The significance and robustness of a plasma free amino acid (PFAA) profile-based multiplex function for detecting lung cancer

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Shingyoji, Masato ^a   Iizasa, Toshihiko ^a   Higashiyama, Masahiko ^b   Imamura, Fumio ^b   Saruki, Nobuhiro ^c   Imaizumi, Akira ^d   Yamamoto, Hiroshi ^d   Daimon, Takashi ^e   Tochikubo, Osamu ^f   Mitsushima, Toru ^g   Yamakado, Minoru ^h   Kimura, Hideki ^a  

^a CHIBA CANCER CENTER   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c GUNMA PREFECTURAL CANCER CENTER   (Japan)

^d AJINOMOTO CO INC   (Japan)

^e HYOGO COLLEGE OF MEDICINE   (Japan)

^f Kanagawa Health Service Association   (Japan)

^g KAMEDA MEDICAL CENTER   (Japan)

^h MITSUI MEMORIAL HOSPITAL   (Japan)

Author keywords

Amino acid; Early detection; Lung cancer; Plasma

Indexed keywords

AMINO ACID; TUMOR MARKER;

ADULT; AGED; AMINO ACID ANALYSIS; AMINO ACID BLOOD LEVEL; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LUNG CANCER; MAJOR CLINICAL STUDY; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EARLY DETECTION OF CANCER; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84873714106     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-77     Document Type: Article

References (41)

1. Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, et al. Detection of microRNA expression in human peripheral blood microvesicles. PLoS One 2008, 3(11):e3694. 10.1371/journal.pone.0003694, 2577891, 19002258.
2. Roth C, Kasimir-Bauer S, Pantel K, Schwarzenbach H. Screening for circulating nucleic acids and caspase activity in the peripheral blood as potential diagnostic tools in lung cancer. Mol Oncol 2011, 5(3):281-291. 10.1016/j.molonc.2011.02.002, 21398193.
3. Roth C, Rack B, Muller V, Janni W, Pantel K, Schwarzenbach H. Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Canc Res 2010, 12(6):R90.
4. Chadeau-Hyam M, Ebbels TM, Brown IJ, Chan Q, Stamler J, Huang CC, Daviglus ML, Ueshima H, Zhao L, Holmes E, et al. Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification. J Proteome Res 2010, 9(9):4620-4627. 10.1021/pr1003449, 2941198, 20701291.
5. Lee K, Hwang D, Yokoyama T, Stephanopoulos G, Stephanopoulos GN, Yarmush ML. Identification of optimal classification functions for biological sample and state discrimination from metabolic profiling data. Bioinformatics 2004, 20(6):959-969. 10.1093/bioinformatics/bth015, 14751977.
6. Kim Y, Koo I, Jung BH, Chung BC, Lee D. Multivariate classification of urine metabolome profiles for breast cancer diagnosis. BMC Bioinforma 2010, 11(2):S4.
7. Nolen B, Velikokhatnaya L, Marrangoni A, De Geest K, Lomakin A, Bast RC, Lokshin A. Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass. Gynecol Oncol 2010, 117(3):440-445. 10.1016/j.ygyno.2010.02.005, 2873171, 20334903.
8. Pasikanti KK, Esuvaranathan K, Ho PC, Mahendran R, Kamaraj R, Wu QH, Chiong E, Chan EC. Noninvasive urinary metabonomic diagnosis of human bladder cancer. J Proteome Res 2010, 9(6):2988-2995. 10.1021/pr901173v, 20337499.
9. Qiu Y, Cai G, Su M, Chen T, Zheng X, Xu Y, Ni Y, Zhao A, Xu LX, Cai S, et al. Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS. J Proteome Res 2009, 8(10):4844-4850. 10.1021/pr9004162, 19678709.
10. Qiu Y, Patwa TH, Xu L, Shedden K, Misek DE, Tuck M, Jin G, Ruffin MT, Turgeon DK, Synal S, et al. Plasma glycoprotein profiling for colorectal cancer biomarker identification by lectin glycoarray and lectin blot. J Proteome Res 2008, 7(4):1693-1703. 10.1021/pr700706s, 2751808, 18311904.
11. Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Humpfer E, Spraul M, Carreira IM, Melo JB, Bernardo J, Gomes A, et al. Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy. J Proteome Res 2010, 9(1):319-332. 10.1021/pr9006574, 19908917.
12. Urayama S, Zou W, Brooks K, Tolstikov V. Comprehensive mass spectrometry based metabolic profiling of blood plasma reveals potent discriminatory classifiers of pancreatic cancer. Rapid Commun Mass Spectrom 2010, 24(5):613-620. 10.1002/rcm.4420, 20143319.
13. Felig P, Marliss E, Ohman JL, Cahill CF. Plasma amino acid levels in diabetic ketoacidosis. Diabetes 1970, 19(10):727-728.
14. Felig P, Wahren J, Raf L. Evidence of inter-organ amino-acid transport by blood cells in humans. Proc Natl Acad Sci USA 1973, 70(6):1775-1779. 10.1073/pnas.70.6.1775, 433594, 4515937.
15. Fischer JE, Funovics JM, Aguirre A, James JH, Keane JM, Wesdorp RI, Yoshimura N, Westman T. The role of plasma amino acids in hepatic encephalopathy. Surgery 1975, 78(3):276-290.
16. Fischer JE, Rosen HM, Ebeid AM, James JH, Keane JM, Soeters PB. The effect of normalization of plasma amino acids on hepatic encephalopathy in man. Surgery 1976, 80(1):77-91.
17. Kimura T, Noguchi Y, Shikata N, Takahashi M. Plasma amino acid analysis for diagnosis and amino acid-based metabolic networks. Curr Opin Clin Nutr Metab Care 2009, 12(1):49-53. 10.1097/MCO.0b013e3283169242, 19057187.
18. Noguchi Y, Zhang QW, Sugimoto T, Furuhata Y, Sakai R, Mori M, Takahashi M, Kimura T. Network analysis of plasma and tissue amino acids and the generation of an amino index for potential diagnostic use. Am J Clin Nutr 2006, 83(2):513S-519S.
19. Cascino A, Cangiano C, Ceci F, Franchi F, Mineo T, Mulieri M, Muscaritoli M, Rossi Fanelli F. Increased plasma free tryptophan levels in human cancer: a tumor related effect?. Anticancer Res 1991, 11(3):1313-1316.
20. Cascino A, Muscaritoli M, Cangiano C, Conversano L, Laviano A, Ariemma S, Meguid MM, Rossi Fanelli F. Plasma amino acid imbalance in patients with lung and breast cancer. Anticancer Res 1995, 15(2):507-510.
21. Kubota A, Meguid MM, Hitch DC. Amino acid profiles correlate diagnostically with organ site in three kinds of malignant tumors. Cancer 1992, 69(9):2343-2348. 10.1002/1097-0142(19920501)69:9<2343::AID-CNCR2820690924>3.0.CO;2-S, 1562982.
22. Lai HS, Lee JC, Lee PH, Wang ST, Chen WJ. Plasma free amino acid profile in cancer patients. Semin Canc Biol 2005, 15(4):267-276.
23. Laviano A, Cascino A, Muscaritoli M, Fanfarillo F, Rossi Fanelli F. Tumor-induced changes in host metabolism: a possible role for free tryptophan as a marker of neoplastic disease. Adv Exp Med Biol 2003, 527:363-366. 10.1007/978-1-4615-0135-0_41, 15206751.
24. Naini AB, Dickerson JW, Brown MM. Preoperative and postoperative levels of plasma protein and amino acid in esophageal and lung cancer patients. Cancer 1988, 62(2):355-360. 10.1002/1097-0142(19880715)62:2<355::AID-CNCR2820620221>3.0.CO;2-E, 3383136.
25. Norton JA, Gorschboth CM, Wesley RA, Burt ME, Brennan MF. Fasting plasma amino acid levels in cancer patients. Cancer 1985, 56(5):1181-1186. 10.1002/1097-0142(19850901)56:5<1181::AID-CNCR2820560535>3.0.CO;2-8, 3926295.
26. Proenza AM, Oliver J, Palou A, Roca P. Breast and lung cancer are associated with a decrease in blood cell amino acid content. J Nutr Biochem 2003, 14(3):133-138. 10.1016/S0955-2863(02)00225-5, 12742540.
27. Vissers YL, Dejong CH, Luiking YC, Fearon KC, von Meyenfeldt MF, Deutz NE. Plasma arginine concentrations are reduced in cancer patients: evidence for arginine deficiency?. Am J Clin Nutr 2005, 81(5):1142-1146.
28. Fontana S, Alessandro R, Barranca M, Giordano M, Corrado C, Zanella-Cleon I, Becchi M, Kohn EC, De Leo G. Comparative proteome profiling and functional analysis of chronic myelogenous leukemia cell lines. J Proteome Res 2007, 6(11):4330-4342. 10.1021/pr0704128, 17935311.
29. Shimbo K, Kubo S, Harada Y, Oonuki T, Yokokura T, Yoshida H, Amao M, Nakamura M, Kageyama N, Yamazaki J, et al. Automated precolumn derivatization system for analyzing physiological amino acids by liquid chromatography/mass spectrometry. Biomed Chromatogr 2009, 24(7):683-691.
30. Shimbo K, Oonuki T, Yahashi A, Hirayama K, Miyano H. Precolumn derivatization reagents for high-speed analysis of amines and amino acids in biological fluid using liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom 2009, 23(10):1483-1492. 10.1002/rcm.4026, 19350529.
31. Shimbo K, Yahashi A, Hirayama K, Nakazawa M, Miyano H. Multifunctional and highly sensitive precolumn reagents for amino acids in liquid chromatography/tandem mass spectrometry. Anal Chem 2009, 81(13):5172-5179. 10.1021/ac900470w, 19480430.
32. Maeda J, Higashiyama M, Imaizumi A, Nakayama T, Yamamoto H, Daimon T, Yamakado M, Imamura F, Kodama K. Possibility of multivariate function composed of plasma amino acid profiles as a novel screening index for non-small cell lung cancer: a case control study. BMC Canc 2010, 10(1):690.
33. Okamoto N, Miyagi Y, Chiba A, Akaike M, Shiozawa M, Imaizumi A, Yamamoto H, Ando T, Yamakado M, Tochikubo O. Diagnostic modeling with differences in plasma amino acid profiles between non-cachectic colorectal/breast cancer patients and healthy individuals. Int J Med Med Sci 2009, 1(1):1-8.
34. Miyagi Y, Higashiyama M, Gochi A, Akaike M, Ishikawa T, Miura T, Saruki N, Bando E, Kimura H, Imamura F, et al. Plasma free amino acid profiling of five types of cancer patients and its application for early detection. PLoS One 2011, 6(9):e24143. 10.1371/journal.pone.0024143, 3168486, 21915291.
35. Okamoto N. Cancer screening using " AminoIndex Technology" Ningen Dock 2011, 26(3):454-466.
36. Asamura H, Goya T, Koshiishi Y, Sohara Y, Eguchi K, Mori M, Nakanishi Y, Tsuchiya R, Shimokata K, Inoue H, et al. A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers. J Thorac Oncol 2008, 3(1):46-52. 10.1097/JTO.0b013e31815e8577, 18166840.
37. Sumitani M, Takifuji N, Nanjyo S, Imahashi Y, Kiyota H, Takeda K, Yamamoto R, Tada H. Clinical relevance of sputum cytology and chest X-ray in patients with suspected lung tumors. Intern Med 2008, 47(13):1199-1205. 10.2169/internalmedicine.47.0777, 18591840.
38. Sobin L, Wittekind C. TNM Classification of Malignant Tumours, Sixth Edition 2002, New York: Wiley-Liss.
39. Ando S, Kimura H, Iwai N, Kakizawa K, Shima M, Ando M. The significance of tumour markers as an indication for mediastinoscopy in non-small cell lung cancer. Respirology 2003, 8(2):163-167. 10.1046/j.1440-1843.2003.00443.x, 12753530.
40. Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982, 143(1):29-36.
41. Molina R, Auge JM, Filella X, Vinolas N, Alicarte J, Domingo JM, Ballesta AM. Pro-gastrin-releasing peptide (proGRP) in patients with benign and malignant diseases: comparison with CEA, SCC, CYFRA 21-1 and NSE in patients with lung cancer. Anticancer Res 2005, 25(3A):1773-1778.