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Volumn 24, Issue 2, 2013, Pages 283-291

Human epidermal growth factor receptor-2-positive breast cancer: Does estrogen receptor status define two distinct subtypes?

Author keywords

Breast cancer; Estrogen receptor; Human epidermal growth factor receptor 2; Outcomes; Subtypes

Indexed keywords

ANASTROZOLE; ANDROGEN RECEPTOR; BIOLOGICAL MARKER; CAPECITABINE; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; GEFITINIB; LAPATINIB; LETROZOLE; NAVELBINE; PACLITAXEL; PERTUZUMAB; TRASTUZUMAB;

EID: 84873881934     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mds286     Document Type: Review
Times cited : (59)

References (91)
  • 1
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 2000; 406: 747-752.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 2
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG et al. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987; 235: 177-182.
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3
  • 3
    • 0037440261 scopus 로고    scopus 로고
    • Quantitative association between HER-2/ neu and steroid hormone receptors in hormone receptor-positive primary breast cancer
    • Konecny G, Pauletti G, Pegram M et al. Quantitative association between HER-2/ neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. J Natl Cancer Inst 2003; 95: 142-153.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 142-153
    • Konecny, G.1    Pauletti, G.2    Pegram, M.3
  • 4
    • 0027756932 scopus 로고
    • Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades
    • Marsigliante S, Muscella A, Ciardo V et al. Enzyme-linked immunosorbent assay of HER-2/neu gene product (p185) in breast cancer: its correlation with sex steroid receptors, cathepsin D and histologic grades. Cancer Lett 1993; 75: 195-206.
    • (1993) Cancer Lett , vol.75 , pp. 195-206
    • Marsigliante, S.1    Muscella, A.2    Ciardo, V.3
  • 5
    • 81155151823 scopus 로고    scopus 로고
    • High false-negative rate of HER2 quantitative reverse transcription polymerase chain reaction of the Oncotype DX test: an independent quality assurance study
    • Dabbs DJ, Klein ME, Mohsin SK et al. High false-negative rate of HER2 quantitative reverse transcription polymerase chain reaction of the Oncotype DX test: an independent quality assurance study. J Clin Oncol 2011; 29: 4279-4285.
    • (2011) J Clin Oncol , vol.29 , pp. 4279-4285
    • Dabbs, D.J.1    Klein, M.E.2    Mohsin, S.K.3
  • 6
    • 78049427278 scopus 로고    scopus 로고
    • Human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories
    • Baehner FL, Achacoso N, Maddala T et al. Human epidermal growth factor receptor 2 assessment in a case-control study: comparison of fluorescence in situ hybridization and quantitative reverse transcription polymerase chain reaction performed by central laboratories. J Clin Oncol 2010; 28: 4300-4306.
    • (2010) J Clin Oncol , vol.28 , pp. 4300-4306
    • Baehner, F.L.1    Achacoso, N.2    Maddala, T.3
  • 7
    • 77954526150 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer
    • Hammond ME, Hayes DF, Dowsett M et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Clin Oncol 2010; 28(16):2784-2795.
    • (2010) J Clin Oncol , vol.28 , Issue.16 , pp. 2784-2795
    • Hammond, M.E.1    Hayes, D.F.2    Dowsett, M.3
  • 8
    • 79957492068 scopus 로고    scopus 로고
    • Clinical Notice for American Society of Clinical Oncology-College of American Pathologists guideline recommendations on ER/PgR and HER2 testing in breast cancer
    • Hammond ME, Hayes DF, Wolff AC. Clinical Notice for American Society of Clinical Oncology-College of American Pathologists guideline recommendations on ER/PgR and HER2 testing in breast cancer. J Clin Oncol 2011; 29: e458.
    • (2011) J Clin Oncol , vol.29
    • Hammond, M.E.1    Hayes, D.F.2    Wolff, A.C.3
  • 9
    • 45149107241 scopus 로고    scopus 로고
    • Estrogen-and progesterone-receptor status in ECOG 2197, comparison of immunohistochemistry by local and central laboratories and quantitative reverse transcription polymerase chain reaction by central laboratory
    • Badve SS, Baehner FL, Gray RP et al. Estrogen- and progesterone-receptor status in ECOG 2197: comparison of immunohistochemistry by local and central laboratories and quantitative reverse transcription polymerase chain reaction by central laboratory. J Clin Oncol 2008; 26: 2473-2481.
    • (2008) J Clin Oncol , vol.26 , pp. 2473-2481
    • Badve, S.S.1    Baehner, F.L.2    Gray, R.P.3
  • 10
    • 33847147313 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, Hammond ME, Schwartz JN et al. American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J Clin Oncol 2007; 25: 118-145.
    • (2007) J Clin Oncol , vol.25 , pp. 118-145
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 11
    • 0035845511 scopus 로고    scopus 로고
    • Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
    • Sorlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001; 98: 10869-10874.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10869-10874
    • Sorlie, T.1    Perou, C.M.2    Tibshirani, R.3
  • 12
    • 0037478605 scopus 로고    scopus 로고
    • Repeated observation of breast tumor subtypes in independent gene expression data sets
    • Sorlie T, Tibshirani R, Parker J et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci USA 2003; 100: 8418-8423.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8418-8423
    • Sorlie, T.1    Tibshirani, R.2    Parker, J.3
  • 13
    • 18244409687 scopus 로고    scopus 로고
    • Gene expression profiling predicts clinical outcome of breast cancer
    • van't Veer LJ, Dai H, van de Vijver MJ et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 2002; 415: 530-536.
    • (2002) Nature , vol.415 , pp. 530-536
    • van't Veer, L.J.1    Dai, H.2    van de Vijver, M.J.3
  • 14
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 2009; 69: 4116-4124.
    • (2009) Cancer Res , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1    Gonzalez-Angulo, A.M.2    Stemke-Hale, K.3
  • 15
    • 78049308800 scopus 로고    scopus 로고
    • Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
    • Prat A, Parker JS, Karginova O et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 2010; 12: R68.
    • (2010) Breast Cancer Res , vol.12
    • Prat, A.1    Parker, J.S.2    Karginova, O.3
  • 16
    • 58149330982 scopus 로고    scopus 로고
    • Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
    • Wirapati P, Sotiriou C, Kunkel S et al. Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 2008; 10: R65.
    • (2008) Breast Cancer Res , vol.10
    • Wirapati, P.1    Sotiriou, C.2    Kunkel, S.3
  • 17
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/ progenitor cell population driving tumorigenesis and invasion
    • Korkaya H, Paulson A, Iovino F et al. HER2 regulates the mammary stem/ progenitor cell population driving tumorigenesis and invasion. Oncogene 2008; 27: 6120-6130.
    • (2008) Oncogene , vol.27 , pp. 6120-6130
    • Korkaya, H.1    Paulson, A.2    Iovino, F.3
  • 18
    • 60849097255 scopus 로고    scopus 로고
    • Gene-expression signatures in breast cancer
    • Sotiriou C, Pusztai L. Gene-expression signatures in breast cancer. N Engl J Med 2009; 360: 790-800.
    • (2009) N Engl J Med , vol.360 , pp. 790-800
    • Sotiriou, C.1    Pusztai, L.2
  • 19
    • 79960980007 scopus 로고    scopus 로고
    • Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
    • Goldhirsch A, Wood WC, Coates AS et al. Strategies for subtypes-dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 2011; 22: 1736-1747.
    • (2011) Ann Oncol , vol.22 , pp. 1736-1747
    • Goldhirsch, A.1    Wood, W.C.2    Coates, A.S.3
  • 20
    • 78951482208 scopus 로고    scopus 로고
    • Deconstructing the molecular portraits of breast cancer
    • Prat A, Perou CM. Deconstructing the molecular portraits of breast cancer. Mol Oncol 2010; 5: 5-23.
    • (2010) Mol Oncol , vol.5 , pp. 5-23
    • Prat, A.1    Perou, C.M.2
  • 21
    • 62449131093 scopus 로고    scopus 로고
    • Supervised risk predictor of breast cancer based on intrinsic subtypes
    • Parker JS, Mullins M, Cheang MC et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J Clin Oncol 2009; 27: 1160-1167.
    • (2009) J Clin Oncol , vol.27 , pp. 1160-1167
    • Parker, J.S.1    Mullins, M.2    Cheang, M.C.3
  • 22
    • 55249092391 scopus 로고    scopus 로고
    • The genomic profile of HER2-amplified breast cancers: the influence of ER status
    • Marchio C, Natrajan R, Shiu KK et al. The genomic profile of HER2-amplified breast cancers: the influence of ER status. J Pathol 2008; 216: 399-407.
    • (2008) J Pathol , vol.216 , pp. 399-407
    • Marchio, C.1    Natrajan, R.2    Shiu, K.K.3
  • 23
    • 77957940993 scopus 로고    scopus 로고
    • High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer
    • Staaf J, Jonsson G, Ringner M et al. High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer. Breast Cancer Res 2010; 12: R25.
    • (2010) Breast Cancer Res , vol.12
    • Staaf, J.1    Jonsson, G.2    Ringner, M.3
  • 24
    • 82355179662 scopus 로고    scopus 로고
    • Response to neoadjuvant trastuzumab and chemotherapy in ER+ and ER- HER2-positive breast cancers: gene expression analysis [abstract]
    • Bianchini G, Prat A, Pickl M et al. Response to neoadjuvant trastuzumab and chemotherapy in ER+ and ER- HER2-positive breast cancers: gene expression analysis [abstract]. J Clin Oncol 2011; 29(Suppl): a529.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Bianchini, G.1    Prat, A.2    Pickl, M.3
  • 25
    • 84856806836 scopus 로고    scopus 로고
    • Neoadjuvant pertuzumab and trastuzumab: biomarker analyses of a 4-arm randomized phase II study (NeoSphere) in patients with HER2-positive breast cancer [abstract]
    • Gianni L, Bianchini G, Kiermaier A et al. Neoadjuvant pertuzumab and trastuzumab: biomarker analyses of a 4-arm randomized phase II study (NeoSphere) in patients with HER2-positive breast cancer [abstract]. Cancer Res 2011; 71(Suppl 24):a109s.
    • (2011) Cancer Res , vol.71 , Issue.SUPPL. 24
    • Gianni, L.1    Bianchini, G.2    Kiermaier, A.3
  • 26
    • 20144387695 scopus 로고    scopus 로고
    • PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma
    • Saal LH, Holm K, Maurer M et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res 2005; 65: 2554-2559.
    • (2005) Cancer Res , vol.65 , pp. 2554-2559
    • Saal, L.H.1    Holm, K.2    Maurer, M.3
  • 27
    • 76349117455 scopus 로고    scopus 로고
    • Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation
    • Niemeier LA, Dabbs DJ, Beriwal S et al. Androgen receptor in breast cancer: expression in estrogen receptor-positive tumors and in estrogen receptor-negative tumors with apocrine differentiation. Mod Pathol 2010; 23: 205-212.
    • (2010) Mod Pathol , vol.23 , pp. 205-212
    • Niemeier, L.A.1    Dabbs, D.J.2    Beriwal, S.3
  • 28
    • 77649188673 scopus 로고    scopus 로고
    • Expression of androgen receptors in primary breast cancer
    • Park S, Koo J, Park HS et al. Expression of androgen receptors in primary breast cancer. Ann Oncol 2010; 21: 488-492.
    • (2010) Ann Oncol , vol.21 , pp. 488-492
    • Park, S.1    Koo, J.2    Park, H.S.3
  • 29
    • 79959998479 scopus 로고    scopus 로고
    • Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study
    • Collins LC, Cole KS, Marotti JD et al. Androgen receptor expression in breast cancer in relation to molecular phenotype: results from the Nurses' Health Study. Mod Pathol 2011; 24: 924-931.
    • (2011) Mod Pathol , vol.24 , pp. 924-931
    • Collins, L.C.1    Cole, K.S.2    Marotti, J.D.3
  • 30
    • 84355162906 scopus 로고    scopus 로고
    • Coordinated expression of oestrogen and androgen receptors in HER2-positive breast carcinomas: impact on proliferative activity
    • Lin Fde M, Pincerato KM, Bacchi CE et al. Coordinated expression of oestrogen and androgen receptors in HER2-positive breast carcinomas: impact on proliferative activity. J Clin Pathol 2011; 65: 64-68.
    • (2011) J Clin Pathol , vol.65 , pp. 64-68
    • Lin Fde, M.1    Pincerato, K.M.2    Bacchi, C.E.3
  • 31
    • 68049128114 scopus 로고    scopus 로고
    • Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer
    • Peters AA, Buchanan G, Ricciardelli C et al. Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res 2009; 69: 6131-6140.
    • (2009) Cancer Res , vol.69 , pp. 6131-6140
    • Peters, A.A.1    Buchanan, G.2    Ricciardelli, C.3
  • 32
    • 79953315588 scopus 로고    scopus 로고
    • Androgen receptor expression and breast cancer survival in postmenopausal women
    • Hu R, Dawood S, Holmes MD et al. Androgen receptor expression and breast cancer survival in postmenopausal women. Clin Cancer Res 2011; 17: 1867-1874.
    • (2011) Clin Cancer Res , vol.17 , pp. 1867-1874
    • Hu, R.1    Dawood, S.2    Holmes, M.D.3
  • 33
    • 33745603978 scopus 로고    scopus 로고
    • An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen
    • Doane AS, Danso M, Lal P et al. An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 2006; 25: 3994-4008.
    • (2006) Oncogene , vol.25 , pp. 3994-4008
    • Doane, A.S.1    Danso, M.2    Lal, P.3
  • 34
    • 79960050587 scopus 로고    scopus 로고
    • Targeting androgen receptor in estrogen receptornegative breast cancer
    • Ni M, Chen Y, Lim E et al. Targeting androgen receptor in estrogen receptornegative breast cancer. Cancer Cell 2011; 20: 119-131.
    • (2011) Cancer Cell , vol.20 , pp. 119-131
    • Ni, M.1    Chen, Y.2    Lim, E.3
  • 35
    • 84855297353 scopus 로고    scopus 로고
    • Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial
    • Gianni L, Pienkowski T, Im YH et al. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2011; 13: 25-32.
    • (2011) Lancet Oncol , vol.13 , pp. 25-32
    • Gianni, L.1    Pienkowski, T.2    Im, Y.H.3
  • 36
    • 33748068094 scopus 로고    scopus 로고
    • Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive HER-2/neu-positive breast cancer
    • Massarweh S, Osborne CK, Jiang S et al. Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive, HER-2/neu-positive breast cancer. Cancer Res 2006; 66: 8266-8273.
    • (2006) Cancer Res , vol.66 , pp. 8266-8273
    • Massarweh, S.1    Osborne, C.K.2    Jiang, S.3
  • 37
    • 2942652871 scopus 로고    scopus 로고
    • Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    • Shou J, Massarweh S, Osborne CK et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. J Natl Cancer Inst 2004; 96: 926-935.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 926-935
    • Shou, J.1    Massarweh, S.2    Osborne, C.K.3
  • 38
    • 82155187061 scopus 로고    scopus 로고
    • Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-positive breast cancers-role of estrogen receptor and HER2 reactivation
    • Wang YC, Morrison G, Gillihan R et al. Different mechanisms for resistance to trastuzumab versus lapatinib in HER2-positive breast cancers-role of estrogen receptor and HER2 reactivation. Breast Cancer Res 2011; 13: R121.
    • (2011) Breast Cancer Res , vol.13
    • Wang, Y.C.1    Morrison, G.2    Gillihan, R.3
  • 39
    • 18744395754 scopus 로고    scopus 로고
    • Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study
    • Burstein HJ, Harris LN, Gelman R et al. Preoperative therapy with trastuzumab and paclitaxel followed by sequential adjuvant doxorubicin/cyclophosphamide for HER2 overexpressing stage II or III breast cancer: a pilot study. J Clin Oncol 2003; 21: 46-53.
    • (2003) J Clin Oncol , vol.21 , pp. 46-53
    • Burstein, H.J.1    Harris, L.N.2    Gelman, R.3
  • 40
    • 20544460650 scopus 로고    scopus 로고
    • Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer
    • Buzdar AU, Ibrahim NK, Francis D et al. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 2005; 23: 3676-3685.
    • (2005) J Clin Oncol , vol.23 , pp. 3676-3685
    • Buzdar, A.U.1    Ibrahim, N.K.2    Francis, D.3
  • 41
    • 75149182096 scopus 로고    scopus 로고
    • Hormone-receptor status and likelihood of predicting pathological complete response in the NOAH trial of neoadjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer [abstract]
    • Eiermann W, Baselga J, Semiglazov V et al. Hormone-receptor status and likelihood of predicting pathological complete response in the NOAH trial of neoadjuvant trastuzumab in patients with HER2-positive locally advanced breast cancer [abstract]. Eur J Cancer, 2008; 67(Suppl 115): a228.
    • (2008) Eur J Cancer , vol.67 , Issue.SUPPL 115
    • Eiermann, W.1    Baselga, J.2    Semiglazov, V.3
  • 42
    • 77951624086 scopus 로고    scopus 로고
    • Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study
    • Untch M, Rezai M, Loibl S et al. Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study. J Clin Oncol 2010; 28: 2024-2031.
    • (2010) J Clin Oncol , vol.28 , pp. 2024-2031
    • Untch, M.1    Rezai, M.2    Loibl, S.3
  • 43
    • 80054100462 scopus 로고    scopus 로고
    • Final results of a phase II randomized trial of neoadjuvant anthracycline-taxane chemotherapy plus lapatinib, trastuzumab, or both in HER2-positive breast cancer (CHER-LOB trial) [abstract]
    • Guarneri V, Frassoldati A, Bottini A et al. Final results of a phase II randomized trial of neoadjuvant anthracycline-taxane chemotherapy plus lapatinib, trastuzumab, or both in HER2-positive breast cancer (CHER-LOB trial) [abstract]. J Clin Oncol 2011; 29(Suppl): a507.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Guarneri, V.1    Frassoldati, A.2    Bottini, A.3
  • 44
    • 84857236823 scopus 로고    scopus 로고
    • Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial
    • Baselga J, Bradbury I, Eidtmann H et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet 2012; 379: 633-40.
    • (2012) Lancet , vol.379 , pp. 633-640
    • Baselga, J.1    Bradbury, I.2    Eidtmann, H.3
  • 45
    • 0002477351 scopus 로고    scopus 로고
    • The EGFR-selective tyrosine kinase inhibitor ZD 1839 (Iressa) is an effective inhibitor of tamoxifen-resistant breast cancer growth [abstract]
    • Gee JM, Hutcheson IR, Knowlden JM et al. The EGFR-selective tyrosine kinase inhibitor ZD 1839 (Iressa) is an effective inhibitor of tamoxifen-resistant breast cancer growth [abstract]. Proc Am Soc Clin Oncol 2001; 20: 71a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Gee, J.M.1    Hutcheson, I.R.2    Knowlden, J.M.3
  • 46
    • 0027405070 scopus 로고
    • Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region
    • Ali S, Metzger D, Bornert JM et al. Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region. EMBO J 1993; 12: 1153-1160.
    • (1993) EMBO J , vol.12 , pp. 1153-1160
    • Ali, S.1    Metzger, D.2    Bornert, J.M.3
  • 47
    • 0001392322 scopus 로고    scopus 로고
    • AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor
    • Font de Mora J, Brown M. AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor. Mol Cell Biol 2000; 20: 5041-5047.
    • (2000) Mol Cell Biol , vol.20 , pp. 5041-5047
    • Font de Mora, J.1    Brown, M.2
  • 48
    • 34249739172 scopus 로고    scopus 로고
    • Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy
    • Arpino G, Gutierrez C, Weiss H et al. Treatment of human epidermal growth factor receptor 2-overexpressing breast cancer xenografts with multiagent HER-targeted therapy. J Natl Cancer Inst 2007; 99: 694-705.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 694-705
    • Arpino, G.1    Gutierrez, C.2    Weiss, H.3
  • 49
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study
    • Kaufman B, Mackey JR, Clemens MR et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009; 27: 5529-5537.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3
  • 50
    • 73149115341 scopus 로고    scopus 로고
    • Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptorpositive metastatic breast cancer
    • Johnston S, Pippen J, Jr, Pivot X et al. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptorpositive metastatic breast cancer. J Clin Oncol 2009; 27: 5538-5546.
    • (2009) J Clin Oncol , vol.27 , pp. 5538-5546
    • Johnston, S.1    Pippen Jr, J.2    Pivot, X.3
  • 51
    • 80051508992 scopus 로고    scopus 로고
    • TBCRC 006 A multicenter phase II study of neoadjuvant lapatinib and trastuzumab in patients with HER2-overexpressing breast cancer [abstract]
    • Chang JCN, Mayer IA, Forero-Torres A et al. TBCRC 006: A multicenter phase II study of neoadjuvant lapatinib and trastuzumab in patients with HER2-overexpressing breast cancer [abstract]. J Clin Oncol 2011; 29(Suppl): a505.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Chang, J.C.N.1    Mayer, I.A.2    Forero-Torres, A.3
  • 52
    • 0033050164 scopus 로고    scopus 로고
    • Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy
    • Kuerer HM, Newman LA, Smith TL et al. Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy. J Clin Oncol 1999; 17: 460-469.
    • (1999) J Clin Oncol , vol.17 , pp. 460-469
    • Kuerer, H.M.1    Newman, L.A.2    Smith, T.L.3
  • 53
    • 33644973070 scopus 로고    scopus 로고
    • Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors
    • Guarneri V, Broglio K, Kau SW et al. Prognostic value of pathologic complete response after primary chemotherapy in relation to hormone receptor status and other factors. J Clin Oncol 2006; 24: 1037-1044.
    • (2006) J Clin Oncol , vol.24 , pp. 1037-1044
    • Guarneri, V.1    Broglio, K.2    Kau, S.W.3
  • 54
    • 12344277756 scopus 로고    scopus 로고
    • Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer
    • Ring AE, Smith IE, Ashley S et al. Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. Br J Cancer 2004; 91: 2012-2017.
    • (2004) Br J Cancer , vol.91 , pp. 2012-2017
    • Ring, A.E.1    Smith, I.E.2    Ashley, S.3
  • 55
    • 5144219905 scopus 로고    scopus 로고
    • Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment
    • Colleoni M, Viale G, Zahrieh D et al. Chemotherapy is more effective in patients with breast cancer not expressing steroid hormone receptors: a study of preoperative treatment. Clin Cancer Res 2004; 10: 6622-6628.
    • (2004) Clin Cancer Res , vol.10 , pp. 6622-6628
    • Colleoni, M.1    Viale, G.2    Zahrieh, D.3
  • 56
    • 34447333123 scopus 로고    scopus 로고
    • Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in estrogen receptor-positive breast cancers
    • Mazouni C, Kau SW, Frye D et al. Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in estrogen receptor-positive breast cancers. Ann Oncol 2007; 18: 874-880.
    • (2007) Ann Oncol , vol.18 , pp. 874-880
    • Mazouni, C.1    Kau, S.W.2    Frye, D.3
  • 57
    • 33847063053 scopus 로고    scopus 로고
    • The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes
    • Carey LA, Dees EC, Sawyer L et al. The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007; 13: 2329-2334.
    • (2007) Clin Cancer Res , vol.13 , pp. 2329-2334
    • Carey, L.A.1    Dees, E.C.2    Sawyer, L.3
  • 58
    • 41649102048 scopus 로고    scopus 로고
    • Response to neoadjuvant therapy and longterm survival in patients with triple-negative breast cancer
    • Liedtke C, Mazouni C, Hess KR et al. Response to neoadjuvant therapy and longterm survival in patients with triple-negative breast cancer. J Clin Oncol 2008; 26: 1275-1281.
    • (2008) J Clin Oncol , vol.26 , pp. 1275-1281
    • Liedtke, C.1    Mazouni, C.2    Hess, K.R.3
  • 59
    • 79952823649 scopus 로고    scopus 로고
    • Molecular subtypes and tumor response to neoadjuvant chemotherapy in patients with locally advanced breast cancer
    • Kim SI, Sohn J, Koo JS et al. Molecular subtypes and tumor response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. Oncology 2011; 79: 324-330.
    • (2011) Oncology , vol.79 , pp. 324-330
    • Kim, S.I.1    Sohn, J.2    Koo, J.S.3
  • 60
    • 75149128222 scopus 로고    scopus 로고
    • Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy
    • Darb-Esfahani S, Loibl S, Muller BM et al. Identification of biology-based breast cancer types with distinct predictive and prognostic features: role of steroid hormone and HER2 receptor expression in patients treated with neoadjuvant anthracycline/taxane-based chemotherapy. Breast Cancer Res 2009; 11: R69.
    • (2009) Breast Cancer Res , vol.11
    • Darb-Esfahani, S.1    Loibl, S.2    Muller, B.M.3
  • 61
    • 84862303759 scopus 로고    scopus 로고
    • Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes
    • Von Minckwitz G, Untch M, Blohmer JU et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012; 30: 1796-804.
    • (2012) J Clin Oncol , vol.30 , pp. 1796-1804
    • Von Minckwitz, G.1    Untch, M.2    Blohmer, J.U.3
  • 62
    • 26844536978 scopus 로고    scopus 로고
    • Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
    • Romond EH, Perez EA, Bryant J et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353: 1673-1684.
    • (2005) N Engl J Med , vol.353 , pp. 1673-1684
    • Romond, E.H.1    Perez, E.A.2    Bryant, J.3
  • 63
    • 44849117186 scopus 로고    scopus 로고
    • Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial
    • Untch M, Gelber RD, Jackisch C et al. Estimating the magnitude of trastuzumab effects within patient subgroups in the HERA trial. Ann Oncol 2008; 19: 1090-1096.
    • (2008) Ann Oncol , vol.19 , pp. 1090-1096
    • Untch, M.1    Gelber, R.D.2    Jackisch, C.3
  • 64
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials
    • Early Breast Cancer Trialists Collaborative Group (EBCTCG)
    • Early Breast Cancer Trialists Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 65
    • 33645729203 scopus 로고    scopus 로고
    • Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer
    • Berry DA, Cirrincione C, Henderson IC et al. Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. J Am Med Assoc 2006; 295: 1658-1667.
    • (2006) J Am Med Assoc , vol.295 , pp. 1658-1667
    • Berry, D.A.1    Cirrincione, C.2    Henderson, I.C.3
  • 66
    • 21144435932 scopus 로고    scopus 로고
    • Adjuvant docetaxel for node-positive breast cancer
    • Martin M, Pienkowski T, Mackey J et al. Adjuvant docetaxel for node-positive breast cancer. N Engl J Med 2005; 352: 2302-2313.
    • (2005) N Engl J Med , vol.352 , pp. 2302-2313
    • Martin, M.1    Pienkowski, T.2    Mackey, J.3
  • 67
    • 35248895346 scopus 로고    scopus 로고
    • HER2 and response to paclitaxel in nodepositive breast cancer
    • Hayes DF, Thor AD, Dressler LG et al. HER2 and response to paclitaxel in nodepositive breast cancer. N Engl J Med 2007; 357: 1496-1506.
    • (2007) N Engl J Med , vol.357 , pp. 1496-1506
    • Hayes, D.F.1    Thor, A.D.2    Dressler, L.G.3
  • 68
    • 80053539103 scopus 로고    scopus 로고
    • Adjuvant trastuzumab in HER2-positive breast cancer
    • Slamon D, Eiermann W, Robert N et al. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011; 365: 1273-1283.
    • (2011) N Engl J Med , vol.365 , pp. 1273-1283
    • Slamon, D.1    Eiermann, W.2    Robert, N.3
  • 69
    • 80052728749 scopus 로고    scopus 로고
    • Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31
    • Perez EA, Romond EH, Suman VJ et al. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011; 29: 3366-3373.
    • (2011) J Clin Oncol , vol.29 , pp. 3366-3373
    • Perez, E.A.1    Romond, E.H.2    Suman, V.J.3
  • 70
    • 77954740501 scopus 로고    scopus 로고
    • Metastatic behavior of breast cancer subtypes
    • Kennecke H, Yerushalmi R, Woods R et al. Metastatic behavior of breast cancer subtypes. J Clin Oncol 2010; 28: 3271-3277.
    • (2010) J Clin Oncol , vol.28 , pp. 3271-3277
    • Kennecke, H.1    Yerushalmi, R.2    Woods, R.3
  • 71
    • 84894061059 scopus 로고    scopus 로고
    • Impact of hormone receptor (HR) status on clinicopathological features, patterns of recurrence and clinical outcomes among patients (pts) with human epidermal growth factor receptor-2 positive (HER2) breast cancer (BC) in the national comprehensive cancer network (NCCN) [abstract]
    • Vaz-Luis I, Ottesen R, Hughes M et al. Impact of hormone receptor (HR) status on clinicopathological features, patterns of recurrence and clinical outcomes among patients (pts) with human epidermal growth factor receptor-2 positive (HER2) breast cancer (BC) in the national comprehensive cancer network (NCCN) [abstract]. J Clin Oncol 2012; 30(Suppl): a599.
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Vaz-Luis, I.1    Ottesen, R.2    Hughes, M.3
  • 72
    • 0037367214 scopus 로고    scopus 로고
    • Estrogen receptors and distinct patterns of breast cancer relapse
    • Hess KR, Pusztai L, Buzdar AU et al. Estrogen receptors and distinct patterns of breast cancer relapse. Breast Cancer Res Treat 2003; 78: 105-118.
    • (2003) Breast Cancer Res Treat , vol.78 , pp. 105-118
    • Hess, K.R.1    Pusztai, L.2    Buzdar, A.U.3
  • 73
    • 77954676724 scopus 로고    scopus 로고
    • Patterns of relapse and metastatic spread in HER2-overexpressing breast cancer according to estrogen receptor status
    • Park YH, Lee S, Cho EY et al. Patterns of relapse and metastatic spread in HER2-overexpressing breast cancer according to estrogen receptor status. Cancer Chemother Pharmacol 2010; 66: 507-16.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 507-516
    • Park, Y.H.1    Lee, S.2    Cho, E.Y.3
  • 74
    • 0024708518 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev 1989; 8: 98-101.
    • (1989) 1889. Cancer Metastasis Rev , vol.8 , pp. 98-101
    • Paget, S.1
  • 75
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y, Siegel PM, Shu W et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 2003; 3: 537-549.
    • (2003) Cancer Cell , vol.3 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 76
    • 23144461051 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to lung
    • Minn AJ, Gupta GP, Siegel PM et al. Genes that mediate breast cancer metastasis to lung. Nature 2005; 436: 518-524.
    • (2005) Nature , vol.436 , pp. 518-524
    • Minn, A.J.1    Gupta, G.P.2    Siegel, P.M.3
  • 77
    • 67649300721 scopus 로고    scopus 로고
    • Genes that mediate breast cancer metastasis to the brain
    • Bos PD, Zhang XH, Nadal C et al. Genes that mediate breast cancer metastasis to the brain. Nature 2009; 459: 1005-1009.
    • (2009) Nature , vol.459 , pp. 1005-1009
    • Bos, P.D.1    Zhang, X.H.2    Nadal, C.3
  • 78
    • 60949088751 scopus 로고    scopus 로고
    • Identification of brain- and bone-specific breast cancer metastasis genes
    • Klein A, Olendrowitz C, Schmutzler R et al. Identification of brain- and bone-specific breast cancer metastasis genes. Cancer Lett 2009; 276: 212-220.
    • (2009) Cancer Lett , vol.276 , pp. 212-220
    • Klein, A.1    Olendrowitz, C.2    Schmutzler, R.3
  • 79
    • 32944462896 scopus 로고    scopus 로고
    • Hormone receptor status does not affect the clinical benefit of trastuzumab therapy for patients with metastatic breast cancer
    • Brufsky A, Lembersky B, Schiffman K et al. Hormone receptor status does not affect the clinical benefit of trastuzumab therapy for patients with metastatic breast cancer. Clin Breast Cancer 2005; 6: 247-252.
    • (2005) Clin Breast Cancer , vol.6 , pp. 247-252
    • Brufsky, A.1    Lembersky, B.2    Schiffman, K.3
  • 80
    • 46949109559 scopus 로고    scopus 로고
    • A phase II study of weekly vinorelbine and trastuzumab in patients with HER2-positive metastatic breast cancer
    • Bayo-Calero JL, Mayordomo JI, Sanchez-Rovira P et al. A phase II study of weekly vinorelbine and trastuzumab in patients with HER2-positive metastatic breast cancer. Clin Breast Cancer 2008; 8: 264-268.
    • (2008) Clin Breast Cancer , vol.8 , pp. 264-268
    • Bayo-Calero, J.L.1    Mayordomo, J.I.2    Sanchez-Rovira, P.3
  • 81
    • 77949893849 scopus 로고    scopus 로고
    • Randomized phase II trial of firstline trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer
    • Wardley AM, Pivot X, Morales-Vasquez F et al. Randomized phase II trial of firstline trastuzumab plus docetaxel and capecitabine compared with trastuzumab plus docetaxel in HER2-positive metastatic breast cancer. J Clin Oncol 2009; 28: 976-983.
    • (2009) J Clin Oncol , vol.28 , pp. 976-983
    • Wardley, A.M.1    Pivot, X.2    Morales-Vasquez, F.3
  • 82
    • 66949111527 scopus 로고    scopus 로고
    • Phase II trial of vinorelbine and trastuzumab in patients with HER2-positive metastatic breast cancer. A prospective, open label, non-controlled, multicenter phase II trial (to investigate efficacy and safety of this combination chemotherapy)
    • Schilling G, Bruweleit M, Harbeck N et al. Phase II trial of vinorelbine and trastuzumab in patients with HER2-positive metastatic breast cancer. A prospective, open label, non-controlled, multicenter phase II trial (to investigate efficacy and safety of this combination chemotherapy). Invest New Drugs 2009; 27: 166-172.
    • (2009) Invest New Drugs , vol.27 , pp. 166-172
    • Schilling, G.1    Bruweleit, M.2    Harbeck, N.3
  • 83
    • 84873860837 scopus 로고    scopus 로고
    • registHER: trastuzumab-based taxane or vinorelbine treatment selection in patients with HER2/neu-positive metastatic breast cancer: patient characteristics and preliminary outcomes [abstract]
    • Kaufman PA, Mayer M, Paik S et al. registHER: trastuzumab-based taxane or vinorelbine treatment selection in patients with HER2/neu-positive metastatic breast cancer: patient characteristics and preliminary outcomes [abstract]. In San Antonio Breast Cancer Symposium, 2006, Suppl, a2066.
    • (2006) In San Antonio Breast Cancer Symposium , Issue.SUPPL.
    • Kaufman, P.A.1    Mayer, M.2    Paik, S.3
  • 84
    • 69849105168 scopus 로고    scopus 로고
    • Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer
    • Finn RS, Press MF, Dering J et al. Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatment in HER2-negative or unknown metastatic breast cancer. J Clin Oncol 2009; 27: 3908-3915.
    • (2009) J Clin Oncol , vol.27 , pp. 3908-3915
    • Finn, R.S.1    Press, M.F.2    Dering, J.3
  • 85
    • 56549113680 scopus 로고    scopus 로고
    • A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses
    • Cameron D, Casey M, Press M et al. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008; 112: 533-543.
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 533-543
    • Cameron, D.1    Casey, M.2    Press, M.3
  • 86
    • 77249179256 scopus 로고    scopus 로고
    • Time to first tumor progression as outcome predictor of a second trasuzumab-based therapy beyond progression in HER-2 positive metastatic breast cancer
    • Metro G, Giannarelli D, Gemma D et al. Time to first tumor progression as outcome predictor of a second trasuzumab-based therapy beyond progression in HER-2 positive metastatic breast cancer. Breast J 2010; 16: 66-72.
    • (2010) Breast J , vol.16 , pp. 66-72
    • Metro, G.1    Giannarelli, D.2    Gemma, D.3
  • 87
    • 80053362290 scopus 로고    scopus 로고
    • Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer
    • von Minckwitz G, Schwedler K, Schmidt M et al. Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer. Eur J Cancer 2011; 47: 2273-2281.
    • (2011) Eur J Cancer , vol.47 , pp. 2273-2281
    • von Minckwitz, G.1    Schwedler, K.2    Schmidt, M.3
  • 88
    • 77949903478 scopus 로고    scopus 로고
    • Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
    • Baselga J, Gelmon KA, Verma S et al. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010; 28: 1138-44.
    • (2010) J Clin Oncol , vol.28 , pp. 1138-1144
    • Baselga, J.1    Gelmon, K.A.2    Verma, S.3
  • 89
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J, Cortes J, Kim SB et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012; 366: 109-19.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortes, J.2    Kim, S.B.3
  • 90
    • 58149153020 scopus 로고    scopus 로고
    • A phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer
    • Arteaga CL, O'Neill A, Moulder SL et al. A phase I-II study of combined blockade of the ErbB receptor network with trastuzumab and gefitinib in patients with HER2 (ErbB2)-overexpressing metastatic breast cancer. Clin Cancer Res 2008; 14: 6277-83.
    • (2008) Clin Cancer Res , vol.14 , pp. 6277-6283
    • Arteaga, C.L.1    O'Neill, A.2    Moulder, S.L.3
  • 91
    • 39749176127 scopus 로고    scopus 로고
    • Predicting features of breast cancer with gene expression patterns
    • Lu X, Wang ZC, Iglehart JD et al. Predicting features of breast cancer with gene expression patterns. Breast Cancer Res Treat 2008; 108: 191-201.
    • (2008) Breast Cancer Res Treat , vol.108 , pp. 191-201
    • Lu, X.1    Wang, Z.C.2    Iglehart, J.D.3


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