Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells

International Journal of Oncology

Volumn 42, Issue 1, 2013, Pages 269-276

  Wang, Jinheng ^a   Li, Junying ^b   Huang, Yanmei ^a   Song, Xiangfeng ^a   Niu, Zhiguo ^a   Gao, Zhitao ^a   Wang, Hui ^a  

^a XINXIANG MEDICAL UNIVERSITY   (China)

^b Henan Province Red Cross Blood Center   (China)

Author keywords

Bay 11 7082; Bcl 3; Human T cell leukemia virus type 1; NF B activation; P65 nuclear translocation; Tax

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; BETA ACTIN; CYCLIN D1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 3; PROTEIN P100; PROTEIN P105; PROTEIN P50; SYNAPTOTAGMIN I;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA CELL LINE; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ADULT; APOPTOSIS; BLOTTING, WESTERN; CELL NUCLEUS; CELL PROLIFERATION; CYTOPLASM; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; NF-KAPPA B; NITRILES; PLASMIDS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS; RNA, SMALL INTERFERING; SULFONES; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

EID: 84873692403     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1685     Document Type: Article

References (35)

1. Gessain A, Barin F, Vernant JC, et al: Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 2: 407-410, 1985. (Pubitemid 15231248)
2. Yoshida M, Miyoshi I and Hinuma Y: Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci USA 79: 2031-2035, 1982. (Pubitemid 12088563)
3. Osame M, Usuku K, Izumo S, et al: HTLV-I associated myelopathy, a new clinical entity. Lancet 1: 1031-1032, 1986. (Pubitemid 16102987)
4. Harhaj E and Harhaj N: Mechanisms of Persistent NF-κB Activation by HTLV-I Tax. Int Union Biochem Mol Biol: Life 57: 83-91, 2005. (Pubitemid 40632298)
5. Shvarzbeyn J and Huleihel M: Effect of propolis and caffeic acid phenethyl ester (CAPE) on NFκB activation by HTLV-1 Tax. Antiviral Res 90: 108-115, 2011.
6. Yasunaga J, Lin FC, Lu X and Jeang KT: Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-κB signaling. J Virol 85: 6212-6219, 2011.
7. Azran I, Jeang K-T and Aboud M: High levels of cytoplasmic HTLV-1 Tax mutant proteins retain a Tax-NF-κB-CBP ternary complex in the cytoplasm. Oncogene 24: 4521-4530, 2005. (Pubitemid 41032615)
8. Hayden MS, West AP and Ghosh S: SnapShot: NF-κB signaling Pathways. Cell 127: 1286-1287, 2006.
9. Hironaka N, Mochida K, Mori N, Maeda M, Yamamoto N and Yamaoka S: Tax-independent constitutive IκB kinase activation in adult T-cell leukemia cells. Neoplasia 6: 266-278, 2004. (Pubitemid 38657083)
10. Michel F, Soler-Lopez M, Petosa C, Cramer P, Siebenlist U and Muller CW: Crystal structure of the ankyrin repeat domain of Bcl-3: a unique member of the IkappaB protein family. EMBO J 20: 6180-6190, 2001. (Pubitemid 33078692)
11. Courtois G and Gilmore TD: Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene 25: 6831-6843, 2006. (Pubitemid 44657855)
12. Palmer S and Chen YH: Bcl-3, a multifaceted modulator of NF-κB-mediated gene transcription. Immunol Res 42: 210-218, 2008.
13. McKeithan TW, Takimoto GS, Ohno H, et al: BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study. Genes Chromosomes Cancer 20: 64-72, 1997. (Pubitemid 27377101)
14. Bundy DL and McKeithan TW: Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA. J Biol Chem 272: 33132-33139, 1997. (Pubitemid 28023657)
15. Fujita T, Nolan GP, Liou HC, Scott ML and Baltimore D: The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 7: 1354-1363, 1993. (Pubitemid 23210884)
16. Franzoso G, Bours V, Azarenko V, et al: The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites. EMBO J 12: 3893-3901, 1993. (Pubitemid 23282765)
17. Bours V, Franzoso G, Azarenko V, et al: The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 72: 729-739, 1993. (Pubitemid 23093881)
18. Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K and Siebenlist U: The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition. Nature 359: 339-342, 1992.
19. Inoue J, Takahara T, Akizawa T and Hino O: Bcl-3, a member of the I kappa B proteins, has distinct specificity towards the Rel family of proteins. Oncogene 8: 2067-2073, 1993. (Pubitemid 23226939)
20. Nolan GP, Fujita T, Bhatia K, et al: The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner. Mol Cell Biol 13: 3557-3566, 1993. (Pubitemid 23157293)
21. Caamano JH, Perez P, Lira SA and Bravo R: Constitutive expression of Bc1-3 in thymocytes increases the DNA binding of NF-kappaB1 (p50) homodimers in vivo. Mol Cell Biol 16: 1342-1348, 1996. (Pubitemid 26095604)
22. Kabuta T, Hakuno F, Cho Y, et al: Insulin receptor substrate-3, interacting with Bcl-3, enhances p50 NF-κB activity. Biochem Biophys Res Commun 394: 697-702, 2010.
23. Brocke-Heidrich K, Ge B, Cvijic H, et al: BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription. Oncogene 25: 7297-7304, 2006. (Pubitemid 44809095)
24. Kim YM, Sharma N and Nyborg JK: The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter. J Virol 82: 11939-11947, 2008.
25. Saito K, Saito M, Taniura N, Okuwa T and Ohara Y: Activation of the PI3K-Akt pathway by human T cell leukemia virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of HTLV-1-infected T cells. Virology 403: 173-180, 2010.
26. Xia Y SY, Gao Y, Guo JQ, Song XF and Wang H: Establishment of the tax gene expression cell lines and their biological activity. Zhongguo Shi Yan Xue Ye Xue Za Zhi 16: 1425-1429, 2008.
27. Kress AK, Schneider G, Pichler K, Kalmer M, Fleckenstein B and Grassmann R: Elevated cyclic AMP levels in T lymphocytes transformed by human T-cell lymphotropic virus type 1. J Virol 84: 8732-8742, 2010.
28. Ishikawa C, Nakachi S, Senba M, Sugai M and Mori N: Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis. Carcinogenesis 32: 110-119, 2011.
29. Boxus M, Twizere J-C, Legros S, Dewulf J-F, Kettmann R and Willems L: The HTLV-1 Tax interactome. Retrovirology 5: 76, 2008.
30. Sun SC and Ballard DW: Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases. Oncogene 18: 6948-6958, 1999.
31. Li XH and Gaynor RB: Mechanisms of NF-kappaB activation by the HTLV type 1 tax protein. AIDS Res Hum Retroviruses 16: 1583-1590, 2000.
32. Kfoury Y, Nasr R, Hermine O, de The H and Bazarbachi A: Proapoptotic regimes for HTLV-I-transformed cells: targeting Tax and the NF-kappaB pathway. Cell Death Differ 12 (Suppl 1): 871-877, 2005. (Pubitemid 41030603)
33. Mori N, Yamada Y, Ikeda S, et al: Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 100: 1828-1834, 2002. (Pubitemid 34925163)
34. O'Mahony AM: Human T-cell lymphotropic virus type 1 Tax induction of biologically active NF-κB requires IκB kinase-1-mediated phosphorylation of RelA/p65. J Biol Chem 279: 18137-18145, 2004. (Pubitemid 38623226)
35. Sun SC, Elwood J, Beraud C and Greene WC: Human T-cell leukemia virus type I Tax activation of NF-kappa B/Rel involves phosphorylation and degradation of I kappa B alpha and RelA (p65)-mediated induction of the c-rel gene. Mol Cell Biol 14: 7377-7384, 1994. (Pubitemid 24326402)