Different impact of the appropriateness of empirical antibiotics for bacteremia among younger adults and the elderly in the ED

American Journal of Emergency Medicine

Volumn 31, Issue 2, 2013, Pages 282-290

  Lee, Ching Chi ^a   Chang, Chia Ming ^a   Hong, Ming Yuan ^a   Hsu, Hsiang Chin ^a   Ko, Wen Chien ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CREATININE;

ADULT; AGED; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTEREMIA; CASE CONTROL STUDY; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CREATININE BLOOD LEVEL; EMERGENCY WARD; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MORTALITY; PREDICTION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SURVIVOR; URINARY TRACT INFECTION;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; BACTEREMIA; EMERGENCY SERVICE, HOSPITAL; FEMALE; FOLLOW-UP STUDIES; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INAPPROPRIATE PRESCRIBING; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDIES; TAIWAN; TREATMENT OUTCOME;

EID: 84873675467     PISSN: 07356757     EISSN: 15328171     Source Type: Journal    
DOI: 10.1016/j.ajem.2012.07.024     Document Type: Article

References (31)

1. D.W. Bates, K.E. Pruess, and T.H. Lee How bad are bacteremia and sepsis? Outcomes in a cohort with suspected bacteremia Arch Intern Med 155 1995 593 598
2. J.B. Haug, S. Harthug, T. Kalager, A. Digranes, and C.O. Solberg Bloodstream infections at a Norwegian university hospital, 1974-1979 and 1988-1989: changing etiology, clinical features, and outcome Clin Infect Dis 19 1994 246 256
3. L. Leibovici, I. Shraga, M. Drucker, H. Konigsberger, Z. Samra, and S.D. Pitlik The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection J Intern Med 244 1998 379 386
4. S. Harbarth, J. Garbino, J. Pugin, J.A. Romand, D. Lew, and D. Pittet Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis Am J Med 115 2003 529 535
5. R. Salomao, A. Castelo Filho, A.C. Pignatari, and S.B. Wey Nosocomial and community acquired bacteremia: variables associated with outcomes Rev Paul Med 111 1993 456 461
6. B. Grubeck-Loebenstein, and G. Wick The aging of the immune system Adv Immunol 80 2002 243 284
7. G. Gavazzi, and K.H. Krause Ageing and infection Lancet Infect Dis 2 2002 659 666
8. S.M. Opal, T.D. Girard, and E.W. Ely The immunopathogenesis of sepsis in elderly patients Clin Infect Dis 41 Suppl. 7 2005 S504 S512
9. G.S. Martin, D.M. Mannino, and M. Moss The effect of age on the development and outcome of adult sepsis Crit Care Med 34 2006 15 21
10. O. Lesens, C. Methlin, Y. Hansmann, V. Remy, M. Martinot, and C. Bergin Role of comorbidity in mortality related to Staphylococcus aureus bacteremia: a prospective study using the Charlson weighted index of comorbidity Infect Control Hosp Epidemiol 24 2003 890 896
11. G.R. Strange, E.H. Chen, and A.B. Sanders Use of emergency departments by elderly patients: projections from a multicenter data base Ann Emerg Med 21 1992 819 824
12. J.P. Richardson Bacteremia in the elderly J Gen Intern Med 8 1993 89 92
13. P.G. Jarrett, K. Rockwood, D. Carver, P. Stolee, and S. Cosway Illness presentation in elderly patients Arch Intern Med 155 1995 1060 1064
14. T.T. Yoshikawa Perspective: aging and infectious diseases: past, present, and future J Infect Dis 176 1997 1053 1057
15. S.J. Weiss, R. Derlet, J. Arndahl, A.A. Ernst, J. Richards, and M. Fernandez-Frackelton Estimating the degree of emergency department overcrowding in academic medical centers: results of the National ED Overcrowding Study (NEDOCS) Acad Emerg Med 11 2004 38 50
16. J.N. Lin, Y.S. Tsai, C.H. Lai, Y.H. Chen, S.S. Tsai, and H.L. Lin Risk factors for mortality of bacteremic patients in the emergency department Acad Emerg Med 16 2009 749 755
17. Clinical and Laboratory Standards Institute Performance standards for antimicrobial disk susceptibility tests, 17th informational supplement. document M100-S16 2007 CLSI Wayne (Pa)
18. C.C. Lee, W.J. Lin, H.I. Shih, C.J. Wu, P.L. Chen, and H.C. Lee Clinical significance of potential contaminants in blood cultures among patients in a medical center J Microbiol Immunol Infect 40 2007 438 444
19. Y. Siegman-Igra, B. Fourer, R. Orni-Wasserlauf, Y. Golan, A. Noy, and D. Schwartz Reappraisal of community-acquired bacteremia: a proposal of a new classification for the spectrum of acquisition of bacteremia Clin Infect Dis 34 2002 1431 1439
20. D.L. Paterson, W.C. Ko, A. Von Gottberg, S. Mohapatra, J.M. Casellas, and H. Goossens International prospective study of Klebsiella pneumoniae bacteremia: implications of extended-spectrum beta-lactamase production in nosocomial Infections Ann Intern Med 140 2004 26 32
21. F.G. Schellevis, J. van der Velden, E. van de Lisdonk, J.T. van Eijk, and C. van Weel Comorbidity of chronic diseases in general practice J Clin Epidemiol 46 1993 469 473
22. J.S. Garner, W.R. Jarvis, T.G. Emori, T.C. Horan, and J.M. Hughes CDC definitions for nosocomial infections, 1988 Am J Infect Control 16 1988 128 140
23. H.B. Nguyen, E.P. Rivers, F.M. Abrahamian, G.J. Moran, E. Abraham, and S. Trzeciak Severe sepsis and septic shock: review of the literature and emergency department management guidelines Ann Emerg Med 48 2006 28 54
24. J.M. Pines, M.J. Morton, E.M. Datner, and J.E. Hollander Systematic delays in antibiotic administration in the emergency department for adult patients admitted with pneumonia Acad Emerg Med 13 2006 939 945
25. N. Proulx, D. Frechette, B. Toye, J. Chan, and S. Kravcik Delays in the administration of antibiotics are associated with mortality from adult acute bacterial meningitis QJM 98 2005 291 298
26. J.D. McCue Gram-negative bacillary bacteremia in the elderly: incidence, ecology, etiology, and mortality J Am Geriatr Soc 35 1987 213 218
27. L. Leibovici, S.D. Pitlik, H. Konisberger, and M. Drucker Bloodstream infections in patients older than eighty years Age Ageing 22 1993 431 442
28. C.I. Lee, N.Y. Lee, J.J. Yan, H.C. Lee, N.Y. Ko, and C.M. Chang Extended-spectrum beta-lactamase-producing phenotype signifies a poor prognosis for patients with cefpodoxime-resistant Escherichia coli or Klebsiella pneumoniae bacteremia J Microbiol Immunol Infect 42 2009 303 309
29. V.L. Yu, C.C. Chiou, C. Feldman, A. Ortqvist, J. Rello, and A.J. Morris An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome Clin Infect Dis 37 2003 230 237
30. F.Y. Chang, J.E. Peacock Jr., D.M. Musher, P. Triplett, B.B. MacDonald, and J.M. Mylotte Staphylococcus aureus bacteremia: recurrence and the impact of antibiotic treatment in a prospective multicenter study Medicine (Baltimore) 82 2003 333 339
31. C.C. Lee, C.H. Lee, M.C. Chuang, M.Y. Hong, H.C. Hsu, and W.C. Ko Impact of inappropriate empirical antibiotic therapy on outcome of bacteremic adults visiting the ED Am J Emerg Med 2011 (in press)