Use of N-acetylcysteine during liver procurement: A prospective randomized controlled study

Liver Transplantation

Volumn 19, Issue 2, 2013, Pages 135-144

  D'Amico, Francesco ^a   Vitale, Alessandro ^a   Piovan, Donatella ^a   Bertacco, Alessandra ^a   Ramirez Morales, Rafael ^b   Chiara Frigo, Anna ^a   Bassi, Domenico ^a   Bonsignore, Pasquale ^a   Gringeri, Enrico ^a   Valmasoni, Michele ^a   Garbo, Greta ^a   Lodo, Enrico ^a   D'Amico, Francesco Enrico ^a   Scopelliti, Michele ^a   Carraro, Amedeo ^a   Gambato, Martina ^a   Brolese, Alberto ^a   Zanus, Giacomo ^a   Neri, Daniele ^a   Cillo, Umberto ^a  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE;

ADULT; AGED; ARTERY CLAMP; ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; GRAFT SURVIVAL; HUMAN; LIVER DYSFUNCTION; LIVER FAILURE; LIVER TRANSPLANTATION; LIVING DONOR; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE; SINGLE BLIND PROCEDURE;

ACETYLCYSTEINE; ADOLESCENT; ADULT; AGED; ANTIOXIDANTS; CHI-SQUARE DISTRIBUTION; FEMALE; GRAFT SURVIVAL; HUMANS; INFUSIONS, INTRAVENOUS; ITALY; KAPLAN-MEIER ESTIMATE; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; PORTAL VEIN; PRIMARY GRAFT DYSFUNCTION; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; TIME FACTORS; TISSUE AND ORGAN HARVESTING; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84873696578     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.23527     Document Type: Article

References (21)

1. Briceño J, Ciria R, de la Mata M, Rufián S, Lõpez-Cillero P,. Prediction of graft dysfunction based on extended criteria donors in the Model for End-Stage Liver Disease score era. Transplantation 2010; 90: 530-539.
2. Silberhumer GR, Pokorny H, Hetz H, Herkner H, Rasoul-Rockenschaub S, Soliman T, et al. Combination of extended donor criteria and changes in the Model for End-Stage Liver Disease score predict patient survival and primary dysfunction in liver transplantation: a retrospective analysis. Transplantation 2007; 83: 588-592. (Pubitemid 46440248)
3. Feng S, Goodrich NP, Bragg-Gresham JL, Dykstra DM, Punch JD, DebRoy MA, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006; 6: 783-790. (Pubitemid 43345017)
4. Sener G, Tosun O, Sehirli AO, Kaçmaz A, Arbak S, Ersoy Y, Ayanoǧlu-Dülger G,. Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion. Life Sci 2003; 72: 2707-2718. (Pubitemid 36388760)
5. Pratschke S, Angele MK, Grützner U, Tufman A, Bilzer M, Loehe F, et al. GSH attenuates organ injury and improves function after transplantation of fatty livers. Eur Surg Res 2010; 45: 13-19.
6. Aitio ML,. N-Acetylcysteine-passe-partout or much ado about nothing? Br J Clin Pharmacol 2006; 61: 5-15.
7. Vitale A, Saracino E, D'Amico FE, Grigoletto F, Burra P, Angeli P, et al. Prospective validation of a new priority allocation model for liver transplant candidates: an interim analysis. Transplant Proc 2009; 41: 1092-1095.
8. D'Amico F, Vitale A, Gringeri E, Valmasoni M, Carraro A, Brolese A, et al. Liver transplantation using suboptimal grafts: impact of donor harvesting technique. Liver Transpl 2007; 13: 1444-1450. (Pubitemid 47629579)
9. Pokorny H, Langer F, Herkner H, Schernberger R, Plöchl W, Soliman T, et al. Influence of cumulative number of marginal donor criteria on primary organ dysfunction in liver recipients. Clin Transplant 2005; 19: 532-536. (Pubitemid 40990666)
10. D'Amico F, Vitale A, Gringeri E, Valmasoni M, Carraro A, Brolese A, et al. Systemic and loco-regional infusion of N'acetilcisteina during liver procurement: a prospective randomized controlled study [abstract]. Liver Transpl 2008; 14 (suppl 1): S205.
11. Zhai Y, Busuttil RW, Kupiec-Weglinski JW,. Liver ischemia and reperfusion injury: new insights into mechanisms of innate-adaptive immune-mediated tissue inflammation. Am J Transplant 2011; 11: 1563-1569.
12. Angelico M, Cillo U, Fagiuoli S, Gasbarrini A, Gavrila C, Marianelli T, et al.; for Liver Match Investigators. Liver Match, a prospective observational cohort study on liver transplantation in Italy: study design and current practice of donor-recipient matching. Dig Liver Dis 2011; 43: 155-164.
13. Volk ML, Lok AS, Pelletier SJ, Ubel PA, Hayward RA,. Impact of the Model for End-Stage Liver Disease allocation policy on the use of high-risk organs for liver transplantation. Gastroenterology 2008; 135: 1568-1574.
14. Schaubel DE, Sima CS, Goodrich NP, Feng S, Merion RM,. The survival benefit of deceased donor liver transplantation as a function of candidate disease severity and donor quality. Am J Transplant 2008; 8: 419-425. (Pubitemid 351175358)
15. Weismüller TJ, Negm A, Becker T, Barg-Hock H, Klempnauer J, Manns MP, Strassburg CP,. The introduction of MELD-based organ allocation impacts 3-month survival after liver transplantation by influencing pretransplant patient characteristics. Transpl Int 2009; 22: 970-978.
16. Hoffmann K, Büchler MW, Schemmer P,. Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation-where do we stand today? Clin Nutr 2011; 30: 143-147.
17. Jegatheeswaran S, Siriwardena AK,. Experimental and clinical evidence for modification of hepatic ischaemia-reperfusion injury by N-acetylcysteine during major liver surgery. HPB (Oxford) 2011; 13: 71-78.
18. Regueira FM, Cienfuegos JA, Pardo F, Hernández JL, Díez-Caballero A, Sierra A, et al. Improvement in early function of the hepatic graft after treatment of the donor with N-acetylcysteine: clinical study. Transplant Proc 1997; 29: 3350-3352. (Pubitemid 28008504)
19. Schaubel DE, Guidinger MK, Biggins SW, Kalbfleisch JD, Pomfret EA, Sharma P, Merion RM,. Survival benefit-based deceased-donor liver allocation. Am J Transplant 2009; 9 (pt 2): 970-981.
20. Cescon M, Grazi GL, Cucchetti A, Ravaioli M, Ercolani G, Vivarelli M, et al. Improving the outcome of liver transplantation with very old donors with updated selection and management criteria. Liver Transpl 2008; 14: 672-679. (Pubitemid 351696280)
21. Dutkowski P, de Rougemont O, Clavien PA,. Machine perfusion for 'marginal' liver grafts. Am J Transplant 2008; 8: 917-924. (Pubitemid 351537756)