Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon
DOI 10.1073/pnas.0402653101
Bielekova B, Richert N, Howard T, et al. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon-beta. Proc Natl Acad Sci USA 2004;101:8705-8708. (Pubitemid 38745835)
Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
Bielekova B, Howard T, Packer AN, et al. Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol 2009;66:483-489.
Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results
DOI 10.1212/01.wnl.0000267662.41734.1f, PII 0000611420070821000012
Rose JW, Burns JB, Bjorklund J, Klein J, Watt HE, Carlson NG. Daclizumab phase II trial in relapsing and remitting multiple sclerosis: MRI and clinical results. Neurology 2007;69:785-789. (Pubitemid 47300936)
Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody
DOI 10.1002/ana.20287
Rose JW, Watt HE, White AT, Carlson NG. Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody. Ann Neurol 2004;56:864-867. (Pubitemid 39578450)
Daclizumab in active relapsing multiple sclerosis (choice study): A phase 2 randomised double-blind placebo-controlled add-on trial with interferon beta
Wynn D, Kaufman M, Montalban X, et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol 2010;9:381-390.
Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis
Oh U, Blevins G, Griffith C, et al. Regulatory T cells are reduced during anti-CD25 antibody treatment of multiple sclerosis. Arch Neurol 2009;66:471-479.
A role for inter-leukin-2 trans-presentation in dendritic cell-mediated t cell activation in humans as revealed by daclizumab therapy
Wuest SC, Edwan JH, Martin JF, et al. A role for inter-leukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy. Nat Med 2011;17:604-609.
An IL-2 paradox: Blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells
Martin JF, Perry JS, Jakhete NR, Wang X, Bielekova B. An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells. J Immunol 2010;185:1311-1320.