Immunohistochemical study of p53, Ki-67, MMP-2 and MMP-9 expression at invasive front of squamous cell and verrucous carcinoma in oral cavity

Pathology Research and Practice

Volumn 209, Issue 2, 2013, Pages 110-114

  Mohtasham, Nooshin ^a   Babakoohi, Shahab ^b,c   Shiva, Atena ^d   Shadman, Arash ^e   Kamyab Hesari, Kambiz ^f   Shakeri, Mohammad Taghi ^a   Sharifi Sistani, Noorieh ^g  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c Medstar Good Samaritan Center   (United States)

^d MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHIRAZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^g MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Immunohistochemistry; Invasive front; Oral squamous cell carcinoma; Tumor markers; Verrucous carcinoma

Indexed keywords

GELATINASE A; GELATINASE B; KI 67 ANTIGEN; PROTEIN P53;

ARTICLE; CANCER GRADING; CANCER INFILTRATION; CANCER INVASION; CANCER TISSUE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOUTH MUCOSA; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; RETROSPECTIVE STUDY; VERRUCOUS CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CARCINOMA, VERRUCOUS; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MOUTH NEOPLASMS; NEOPLASM GRADING; NEOPLASM INVASIVENESS; RETROSPECTIVE STUDIES; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84873716825     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2012.11.002     Document Type: Article

References (22)

1. Gimenez-Conti I.B., Collet A.M., Lanfranchi H., Itoiz M.E., Luna M., Xu H.J., Hu S.X., Benedict W.F., Conti C.J. p53, Rb, and cyclin D1 expression in human oral verrucous carcinomas. Cancer 1996, 78:17-23.
2. Gu Z.D., Chen K.N., Li M., Gu J., Li J.Y. Clinical significance of matrix metalloproteinase-9 expression in esophageal squamous cell carcinoma. World J. Gastroenterol. 2005, 11:871-874.
3. Hurta M.C., de Assis L.A., De Souza A.F., De Araújo V.C., Gomez R.S., Aguiar M.C. P53 and P21WAF1/CIP1 overexpression at the invasive front of lower lip squamous cell carcinoma. J. Oral. Pathol. Med. 2007, 36:88-92.
4. Impola U., Uitto V.J., Hietanen J., Hakkinen L., Zhang L., Larjava H., Isaka K., Saarialho-Kere U. Differential expression of matrilysin-1 (MMP-7), 92kD, gelatinase (MMP-9), and metalloelastase (MMP-12) in oral verrucous and squamous cell cancer. J. Pathol. 2004, 202:14-22.
5. Kato K., Kawashiri S., Tanaka A., Noguchi N., Nakaya H., Hase T., Yamamoto E. Predictive value of measuring p53 labeling index at the invasive front of oral squamous cell carcinomas. Pathol. Oncol. Res. 2008, 14:57-61.
6. Kumar V., Abbas A., Fausto N. Robbins and Cotran Pathologic Basis of Disease 2010, Elsevier Printed in China, Copyright, pp. 62-63, 82, 206-209,302-303, 328-331. 8th ed.
7. Kurokawa H., Zhang M., Matsumoto S., Yamashita Y., Tanaka T., Takamori K., Igawa K., Yoshida M., Fukuyama H., Takahashi T., Sakoda S. Reduced syndecan-1 expression is correlated with the histological grade of malignancy at the deep invasive front in oral squamous cell carcinoma. J. Oral. Pathol. Med. 2006, 35:301-306.
8. Mohtasham N., Babakoohi S., Salehinejad J., Montaser-Kouhsari L., Shakeri M.T., Shojaee S., Sistani N.S., Firooz A. Mast cell density and angiogenesis in oral dysplastic epithelium and low- and high-grade oral squamous cell carcinoma. Acta Odontol. Scand. 2010, 68:300-304.
9. Mohtasham N., Babakoohi S., Montaser-Kouhsari L., Memar B., Salehinejad J., Rahpeyma A., Khageh-Ahmady S., Marouzi P., Firooz A., Pazoki-Toroudi H., Anvari K. The expression of heat shock proteins 27 and 105 in squamous cell carcinoma of the tongue and relationship with clinicopathological index. Med. Oral. Patol. Oral. Cir. Bucal. 2011, 16:730-735. e.
10. Neville B.W., Damm D.D., Allen C.M., Bouquot J.E. Oral & Maxillofacial Pathology 2009, Saunders Elsevier Company, Copyright, pp. 388-396, 409-421. 3rd ed.
11. Ondruschka C., Buhtz P., Motsch C., Freigang B., Schneider-Stock R., Roessner A., Boltze C. prognostic value of MMP-2,-9 and TIMP-1,-2 immunoreactive protein at the invasive front in advanced head and neck squamous cell carcinomas. Pathol. Res. Pract. 2002, 198:509-515.
12. Ouban A., Dellis J., Salup R., Morgan M. Immunohistochemical expression of Mdm2 and p53 in Penile Verrucous Carcinoma. Ann. Clin. Lab. Sci. 2003, 33:101-106.
13. Piffkó J., Bánkfalvi A., Ofner D., Kusch F., Böcker W., Joos U., Schmid K.W. In situ assessment of cell proliferation at the invasive front of oral squamous cell carcinomas. Virchows. Arch. 1996, 429:229-234.
14. Regezi J.A., Sciubba J.J., Jordan R.C.K. Oral pathology & Clinical Pathologic Correlation 2008, W B Saunders Company, Philadelphia, pp. 48-67, 73-125. 5th ed.
15. Soares F.A., da Cunha I.W., Guimarães G.C., Nonogaki S., Campos R.S., Lopes A. The expression of metaloproteinases-2 and -9 is different according to the patterns of growth and invasion in squamous cell carcinoma of the penis. Virchows. Arch. 2006, 449:637-646.
16. Spiro R.H., Guillamondegui r., Paulino A.F., Huvos A.G. Pattern of invasion and margin assessment in patients with oral tongue cancer. Head Neck. 1999, 21:408-413.
17. Tanaka N., Odajima T., Ogi K., Ikeda T., Satoh M. Expression of E-cadherin, alpha-catenin, and beta-catenin in the process of lymph node metastasis in oral squamous cell carcinoma. Brit. J. Cancer 2003, 89:557-563.
18. Tang Z.G., Li J.M., Hong Z.Z., Yu Z.W., Liu H. Expression of matrix metalloproteinase 2 in oral verrucous carcinoma and Squamous cell carcinoma. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005, 30:650-652. (Abstract).
19. Tumuluri V., Thomas G.A., raser I.F. The relationship of proliferating cell density at the invasive tumour front with prognostic and risk factors in human oral squamous cell carcinoma. J. Oral. Pathol. Med. 2004, 33:204-209.
20. Watanabe S., Watanabe R., Oton-Leite A.F., Alencar Rde C., Oliveira J.C., Leles C.R., Batista A.C., Mendonça E.F. Analysis of cell proliferation and pattern of invasion in oral squamous cell carcinoma. J. Oral. Sci. 2010, 52:417-424.
21. Yamamoto H., Vinitketkumnuen A., Adachi Y., Taniguchi H., Hirata T., Miyamoto N., Nosho K., Imsumran A., Fujita M., Hosokawa M., Hinoda Y., Imai K. Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma. Carcinogenesis 2004, 25:2353-2360.
22. Yantiss R.K., Bosenberg M.W., Antonioli D.A., Odze R.D. Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma. Am. J. Surg. Pathol. 2002, 26:206-215.