Microwave-assisted synthesis of triazole-linked phthalocyanine-peptide conjugates as potential photosensitizers for photodynamic therapy

Synthesis (Germany)

Volumn 45, Issue 4, 2013, Pages 556-561

  Sokolova, Nadezhda V ^a   Schotten, Theo ^b   Berthold, Herwig J ^c   Thiem, Joachim ^d   Nenajdenko, Valentine G ^a  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b CAN GmbH   (Germany)

^c ATOTECH DEUTSCHLAND GMBH   (Germany)

^d UNIVERSITY OF HAMBURG   (Germany)

Author keywords

azidopeptides; click chemistry; photosensitizers; phthalocyanines; water soluble conjugates

Indexed keywords

1 ,3-DIPOLARCYCLOADDITION; AMIDE FUNCTIONALITIES; AZIDOPEPTIDES; CLICK CHEMISTRY; CONCENTRATION RANGES; DEPROTECTION; MICROWAVE ASSISTED SYNTHESIS; MICROWAVE-ASSISTED; PHTHALOCYANINES; THERAPEUTIC USE; WATER-SOLUBLE CONJUGATES;

CYCLOADDITION; PEPTIDES; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS;

NITROGEN COMPOUNDS;

[2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 (ALANYLAMINO)ETHYL]AMINO] 3 METHYLBUTYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 (ISOLEUCYLAMINO)PROPYL]AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 [[N (TERT BUTOXYCARBONYL)ALANYL](2,4 DIMETHOXYBENZYL)AMINO]ETHYL]AMINO] 3 METHYLBUTYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 [[N (TERT BUTOXYCARBONYL)ISOLEUCYL](2,4 DIMETHOXYBENZYL)AMINO] 2 METHYLPROPYL]AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 [[N (TERT BUTOXYCARBONYL)ISOLEUCYL](4 METHOXYBENZYL)AMINO] 2 METHYLPROPYL]AMINO] 3 PHENYLPROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 [[N (TERT BUTOXYCARBONYL)PHENYLALANYL](2,4 DIMETHOXYBENZYL)AMINO] 2 METHYLPROPYL]AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 [[N (TERT BUTOXYCARBONYL)VALYL](4 METHOXYBENZYL)AMINO] 2 METHYLPROPYL]AMINO] 3 METHYLPENTYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; [2,3,9,10,16,17,23,24 OCTAKIS[[[1 [2 [[2 METHYL 2 (PHENYLALANYLAMINO)PROPYL]AMINO]PROPYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY]METHYL]PHTHALOCYANINATO]ZINC; PEPTIDE; PHOTOSENSITIZING AGENT; PHTHALOCYANINE DERIVATIVE; TRIAZOLE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MICROWAVE RADIATION; PHOTODYNAMIC THERAPY; TOXICITY TESTING;

EID: 84873713400     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1316845     Document Type: Article

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