2006).
53. Weir RA, Murphy CA, Petrie CJ et al. Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction. Circ. Cardiovasc. Imaging 3(4), 360-367 (2010).
54. Lund GK, Stork A, Muellerleile K et al. Prediction of left ventricular remodeling and analysis of infarct resorption in patients with reperfused myocardial infarcts by using contrast-enhanced MR imaging. Radiology 245(1), 95-102 (2007).
55. Masci PG, Ganame J, Strata E et al. Myocardial salvage by CMR correlates with LV remodeling and early ST-segment resolution in acute myocardial infarction. JACC Cardiovasc. Imaging 3(1), 45-51 (2010).
56. Ganame J, Messalli G, Masci PG et al. Time course of infarct healing and left ventricular remodelling in patients with reperfused ST segment elevation myocardial infarction using comprehensive magnetic resonance imaging. Eur. Radiol. 21(4), 693-701 (2011).
57. Møller JE, Hillis GS, Oh JK, Reeder GS, Gersh BJ, Pellikka PA. Wall motion score index and ejection fraction for risk stratification after acute myocardial infarction. Am. Heart J. 151(2), 419-425 (2006).
58. Baks T, van Geuns RJ, Biagini E et al. Effects of primary angioplasty for acute myocardial infarction on early and late infarct size and left ventricular wall characteristics. J. Am. Coll. Cardiol. 47(1), 40-44 (2006).
59. Ibrahim T, Hackl T, Nekolla SG et al. Acute myocardial infarction: serial cardiac MR imaging shows a decrease in delayed enhancement of the myocardium during the 1st week after reperfusion. Radiology 254(1), 88-97 (2010).
60. Francone M, Bucciarelli-Ducci C, Carbone I et al. Impact of primary coronary angioplasty delay on myocardial salvage, infarct size, and microvascular damage in patients with ST-segment elevation myocardial infarction: insight from cardiovascular magnetic resonance. J. Am. Coll. Cardiol. 54(23), 2145-2153 (2009).
61. Nijveldt R, Beek AM, Hirsch A et al. Functional recovery after acute myocardial infarction: comparison between angiography, electrocardiography, and cardiovascular magnetic resonance measures of microvascular injury. J. Am. Coll. Cardiol. 52(3), 181-189 (2008).
62. Choi KM, Kim RJ, Gubernikoff G, Vargas JD, Parker M, Judd RM. Transmural extent of acute myocardial infarction predicts long-term improvement in contractile function. Circulation 104(10), 1101-1107 (2001).
63. Wellnhofer E, Olariu A, Klein C et al. Magnetic resonance low-dose dobutamine test is superior to SCAR quantification for the prediction of functional recovery. Circulation 109(18), 2172-2174 (2004).
64. Barmeyer AA, Stork A, Bansmann M et al. Prediction of myocardial recovery by dobutamine magnetic resonance imaging and delayed enhancement early after reperfused acute myocardial infarction. Eur. Radiol. 18(1), 110-118 (2008).
65. Bodí V, Husser O, Sanchis J et al. Contractile reserve and extent of transmural necrosis in the setting of myocardial stunning: comparison at cardiac MR imaging. Radiology 255(3), 755-763 (2010).
66. Hudsmith LE, Petersen SE, Francis JM, Robson MD, Neubauer S. Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. J. Cardiovasc. Magn. Reson. 7(5), 775-782 (2005).
67. Jensen CJ, Jochims M, Hunold P, Sabin GV, Schlosser T, Bruder O. Right ventricular involvement in acute left ventricular myocardial infarction: prognostic implications of MRI findings. Am. J. Roentgenol. 194(3), 592-598 (2010).
68. Miszalski-Jamka T, Klimeczek P, Tomala M et al. Extent of RV dysfunction and myocardial infarction assessed by CMR are independent outcome predictors early after STEMI treated with primary angioplasty. JACC Cardiovasc. Imaging 3(12), 1237-1246 (2010).
69. Kühl JT, Lønborg J, Fuchs A et al. Assessment of left atrial volume and function: a comparative study between echocardiography, magnetic resonance imaging and multi slice computed tomography. Int. J. Cardiovasc. Imaging 28(5), 1061-1071 (2012).
70. Lønborg JT, Engstrøm T, Møller JE et al. Left atrial volume and function in patients following ST elevation myocardial infarction and the association with clinical outcome: a cardiovascular magnetic resonance study. Eur. Heart J. Cardiovasc. Imaging 14(2), 118-127 (2012).
71. Friedrich MG, Abdel-Aty H, Taylor A, Schulz-Menger J, Messroghli D, Dietz R. The salvaged area at risk in reperfused acute myocardial infarction as visualized by cardiovascular magnetic resonance. J. Am. Coll. Cardiol. 51(16), 1581-1587 (2008).
72. Higgins CB, Herfkens R, Lipton MJ et al. Nuclear magnetic resonance imaging of acute myocardial infarction in dogs: alterations in magnetic relaxation times. Am. J. Cardiol. 52(1), 184-188 (1983).
73. Steen H, Voss F, André F et al. Clinical feasibility study for detection of myocardial oedema by a cine SSFP sequence in comparison to a conventional T2-weighted sequence. Clin. Res. Cardiol. 101(2), 125-131 (2012).
74. Kellman P, Aletras AH, Mancini C, McVeigh ER, Arai AE. T2-prepared SSFP improves diagnostic confidence in edema imaging in acute myocardial infarction compared to turbo-spin-echo. Magn. Reson. Med. 57(5), 891-897 (2007).
75. Ubachs JF, Sorensson P, Engblom H et al. Myocardium at risk by magnetic resonance imaging: head-to-head comparison of T2-weighted imaging and contrastenhanced steady-state free precession. Eur. Heart J. Cardiovasc. Imaging 13(12), 1008-1015 (2012).
76. Sörensson P, Heiberg E, Saleh N et al. Assessment of myocardium at risk with contrast enhanced steady-state free precession cine cardiovascular magnetic resonance compared to single-photon emission computed tomography. J. Cardiovasc. Magn. Reson. 12(1), 25 (2010).
77. Desch S, Engelhardt H, Meissner J et al. Reliability of myocardial salvage assessment by cardiac magnetic resonance imaging in acute reperfused myocardial infarction. Int. J. Cardiovasc. Imaging 28(2), 263-272 (2012).
78. Ugander M, Bagi PS, Oki AJ et al. Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction. JACC. Cardiovasc. Imaging 5(6), 596-603 (2012).
79. Dall'Armellina E, Karia N, Lindsay AC et al. Dynamic changes of edema and late gadolinium enhancement after acute myocardial infarction and their relationship to functional recovery and salvage index. Circ. Cardiovasc. Imaging 4(3), 228-236 (2011).
80. Matsumoto H, Matsuda T, Miyamoto K, Shimada T, Mikuri M, Hiraoka Y. Peri-infarct zone on early contrastenhanced CMR imaging in patients with acute myocardial infarction. JACC Cardiovasc. Imaging 4(6), 610-618 (2011).
81. Lønborg J, Engstrøm T, Mathiasen AB, Vejlstrup N. Myocardial area at risk after ST-elevation myocardial infarction measured with the late gadolinium enhancement after scar remodeling and T2-weighted cardiac magnetic resonance imaging. Int. J. Cardiovasc. Imaging 28(6), 1455-1464 (2012).
82. Fuernau G, Eitel I, Franke V et al. Myocardium at risk in ST-segment elevation myocardial infarction comparison of T2-weighted edema imaging with the MR-assessed endocardial surface area and validation against angiographic scoring. JACC Cardiovasc. Imaging 4(9), 967-976 (2011).
83. Eitel I, Desch S, de Waha S et al. Longterm prognostic value of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. Heart 97(24), 2038-2045 (2011).
84. Sjögren J, Ubachs JF, Engblom H, Carlsson M, Arheden H, Heiberg E. Semi-automatic segmentation of myocardium at risk in T2-weighted cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 14, 10 (2012).
85. Oh-I D, Ridgway JP, Kuehne T et al. Cardiovascular magnetic resonance of myocardial edema using a short inversion time inversion recovery (STIR) black-blood technique: diagnostic accuracy of visual and semi-quantitative assessment. J. Cardiovasc. Magn. Reson. 14, 22 (2012).
86. Lotan CS, Miller SK, Cranney GB, Pohost GM, Elgavish GA. The effect of postinfarction intramyocardial hemorrhage on transverse relaxation time. Magn. Reson. Med. 23(2), 346-355 (1992).
87. Mikami Y, Sakuma H, Nagata M et al. Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction. Am. J. Roentgenol. 193(4), W321-W326 (2009).
88. Asanuma T, Tanabe K, Ochiai K et al. Relationship between progressive microvascular damage and intramyocardial hemorrhage in patients with reperfused anterior myocardial infarction: myocardial contrast echocardiographic study. Circulation 96(2), 448-453 (1997).
89. García-Dorado D, Oliveras J, Gili J et al. Analysis of myocardial oedema by magnetic resonance imaging early after coronary artery occlusion with or without reperfusion. Cardiovasc. Res. 27(8), 1462-1469 (1993).
90. Christian TF, Schwartz RS, Gibbons RJ. Determinants of infarct size in reperfusion therapy for acute myocardial infarction. Circulation 86(1), 81-90 (1992).
91. Ortiz-Pérez JT, Betriu A, Lee DC et al. Angiographic and magnetic resonance imaging evaluation of in-hospital delay in primary percutaneous intervention delivery on myocardial salvage. Am. J. Cardiol. 106(7), 924-930 (2010).
92. Ndrepepa G, Alger P, Fusaro M et al. Impact of perfusion restoration at epicardial and tissue levels on markers of myocardial necrosis and clinical outcome of patients with acute myocardial infarction. EuroIntervention 7(1), 128-135 (2011).
93. Eitel I, Desch S, Fuernau G et al. Prognostic significance and determinants of myocardial salvage assessed by cardiovascular magnetic resonance in acute reperfused myocardial infarction. J. Am. Coll. Cardiol. 55(22), 2470-2479 (2010).
94. Shin T, Hu HH, Pohost GM, Nayak KS. Three dimensional first-pass myocardial perfusion imaging at 3T: feasibility study. J. Cardiovasc. Magn. Reson. 10, 57 (2008).
95. Mayr A, Klug G, Schocke M et al. Late microvascular obstruction after acute myocardial infarction: relation with cardiac and inflammatory markers. Int. J. Cardiol. 157(3), 391-396 (2012).
96. Kellman P, Arai AE, McVeigh ER, Aletras AH. Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement. Magn. Reson. Med. 47(2), 372-383 (2002).
97. Klein C, Schmal TR, Nekolla SG, Schnackenburg B, Fleck E, Nagel E. Mechanism of late gadolinium enhancement in patients with acute myocardial infarction. J. Cardiovasc. Magn. Reson. 9(4), 653-658 (2007).
98. Hsu LY, Ingkanisorn WP, Kellman P, Aletras AH, Arai AE. Quantitative myocardial infarction on delayed enhancement MRI. Part II: clinical application of an automated feature analysis and combined thresholding infarct sizing algorithm. J. Magn. Reson. Imaging 23(3), 309-314 (2006).
99. Bondarenko O, Beek AM, Hofman MB et al. Standardizing the definition of hyperenhancement in the quantitative assessment of infarct size and myocardial viability using delayed contrast-enhanced CMR. J. Cardiovasc. Magn. Reson. 7(2), 481-485 (2005).
100. Heiberg E, Ugander M, Engblom H et al. Automated quantification of myocardial infarction from MR images by accounting for partial volume effects: animal, phantom, and human study. Radiology 246(2), 581-588 (2008).
101. Oshinski JN, Yang Z, Jones JR, Mata JF, French BA. Imaging time after Gd-DTPA injection is critical in using delayed enhancement to determine infarct size accurately with magnetic resonance imaging. Circulation 104(23), 2838-2842 (2001).
102. Jaffe R, Charron T, Puley G, Dick A, Strauss BH. Microvascular obstruction and the no-reflow phenomenon after percutaneous coronary intervention. Circulation 117(24), 3152-3156 (2008).
103. Lima JA, Judd RM, Bazille A, Schulman SP, Atalar E, Zerhouni EA. Regional heterogeneity of human myocardial infarcts demonstrated by contrast-enhanced MRI. Potential mechanisms. Circulation 92(5), 1117-1125 (1995).
104. Judd RM, Lugo-Olivieri CH, Arai M et al. Physiological basis of myocardial contrast enhancement in fast magnetic resonance images of 2-day-old reperfused canine infarcts. Circulation 92(7), 1902-1910 (1995).
105. Hombach V, Grebe O, Merkle N et al. Sequelae of acute myocardial infarction regarding cardiac structure and function and their prognostic significance as assessed by magnetic resonance imaging. Eur. Heart J. 26(6), 549-557 (2005).
106. Porto I, Burzotta F, Brancati M et al. Relation of myocardial blush grade to microvascular perfusion and myocardial infarct size after primary or rescue percutaneous coronary intervention. Am. J. Cardiol. 99(12), 1671-1673 (2007).
107. Wu KC, Kim RJ, Bluemke DA et al. Quantification and time course of microvascular obstruction by contrastenhanced echocardiography and magnetic resonance imaging following acute myocardial infarction and reperfusion. J. Am. Coll. Cardiol. 32(6), 1756-1764 (1998).
108. Niccoli G, Spaziani C, Cosentino N et al. Predictors of myocardial microvascular obstruction in patients treated by primary percutaneous coronary intervention and a short ischemic time. Int. J. Cardiol. 153(1), 113-115 (2011).
109. Yip HK, Chen MC, Chang HW et al. Angiographic morphologic features of infarct-related arteries and timely reperfusion in acute myocardial infarction: predictors of slow-flow and no-reflow phenomenon. Chest 122(4), 1322-1332 (2002).
110. Wu KC, Zerhouni EA, Judd RM et al. Prognostic significance of microvascular obstruction by magnetic resonance imaging in patients with acute myocardial infarction. Circulation 97(8), 765-772 (1998).
111. Arheden H, Saeed M, Higgins CB et al. Measurement of the distribution volume of gadopentetate dimeglumine at echo-planar MR imaging to quantify myocardial infarction: comparison with 99mTc-DTPA autoradiography in rats. Radiology 211(3), 698-708 (1999).
112. Mahrholdt H, Wagner A, Judd RM, Sechtem U. Assessment of myocardial viability by cardiovascular magnetic resonance imaging. Eur. Heart J. 23(8), 602-619 (2002).
113. Metzler B, Hammerer-Lercher A, Jehle J et al. Plasma cardiac troponin T closely correlates with infarct size in a mouse model of acute myocardial infarction. Clin. Chim. Acta 325(1-2), 87-90 (2002).
114. Voelkl JG, Haubner BJ, Kremser C et al. Cardiac imaging using clinical 1.5 T MRI scanners in a murine ischemia/reperfusion model. J. Biomed. Biotechnol. 2011, 185683 (2011).
115. Thiele H, Kappl MJ, Linke A et al. Influence of time-to-treatment, TIMI-flow grades, and ST-segment resolution on infarct size and infarct transmurality as assessed by delayed enhancement magnetic resonance imaging. Eur. Heart J. 28(12), 1433-1439 (2007).
116. de Waha S, Eitel I, Desch S et al. Timedependency, predictors and clinical impact of infarct transmurality assessed by magnetic resonance imaging in patients with ST-elevation myocardial infarction reperfused by primary coronary percutaneous intervention. Clin. Res. Cardiol. 101(3), 191-200 (2012).
117. Brodie BR, Webb J, Cox DA et al.; EMERALD Investigators. Impact of time to treatment on myocardial reperfusion and infarct size with primary percutaneous coronary intervention for acute myocardial infarction (from the EMERALD Trial). Am. J. Cardiol. 99(12), 1680-1686 (2007).
118. Tarantini G, Cacciavillani L, Corbetti F et al. Duration of ischemia is a major determinant of transmurality and severe microvascular obstruction after primary angioplasty: a study performed with contrast-enhanced magnetic resonance. J. Am. Coll. Cardiol. 46(7), 1229-1235 (2005).
119. Hahn JY, Song YB, Gwon HC et al. Relation of left ventricular infarct transmurality and infarct size after primary percutaneous coronary angioplasty to time from symptom onset to balloon inflation. Am. J. Cardiol. 102(9), 1163-1169 (2008).
120. Reimer KA, Jennings RB. The 'wavefront phenomenon' of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow. Lab. Invest. 40(6), 633-644 (1979).
121. Roes SD, Kelle S, Kaandorp TA et al. Comparison of myocardial infarct size assessed with contrast-enhanced magnetic resonance imaging and left ventricular function and volumes to predict mortality in patients with healed myocardial infarction. Am. J. Cardiol. 100(6), 930-936 (2007).
122. Wu E, Ortiz JT, Tejedor P et al. Infarct size by contrast enhanced cardiac magnetic resonance is a stronger predictor of outcomes than left ventricular ejection fraction or end-systolic volume index: prospective cohort study. Heart 94(6), 730-736 (2008).
123. Schroeder AP, Houlind K, Pedersen EM, Nielsen TT, Egeblad H. Serial magnetic resonance imaging of global and regional left ventricular remodeling during 1 year after acute myocardial infarction. Cardiology 96(2), 106-114 (2001).
124. Peel SA, Hussain T, Schaeffter T, Greil GF, Lagemaat MW, Botnar RM. Cross-sectional and in-plane coronary vessel wall imaging using a local inversion prepulse and spiral read-out: a comparison between 1.5 and 3 Tesla. J. Magn. Reson. Imaging 35(4), 969-975 (2012).
125. Frick M, Klug G, Zwick RH et al. Different effects of rosuvastatin and simvastatin on myocardial high-energy phosphate metabolism. Int. J. Cardiol. 148(1), 112-114 (2011).
126. Klug G, Zwick RH, Frick M et al. Impact of exercise capacity on myocardial high-energy phosphate metabolism. Int. J. Sports Med. 28(8), 667-672 (2007).
127. Klug G, Zwick RH, Mayr A et al. Correlation of cardiovascular risk scores with myocardial high-energy phosphate metabolism. Int. J. Cardiol. 150(2), 208-210 (2011).
128. Bottomley PA, Wu KC, Gerstenblith G, Schulman SP, Steinberg A, Weiss RG. Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study. Circulation 119(14), 1918-1924 (2009).
129. Klug G, Kampf T, Bloemer S et al. Intracellular and extracellular T1 and T2 relaxivities of magneto-optical nanoparticles at experimental high fields. Magn. Reson. Med. 64(6), 1607-1615 (2010).
130. Klug G, Kampf T, Ziener C et al. Murine atherosclerotic plaque imaging with the USPIO Ferumoxtran-10. Front. Biosci. 14, 2546-2552 (2009).
131. Messroghli DR, Walters K, Plein S et al. Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn. Reson. Med. 58(1), 34-40 (2007).
132. Wacker CM, Hartlep AW, Pfleger S, Schad LR, Ertl G, Bauer WR. Susceptibilitysensitive magnetic resonance imaging detects human myocardium supplied by a stenotic coronary artery without a contrast agent. J. Am. Coll. Cardiol. 41(5), 834-840 (2003).
133. Arnold JR, Karamitsos TD, Bhamra-Ariza P et al. Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 Tesla. J. Am. Coll. Cardiol. 59(22), 1954-1964 (2012).
134. Ghugre NR, Ramanan V, Pop M et al. Myocardial BOLD imaging at 3 T using quantitative T2: application in a myocardial infarct model. Magn. Reson. Med. 66(6), 1739-1747 (2011).
135. Egred M, Al-Mohammad A, Waiter GD et al. Detection of scarred and viable myocardium using a new magnetic resonance imaging technique: blood oxygen level dependent (BOLD) MRI. Heart 89(7), 738-744 (2003).
136. Ferreira VM, Piechnik SK, Dall'Armellina E et al. Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 14, 42 (2012).
137. Ugander M, Oki AJ, Hsu LY et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and sub-clinical myocardial pathology. Eur. Heart J. 33(10), 1268-1278 (2012).
138. Wong TC, Piehler K, Meier CG et al. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 126(10), 1206-1216 (2012).
139. Sosnovik DE, Nahrendorf M, Deliolanis N et al. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation 115(11), 1384-1391 (2007).
140. Nahrendorf M, Jaffer FA, Kelly KA et al. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation 114(14), 1504-1511 (2006).
141. Michalska M, Machtoub L, Manthey HD et al. Visualization of vascular inflammation in the atherosclerotic mouse by ultrasmall superparamagnetic iron oxide vascular cell adhesion molecule-1-specific nanoparticles. Arterioscler. Thromb. Vasc. Biol. 32(10), 2350-2357 (2012).
142. Alam SR, Shah AS, Richards J et al. Ultrasmall superparamagnetic particles of iron oxide in patients with acute myocardial infarction: early clinical experience. Circ. Cardiovasc. Imaging 5(5), 559-565 (2012).
143. Yilmaz A, Rösch S, Klingel K et al. Magnetic resonance imaging (MRI) of inflamed myocardium using iron oxide nanoparticles in patients with acute myocardial infarction -preliminary results. Int. J. Cardiol. 101(4), 255-261 (2011).
144. Parczyk M, Herold V, Klug G, Bauer WR, Rommel E, Jakob PM. Regional in vivo transit time measurements of aortic pulse wave velocity in mice with high-field CMR at 17.6 Tesla. J. Cardiovasc. Magn. Reson. 12, 72 (2010).
145. Herold V, Parczyk M, Mörchel P et al. In vivo measurement of local aortic pulse-wave velocity in mice with MR microscopy at 17.6 Tesla. Magn. Reson. Med. 61(6), 1293-1299 (2009).
146. Delfino JG, Fornwalt BK, Eisner RL, Leon AR, Oshinski JN. Determination of transmural, endocardial, and epicardial radial strain and strain rate from phase contrast MR velocity data. J. Magn. Reson. Imaging 27(3), 522-528 (2008).
147. Carlsson M, Andersson R, Bloch KM et al. Cardiac output and cardiac index measured with cardiovascular magnetic resonance in healthy subjects, elite athletes and patients with congestive heart failure. J. Cardiovasc. Magn. Reson. 14, 51 (2012).
148. Bloch KM, Carlsson M, Arheden H, Ståhlberg F. Quantifying coronary sinus flow and global LV perfusion at 3T. BMC Med. Imaging 9, 9 (2009).
149. Uribe S, Beerbaum P, Sørensen TS, Rasmusson A, Razavi R, Schaeffter T. Four-dimensional (4D) flow of the whole heart and great vessels using real-time respiratory self-gating. Magn. Reson. Med. 62(4), 984-992 (2009).
150. Schiros CG, Dell'Italia LJ, Gladden JD et al. Magnetic resonance imaging with 3-dimensional analysis of left ventricular remodeling in isolated mitral regurgitation: implications beyond dimensions. Circulation 125(19), 2334-2342 (2012).
151. Klug G, Feistritzer H, Kremer M et al. Impact of cardiovascular risk factors on aortic pulse wave velocity: a comparison of healthy volunteers and patients after acute STEMI. Eur. H. J. Suppl. Abstract 632 (2012)
152. Hirsch GA, Ingkanisorn WP, Schulman SP et al. Age-related vascular stiffness and left ventricular size after myocardial infarction. Am. J. Geriatr. Cardiol. 16(4), 222-228 (2007).
153. Klug G, Kremer M, Feistritzer HJ et al. Impact of aortic stiffness on NT-pro BNP levels 4-months after acute STEMI. EuroCMR, Vienna, Austria (2012).
154. Wagner A, Bruder O, Schneider S et al. Current variables, definitions and endpoints of the European cardiovascular magnetic resonance registry. J. Cardiovasc. Magn. Reson. 11, 43 (2009).
155. Schwitter J, Wacker CM, Wilke N et al.; for the MR-IMPACT Investigators. MR-IMPACT II: Magnetic Resonance Imaging for Myocardial Perfusion Assessment in Coronary artery disease Trial: perfusion-cardiac magnetic resonance vs. single-photon emission computed tomography for the detection of coronary artery disease: a comparative multicentre, multivendor trial. Eur. Heart J. doi:10.1093/eurheartj/ehs022 (2012) (Epub ahead of print).