Antihyperglycemic and antihyperlipidemic activities of ethanolic extract of Zygophyllum album in streptozotocin-induced diabetic mice

Toxicology and Industrial Health

Volumn 29, Issue 1, 2013, Pages 43-51

  Ghoul, Jamel El ^a   Boughattas, Naceur A ^b   Ben Attia, Mossadok ^a  

^a Struggle and Prevention   (Tunisia)

^b UNIVERSITY OF MONASTIR   (Tunisia)

Author keywords

antihyperglycemia; blood biochemical parameters; blood glucose; diabetes mellitus; plant extract; Streptozotocin; Zygophyllum album

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; CHOLESTEROL; GLICLAZIDE; GLUCOKINASE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCOGEN; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; ZYGOPHYLLUM ALBUM EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETES CONTROL; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOGEN ANALYSIS; INSULIN BLOOD LEVEL; MALE; MOUSE; NONHUMAN; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; ZYGOPHYLLACEAE; ZYGOPHYLLUM ALBUM;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; ETHANOL; FEMALE; GLUCOSEPHOSPHATE DEHYDROGENASE; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; INSULIN; LIPOPROTEINS, HDL; LIVER; LIVER GLYCOGEN; MALE; MICE; PHOSPHOFRUCTOKINASES; PLANT EXTRACTS; ZYGOPHYLLUM;

EID: 84873837931     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233712442706     Document Type: Article

References (51)

1. Andersen L, Dinesen B, Jorgensen PN, Poulsen F, Roder MF (1993) Enzyme immunoassay for intact human insulin in serum or plasma. Clinical Chemistry 38: 578–582.
2. Bergmeyer HU (1984) Glucose-6-phosphate dehydrogenase. In: Bergmeyer HU (ed.) Methods of Enzymatic Analysis. Vol. 2. Weinheim: Verlag Chemie, pp.222–223.
3. Bottomely JM, Raymond FD (2007) Pharmaco-economic issues for diabetes therapy. Best Practice and Research Clinical Endocrinology and Metabolism 21: 657–685.
4. Bradford MM (1976) A refined and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248–254.
5. Castano JG, Nieto A, Felıu JE (1979) Inactivation of phosphofructokinase by glucagon in rat hepatocytes. Journal of Biological Chemistry 13: 5576–5579.
6. Choi JS, Yokozawa T, Oura H (1991) Improvement of hyperglycemia and hyperlipemia in streptozotocin-diabetic rats by a methanolic extract of Prunus da6idiana stems and its main component, prunin. Planta Medica 57: 208–211.
7. Elder C (2004) Ayurveda for diabetes mellitus: a review of the biomedical literature. Alternative Therapies in Health and Medicine 10: 44–50.
8. Fontbonne A, Eschwege E, Cambien F, Richard JL, Ducimetiere P, Thibult N et al., (1989) Hypertriglyceridaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Diabetologia 32: 300–304.
9. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18: 499–502.
10. Gandhi HR (2001) Diabetes and coronary artery disease: importance of risk factors. Cardioliology Today 1: 31–34.
11. Ghule BV, Ghante MH, Saoji AN, Yeole PG (2009) Antihyperlipidemic effect of the methanolic extract from Lagenaria siceraria stand. Fruit in hyperlipidemic rats. Journal of Ethnopharmacology 124: 333–337.
12. Gibbons S, Oriowo MA (2001) The Anti-hypertensive effects of Zygophyllum coccineum extracts in Rats. Phytotherapy Research 15: 452–455.
13. Gupta R, Gupta HP, Kumar N, Joshi AK, Gupta VP (1994) Lipoprotein lipids and prevalence of hyperlipidemia in rural India. Journal of Cardiovascular Risk 1: 179–184.
14. Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V, Watal G (2005) Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. Journal of Ethnopharmacology 99(1): 75–81.
15. Gupta S, Sharma SB, Bansal SK, Prabhu KM (2009) Antihyperglycemic and hypolipidemic activity of aqueous extract of Cassia auriculata L. leaves in experimental diabetes. Journal of Ethnopharmacology 123: 499–503.
16. Huang MT, Smart RC, Wong CQ, Conney AH (1988) Inhibitory effect of curcumin, chlorogenicacide, coffeic acid, and ferric acid on tumour promotion in mouse skin by 12-O-tertradecanoyl. Phorobiology 13: 5941–5946.
17. Jaouhari JT, Lazrek HB, Jana M (2000) The hypoglycemic activity of Zygophyllum gaetullum extracts in alloxan-induced hyperglycemic rats. Journal of Ethnopharmacology 69: 17–20.
18. Jia W, Gao WY, Xiao PG (2003) Antidiabetic drugs of plant origin used in China: composition, pharmacology and hypoglycemic mechanisms. Zhongguo Zhong Yao Za Zhi 28: 108–113.
19. Kalendra B, Oztruk M, Tuncdemir M, Usyal O, Dagistanli FK, Yagenaga I et al., (2002) Renoprotective effect of valsartan and enalapril in STZ-induced diabetes in rats. Acta Histochemica 104: 123–130.
20. Karunanayake EH, Tennekoon KH (1993) Search of novel hypoglycemic agents from medicinal plants. In: Sharma AK (ed.) Diabetes Mellitus and its Complications. An Update. New Delhi, India: Macmillan India Ltd, pp.192–205.
21. Kasetti RB, Rajasekhar MD, Kondeti VK, Fatima SS, Kumar EGT, Swapna S et al., (2010) Antihyperglycemic and antihyperlipidemic activities of methanol: water (4:1) fraction isolated from aqueous extract of Syzygium alternifolium seeds in streptozotocin induced diabetic rats. Food and Chemical Toxicology 48: 1078–1084.
22. Kim MJ, Ryu GR, Chung JS, Sim SS, Min Dos Rhie DJ, Yoon SH et al., (2003) Protective effect of epicatechin against the toxic effects of STZ on rat pancreatic islets: in vivo and in vitro. Pancreas 26: 292–299.
23. Kim SH, Hyun SH, Choung SY (2006) Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. Journal of Ethnopharmacology 104: 119–123.
24. Kumar G, Murugesan AG, Rajasekara Pandian M (2006) Effect of Helicteres isora L. bark extract on blood glucose and hepatic enzymes in streptozotocin induced diabetic rats. Pharmazie 61: 353–355.
25. Loci AS, Shaabha M, Khazraji AL, Husain A, Twaija A (1994) Hypoglycemic effect of a valuable extract of artemicisia herb alba II. Effect of a valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology 43: 167–171.
26. Maghrani M, Lemhadri A, Zeggwagh NA, El Amraoui M, Haloui M, Jouad H et al., (2004) Effects of an aqueous extract of Triticum repens on lipid metabolism in normal and recent-onset diabetic rats. Journal of Ethnopharmacology 90: 331–337.
27. Motta M, Giugno I, Bosco S, Pistone G, Ruello P, Maugeri D et al., (2001) Serum lipoprotein(a) changes in acute myocardial infraction. Panminevra Medica 43: 77–80.
28. Musabayane CT, Mahlalela N, Shode FO, Ojewole JA (2005) Effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocin-induced diabetic rats. Journal of Ethanopharmacology 97: 485–490.
29. Narayana DB, Dobriyal RM (2000) Complimentary medicines and 21st century therapeutics: challenges for pharmacologist. In: Gupta SK (ed.) Pharmacology and Therapeutics in the New Millennium. New Delhi, India: Narosa Publishing House, pp.326–335.
30. Newgard CB, Hirsch LJ, Foster DW, McGary JD (1983) Glycogen synthesis in the rat. Journal of Biological Chemistry 258: 8046–8052.
31. Oliveira HC, Dos Santos MP, Grigulo R, Lima LL, Martins DTO, Lima JCS et al., (2008) Antidiabetic activity of Vatairea macrocarpa extract in rats. Journal of Ethnopharmacology 115: 515–519.
32. Ong KC, Khoo HE (2000) Effects of myricetin on glycemia and glycogen metabolism in diabetic rats. Life Sciences 67: 1695–1705.
33. Pandikumar P, Prakash Babu N, Ignacimuthu S (2009) Hypoglycemic and antihyperglycemic effect of Begonia malabarica Lam. in normal and streptozotocin induced diabetic rats. Journal of Ethnopharmacology 124: 111–115.
34. Panneerselvam RS, Govindaswamy S (2002) Effect of sodium molybdate on carbohydrate metabolizing enzymes in alloxan induced diabetic rats. Journal of Nutritional Biochemistry 13: 21–26.
35. Patel K, Srinivasan K (1997) Plant foods in the management of diabetes mellitus: vegetables as potential hypoglycemic agents. Nahrung-Food 41: 68–74.
36. Platel K, Shurpalekar KS, Srinivasan K (1993) Effect of bitter gourd (Momordica charantia) on growth and blood constituents in albino rats. Nahrung-Food 37: 156–160.
37. Prince PSM, Menon VP, Gunasekaran G (1999) Hypolipidaemic action of Tinospora cordifolia roots in alloxan diabetic rats. Journal of Ethnopharmacology 64: 53–57.
38. Rao BK, Kesavulu MM, Giri R, Rao CA (1999) Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook. Fruit powder in alloxan-diabetic rats. Journal of Ethnopharmacology 67: 103–109.
39. Sasaki T, Matsy S, Sonae A (1972) Effect of acetic acid concentration on the colour reaction in the O-toluidine boric acid method for blood glucose estimation. Rinshb Kagaku 1: 346–353.
40. Sharma SB, Nasir A, Prabhu KM, Murthy PS (2006) Antihyperglycemic effect of the fruit-pulp of Eugenia jambolana in experimental diabetes mellitus. Journal of Ethnopharmacology 104: 367–373.
41. Sharma SR, Dwivedi SK, Swarup D (1997) Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. Journal of Ethnopharmacology 58: 39–44.
42. Shokeen P, Anand P, Murali YK, Tandon V (2008) Antidiabetic activity of 50% ethanolic extract of Ricinus communis and its purified fractions. Food and Chemical Toxicology 46: 3458–3466.
43. Siddique O, Sun Y, Lin JC, Chien YW (1987) Facilité de transport transdermique de l'insuline. Journal of Pharmaceutical Sciences 76: 341–345.
44. Singh SK, Kesari AN, Gupta RK, Jaiswal D, Watal G (2007) Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats. Journal of Ethnopharmacology 114: 174–179.
45. Stefek M, Tribulova N, Gajdoski A, Gajdosikova A (2002) The pyridoindole antioxidant stobadine attenuates histochemical changes in kidney of STZ-induced diabetic rats. Acta Histochemica 104: 413–417.
46. Tan BK, Tan CH, Pushparaj PN (2005) Anti-diabetic activity of the semipurified fractions of Averrhoa bilimbi in high fat diet fed-streptozotocin induced diabetic rats. Life Sciences 76: 2827–2839.
47. Temme EH, Van Hoydonck PG, Schouten EG, Kesteloot H (2002) Effects of a plant sterol enriched spread on serum lipids and lipoproteins in mildly hypercholesterolemic subjects. Acta Cardiologica 57: 111–115.
48. Ugochukwu NH, Babady NE (2003) Antihyperglycemic effect of aqueous and ethanolic extracts of Gongronema latifolium leaves on glucose and glycogen metabolism in livers of normal and streptozotocin-induced diabetic rats. Life Sciences 73: 1925–1938.
49. Vats V, Yadav SP, Grover JK (2004) Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. Journal of Ethnopharmacology 90: 155–160.
50. Yadav JP, Saini S, Kalia AN, Dangi AS (2008) Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvodora oleoides in normal and alloxan-induced diabetic rats. Indian Journal of Pharmacology 1: 23–27.
51. Yamagishi N, Nakayama K, Wakatsuki T, Hatayama T (2001) Characteristic changes of stress protein expression in streptozotocin induced diabetic rats. Life Sciences 9: 2603–2609.