Inhibitory effects of Akebia quinata ethanol extracton TNF-α-mediated vascular inflammation in human aortic smooth muscle cells

Molecular Medicine Reports

Volumn 7, Issue 2, 2013, Pages 379-383

  Koo, Hyun Jung ^a   Sung, Yoon Young ^a   Kim, Ho Kyoung ^a  

^a Korea Institute of Oriental Medicine (KIOM)   (South Korea)

Author keywords

Adhesion molecules; Akebia quinata; Atherosclerosis; Cyclooxygenase 2; Inflammation

Indexed keywords

AKEBIA QUINATA EXTRACT; ALCOHOL; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PLANT EXTRACT; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AKEBIA QUINATA; ANTIINFLAMMATORY ACTIVITY; AORTA; AORTITIS; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL NUCLEUS; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEDICINAL PLANT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION;

ANTI-INFLAMMATORY AGENTS; AORTA; AORTITIS; CELL ADHESION; CELL ADHESION MOLECULES; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; E-SELECTIN; EMBRYOPHYTA; ETHANOL; HUMANS; MYOCYTES, SMOOTH MUSCLE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLANT EXTRACTS; PLANT STEMS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84873860518     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1193     Document Type: Article

References (25)

1. Lusis AJ: Atherosclerosis. Nature 407: 233-241, 2000.
2. Ross R: Atherosclerosis an inflammatory disease. N Engl J Med 340: 115-126, 1999.
3. Bevilacqua MP, Nelson RM, Mannori G and Cecconi O: Endothelial leukocyte adhesion molecules in human disease. Annu Rev Med 45: 361-378, 1994.
4. Bobryshev YV, Lord RS, Rainer SP and Munro VF: VCAM 1 expression and network of VCAM 1 positive vascular dendritic cells in advanced atherosclerotic lesions of carotid arteries and aortas. Acta Histochem 98: 185-194, 1996.
5. O'Brien KD, McDonald TO, Chait A, Allen MD and Alpers CE: Neovascular expression of E selectin, intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation 93: 672-682, 1996.
6. O'Brien KD, Allen MD, McDonald TO, Chait A, Harlan JM, Fishbein D, McCarty J, Ferguson M, Hudkins K and Benjamin CD: Vascular cell adhesion molecule 1 is expressed in human coronary atherosclerotic plaques. Implications for the mode of progression of advanced coronary atherosclerosis. J Clin Invest 92: 945-951, 1993.
7. Owens GK, Kumar MS and Wamhoff BR: Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84: 767-801, 2004.
8. Falk E: Pathogenesis of atherosclerosis. J Am Coll Cardiol 47 (Suppl8): C7-C12, 2006.
9. Braun M, Pietsch P, Schrör K, Baumann G and Felix SB: Cellular adhesion molecules on vascular smooth muscle cells. Cardiovasc Res 41: 395-401, 1999.
10. Jang Y, Lincoff AM, Plow EF and Topol EJ: Cell adhesion molecules in coronary artery disease. J Am Coll Cardiol 24: 1591-1601, 1994.
11. Davies MJ, Gordon JL, Gearing AJ, Pigott R, Woolf N, Katz D and Kyriakopoulos A: The expression of the adhesion molecules ICAM 1, VCAM 1, PECAM and E selectin in human atherosclerosis. J Pathol 171: 223-229, 1993.
12. Libby P and Li H: Vascular cell adhesion molecule 1 and smooth muscle cell activation during atherogenesis. J Clin Invest 92: 538-539, 1993.
13. Printseva OYu, Peclo MM and Gown AM: Various cell types in human atherosclerotic lesions express ICAM 1. Further immunocytochemical and immunochemical studies employing monoclonal antibody 10F3. Am J Pathol 140: 889-896, 1992.
14. Huo Y and Ley K: Adhesion molecules and atherogenesis. Acta Physiol Scand 173: 35-43, 2001.
15. Kitaoka F, Kakiuchi N, Long C, Itoga M, Mitsue A, Mouri C and Mikage M: Molecular characterization of akebia plants and the derived traditional herbal medicine. Biol Pharm Bull 32: 665-670, 2009.
16. Mimaki Y, Doi S, Kuroda M and Yokosuka A: Triterpene glycosides from the stems of Akebia quinata. Chem Pharm Bull 55: 1319-1324, 2007.
17. Choi J, Jung HJ, Lee KT and Park HJ: Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata. J Med Food 8: 78-85, 2005.
18. Tsuchiya S, Yamabe M, Yamaguchi Y, Kobayashi Y, Konno T and Tada K: Establishment and characterization of a human acute monocytic leukemia cell line (THP 1). Int J Cancer 26: 171-176, 1980.
19. Chen C, Chou C, Sun Y and Huang W: Tumor necrosis factor alpha induced activation of downstream NF kappaB site of the promoter mediates epithelial ICAM 1 expression and monocyte adhesion. Involvement of PKCalpha, tyrosine kinase and IKK2, but not MAPKs, pathway. Cell Signal 13: 543-553, 2001.
20. Collins T, Read MA, Neish AS, Whitley MZ, Thanos D and Maniatis T: Transcriptional regulation of endothelial cell adhesion molecules: NF kappa B and cytokine inducible enhancers. FASEB J 9: 899-909, 1995.
21. Ju JW, Kim SJ, Jun CD and Chun JS: p38 kinase and c Jun N terminal kinase oppositely regulates tumor necrosis factor alpha induced vascular cell adhesion molecule 1 expression and cell adhesion in chondrosarcoma cells. IUBMB Life 54: 293-299, 2002.
22. Ho AW, Wong CK and Lam CW: Tumor necrosis factor alpha up regulates the expression of CCL2 and adhesion molecules of human proximal tubular epithelial cells through MAPK signaling pathways. Immunobiology 213: 533-544, 2008.
23. Brasier AR: The nuclear factor kappaB interleukin 6 signalling pathway mediating vascular inflammation. Cardiovasc Res 86: 211-218, 2010.
24. Pahl HL: Activators and target genes of Rel/NF kappaB transcription factors. Oncogene 18: 6853-6866, 1999.
25. Waddick KG and Uckun FM: Innovative treatment programs against cancer: II. Nuclear factor kappaB (NF kappaB) as a molecular target. Biochem Pharmacol 57: 9-17, 1999.