Randomized, double-blind placebo-controlled trial with Bryophyllum pinnatum versus placebo for the treatment of overactive bladder in postmenopausal women

Phytomedicine

Volumn 20, Issue 3-4, 2013, Pages 351-358

  Betschart, Cornelia ^a   Von Mandach, Ursula ^b   Seifert, Burkhardt ^c   Scheiner, David ^a   Perucchini, Daniele ^a   Fink, Daniel ^a   Geissbühler, Verena ^d,e  

^a UNIVERSITÄTSSPITAL ZÜRICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d CANTONAL HOSPITAL WINTERTHUR   (Switzerland)

^e Hopital Cantonal de Fribourg   (Switzerland)

Author keywords

Bryophyllum pinnatum; Micturition frequency; Overactive bladder (OAB); Placebo; Quality of life (QoL)

Indexed keywords

ANTIBIOTIC AGENT; BRYOPHYLLUM PINNATUM EXTRACT; PLACEBO; PLANT EXTRACT; UNCLASSIFIED DRUG;

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; BRYOPHYLLUM PINNATUM; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DYSENTERY; FEMALE; HUMAN; MALE; MEDICINAL PLANT; OVERACTIVE BLADDER; PHASE 2 CLINICAL TRIAL; POSTMENOPAUSE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RASH; TREATMENT OUTCOME; TREMOR; UNSPECIFIED SIDE EFFECT; URINARY FREQUENCY; URINARY TRACT INFECTION;

AGED; DOUBLE-BLIND METHOD; FEMALE; HUMANS; KALANCHOE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; POSTMENOPAUSE; PROSPECTIVE STUDIES; QUALITY OF LIFE; URINARY BLADDER, OVERACTIVE;

KALANCHOE PINNATA; SUS;

EID: 84873720883     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2012.10.007     Document Type: Article

References (34)

1. C.V. Asche, J. Kim, A.S. Kulkarni, P. Chakravarti, and K.E. Andersson Presence of central nervous system, cardiovascular and overall co-morbidity burden in patients with overactive bladder disorder in a real-world setting BJU International 109 4 2011 572 580
2. J.A. Astin Why patients use alternative medicine: results of a national study The Journal of the American Medical Association 279 19 1998 1548 1553
3. K. Avery, J. Donovan, T.J. Peters, C. Shaw, M. Gotoh, and P. Abrams ICIQ: a brief and robust measure for evaluating the symptoms and impact of urinary incontinence Neurourology and Urodynamics 23 4 2004 322 330
4. J.S. Benner, M.B. Nichol, E.S. Rovner, Z. Jumadilova, J. Alvir, M. Hussein, K. Fanning, J.N. Trocio, and L. Brubaker Patient-reported reasons for discontinuing overactive bladder medication BJU International 105 9 2010 1276 1282
5. V. Bjelic-Radisic, M. Dorfer, K. Tamussino, and E. Greimel Psychometric properties and validation of the German-language King's Health Questionnaire in women with stress urinary incontinence Neurourology and Urodynamics 24 2005 63 68
6. V.E. Borchert, P. Czyborra, C. Fetscher, M. Goepel, and M.C. Michel Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction Naunyn-Schmiedeberg's Archives of Pharmacology 369 2004 281 286
7. A.F. Brading Myogenic basis for the overactive bladder Urology 50 1997 57 67
8. R. Capasso, F. Borrelli, F. Capasso, N. Mascolo, and A.A. Izzo Inhibitory effect of the antidepressant St. John's wort (Hypericum perforatum) on rat bladder contractility in vitro Urology 64 2004 168 172
9. W. DeGroat A neurologic basis for the overactive bladder Urology 50 6A Suppl. 1997 36 52
10. R.R. Dmochowski, and A. Gomelsky Update on the treatment of overactive bladder Current Opinion in Urology 21 2011 286 290
11. M. Feinberg The problems of anticholinergic adverse effects in older patients Drugs and Aging 3 1993 335 348
12. K. Fürer, O. Potterat, M. Raith, R. Brenneisen, M. Mennet, M. Schnelle, A.P. Simões-Wüst, U. von Mandach, and M. Hamburger Bryophyllum pinnatum, a well regarded phytomedicine in obstetrics and gynecology-new data on its chemical composition Abstract, 5th Swiss Pharma Science Day Berne 29.08.2012 2012
13. D. Griffiths, S. Derbyshire, A. Stenger, and N. Resnick Brain control of normal and overactive bladder Journal of Urology 174 2005 1862 1867
14. B. Gwehenberger, L. Rist, R. Huch, and U. von Mandach Effect of Bryophyllum pinnatum versus fenoterol on uterine contractility European Journal of Obstetrics, Gynecology, and Reproductive Biology 113 2004 164 171
15. B.T. Haylen, D. de Ridder, R.M. Freeman, S.E. Swift, B. Berghmans, J. Lee, A. Monga, E. Petri, D.E. Rizk, P.K. Sand, and G.N. Schaer An International Urogynecologica Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction International Urogynecology Journal 21 1 2010 5 26
16. D.E. Irwin, I. Milsom, S. Hunskaar, K. Reilly, Z. Kopp, S. Herschorn, K. Coyne, C. Kelleher, C. Hampel, W. Artibani, and P. Abrams Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC Study European Urology 50 2006 1306 1314
17. G.G. Kay, and U. Ebinger Preserving cognitive function for patients with overactive bladder: evidence for a differential effect with darifenacin Journal of Clinical Practice 62 2008 1792 1800
18. R. Khasriya, S. Khan, R. Lunawat, S. Bishara, J. Bignall, M. Malone-Lee, H. Ishii, D. O'Connor, M. Kelsey, and J. Malone-Lee The inadequacy of urinary dipstick and microscopy as surrogate markers of urinary tract infection in urological outpatients with lower urinary tract symptoms without acute frequency and dysuria Journal of Urology 183 5 2010 1843 1847
19. H. Kim, H.M. Yang, D.H. Kim, H.G. Kim, W.C. Jang, and Y.R. Lee Effects of ylang-ylang essential oil on the relaxation of rat bladder muscle in vitro and white rabbit bladder in vivo Journal of Korean Medical Science 18 2003 409 414
20. J.L. Locher, P.S. Goode, D.L. Roth, R.L. Worrell, and K.L. Burgio Reliability assessment of the bladder diary for urinary incontinence in older women Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 56 1 2001 M32 M35
21. S. Mahata, S. Maru, S. Shukla, A. Pandey, G. Mugesh, B.C. Das, and A.C. Bharti Anticancer property of Bryophyllum pinnata (Lam.) Oken leaf on human cervical cancer cells BMC Complementary and Alternative Medicine 10 12 2012 15
22. J.L. Martin, K.S. Williams, K.R. Abrams, D.A. Turner, A.J. Sutton, C. Chapple, R.P. Assassa, C. Shaw, and F. Cheater Systematic review and evaluation of methods assessing urinary incontinence Health Technology Assessment 10 6 2006 1 132
23. I. Milsom, P. Abrams, L. Cardozo, R.G. Roberts, J. Thüroff, and A.J. Wein How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study BJU International 87 2001 760 766
24. B. Oliver-Bever Medicinal plants in tropical West Africa. III: antiinfection therapy with higher plants Journal of Ethnopharmacology 9 1983 1 3
25. S. Pal, T. Sent, and A. Nag Chaudhure Neuropsychopharmacologica profile of the methanolic fraction of Bryophyllum pinnatum leaf extract Journal of Pharmacy and Pharmacology 51 1999 313 338
26. N. Plangger, L. Rist, R. Zimmermann, and U. von Mandach Intravenous tocolysis with Bryophyllum pinnatum is better tolerated than beta-agonist application European Journal of Obstetrics, Gynecology, and Reproductive Biology 124 2006 168 172
27. F.T. Shaya, S. Blume, A. Gu, T. Zyczynski, and Z. Jumadilova Persistence with overactive bladder pharmacotherapy in a Medicaid population American Journal of Managed Care 11 4 Suppl. 2005 S121 S129
28. V. Schuler, K. Suter, K. Fürer, D. Eberli, M. Horst, C. Betschart, R. Brenneisen, M. Hamburger, M. Mennet-von Eiff, M. Schnelle, A.P. Simões-Wüst, and U. von Mandach Bryophyllum pinnatum inhibits detrusor contractility in porcine bladder strips-a pharmacological study toward a new treatment option of overactive bladder Phytomedicine 19 2012 947 951
29. A.P. Simões-Wüst, M. Grãos, C.B. Duarte, R. Brenneisen, M. Hamburger, M. Mennet, M.H. Ramos, M. Schnelle, R. Wächter, A.M. Worel, and U. von Mandach Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells Phytomedicine 17 2010 980 986
30. S.L. Slavin, R.G. Rogers, Y. Komesu, T. Omotosho, S. Hammil, C. Lewis, and R. Sapien Complementary and alternative medicine (CAM) use in women with pelvic floor disorders: a cohort study International Urogynecology Journal 21 4 2010 431 437
31. R. Wächter, R. Brenneisen, M. Hamburger, M. Mennet, M. Schnelle, A.M. Worel, A.P. Simões-Wüst, and U. von Mandach Leaf press juice from Bryophyllum pinnatum (Lamarck) Oken induces myometrial relaxation Phytomedicine 19 2011 74 82
32. A.J. Wein, and R.R. Rackley Overactive bladder: a better understanding of pathophysiology, diagnosis and management Journal of Urology 175 2006 5 10
33. T. Yamagishi, X.Z. Yan, R.Y. Wu, D.R. McPhail, A.T. McPhail, and K.H. Lee Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum Chemical and Pharmaceutical Bulletin 36 1988 1615 1617
34. T. Yamagishi, M. Haruna, X.Z. Yan, J.J. Chang, and K.H. Lee Antitumor agents, 1101,2 bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum Journal of Natural Products 52 1989 1071 1079