Prehospital thrombolysis in acute stroke: Results of the PHANTOM-S pilot study

Neurology

Volumn 80, Issue 2, 2013, Pages 163-168

  Weber, Joachim E ^a,b   Ebinger, Martin ^a,b   Rozanski, Michal ^a,b   Waldschmidt, Carolin ^a   Wendt, Matthias ^a   Winter, Benjamin ^a,b   Kellner, Philipp ^d   Baumann, André ^d   Fiebach, Jochen B ^b   Villringer, Kersten ^b   Kaczmarek, Sabina ^d   Endres, Matthias ^a,c   Audebert, Heinrich J ^a,b  

^a Klinik und Hochschulambulanz für Neurologie   (Germany)

^b Center for Stroke Research Berlin   (Germany)

^c Excellence Cluster NeuroCure ^*  (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TISSUE PLASMINOGEN ACTIVATOR;

AGED; ALGORITHM; AMBULANCE; ARTICLE; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COMPUTED TOMOGRAPHY SCANNER; DETERIORATION; DRUG SAFETY; EMERGENCY CARE; EQUIPMENT FAILURE; FEASIBILITY STUDY; FEMALE; FIBRINOLYTIC THERAPY; HUMAN; LABORATORY DEVICE; MAJOR CLINICAL STUDY; MALE; NEUROLOGIC DISEASE; NEUROLOGIST; PARAMEDICAL PERSONNEL; PILOT STUDY; POINT OF CARE TESTING; PRIORITY JOURNAL; RADIOLOGIST; RANKIN SCALE; RELIABILITY; SIDE EFFECT; SOMNOLENCE; TELERADIOLOGY; TIME TO TREATMENT; TREATMENT DURATION;

AGED; AGED, 80 AND OVER; ALGORITHMS; AMBULANCES; DOCUMENTATION; EMERGENCY MEDICAL SERVICES; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PATIENT SAFETY; PILOT PROJECTS; REPRODUCIBILITY OF RESULTS; STROKE; THROMBOLYTIC THERAPY; TISSUE PLASMINOGEN ACTIVATOR; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84873664206     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e31827b90e5     Document Type: Article

References (30)

1. Lees KR, Bluhmki E, von Kummer R, et al. Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet 2010;375:1695-1703.
2. Adams HP Jr, del Zoppo G, Alberts MJ, et al. Guidelines for the early management of adults with ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council, Clinical Cardiology Council, Cardiovascular Radiology and Intervention Council, and the Atherosclerotic Peripheral Vascular Disease and Quality of Care Outcomes in Research Interdisciplinary Working Groups: the American Academy of Neurology affirms the value of this guideline as an educational tool for neurologists. Circulation 2007;115:e478-e534.
3. European Stroke Organisation (ESO) Executive Committee; ESO Writing Committee. Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. Cerebrovasc Dis 2008;25:457-507.
4. Bouckaert M, Lemmens R, Thijs V. Reducing prehospital delay in acute stroke. Nat Rev Neurol 2009;5:477-483.
5. Buck BH, Starkman S, Eckstein M, et al. Dispatcher recognition of stroke using the National Academy Medical Priority Dispatch System. Stroke 2009;40:2027-2030.
6. Jungehulsing GJ, Rossnagel K, Nolte CH, et al. Emergency department delays in acute stroke: analysis of time between ED arrival and imaging. Eur J Neurol 2006;13:225-232.
7. Tveiten A, Mygland A, Ljostad U, Thomassen L. Intravenous thrombolysis for ischaemic stroke: short delays and high community-based treatment rates after organisational changes in a previously inexperienced centre. Emerg Med J 2009;26:324-326.
8. Rose KM, Rosamond WD, Huston SL, Murphy CV, Tegeler CH. Predictors of time from hospital arrival to initial brain-imaging among suspected stroke patients: the North Carolina Collaborative Stroke Registry. Stroke 2008;39: 3262-3267.
9. Hacke W, Donnan G, Fieschi C, et al. Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004;363:768-774.
10. Kwan J, Hand P, Sandercock P. Improving the efficiency of delivery of thrombolysis for acute stroke: a systematic review. QJM 2004;97:273-279. (Pubitemid 38659762)
11. Schwamm LH, Pancioli A, Acker JE, et al. Recommendations for the establishment of stroke systems of care: recommendations from the American Stroke Association's Task Force on the Development of Stroke Systems. Circulation 2005;111:1078-1091. (Pubitemid 40354528)
12. Kohrmann M, Schellinger PD, Breuer L, et al. Avoiding in hospital delays and eliminating the three-hour effect in thrombolysis for stroke. Int J Stroke 2011;6:493-497.
13. Audebert HJ, Schwamm L. Telestroke: scientific results. Cerebrovasc Dis 2009;27:15-20.
14. Walter S, Kostopoulos P, Haass A, et al. Point-of-care laboratory halves door-to-therapy-decision time in acute stroke. Ann Neurol 2011;69:581-586.
15. Nolte CH, Malzahn U, Kuhnle Y, et al. Improvement of door-to-imaging time in acute stroke patients by implementation of an all-points alarm. J Stroke Cerebrovasc Dis Epub 2011 Sep 7.
16. Krebes S, Ebinger M, Baumann AM, et al. Development and validation of a dispatcher identification algorithm for stroke emergencies. Stroke 2012;43:776-781.
17. Ebinger M, Rozanski M, Waldschmidt C, et al. PHAN-TOM-S: the prehospital acute neurological therapy and optimization of medical care in stroke patients-study. Int J Stroke 2012;7:348-353.
18. Clark WR Jr. Emergency medical services education and licensure: a road map for the future. J La State Med Soc 2009;161:290-292.
19. Fassbender K, Walter S, Liu Y, et al. "Mobile stroke unit" for hyperacute stroke treatment. Stroke 2003;34:e44.
20. Kostopoulos P, Walter S, Haass A, et al. Mobile stroke unit for diagnosis-based triage of persons with suspected stroke. Neurology 2012;78:1849-1852.
21. Walter S, Kostopoulos P, Haass A, et al. Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial. Lancet Neurol 2012;11:397-404.
22. Roberts MJ, McNeill AJ, MacKenzie G, Adgey AA. Time delays to lytic therapy and outcome in 100 consecutive patients with a history suggestive of acute myocardial infarction in an area with access to a mobile coronary care unit. Eur Heart J 1994;15:594-601. (Pubitemid 24186324)
23. Sablot D, Magnaudeix M, Akouz A, et al. Impact of mobile intensive care units on treating stroke within the 3-hour time window in a semi-rural area [in French]. Presse Med 2008;37:401-405.
24. Micieli G, Marcheselli S, Tosi PA. Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag 2009;5:397-409.
25. Heuschmann PU, Kolominsky-Rabas PL, Roether J, et al. Predictors of in-hospital mortality in patients with acute ischemic stroke treated with thrombolytic therapy. JAMA 2004;292:1831-1838. (Pubitemid 40169293)
26. Pervez MA, Silva G, Masrur S, et al. Remote supervision of IV-tPA for acute ischemic stroke by telemedicine or telephone before transfer to a regional stroke center is feasible and safe. Stroke 2010;41:e18-e24.
27. Pfefferkorn T, Holtmannspotter M, Schmidt C, et al. Drip, ship, and retrieve: cooperative recanalization therapy in acute basilar artery occlusion. Stroke 2010;41:722-726.
28. Martin-Schild S, Morales MM, Khaja AM, et al. Is the drip-and-ship approach to delivering thrombolysis for acute ischemic stroke safe? J Emerg Med 2011;41:135-141.
29. Silverman IE, Beland DK, Chhabra J, McCullough LD. The "drip-and-ship" approach: starting IV t-PA for acute ischemic stroke at outside hospitals prior to transfer to a regional stroke center. Conn Med 2005;69:613-620. (Pubitemid 41709485)
30. Chalela JA, Kasner SE, Jauch EC, Pancioli AM. Safety of air medical transportation after tissue plasminogen activator administration in acute ischemic stroke. Stroke 1999;30:2366-2368. (Pubitemid 29517736)