메뉴 건너뛰기




Volumn 405, Issue 5, 2013, Pages 1569-1576

Sports drug testing using immuno-MS: Clinical study comprising administration of human chorionic gonadotropin to males

Author keywords

Clinical study; Doping analysis; Human chorionic gonadotropin; LC MS MS; Signature peptide; Tryptic digestion

Indexed keywords

DRUG PRODUCTS; MASS SPECTROMETRY; RISK ASSESSMENT; SPORTS;

EID: 84873714207     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6566-6     Document Type: Article
Times cited : (21)

References (24)
  • 1
    • 33750218125 scopus 로고    scopus 로고
    • The classification, functions and clinical use of different isoforms of HCG
    • 10.1093/humupd/dml029 10.1093/humupd/dml029 1:CAS:528:DC%2BD28XhtFeisbzJ
    • Stenman U-H, Tiitinen A, Alfthan H, Valmu L (2006) The classification, functions and clinical use of different isoforms of HCG. Hum Reprod Update 12(6):769-784. doi: 10.1093/humupd/dml029
    • (2006) Hum Reprod Update , vol.12 , Issue.6 , pp. 769-784
    • Stenman, U.-H.1    Tiitinen, A.2    Alfthan, H.3    Valmu, L.4
  • 2
    • 33646435277 scopus 로고    scopus 로고
    • The rationale for banning human chorionic gonadotropin and estrogen blockers in sport
    • 10.1210/jc.2005-2569 10.1210/jc.2005-2569 1:CAS:528:DC%2BD28XkslCntrk%3D
    • Handelsman DJ (2006) The rationale for banning human chorionic gonadotropin and estrogen blockers in sport. J Clin Endocrinol Metab 91(5):1646-1653. doi: 10.1210/jc.2005-2569
    • (2006) J Clin Endocrinol Metab , vol.91 , Issue.5 , pp. 1646-1653
    • Handelsman, D.J.1
  • 3
    • 84864854521 scopus 로고    scopus 로고
    • World Anti-Doping Agency Retrieved 25 Sept
    • World Anti-Doping Agency (2012) The 2012 Prohibited List. Retrieved 25 Sept from http://www.wada-ama.org/Documents/World-Anti-Doping-Program/WADP- Prohibited-list/2012/WADA-Prohibited-List-2012-EN.pdf
    • (2012) The 2012 Prohibited List
  • 4
    • 0025914158 scopus 로고
    • Human chorionic gonadotropin and sport
    • 10.1136/bjsm.25.2.73 1:STN:280:DyaK38%2FovFOlsA%3D%3D
    • Kicman AT, Brooks RV, Cowan DA (1991) Human chorionic gonadotropin and sport. Br J Sports Med 25:73-80
    • (1991) Br J Sports Med , vol.25 , pp. 73-80
    • Kicman, A.T.1    Brooks, R.V.2    Cowan, D.A.3
  • 5
    • 44349182525 scopus 로고    scopus 로고
    • Gonadotropins in doping: Pharmacological basis and detection of illicit use
    • 10.1038/bjp.2008.102 1:CAS:528:DC%2BD1cXmt1KqtL8%3D
    • Stenman UH, Hotakainen K, Alfthan H (2008) Gonadotropins in doping: pharmacological basis and detection of illicit use. Br J Pharmacol 154(3):569-583
    • (2008) Br J Pharmacol , vol.154 , Issue.3 , pp. 569-583
    • Stenman, U.H.1    Hotakainen, K.2    Alfthan, H.3
  • 7
    • 0034716483 scopus 로고    scopus 로고
    • Limitations of tests for human chorionic gonadotropin
    • 10.1016/S0140-6736(00)00066-0 1:STN:280:DC%2BD3c7ms1Ggtw%3D%3D
    • Bagshawe KD (2000) Limitations of tests for human chorionic gonadotropin. Lancet 355(9205):671
    • (2000) Lancet , vol.355 , Issue.9205 , pp. 671
    • Bagshawe, K.D.1
  • 8
    • 0036124932 scopus 로고    scopus 로고
    • The ISOBM TD-7 workshop on hCG and related molecules - Towards user-oriented standardization of pregnancy and tumor diagnosis: Assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives
    • 10.1159/000048686 1:CAS:528:DC%2BD38XhvVSkt7s%3D
    • Berger P, Sturgeon C, Bidart JM, Paus E, Gerth R, Niang M, Bristow A, Birken S, Stenman UH (2002) The ISOBM TD-7 workshop on hCG and related molecules - towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives. Tumor Biol 23(1):1-38
    • (2002) Tumor Biol , vol.23 , Issue.1 , pp. 1-38
    • Berger, P.1    Sturgeon, C.2    Bidart, J.M.3    Paus, E.4    Gerth, R.5    Niang, M.6    Bristow, A.7    Birken, S.8    Stenman, U.H.9
  • 9
    • 70350049242 scopus 로고    scopus 로고
    • Human chorionic gonadotropin tests
    • doi:10.1586/erm.09.51 10.1586/erm.09.51 1:CAS:528:DC%2BD1MXht1CmurrK
    • Cole LA (2009) Human chorionic gonadotropin tests. Expert Rev Mol Diagn 9(7):721-747. doi: doi:10.1586/erm.09.51
    • (2009) Expert Rev Mol Diagn , vol.9 , Issue.7 , pp. 721-747
    • Cole, L.A.1
  • 10
    • 2142765292 scopus 로고    scopus 로고
    • Between-method variation in human chorionic gonadotropin test results
    • 10.1373/clinchem.2003.026989 10.1373/clinchem.2003.026989 1:CAS:528:DC%2BD2cXjvVakt7k%3D
    • Cole LA, Sutton JM, Higgins TN, Cembrowski GS (2004) Between-method variation in human chorionic gonadotropin test results. Clin Chem 50(5):874-882. doi: 10.1373/clinchem.2003.026989
    • (2004) Clin Chem , vol.50 , Issue.5 , pp. 874-882
    • Cole, L.A.1    Sutton, J.M.2    Higgins, T.N.3    Cembrowski, G.S.4
  • 11
    • 68149169590 scopus 로고    scopus 로고
    • Differences in recognition of the 1st WHO international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin
    • on behalf of the IFCC Working Group on hCG 10.1373/clinchem.2009.124578 10.1373/clinchem.2009.124578 1:CAS:528:DC%2BD1MXptleis7o%3D
    • Sturgeon CM, Berger P, Bidart J-M, Birken S, Burns C, Norman RJ, Stenman U-H, on behalf of the IFCC Working Group on hCG (2009) Differences in recognition of the 1st WHO international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin. Clin Chem 55(8):1484-1491. doi: 10.1373/clinchem.2009.124578
    • (2009) Clin Chem , vol.55 , Issue.8 , pp. 1484-1491
    • Sturgeon, C.M.1    Berger, P.2    Bidart, J.-M.3    Birken, S.4    Burns, C.5    Norman, R.J.6    Stenman, U.-H.7
  • 12
    • 47849104898 scopus 로고    scopus 로고
    • History of mass spectrometry at the Olympic Games
    • 10.1002/jms.1445 1:CAS:528:DC%2BD1cXptVehurw%3D
    • Hemmersbach P (2008) History of mass spectrometry at the Olympic Games. J Mass Spectrom 43(7):839-853
    • (2008) J Mass Spectrom , vol.43 , Issue.7 , pp. 839-853
    • Hemmersbach, P.1
  • 13
    • 84864438319 scopus 로고    scopus 로고
    • Analytical challenges in the detection of peptide hormones for anti-doping purposes
    • 10.4155/bio.12.128 10.4155/bio.12.128 1:CAS:528:DC%2BC38XhtFSqt7fM
    • Barroso O, Handelsman DJ, Strasburger C, Thevis M (2012) Analytical challenges in the detection of peptide hormones for anti-doping purposes. Bioanalysis 4(13):1577-1590. doi: 10.4155/bio.12.128
    • (2012) Bioanalysis , vol.4 , Issue.13 , pp. 1577-1590
    • Barroso, O.1    Handelsman, D.J.2    Strasburger, C.3    Thevis, M.4
  • 14
    • 79960556066 scopus 로고    scopus 로고
    • Current role of LC-MS(/MS) in doping control
    • 10.1007/s00216-011-4859-9 10.1007/s00216-011-4859-9 1:CAS:528: DC%2BC3MXjsFGhsbk%3D
    • Thevis M, Thomas A, Schänzer W (2011) Current role of LC-MS(/MS) in doping control. Anal Bioanal Chem 401(2):405-420. doi: 10.1007/s00216-011-4859-9
    • (2011) Anal Bioanal Chem , vol.401 , Issue.2 , pp. 405-420
    • Thevis, M.1    Thomas, A.2    Schänzer, W.3
  • 15
    • 84866415757 scopus 로고    scopus 로고
    • Immuno MS-based targeted proteomics: Highly specific, sensitive and reproducible hCG determination for clinical diagnostics and doping analysis
    • doi: 10.1021/ac301418f
    • Lund H, Løvsletten K, Paus E, Halvorsen TG, Reubsaet L (2012) Immuno MS-based targeted proteomics: highly specific, sensitive and reproducible hCG determination for clinical diagnostics and doping analysis. Anal Chem. doi: 10.1021/ac301418f
    • (2012) Anal Chem
    • Lund H, L.1
  • 16
    • 70449450325 scopus 로고    scopus 로고
    • Exploring the complementary selectivity of immunocapture and MS detection for the differentiation between hCG isoforms in clinically relevant samples
    • 10.1021/pr900580n 1:CAS:528:DC%2BD1MXhtFGiu77O
    • Lund H, Torsetnes SB, Paus E, Nustad K, Lo R, Halvorsen TG (2009) Exploring the complementary selectivity of immunocapture and MS detection for the differentiation between hCG isoforms in clinically relevant samples. J Proteome Res 8(11):5241-5252
    • (2009) J Proteome Res , vol.8 , Issue.11 , pp. 5241-5252
    • Lund, H.1    Torsetnes, S.B.2    Paus, E.3    Nustad, K.4    Lo, R.5    Halvorsen, T.G.6
  • 17
    • 84873729401 scopus 로고    scopus 로고
    • Norwegian Medicines Agency Retrieved 25 Sept
    • Norwegian Medicines Agency (2011) Preparatsøk. Preparatomtale. Retrieved 25 Sept from http://www.legemiddelverket.no/custom/Preparatsok/ prepSearch-80333.aspx
    • (2011) Preparatsøk. Preparatomtale
  • 19
    • 0038307595 scopus 로고    scopus 로고
    • Immunoaffinity extraction and tandem mass spectrometric analysis of human chorionic gonadotropin in doping analysis
    • 10.1016/S1570-0232(03)00264-2 1:CAS:528:DC%2BD3sXlt1aktrk%3D
    • Gam L-H, Tham S-Y, Latiff A (2003) Immunoaffinity extraction and tandem mass spectrometric analysis of human chorionic gonadotropin in doping analysis. J Chromatogr B 792(2):187-196
    • (2003) J Chromatogr B , vol.792 , Issue.2 , pp. 187-196
    • Gam, L.-H.1    Tham, S.-Y.2    Latiff, A.3
  • 20
    • 0030788079 scopus 로고    scopus 로고
    • Immunoprocedures for detecting human chorionic gonadotropin: Clinical aspects and doping control
    • 1:CAS:528:DyaK2sXktlCkur4%3D
    • Stenman U-H, Unkila-Kallio L, Korhonen J, Alfthan H (1997) Immunoprocedures for detecting human chorionic gonadotropin: clinical aspects and doping control. Clin Chem 43(7):1293-1298
    • (1997) Clin Chem , vol.43 , Issue.7 , pp. 1293-1298
    • Stenman, U.-H.1    Unkila-Kallio, L.2    Korhonen, J.3    Alfthan, H.4
  • 21
    • 68949221165 scopus 로고    scopus 로고
    • Effects of recombinant human LH and hCG on serum and urine LH and androgens in men
    • 10.1111/j.1365-2265.2008.03516.x 10.1111/j.1365-2265.2008.03516.x 1:CAS:528:DC%2BD1MXhtFagtLzK
    • Handelsman DJ, Goebel C, Idan A, Jimenez M, Trout G, Kazlauskas R (2009) Effects of recombinant human LH and hCG on serum and urine LH and androgens in men. Clin Endocrin 71(3):417-428. doi: 10.1111/j.1365-2265.2008.03516.x
    • (2009) Clin Endocrin , vol.71 , Issue.3 , pp. 417-428
    • Handelsman, D.J.1    Goebel, C.2    Idan, A.3    Jimenez, M.4    Trout, G.5    Kazlauskas, R.6
  • 22
    • 82955163026 scopus 로고    scopus 로고
    • Loss of human chorionic gonadotropin in urine during storage at -20 C
    • 10.1016/j.cca.2011.09.038 10.1016/j.cca.2011.09.038
    • Lempiäinen A, Hotakainen K, Alfthan H, Stenman U-H (2012) Loss of human chorionic gonadotropin in urine during storage at -20 C. Clin Chim Acta 413(1-2):232-236. doi: 10.1016/j.cca.2011.09.038
    • (2012) Clin Chim Acta , vol.413 , Issue.1-2 , pp. 232-236
    • Lempiäinen, A.1    Hotakainen, K.2    Alfthan, H.3    Stenman, U.-H.4
  • 23
    • 77953318032 scopus 로고    scopus 로고
    • Evaluation of two immunoassays for the measurement of human chorionic gonadotropin in urine for anti-doping purposes
    • 1:CAS:528:DC%2BC3cXhtVSlu77P
    • Robinson N, Sottas P-E, Saugy M (2010) Evaluation of two immunoassays for the measurement of human chorionic gonadotropin in urine for anti-doping purposes. Clin Lab 56(5-6):197-206
    • (2010) Clin Lab , vol.56 , Issue.5-6 , pp. 197-206
    • Robinson, N.1    Sottas, P.-E.2    Saugy, M.3
  • 24
    • 62149105580 scopus 로고    scopus 로고
    • New discoveries on the biology and detection of human chorionic gonadotropin
    • 10.1186/1477-7827-7-8
    • Cole L (2009) New discoveries on the biology and detection of human chorionic gonadotropin. Reprod Biol Endocrin 7(1):8
    • (2009) Reprod Biol Endocrin , vol.7 , Issue.1 , pp. 8
    • Cole, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.