Inspiratory muscle training in heart disease and heart failure: A review of the literature with a focus on method of training and outcomes

Expert Review of Cardiovascular Therapy

Volumn 11, Issue 2, 2013, Pages 161-177

  Cahalin, Lawrence P ^a   Arena, Ross ^b   Guazzi, Marco ^c   Myers, Jonathan ^d   Cipriano, Gerson ^e   Chiappa, Gaspar ^f   Lavie, Carl J ^g,h   Forman, Daniel E ⁱ  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MILAN   (Italy)

^d STANFORD UNIVERSITY   (United States)

^e UNIVERSITY OF BRASILIA   (Brazil)

^f FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^g JOHN OCHSNER HEART AND VASCULAR INSTITUTE   (United States)

^h PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

breathing; heart failure; inspiratory muscle training; maximal inspiratory pressure

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; C REACTIVE PROTEIN; TUMOR NECROSIS FACTOR;

AEROBIC EXERCISE; ARTICLE; BODY EQUILIBRIUM; BREATHING; BREATHING EXERCISE; BREATHING MUSCLE; BREATHING RATE; DYSPNEA; ERGOMETRY; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART RATE VARIABILITY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INSPIRATORY MUSCLE TRAINING; ISCHEMIC HEART DISEASE; LUNG FUNCTION TEST; MEDICAL DEVICE; MUSCLE EXERCISE; MUSCLE FUNCTION; MUSCLE STRENGTH; MUSCLE TRAINING; OXYGEN CONSUMPTION; PERIPHERAL CIRCULATION; QUALITY OF LIFE; TREATMENT DURATION; TREATMENT OUTCOME; VASODILATATION;

BREATHING EXERCISES; CLINICAL TRIALS AS TOPIC; COMBINED MODALITY THERAPY; EVIDENCE-BASED MEDICINE; EXERCISE; HEART DISEASES; HEART FAILURE; HUMANS; PROGNOSIS;

EID: 84873888176     PISSN: 14779072     EISSN: 17448344     Source Type: Journal    
DOI: 10.1586/erc.12.191     Document Type: Article

References (63)

1. West JB. Respiratory Physiology: The Essentials (8th Edition). Lippincott Williams & Wilkins, Baltimore, MD, USA (2008).
2. West JB. Pulmonary Pathophysiology: The Essentials (7th Edition). Lippincott Williams & Wilkins, Baltimore, MD, USA (2008).
3. Ribeiro JP, Chiappa GR, Neder JA, Frankenstein L. Respiratory muscle function and exercise intolerance in heart failure. Curr. Heart Fail. Rep. 6(2), 95-101 (2009).
4. Mancini DM, Henson D, La Manca J, Donchez L, Levine S. Benefit of selective respiratory muscle training on exercise capacity in patients with chronic congestive heart failure. Circulation 91(2), 320-329 (1995).
5. Cahalin LP, Semigran MJ, Dec GW. Inspiratory muscle training in patients with chronic heart failure awaiting cardiac transplantation: results of a pilot clinical trial. Phys. Ther. 77(8), 830-838 (1997).
6. Johnson PH, Cowley AJ, Kinnear WJ. A randomized controlled trial of inspiratory muscle training in stable chronic heart failure. Eur. Heart J. 19(8), 1249-1253 (1998).
7. Darnley GM, Gray AC, McClure SJ et al. Effects of resistive breathing on exercise capacity and diaphragm function in patients with ischaemic heart disease. Eur. J. Heart Fail. 1(3), 297-300 (1999).
8. Weiner P, Waizman J, Magadle R, Berar-Yanay N, Pelled B. The effect of specific inspiratory muscle training on the sensation of dyspnea and exercise tolerance in patients with congestive heart failure. Clin. Cardiol. 22(11), 727-732 (1999).
9. Martinez A, Lisboa C, Jalil J et al. Selective training of respiratory muscles in patients with chronic heart failure. Rev. Med. Chil. 129(2), 133-139 (2001).
10. Cahalin L, Wagenaar R, Dec GW, Semigran MJ Endurance training in heart failure -a pilot study of the effects of cycle versus ventilatory muscle training. Circulation 104(17), II-453 (2001).
11. Laoutaris I, Dritsas A, Brown MD, Manginas A, Alivizatos PA, Cokkinos DV. Inspiratory muscle training using an incremental endurance test alleviates dyspnea and improves functional status in patients with chronic heart failure. Eur. J. Cardiovasc. Prev. Rehabil. 11(6), 489-496 (2004).
12. Hulzebos EHJ, Helders PJM, Favie NJ, De Bie RA, Brutel de la Riviere A, Van Meeteren NLU. Preoperative intensive inspiratory muscle training to prevent postoperative pulmonary complications in high-risk patients undergoing CABG surgery. JAMA 296, 1851-1857 (2006).
13. Dall'Ago P, Chiappa GR, Guths H, Stein R, Ribeiro JP. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. J. Am. Coll. Cardiol. 47(4), 757-763 (2006).
14. Laoutaris ID, Dritsas A, Brown MD et al. Immune response to inspiratory muscle training in patients with chronic heart failure. Eur. J. Cardiovasc. Prev. Rehabil. 14(5), 679-685 (2007).
15. Laoutaris ID, Dritsas A, Brown MD et al. Effects of inspiratory muscle training on autonomic activity, endothelial vasodilator function, and N-terminal pro-brain natriuretic peptide levels in chronic heart failure. J. Cardiopulm. Rehabil. Prev. 28(2), 99-106 (2008).
16. Chiappa GR, Roseguini BT, Vieira PJ et al. Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure. J. Am. Coll. Cardiol. 51(17), 1663-1671 (2008).
17. Padula CA, Yeaw E, Mistry S. A home-based nurse-coached inspiratory muscle training intervention in heart failure. Appl. Nurs. Res. 22(1), 18-25 (2009).
18. Stein R, Chiappa GR, Güths H, Dall'Ago P, Ribeiro JP. Inspiratory muscle training improves oxygen uptake efficiency slope in patients with chronic heart failure. J. Cardiopulm. Rehabil. Prev. 29(6), 392-395 (2009).
19. Winkelmann ER, Chiappa GR, Lima CO, Viecili PR, Stein R, Ribeiro JP. Addition of inspiratory muscle training to aerobic training improves cardiorespiratory responses to exercise in patients with heart failure and inspiratory muscle weakness. Am. Heart J. 158(5), 768.e1-768.e7 (2009).
20. Bosnak-Guclu M, Arikan H, Savci S et al. Effects of inspiratory muscle training in patients with heart failure. Respir. Med. 105(11), 1671-1681 (2011).
21. Mello PR, Guerra GM, Borile S et al. Inspiratory muscle training reduces sympathetic nervous activity and improves inspiratory muscle weakness and quality of life in patients with chronic heart failure: a clinical trial. J. Cardiopulm. Rehabil. Prev. 32(5), 255-261 (2012).
22. Laoutaris ID, Adamopoulos S, Manginas A et al. Benefits of combined aerobic/ resistance/inspiratory training in patients with chronic heart failure. A complete exercise model? A prospective randomised study. Int. J. Cardiol. doi:10.1016/j. ijcard.2012.05.019 (2012) (Epub ahead of print).
23. McParland C, Krishnan B, Wang Y, Gallagher CG. Inspiratory muscle weakness and dyspnea in congestive heart failure. Am. Rev. Respir. Dis. 146, 467 (1992).
24. Walsh JT, Andrews R, Johnson P, Phillips L, Cowley AJ, Kinnear WJ. Inspiratory muscle endurance in patients with chronic heart failure. Heart 76(4), 332-336 (1996).
25. Meyer FJ, Zugck C, Haass M et al. Inefficient ventilation and reduced respiratory muscle capacity in congestive heart failure. Basic Res. Cardiol. 95(4), 333-342 (2000).
26. Meyer FJ, Borst MM, Zugck C et al. Respiratory muscle dysfunction in congestive heart failure: clinical correlation and prognostic significance. Circulation 103(17), 2153-2158 (2001).
27. Coats AJ, Clark AL, Piepoli M, Volterrani M, Poole-Wilson PA. Symptoms and quality of life in heart failure: the muscle hypothesis. Br. Heart J. 72(Suppl. 2), S36-S39 (1994).
28. Coats AJ. The 'muscle hypothesis' of chronic heart failure. J. Mol. Cell. Cardiol. 28(11), 2255-2262 (1996).
29. Arena R, Guazzi M, Myers J. Ventilatory abnormalities during exercise in heart failure: a mini review. Curr. Respir. Med. Rev. 3, 179-187 (2007).
30. Wasserman K, Zhang YY, Gitt A et al. Lung function and exercise gas exchange in chronic heart failure. Circulation 96(7), 2221-2227 (1997).
31. Scott AC, Francis DP, Davies LC, Ponikowski P, Coats AJ, Piepoli MF. Contribution of skeletal muscle 'ergoreceptors' in the human leg to respiratory control in chronic heart failure. J. Physiol. (Lond.) 529(Pt 3), 863-870 (2000).
32. Seals DR. Robin Hood for the lungs? A respiratory metaboreflex that 'steals' blood flow from locomotor muscles. J. Physiol. (Lond.) 537(Pt 1), 2 (2001).
33. Harms CA, Wetter TJ, McClaran SR et al. Effects of respiratory muscle work on cardiac output and its distribution during maximal exercise. J. Appl. Physiol. 85(2), 609-618 (1998).
34. Witt JD, Guenette JA, Rupert JL, McKenzie DC, Sheel AW. Inspiratory muscle training attenuates the human respiratory muscle metaboreflex. J. Physiol. (Lond.) 584(Pt 3), 1019-1028 (2007).
35. Miller JD, Smith CA, Hemauer SJ, Dempsey JA. The effects of inspiratory intrathoracic pressure production on the cardiovascular response to submaximal exercise in health and chronic heart failure. Am. J. Physiol. Heart Circ. Physiol. 292(1), H580-H592 (2007).
36. Mancini DM, Ferraro N, Nazzaro D, Chance B, Wilson Jr. Respiratory muscle deoxygenation during exercise in patients with heart failure demonstrated with near-infrared spectroscopy. J. Am. Coll. Cardiol. 18(2), 492-498 (1991).
37. Borghi-Silva A, Carrascosa C, Oliveira CC et al. Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure. Am. J. Physiol. Heart Circ. Physiol. 294(6), H2465-H2472 (2008).
38. Bussotti M, Andreini D, Agostoni P. Exercise-induced changes in exhaled nitric oxide in heart failure. Eur. J. Heart Fail. 6(5), 551-554 (2004).
39. Chatham K, Gelder CM, Lines TA, Cahalin LP. Suspected statin-induced respiratory muscle myopathy during long-term inspiratory muscle training in a patient with diaphragmatic paralysis. Phys. Ther. 89(3), 257-266 (2009).
40. Enright SJ, Unnithan VB. Effect of inspiratory muscle training intensities on pulmonary function and work capacity in people who are healthy: a randomized controlled trial. Phys. Ther. 91(6), 894-905 (2011).
41. Enright SJ, Unnithan VB, Heward C, Withnall L, Davies DH. Effect of highintensity inspiratory muscle training on lung volumes, diaphragm thickness, and exercise capacity in subjects who are healthy. Phys. Ther. 86(3), 345-354 (2006).
42. Enright S, Chatham K, Ionescu AA, Unnithan VB, Shale DJ. Inspiratory muscle training improves lung function and exercise capacity in adults with cystic fibrosis. Chest 126(2), 405-411 (2004).
43. Chatham K, Ionescu AA, Nixon LS, Shale DJ. A short-term comparison of two methods of sputum expectoration in cystic fibrosis. Eur. Respir. J. 23(3), 435-439 (2004).
44. Ionescu AA, Chatham K, Davies CA, Nixon LS, Enright S, Shale DJ. Inspiratory muscle function and body composition in cystic fibrosis. Am. J. Respir. Crit. Care Med. 158(4), 1271-1276 (1998).
45. Chatham K, Berrow S, Beeson C, Griffiths L, Brough D, Musa I. Inspiratory pressures in adult cystic fibrosis. Physiotherapy 80(11), 748-752 (1994).
46. Chatham K, Baldwin J, Griffiths H, Summers L, Enright S. Inspiratory muscle training improves shuttle run performance in healthy subjects. Physiotherapy 85(12), 676-683 (1999).
47. Chatham K. Individualized fixed load inspiratory muscle training responses in a patient with severe restrictive lung disease and an elite sportsman. Physiotherapy 86(1), 28-30 (2000).
48. Mickleborough TD, Nichols T, Chatham K, Lindley MR, Ionescu AA, Shale DJ. The effect of high and low-intensity inspiratory muscle training on the physiological response to exercise in recreational runners. Scand. J. Med. Sci. Sports 20(3), 458-468 (2010).
49. Bruton A. A pilot study to investigate any relationship between sustained maximal inspiratory pressure and extubation outcome. Heart Lung 31(2), 141-149 (2002).
50. Cahalin LP, Li R, Almeida AS, Keisling B, Corrado G. Inspiratory muscle performance is significantly related to 2K and maximal incremental ergometry rowing in division 1 women's crew. Northeastern University Research Expo.April, 2011, Abstract 1989.
51. Ramirez-Sarmiento A, Orozco-Levi M, Guell R et al. Inspiratory muscle training in patients with chronic obstructive pulmonary disease: structural adaptation and physiologic outcomes. Am. J. Respir. Crit. Care Med. 166(11), 1491-1497 (2002).
52. Inbar O, Bar-Or O, Skinner JS. The Wingate Anaerobic Test. Human Kinetics, Champaign, IL, USA (1996).
53. Murphy RM, Shah RV, Malhotra R et al. Exercise oscillatory ventilation in systolic heart failure: an indicator of impaired hemodynamic response to exercise. Circulation 124(13), 1442-1451 (2011).
54. Zurek M, Corrà U, Piepoli MF, Binder RK, Saner H, Schmid JP. Exercise training reverses exertional oscillatory ventilation in heart failure patients. Eur. Respir. J. 40(5), 1238-1244 (2012).
55. Guazzi M, Vicenzi M, Arena R. Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study. Eur. J. Heart Fail. 14(1), 82-90 (2012).
56. Plentz RD, Sbruzzi G, Ribeiro RA, Ferreira JB, Dal Lago P. Inspiratory muscle training in patients with heart failure: meta-analysis of randomized trials. Arq. Bras. Cardiol. 99(2), 762-771 (2012).
57. Smart NA, Giallauria F, Dieberg G. Efficacy of inspiratory muscle training in chronic heart failure patients: a systematic review and meta-analysis. Int. J. Cardiol. (2012) doi:10.1016/j.ijcard.2012.04.029 (Epub ahead of print).
58. Laoutaris ID, Dritsas A, Brown MD et al. Inspiratory muscle training in a patient with left ventricular assist device. Hellenic J. Cardiol. 47(4), 238-241 (2006).
59. Laoutaris ID, Dritsas A, Adamopoulos S et al. Benefits of physical training on exercise capacity, inspiratory muscle function, and quality of life in patients with ventricular assist devices long-term postimplantation. Eur. J. Cardiovasc. Prev. Rehabil. 18(1), 33-40 (2011).
60. Mancini DM, Henson D, LaManca J, Levine S. Evidence of reduced respiratory muscle endurance in patients with heart failure. J. Am. Coll. Cardiol. 24(4), 972-981 (1994).
61. Tikunov B, Levine S, Mancini D. Chronic congestive heart failure elicits adaptations of endurance exercise in diaphragmatic muscle. Circulation 95(4), 910-916 (1997).
62. Sheel AW, Derchak PA, Morgan BJ, Pegelow DF, Jacques AJ, Dempsey JA. Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans. J. Physiol. 537, 277-289 (2001).
63. St Croix C, Morgan B, Wetter T, Dempsey J. Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans. J. Physiol. 529, 493-504 (2000).