CYP1A21*F contains the-163C>A substitution and is highly inducible

Pharmacogenetics and Genomics

Volumn 23, Issue 2, 2013, Pages 104-105

  Sim, Sarah C ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 1A2; CYTOCHROME P450 1A21; UNCLASSIFIED DRUG; CYP1A2 PROTEIN, HUMAN;

BLOOD PRESSURE; COFFEE; DNA POLYMORPHISM; DRUG METABOLISM; GENE SEQUENCE; GENETIC RISK; GENOTYPE; HUMAN; LETTER; PRIORITY JOURNAL; AMINO ACID SUBSTITUTION; CLASSIFICATION; ENZYME INDUCTION; GENETIC POLYMORPHISM; GENETICS; SMOKING;

AMINO ACID SUBSTITUTION; COFFEE; CYTOCHROME P-450 CYP1A2; ENZYME INDUCTION; HUMANS; POLYMORPHISM, GENETIC; SMOKING;

EID: 84873824894     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e32835ccc76     Document Type: Letter

References (4)

1. Sachse C, Brockmöller J, Bauer S, Roots I. Functional significance of a C-A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol 1999; 47:445-449.
2. Guessous I, Dobrinas M, Kutalik Z, Pruijm M, Ehret G, Maillard M, et al. Caffeine intake and CYP1A2 variants associated with high caffeine intake protect non-smokers from hypertension. Hum Mol Genet 2012; 21: 3283-3292.
3. Palatini P, Ceolotto G, Ragazzo F, Dorigatti F, Saladini F, Papparella I, et al. CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension. J Hypertens 2009; 27:1594-1601.
4. Ingelman-Sundberg M, Sim SC, Nebert DW. Coffee, myocardial infarction, and CYP nomenclature. JAMA 2006; 296:764-765, author reply 765-766.