Measuring Airway Surface Liquid Depth in Ex Vivo Mouse Airways by X-Ray Imaging for the Assessment of Cystic Fibrosis Airway Therapies

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Morgan, Kaye S ^a   Donnelley, Martin ^b,c   Paganin, David M ^a   Fouras, Andreas ^a   Yagi, Naoto ^d   Suzuki, Yoshio ^d   Takeuchi, Akihisa ^d   Uesugi, Kentaro ^d   Boucher, Richard C ^e   Parsons, David W ^b,c   Siu, Karen K W ^a,f  

^a MONASH UNIVERSITY   (Australia)

^b WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d JAPAN SYNCHROTRON RADIATION RESEARCH INSTITUTE   (Japan)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f AUSTRALIAN SYNCHROTRON   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTONIC SOLUTION; SODIUM CHLORIDE;

ACCURACY; AIRWAY SURFACE LIQUID; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; CYSTIC FIBROSIS; EX VIVO STUDY; FEMALE; IMAGE ANALYSIS; IN VIVO STUDY; LUNG ALVEOLUS EPITHELIUM; MOUSE; NON INVASIVE PROCEDURE; NONHUMAN; OUTCOME ASSESSMENT; RESPIRATORY TRACT PARAMETERS; THORAX RADIOGRAPHY; TISSUE CHARACTERIZATION; TISSUE STRUCTURE; TREATMENT INDICATION;

ANIMALS; CYSTIC FIBROSIS; EXTRACELLULAR FLUID; FEMALE; MICE; RESPIRATORY MUCOSA; TIME FACTORS; TRACHEA;

EID: 84873806462     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0055822     Document Type: Article

References (28)

1. Boucher RC, (2004) New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 23: 146-158.
2. Knowles MR, Boucher RC, (2002) Mucus Clearance as a primate inate defense mechanism for mammalian airways. J Clin Invest 109: 571-577.
3. Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, et al. (1998) Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95: 1005-1015.
4. Boucher RC, (2007) Evidence for airway surface dehydration as the initiating event in CF airway disease. J Intern Med 261: 5-16.
5. Ratjen R, Grasemann H, (2012) New Therapies in Cystic Fibrosis. Current Pharmaceutical Design 18: 614-627.
6. Daviskas E, Anderson SD, Gonda I, Eberl S, Meikle S, et al. (1996) Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. ERJ 9: 725-732.
7. Elkins MR, Robinson M, Rose BR, Harbour C, Moriarty RN, et al. (2006) A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354: 229-240.
8. Donaldson S, Bennett W, Zeman K, Knowles MR, Tarran R, et al. (2006) Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N Engl J Med 354: 250.
9. Griesenbach U, Boyd AC, (2005) Pre-clinical and clinical endpoint assays for cystic fibrosis gene therapy. J Cyst Fibros 4: 89-100.
10. Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, et al. (2011) A CFTR potentiator in patients with cystic fibrosis and the G551D mutation. N Engl J Med 365: 1663-72.
11. Brody AS, Tiddens HAWM, Castile RG, Coxson HO, de Jong PA, et al. (2005) Computed Tomography in the Evaluation of Cystic Fibrosis Lung Disease. Am J Respir Crit Care Med 172: 1246-1252.
12. Tarran R, Button B, Picher M, Paradiso AM, Ribeiro CM, et al. (2005) Normal and cystic fibrosis airway surface liquid homeostasis. The effects of phasic shear stress and viral infections. J Biol Chem 280: 35751-35759.
13. Song Y, Namking W, Nieldson DW, Lee J-W, Finkbeiner WE, et al. (2009) Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. Am J Physiol Lung Cell Mol Physiol 297: L1131-L1140.
14. Morgan KS, Paganin DM, Siu KKW, (2011) Quantitative single-exposure x-ray phase contrast imaging using a single attenuation grid. Opt Express 19: 19781-19789.
15. Morgan KS, Paganin DM, Parsons DW, Donnelley M, Yagi N, et al. (2012) Single grating x-ray imaging for dynamic biological systems. AIP Conf. Proc 1466: 124-129.
16. Cloetens P, Barrett R, Baruchel J, Guigay JP, Schlenker M, (1996) Phase objects in synchrotron radiation hard x-ray imaging. J Phys D: App Phs 29: 133-146.
17. Snigirev A, Snigireva I, Kohn V, Kuznetsov S, Schelokov I, (1995) On the possibilities of x-ray phase contrast microimaging by coherent high-energy synchrotron radiation. Rev Sci Instrum 66: 5486-5492.
18. Davis TJ, Gao D, Gureyev TE, Stevenson AW, Wilkins SW, (1995) Phase-contrast imaging of weakly absorbing materials using hard x-rays. Nature 373: 595-598.
19. Momose A, Kawamoto S, Koyama I, Hamaishi Y, Takai K, et al. (2003) Demonstration of x-ray Talbot interferometry. Jpn J Appl Phys 42: L866-L868.
20. Pfeiffer F, Weitkamp T, Bunk O, David C, (2006) Phase retrieval and differential phase-contrast imaging with low-brilliance x-ray sources. Nature Physics 2: 258-261.
21. Kitchen MJ, Lewis RA, Morgan MJ, Wallace MJ, Siew ML, et al. (2008) Dynamic Measures of Regional Lung Air Volume using Phase Contrast X-ray Imaging. Phys. Med. Biol 53 (21) (): 6065-6077.
22. Donnelley M, Siu K, Morgan K, Skinner W, Suzuki Y, et al. (2010) A new technique to examine individual pollutant particle and fibre deposition and transit behaviour in live mouse trachea. J Synch Radiat 17: 719-729.
23. Hartmann J, (1900) "Bemerkungen über den Bau und die Justirung von Spektrographen". Zt Instrumentenkd 29 (47) ().
24. Shack RV, (1971) "Production and use of a lenticular Hartmann screen". Journal of the Optical Society of America 61 (656) ().
25. Mayo SC, Sexton B, (2004) Refractive microlens array for wavefront analysis in the medium to hard x-ray range. Opt Lett 29: 866-8.
26. Morgan KS, Paganin DM, Siu KKW, (2012a) X-ray phase imaging with a paper analyzer. Appl Phys Lett 100: 124102.
27. Morgan KS, Paganin DM, Siu KKW, (2011a) Quantitative x-ray phase-contrast imaging using a single grating of comparable pitch to sample feature size. Opt Lett 36: 55-57.
28. Tarran R, Grubb BR, Parsons D, Picher M, Hirsh AJ, et al. (2001) The CF salt controversy: in vivo observations and therapeutic approaches. Mol Cell 8: 149-158.