The feasibility of triple-drug chemotherapy combination in older adult patients with oesophagogastric cancer: A randomised trial of the Arbeitsgemeinschaft Internistische Onkologie (FLOT65+)

European Journal of Cancer

Volumn 49, Issue 4, 2013, Pages 835-842

  Al Batran, Salah Eddin ^a   Pauligk, Claudia ^a   Homann, Nils ^b   Hartmann, Jörg T ^c   Moehler, Markus ^d   Probst, Stephan ^e   Rethwisch, Volker ^f   Stoehlmacher Williams, Jan ^g   Prasnikar, Nicole ^h   Hollerbach, Stephan ⁱ   Bokemeyer, Carsten ^j   Mahlberg, Rolf ^k   Hofheinz, Ralf D ^l   Luley, Kim ^b   Kullmann, Frank ^m   Jäger, Elke ^a  

^a KRANKENHAUS NORDWEST   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^e Klinikum Bielefeld   (Germany)

^f Kath Krankenhaus   (Germany)

^g UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^h KLINIKUM LUDWIGSBURG   (Germany)

ⁱ ALLGEMEINES KRANKENHAUS CELLE   (Germany)

^j UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^k Clinic of Nuclear Medicine   (Germany)

^l UNIVERSITY OF HEIDELBERG   (Germany)

^m Klinikum Weiden   (Germany)

more..

Author keywords

Chemotherapy; Elderly; Gastric cancer; Oesophageal cancer

Indexed keywords

DOCETAXEL; FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADVANCED CANCER; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ALLERGY; ALOPECIA; ANEMIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CANCER COMBINATION CHEMOTHERAPY; CONSTIPATION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIARRHEA; DISEASE COURSE; DRUG DOSE REDUCTION; DRUG FATALITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSESTHESIA; ESOPHAGOGASTRIC CANCER; ESOPHAGUS CANCER; FATIGUE; FEMALE; FEVER; FLUID RETENTION; GASTROINTESTINAL TOXICITY; HEALTH STATUS; HUMAN; INFECTION; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MUCOSA INFLAMMATION; NAUSEA; NEUTROPENIA; OVERALL SURVIVAL; PAIN; PARESTHESIA; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SENSORY DYSFUNCTION; SIDE EFFECT; STOMACH CANCER; THROMBOCYTOPENIA; TREATMENT DURATION; TREATMENT RESPONSE; VOMITING;

ADENOCARCINOMA; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ESOPHAGEAL NEOPLASMS; FEASIBILITY STUDIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUCOVORIN; MALE; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; ORGANOPLATINUM COMPOUNDS; PROGNOSIS; PROSPECTIVE STUDIES; QUALITY OF LIFE; SURVIVAL RATE; TAXOIDS;

EID: 84873720456     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2012.09.025     Document Type: Article

References (16)

1. A. Jemal, F. Bray, and M.M. Center Global Cancer Statistics CA Cancer J Clin 61 2011 69 90
2. R.D. Hofheinz, S.E. Al-Batran, and K. Ridwelski Population-based patterns of care in the first-line treatment of patients with advanced esophagogastric adenocarcinoma in Germany Onkologie 33 10 2010 512 518
3. A.D. Wagner, W. Grothe, and J. Haerting Chemotherapy in advanced gastric cancer: a systematic review and meta-analysis based on aggregate data J Clin Oncol 24 18 2006 2903 2909
4. E. Van Cutsem, V.M. Moiseyenko, and S. Tjulandin Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 study group J Clin Oncol 24 2006 4991 4997
5. D.H. Ilson Docetaxel, cisplatin, and fluorouracil in gastric cancer: does the punishment fit the crime? J Clin Oncol 25 2007 3188 3190
6. D. Cunningham, N. Starling, and S. Rao Capecitabine and oxaliplatin for advanced esophagastric cancer N Engl J Med 358 2008 36 46
7. S.-E. Al-Batran, A. Atmaca, and S. Hegewisch-Becker Phase II trial of biweekly infusional fluorouracil, folinic acid, and oxaliplatin in patients with advanced gastric cancer J Clin Oncol 22 2004 658 663
8. S.-E. Al-Batran, J.T. Hartmann, and S. Probst Phase III trial of metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie J Clin Oncol 26 2008 1435 1442
9. S.-E. Al-Batran, J.T. Hartmann, and R. Hofheinz Biweekly fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) for patients with metastatic adenocarcinoma of the stomach or esophagogastric junction: a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie Ann Oncol 19 2008 1882 1887
10. J.P. Caussanel, F. Levi, and S. Brienza Phase I trial of 5-day continuous venous infusion of oxaliplatin at circadian rhythm-modulated rate compared with constant rate J Natl Cancer Inst 82 1990 1046 1050
11. A.B. Miller, B. Hoogstraten, and M. Staquet Reporting results of cancer treatment Cancer 47 1981 207 214
12. D. Osoba, G. Rodrigues, J. Myles, B. Zee, and J. Pater Interpreting the significance of changes in health-related quality-of-life scores J Clin Oncol 16 1 1998 139 144
13. N. Homann, C. Pauligk, and K. Luley Pathological complete remission in patients with oesophagogastric cancer receiving preoperative 5-fluorouracil, oxaliplatin and docetaxel (FLOT) Int J Cancer 130 7 2012 1706 1713
14. M. Extermann Measuring comorbidity in older cancer patients Eur J Cancer 36 2000 453 471
15. M. Trumper, P.J. Ross, and D. Cunningham Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials Eur J Cancer 42 2006 827 834
16. A. Jatoi, N.R. Foster, and J.R. Egner Older versus younger patients with metastatic adenocarcinoma of the esophagus, gastroesophageal junction, and stomach: a pooled analysis of eight consecutive North Central Cancer Treatment Group (NCCTG) trials Int J Oncol 36 2010 601 606