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Volumn 494, Issue 7436, 2013, Pages 234-237

Finding the sources of missing heritability in a yeast cross

Author keywords

[No Author keywords available]

Indexed keywords

DETECTION METHOD; HERITABILITY; LIFE HISTORY TRAIT; PUBLIC HEALTH; YEAST;

EID: 84873722165     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11867     Document Type: Article
Times cited : (342)

References (47)
  • 1
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 2
    • 75449111415 scopus 로고    scopus 로고
    • Understanding and using quantitative genetic variation
    • Hill, W. G. Understanding and using quantitative genetic variation. Phil. Trans. R. Soc. Lond. B 365, 73-85 (2010).
    • (2010) Phil. Trans. R. Soc. Lond B , vol.365 , pp. 73-85
    • Hill, W.G.1
  • 3
    • 67651108806 scopus 로고    scopus 로고
    • The genetics of quantitative traits: Challenges and prospects
    • Mackay, T. F. C., Stone, E. A. & Ayroles, J. F. The genetics of quantitative traits: challenges and prospects. Nature Rev. Genet. 10, 565-577 (2009).
    • (2009) Nature Rev. Genet , vol.10 , pp. 565-577
    • MacKay, T.F.C.1    Stone, E.A.2    Ayroles, J.F.3
  • 4
    • 68449083317 scopus 로고    scopus 로고
    • The genetic architecture of maize flowering time
    • Buckler, E. S. et al. The genetic architecture of maize flowering time. Science 325, 714-718 (2009).
    • (2009) Science , vol.325 , pp. 714-718
    • Buckler, E.S.1
  • 5
    • 77953233453 scopus 로고    scopus 로고
    • Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines
    • Atwell, S. et al. Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature 465, 627-631 (2010).
    • (2010) Nature , vol.465 , pp. 627-631
    • Atwell, S.1
  • 6
    • 84863012360 scopus 로고    scopus 로고
    • The Drosophila melanogaster Genetic Reference Panel
    • Mackay, T. F. et al. The Drosophila melanogaster Genetic Reference Panel. Nature 482, 173-178 (2012).
    • (2012) Nature , vol.482 , pp. 173-178
    • MacKay, T.F.1
  • 7
    • 79957658264 scopus 로고    scopus 로고
    • Genetic analysis of complex traits in the emerging Collaborative Cross
    • Aylor, D. L. et al. Genetic analysis of complex traits in the emerging Collaborative Cross. Genome Res. 21, 1213-1222 (2011).
    • (2011) Genome Res , vol.21 , pp. 1213-1222
    • Aylor, D.L.1
  • 8
    • 84855258100 scopus 로고    scopus 로고
    • The QTN program and the alleles that matter for evolution: All that's gold does not glitter
    • Rockman, M. V. The QTN program and the alleles that matter for evolution: all that's gold does not glitter. Evolution 66, 1-17 (2012).
    • (2012) Evolution , vol.66 , pp. 1-17
    • Rockman, M.V.1
  • 9
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein, D. B. Common genetic variation and human traits. N. Engl. J. Med. 360, 1696-1698 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 10
    • 77954140531 scopus 로고    scopus 로고
    • Common SNPs explain a large proportion of the heritability for human height
    • Yang, J. et al. Common SNPs explain a large proportion of the heritability for human height. Nature Genet. 42, 565-569 (2010).
    • (2010) Nature Genet , vol.42 , pp. 565-569
    • Yang, J.1
  • 12
    • 0034969437 scopus 로고    scopus 로고
    • Are rare variants responsible for susceptibility to complex diseases?
    • Pritchard, J. K. Are rare variants responsible for susceptibility to complex diseases? Am. J. Hum. Genet. 69, 124-137 (2001).
    • (2001) Am. J. Hum. Genet , vol.69 , pp. 124-137
    • Pritchard, J.K.1
  • 13
    • 84856405512 scopus 로고    scopus 로고
    • The mystery of missing heritability: Genetic interactions create phantom heritability
    • Zuk, O., Hechter, E., Sunyaev, S. R. & Lander, E. S. The mystery of missing heritability: genetic interactions create phantom heritability. Proc. Natl Acad. Sci. USA 109, 1193-1198 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 1193-1198
    • Zuk, O.1    Hechter, E.2    Sunyaev, S.R.3    Lander, E.S.4
  • 15
    • 77952557918 scopus 로고    scopus 로고
    • Missing heritability and strategies for finding the underlying causes of complex disease
    • Eichler, E. E. et al. Missing heritability and strategies for finding the underlying causes of complex disease. Nature Rev. Genet. 11, 446-450 (2010).
    • (2010) Nature Rev. Genet , vol.11 , pp. 446-450
    • Eichler, E.E.1
  • 16
    • 77957735769 scopus 로고    scopus 로고
    • Genetic dissection of complex traits in yeast: Insights from studies of gene expression and other phenotypes in the BY3RM cross
    • Ehrenreich, I. M., Gerke, J. P. & Kruglyak, L. Genetic dissection of complex traits in yeast: insights from studies of gene expression and other phenotypes in the BY3RM cross. Cold Spring Harb. Symp. Quant. Biol. 74, 145-153 (2009).
    • (2009) Cold Spring Harb. Symp. Quant. Biol , vol.74 , pp. 145-153
    • Ehrenreich, I.M.1    Gerke, J.P.2    Kruglyak, L.3
  • 17
    • 13444306165 scopus 로고    scopus 로고
    • The landscape of genetic complexity across 5,700 gene expression traits in yeast
    • Brem, R. B. & Kruglyak, L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc. Natl Acad. Sci. USA 102, 1572-1577 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1572-1577
    • Brem, R.B.1    Kruglyak, L.2
  • 18
    • 77951143253 scopus 로고    scopus 로고
    • Dissection of genetically complex traits with extremely large pools of yeast segregants
    • Ehrenreich, I. M. et al. Dissection of genetically complex traits with extremely large pools of yeast segregants. Nature 464, 1039-1042 (2010).
    • (2010) Nature , vol.464 , pp. 1039-1042
    • Ehrenreich, I.M.1
  • 19
    • 33748288159 scopus 로고    scopus 로고
    • Population genomic analysis of outcrossing and recombination in yeast
    • Ruderfer, D. M., Pratt, S. C., Seidel, H. S.& Kruglyak, L. Population genomic analysis of outcrossing and recombination in yeast. Nature Genet. 38, 1077-1081 (2006).
    • (2006) Nature Genet , vol.38 , pp. 1077-1081
    • Ruderfer, D.M.1    Pratt, S.C.2    Seidel, H.S.3    Kruglyak, L.4
  • 20
    • 33645760679 scopus 로고    scopus 로고
    • Assumption-free estimation of heritability fromgenome-wide identity-by-descent sharing between full siblings
    • Visscher, P. M. et al. Assumption-free estimation of heritability fromgenome-wide identity-by-descent sharing between full siblings. PLoS Genet. 2, e41 (2006).
    • (2006) PLoS Genet , vol.2
    • Visscher, P.M.1
  • 21
    • 0034025692 scopus 로고    scopus 로고
    • Adaptation and the cost of complexity
    • Orr, H. A. Adaptation and the cost of complexity. Evolution 54, 13-20 (2000).
    • (2000) Evolution , vol.54 , pp. 13-20
    • Orr, H.A.1
  • 22
    • 23644434473 scopus 로고    scopus 로고
    • Multiple locus linkage analysis of genomewide expression in yeast
    • Storey, J. D., Akey, J. M. & Kruglyak, L. Multiple locus linkage analysis of genomewide expression in yeast. PLoS Biol. 3, e267 (2005).
    • (2005) PLoS Biol , vol.3
    • Storey, J.D.1    Akey, J.M.2    Kruglyak, L.3
  • 23
    • 23644434284 scopus 로고    scopus 로고
    • Genetic interactions between polymorphisms that affect gene expressionin yeast
    • Brem, R. B., Storey, J. D., Whittle, J. & Kruglyak, L. Genetic interactions between polymorphisms that affect gene expressionin yeast.Nature436,701-703(2005).
    • (2005) Nature , vol.436 , pp. 701-703
    • Brem, R.B.1    Storey, J.D.2    Whittle, J.3    Kruglyak, L.4
  • 24
    • 77951530523 scopus 로고    scopus 로고
    • Genotype to phenotype: A complex problem
    • Dowell, R. D. et al. Genotype to phenotype: a complex problem. Science 328, 469 (2010).
    • (2010) Science , vol.328 , pp. 469
    • Dowell, R.D.1
  • 25
    • 40149087235 scopus 로고    scopus 로고
    • Data and theory point to mainly additive genetic variance for complex traits
    • Hill, W. G., Goddard, M. E.& Visscher, P. M. Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet. 4, e1000008 (2008).
    • (2008) PLoS Genet , vol.4
    • Hill, W.G.1    Goddard, M.E.2    Visscher, P.M.3
  • 26
    • 33748309136 scopus 로고    scopus 로고
    • Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration
    • Maller, J. et al. Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration. Nature Genet. 38, 1055-1059 (2006).
    • (2006) Nature Genet , vol.38 , pp. 1055-1059
    • Maller, J.1
  • 27
    • 77957947562 scopus 로고    scopus 로고
    • Hundreds of variants clustered in genomic loci and biological pathways affect human height
    • Lango Allen, H. et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature 467, 832-838 (2010).
    • (2010) Nature , vol.467 , pp. 832-838
    • Lango Allen, H.1
  • 28
    • 84863556835 scopus 로고    scopus 로고
    • Evolution and functional impact of rare coding variation from deep sequencing of human exomes
    • Tennessen, J. A. et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337, 64-69 (2012).
    • (2012) Science , vol.337 , pp. 64-69
    • Tennessen, J.A.1
  • 29
    • 84860817223 scopus 로고    scopus 로고
    • Recent explosive humanpopulation growth has resulted in an excess of rare genetic variants
    • Keinan, A.&Clark, A. G. Recent explosive humanpopulation growth has resulted in an excess of rare genetic variants. Science 336, 740-743 (2012).
    • (2012) Science , vol.336 , pp. 740-743
    • Keinan, A.1    Clark, A.G.2
  • 30
    • 84863541347 scopus 로고    scopus 로고
    • An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people
    • Nelson, M. R. et al. An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science 337, 100-104 (2012).
    • (2012) Science , vol.337 , pp. 100-104
    • Nelson, M.R.1
  • 32
    • 84855199947 scopus 로고    scopus 로고
    • R Development Core Team. R Foundation for Statistical Computing
    • R Development Core Team. R: A Language and Environment for Statistical Computing (R Foundation for Statistical Computing, 2012).
    • (2012) A Language and Environment for Statistical Computing
  • 33
    • 67649884743 scopus 로고    scopus 로고
    • Fast and accurate short read alignment with Burrows-Wheeler transform
    • Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754-1760 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 1754-1760
    • Li, H.1    Durbin, R.2
  • 34
    • 68549104404 scopus 로고    scopus 로고
    • The Sequence Alignment/Map format and SAMtools
    • Li, H. et al. The Sequence Alignment/Map format and SAMtools. Bioinformatics 25, 2078-2079 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 2078-2079
    • Li, H.1
  • 37
    • 77951959633 scopus 로고    scopus 로고
    • EBImage-an R package for image processing with applications to cellular phenotypes
    • Pau, G., Fuchs, F., Sklyar, O., Boutros, M. & Huber, W. EBImage-an R package for image processing with applications to cellular phenotypes. Bioinformatics 26, 979-981 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 979-981
    • Pau, G.1    Fuchs, F.2    Sklyar, O.3    Boutros, M.4    Huber, W.5
  • 40
    • 79952489475 scopus 로고    scopus 로고
    • Estimating missing heritability for disease from genome-wide association studies
    • Lee, S. H., Wray, N. R., Goddard, M. E. & Visscher, P. M. Estimating missing heritability for disease from genome-wide association studies. Am. J. Hum. Genet. 88, 294-305 (2011).
    • (2011) Am. J. Hum. Genet , vol.88 , pp. 294-305
    • Lee, S.H.1    Wray, N.R.2    Goddard, M.E.3    Visscher, P.M.4
  • 41
    • 85136354327 scopus 로고    scopus 로고
    • Ridge regression and other kernels for genomic selection with R package rrBLUP
    • Endelman, J. B. Ridge regression and other kernels for genomic selection with R package rrBLUP. Plant Genome 4, 250-255 (2011).
    • (2011) Plant Genome , vol.4 , pp. 250-255
    • Endelman, J.B.1
  • 42
    • 33845265069 scopus 로고    scopus 로고
    • Variation of estimates of SNP and haplotype diversity and linkage disequilibrium in samples from the same population due to experimental and evolutionary sample size
    • Visscher, P. M. Variation of estimates of SNP and haplotype diversity and linkage disequilibrium in samples from the same population due to experimental and evolutionary sample size. Ann. Hum. Genet. 71, 119-126 (2007).
    • (2007) Ann. Hum. Genet , vol.71 , pp. 119-126
    • Visscher, P.M.1
  • 44
    • 33747838783 scopus 로고    scopus 로고
    • Relaxed significance criteria for linkage analysis
    • Chen, L. & Storey, J. D. Relaxed significance criteria for linkage analysis. Genetics 173, 2371-2381 (2006).
    • (2006) Genetics , vol.173 , pp. 2371-2381
    • Chen, L.1    Storey, J.D.2
  • 45
    • 0030052609 scopus 로고    scopus 로고
    • Permutation tests for multiple loci affecting a quantitative character
    • Doerge, R. W. & Churchill, G. A. Permutation tests for multiple loci affecting a quantitative character. Genetics 142, 285-294 (1996).
    • (1996) Genetics , vol.142 , pp. 285-294
    • Doerge, R.W.1    Churchill, G.A.2
  • 46
    • 0035094764 scopus 로고    scopus 로고
    • Variation is the spice of life
    • Kruglyak, L. & Nickerson, D. A. Variation is the spice of life. Nature Genet. 27, 234-236 (2001).
    • (2001) Nature Genet , vol.27 , pp. 234-236
    • Kruglyak, L.1    Nickerson, D.A.2
  • 47
    • 34250305146 scopus 로고    scopus 로고
    • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
    • Birney, E. et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799-816 (2007).
    • (2007) Nature , vol.447 , pp. 799-816
    • Birney, E.1


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