Statins do not influence clinical response and B cell depletion after rituximab treatment in rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 72, Issue 3, 2013, Pages 463-464

  Das, Sudipto ^a   Matilla, Meritxell Fernandez ^a   Dass, Shouvik ^a   Buch, Maya H ^a   Rawstron, Andrew C ^b   Vital, Edward M ^a   Emery, Paul ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CD20 ANTIGEN; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; RHEUMATOID FACTOR; RITUXIMAB;

AGED; B LYMPHOCYTE; DISEASE ACTIVITY SCORE; FLOW CYTOMETRY; HUMAN; HUMORAL IMMUNE DEFICIENCY; LETTER; MAJOR CLINICAL STUDY; MEMORY CELL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; TREATMENT RESPONSE;

AGED; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; CLINICAL TRIALS AS TOPIC; FLOW CYTOMETRY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MIDDLE AGED;

EID: 84873701856     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-202454     Document Type: Letter

References (3)

1. Winiarska M, Bil J, Wilczek E., et al Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. PLoS Medicine 2008; 5: e64.
2. Vital EM, Dass S, Rawstron A.C., et al Management of nonresponse to rituximab in rheumatoid arthritis: predictors and outcome of re-treatment. Arthritis Rheum 2010; 62: 1273-9.
3. Arts EE, Jansen TL, Den Broeder A, et al Statins inhibit the antirheumatic effects of rituximab in rheumatoid arthritis: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry. Ann Rheum Dis 2011; 70: 877-8.