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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1407-1411

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

(11) Londregan, Allyn T a Piotrowski, David W a Futatsugi, Kentaro a Warmus, Joseph S a Boehm, Markus a Carpino, Philip A a Chin, Janice E a Janssen, Ann M a Roush, Nicole S a Buxton, Joanne a Hinchey, Terri a

a PFIZER INC (United States)

Author keywords

Small molecule TGR5 agonist; Takeda G protein coupled receptor 5 (TGR5); TGR5 agonist; Type II diabetes

Indexed keywords

5 PHENOXY 1,3 DIMETHYL 1H PYRAZOLE 4 CARBOXAMIDE; PYRAZOLE DERIVATIVE; TAKEDA G PROTEIN COUPLED RECEPTOR 5 AGONIST; UNCLASSIFIED DRUG;

ARTICLE; COMBINATORIAL LIBRARY; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

AMIDES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; PYRAZOLES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873719110 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.12.076 Document Type: Article

Times cited : (21)

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