Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature

Pathology Research and Practice

Volumn 209, Issue 2, 2013, Pages 115-119

  Delas, Audrey ^a   Sophie, Dobbelstein ^b   Brousset, Pierre ^a,c,d   Laurent, Camille ^a,c,d  

^a CHU PURPAN   (France)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

^c CANCER RESEARCH CENTER OF TOULOUSE   (France)

^d UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

Aberrant phenotype; Blastoid variant mantle cell lymphoma; CCND1 IGL translocation; Mantle cell lymphoma; MYC rearrangement

Indexed keywords

CD5 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLIN D1; IMMUNOGLOBULIN LAMBDA CHAIN; MYC PROTEIN;

AGED; ANTIGEN EXPRESSION; ARTICLE; ASTHENIA; BLASTOID VARIANT OF MANTLE CELL LYMPHOMA; BONE MARROW; CASE REPORT; CHROMOSOME 4; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYCLIN D1 GENE; CYTOGENETICS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; GENE OVEREXPRESSION; GENE REARRANGEMENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KARYOTYPE; LYMPH NODE; LYMPHOMA CELL; MANTLE CELL LYMPHOMA; MICROSCOPY; ONCOGENE MYC; PHENOTYPE; TUMOR CELL;

ABNORMAL KARYOTYPE; AGED, 80 AND OVER; CHROMOSOMES, HUMAN, PAIR 11; CHROMOSOMES, HUMAN, PAIR 22; CYCLIN D1; FEMALE; GENES, MYC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOMA, MANTLE-CELL; TRANSLOCATION, GENETIC;

EID: 84873745527     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2012.12.001     Document Type: Article

References (24)

1. Aukema S.M., Siebert R., Schuuring E., van Imhoff G.W., Kluin-Nelemans H.C., Boerma E.J., Kluin P.M. Double-hit B-cell lymphomas. Blood 2011, 117:2319-2331.
2. Bergsagel P.L., Kuehl W.M. Molecular pathogenesis and a consequent classification of multiple myeloma. J. Clin. Oncol. 2005, 23:6333-6338.
3. Bertrand P., Bastard C., Maingonnat C., Jardin F., Maisonneuve C., Courel M.N., Ruminy P., Picquenot J.M., Tilly H. Mapping of MYC breakpoints in 8q24 rearrangements involving non-immunoglobulin partners in B-cell lymphomas. Leukemia 2007, 21:515-523.
4. Boerma E.G., Siebert R., Kluin P.M., Baudis M. Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge. Leukemia 2009, 23:225-234.
5. de Boer C.J., Kluin-Nelemans J.C., Dreef E., Kester M.G., Kluin P.M., Schuuring E., van J.H., Krieken Involvement of the CCND1 gene in hairy cell leukemia. Ann. Oncol. 1996, 7:251-256.
6. Durot E., Patey M., Luquet I., Gaillard B., Kolb B., Delmer A. An aggressive B-cell lymphoma with rearrangements of MYC and CCND1 genes: a rare subtype of double-hit lymphoma. Leuk. Lymphoma 2012, (Epub ahead of print).
7. Ehinger M., Linderoth J., Christensson B., Sander B., Cavallin-Stahl E. A subset of CD5- diffuse large B-cell lymphomas expresses nuclear cyclin D1 with aberrations at the CCND1 locus. Am. J. Clin. Pathol. 2008, 129:630-638.
8. Ek S., Dictor M., Jerkeman M., Jirstrom K., Borrebaeck C.A. Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma. Blood 2008, 111:800-805.
9. Komatsu H., Yoshida K., Seto M., Iida S., Aikawa T., Ueda R., Mikuni C. Overexpression of PRAD1 in a mantle zone lymphoma patient with a t(11;22)(q13;q11) translocation. Br. J. Haematol. 1993, 85:427-429.
10. Liu Z., Dong H.Y., Gorczyca W., Tsang P., Cohen P., Stephenson C.F., Berger C.S., Wu C.D., Weisberger J. CD5- mantle cell lymphoma. Am. J. Clin. Pathol. 2002, 118:216-224.
11. Lucioni M., Novara F., Riboni R., Fiandrino G., Nicola M., Kindl S., Boveri E., Jemos V., Arcaini L., Zuffardi O., Paulli M. CD5(-) diffuse large B-cell lymphoma with peculiar cyclin D1+ phenotype. Pathologic and molecular characterization of a single case. Hum. Pathol. 2011, 42:1204-1208.
12. Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer 2010, Available from:. http://cgap.nci.nih.gov/Chromosomes/Mitelman, F. Mitelman, B. Johansson, F. Mertens (Eds.).
13. Morice W.G., Hodnefield J.M., Kurtin P.J., Hanson C.A. An unusual case of leukemic mantle cell lymphoma with a blastoid component showing loss of CD5 and aberrant expression of CD10. Am. J. Clin. Pathol. 2004, 122:122-127.
14. Reddy K., Ansari-Lari M., Dipasquale B. Blastic mantle cell lymphoma with a Burkitt translocation. Leuk. Lymphoma 2008, 49:740-750.
15. Rocha C.K., Praulich I., Gehrke I., Hallek M., Kreuzer K.A. A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting in a fusion of IGL and CCND1: case report. Mol. Cytogenet. 2011, 4:8.
16. Rodriguez-Justo M., Huang Y., Ye H., Liu H., Chuang S.S., Munson P., Prada-Puentes C., Kim I., Du M.Q., Bacon C.M. Cyclin D1-positive diffuse large B-cell lymphoma. Histopathology 2008, 52:900-903.
17. Sander S., Bullinger L., Leupolt E., Benner A., Kienle D., Katzenberger T., Kalla J., Ott G., Muller-Hermelink H.K., Barth T.F., Moller P., Lichter P., Dohner H., Stilgenbauer S. Genomic aberrations in mantle cell lymphoma detected by interphase fluorescence in situ hybridization. Incidence and clinicopathological correlations. Haematologica 2008, 93:680-687.
18. Sathanoori M., Shekhter-Levin S., Marks S.M., Swerdlow S.H. Derivative (14)t(11;14)(q13;q32)t(11;14)(p11.2;p11.2): a novel unbalanced variant of the t(11;14)(q13;q32) translocation in mantle cell lymphoma. Cancer Genet. Cytogenet. 2007, 172:158-164.
19. Smith S.M., Anastasi J., Cohen K.S., Godley L.A. The impact of MYC expression in lymphoma biology: beyond Burkitt lymphoma. Blood Cells. Mol. Dis. 2010, 45:317-323.
20. Sriganeshan V., Blom T.R., Weissmann D.J. A unique case of mantle cell lymphoma with an aberrant CD5-/CD10+ immunophenotype and typical morphology. Arch. Pathol. Lab. Med. 2008, 132:1346-1349.
21. Swerdlow S.H., Campo E., Seto M., Müller-Hermelink H.K. Mantle cell lymphoma. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues 2008, 229-232. IARC press, Lyon. 4th ed. S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, J. Thiele, J.W. Vardiman (Eds.).
22. Wang X., Asplund A.C., Porwit A., Flygare J., Smith C.I., Christensson B., Sander B. The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival. Br. J. Haematol. 2008, 143:248-252.
23. Wlodarska I., Meeus P., Stul M., Thienpont L., Wouters E., Marcelis L., Demuynck H., Rummens J.L., Madoe V., Hagemeijer A. Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma. Leukemia 2004, 18:1705-1710.
24. Zanetto U., Dong H., Huang Y., Zhang K., Narbaitz M., Sapia S., Kostopoulos I., Liu H., Du M.Q., Bacon C.M. Mantle cell lymphoma with aberrant expression of CD10. Histopathology 2008, 53:20-29.