Bioenergetic Measurements in Children with Bipolar Disorder: A Pilot 31P Magnetic Resonance Spectroscopy Study

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Sikoglu, Elif M ^a   Jensen, J Eric ^b   Vitaliano, Gordana ^b   Liso Navarro, Ana A ^a   Renshaw, Perry F ^c   Frazier, Jean A ^a   Moore, Constance M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE PHOSPHATE; PHOSPHATE; PHOSPHORUS 31;

ADOLESCENT; ADULT; AGE; ARTICLE; BIPOLAR DISORDER; BLOOD LEVEL; BRAIN REGION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; FRONTAL LOBE; HUMAN; IMAGE ANALYSIS; MALE; MANIA; MOLECULAR DYNAMICS; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH MEASUREMENT; PHOSPHOROUS MAGNETIC RESONANCE SPECTROSCOPY; SCHOOL CHILD;

ADOLESCENT; BIPOLAR DISORDER; CHILD; ENERGY METABOLISM; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE IMAGING; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHATES; PHOSPHOCREATINE; YOUNG ADULT;

EID: 84873869239     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054536     Document Type: Article

References (23)

1. Quiroz JA, Gray NA, Kato T, Manji HK, (2008) Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 33: 2551-2565.
2. Rezin GT, Amboni G, Zugno AI, Quevedo J, Streck EL, (2009) Mitochondrial dysfunction and psychiatric disorders. Neurochemical research 34: 1021-1029.
3. Stork C, Renshaw PF, (2005) Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Molecular psychiatry 10: 900-919.
4. Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, et al. (2004) Molecular evidence for mitochondrial dysfunction in bipolar disorder. Archives of general psychiatry 61: 300-308.
5. Calabrese V, Scapagnini G, Giuffrida Stella AM, Bates TE, Clark JB, (2001) Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity. Neurochemical research 26: 739-764.
6. Kato T, Murashita J, Kamiya A, Shioiri T, Kato N, et al. (1998) Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity. European archives of psychiatry and clinical neuroscience 248: 301-306.
7. Kato T, Takahashi S, Shioiri T, Inubushi T, (1992) Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. Journal of affective disorders 26: 223-230.
8. Kato T, Takahashi S, Shioiri T, Inubushi T, (1993) Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. Journal of affective disorders 27: 53-59.
9. Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa H, et al. (1994) Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. Journal of affective disorders 31: 125-133.
10. Hamakawa H, Murashita J, Yamada N, Inubushi T, Kato N, et al. (2004) Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder. Psychiatry and clinical neurosciences 58: 82-88.
11. Dager SR, Friedman SD, Parow A, Demopulos C, Stoll AL, et al. (2004) Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of general psychiatry 61: 450-458.
12. Barbiroli B, Iotti S, Lodi R, (1998) Aspects of human bioenergetics as studied in vivo by magnetic resonance spectroscopy. Biochimie 80: 847-853.
13. Chance B, Im J, Nioka S, Kushmerick M, (2006) Skeletal muscle energetics with PNMR: personal views and historic perspectives. NMR in biomedicine 19: 904-926.
14. Young RC, Biggs JT, Ziegler VE, Meyer DA, (1978) A rating scale for mania: reliability, validity and sensitivity. The British journal of psychiatry: the journal of mental science 133: 429-435.
15. Poznanski E, Mokros H (1996) Children's Depression Rating Scale- Revised (CDRS-R) Manual. Los Angeles: Western Psychological Services.
16. Poznanski EO, Cook SC, Carroll BJ, (1979) A depression rating scale for children. Pediatrics 64: 442-450.
17. Rae C, Scott RB, Lee M, Simpson JM, Hines N, et al. (2003) Brain bioenergetics and cognitive ability. Developmental neuroscience 25: 324-331.
18. Moore CM, Frazier JA, Glod CA, Breeze JL, Dieterich M, et al. (2007) Glutamine and glutamate levels in children and adolescents with bipolar disorder: a 4.0-T proton magnetic resonance spectroscopy study of the anterior cingulate cortex. Journal of the American Academy of Child and Adolescent Psychiatry 46: 524-534.
19. Nissim I, (1999) Newer aspects of glutamine/glutamate metabolism: the role of acute pH changes. The American journal of physiology 277: F493-497.
20. Yildiz A, Moore CM, Sachs GS, Demopulos CM, Tunca Z, et al. (2005) Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled 31P magnetic resonance spectroscopy study. Psychiatry research 138: 51-59.
21. Mato S, Victoria Sanchez-Gomez M, Matute C, (2010) Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes. Glia 58: 1739-1747.
22. Clay HB, Sillivan S, Konradi C, (2011) Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia. International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience 29: 311-324.
23. Pettegrew JW, Keshavan MS, Panchalingam K, Strychor S, Kaplan DB, et al. (1991) Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Archives of general psychiatry 48: 563-568.