Recent advances in pathophysiology of diabetes: Beyond the dirty dozen

Journal of the Pakistan Medical Association

Volumn 63, Issue 2, 2013, Pages 277-280

  Kalra, Sanjay ^a  

^a India   (India)

Author keywords

Insulin deficiency; Multifaceted syndrome; Pathophysiology

Indexed keywords

CANAGLIFLOZIN; DAPAGLIFLOZIN; DOPAMINE; EXENDIN 4; GLITAZONE DERIVATIVE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 1; LINAGLIPTIN; LIRAGLUTIDE; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PIOGLITAZONE; SAXAGLIPTIN; SEROTONIN; SITAGLIPTIN; SODIUM GLUCOSE COTRANSPORTER 2; TESTOSTERONE; VILDAGLIPTIN; VITAMIN D;

ADIPOCYTE; ARTICLE; BRAIN; DIABETES MELLITUS; DISEASE ASSOCIATION; GASTROINTESTINAL TRACT; HUMAN; HYPERGLYCEMIA; INSULIN DEFICIENCY; INSULIN RESISTANCE; KIDNEY; LIVER; MUSCLE; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 84873846496     PISSN: 00309982     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. DeFronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009; 58: 773-95.
2. Lin CY, Gurlo T, Haataja L, Hsueh WA, Butler PC. Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3?-kinase-dependent pathway. J Clin Endocrinol Metab 2005; 90: 6678-86.
3. Miyazaki Y, He H, Mandarino LJ, DeFronzo RA. Rosiglitazone improves downstream insulin-receptor signaling in type 2 diabetic patients. Diabetes 2003; 52: 1943-50.
4. Mu J, Qureshi SA, Brady EJ, Muise ES, Candelore MR, Jiang G et al. Anti-Diabetic Efficacy and Impact on Amino Acid Metabolism of GRA1, a Novel Small-Molecule Glucagon Receptor Antagonist. PLOS ONE 2012; 7: e49572. doi:10.1371/journal.pone.0049572.
5. Mudaliar S, Henry RR. The incretin hormones: from scientific discovery to practical therapeutics. Diabetologia 2012; 55: 1865-8.
6. DeFronzo RA, Davidson JA, Del Prato S. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes, Obesity and Metabolism, 2012; 14: 5-14.
7. Liu JJ, Lee T, DeFronzo RA. Why Do SGLT2 inhibitors inhibit only 30-50% of renal glucose reabsorption in humans? Diabetes 2012; 61: 2199-204.
8. German JP, Thaler JP, Wisse BE, Oh-I S, Sarruf DA, Matsen ME. Leptin activates a novel CNS mechanism for insulin-independent normalization of severe diabetic hyperglycemia. Endocrinology 2011; 152: 394-404.
9. Zachariah S, Sheldon B, Shojaee-Moradie F, Jackson NC, Backhouse K, Johnsen S et al. Insulin Detemir Reduces Weight Gain as a Result of Reduced Food Intake in Patients With Type 1 Diabetes. Diabetes Care 2011; 34: 1487-91.
10. Banks WA. Brain Meets Body: The Blood-Brain Barrier as an Endocrine Interface. Endocrinology 2012 153: 4111-9.
11. Kalra S, Chawla R, Madhu SV. The dirty dozen of diabetes. Ind J Endocrinol Metab 2013; in press.
12. Kalra S, Kalra B, Agrawal N, Kumar S. Dopamine: the forgotten felon in type 2 diabetes. Recent Pat Endocr Metab Immune Drug Discov 2011; 5: 61-5.
13. Gupta V. Vitamin D: Extra-skeletal effects. J Med Nutr Nutraceut 2012; 1: 17-26
14. Cheng Q, Leung PS. An update on the islet renin-angiotensin system. Peptides 2011; 32: 1087-95.
15. Hansen JB, Tonnesen MF, Madsen AN, Hagedorn PH, Friberg J, Grunnet LG, et al. Divalent Metal Transporter 1 Regulates Iron-Mediated ROS and Pancreatic β-Cell Fate in Response to Cytokines. Cell Metab 2012; 16: 449-61.
16. Sumara G, Sumara O, Kim JK, Karsenty G. Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation. Cell Metabolism 2012; 16: 588-600.