Case study: A novel bacterial contamination in cell culture production - Leptospira licerasiae

PDA Journal of Pharmaceutical Science and Technology

Volumn 66, Issue 6, 2012, Pages 580-591

  Chen, Joseph ^a   Bergevin, Jesse ^a   Kiss, Robert ^a   Walker, Gordon ^a   Battistoni, Todd ^a   Lufburrow, Patricia ^a   Lam, Harry ^a   Vinther, Anders ^a  

^a GENENTECH INC   (United States)

Author keywords

Bioreactor contamination; Chinese Hamster Ovary cell culture; Corrective and preventative action; Leptospira licerasiae; Polymerase chain reaction; Seed train bioreactor

Indexed keywords

ENDOGENOUS PYROGEN; LONG CHAIN FATTY ACID;

ARTICLE; BACTERIAL GENE; BACTERIUM CONTAMINATION; BACTERIUM DETECTION; CARBON SOURCE; CASE STUDY; CHO CELL; CULTURE MEDIUM; DRUG INDUSTRY; ENERGY RESOURCE; FED BATCH REACTOR; GENETIC IDENTIFICATION; HIGH TEMPERATURE; INFECTION CONTROL; LEPTOSPIRA; LEPTOSPIRA LICERASIAE; MICROENVIRONMENT; MICROSCOPY; NANOBIOTECHNOLOGY; NONHUMAN; NUTRIENT SUPPLY; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT; ROOT CAUSE ANALYSIS; SCANNING ELECTRON MICROSCOPY; SCREENING TEST; WATER SAMPLING; BACTERIAL COUNT; CELL CULTURE TECHNIQUE; DRUG CONTAMINATION; GENETICS; HUMAN; MEDICAL DEVICE CONTAMINATION; MICROBIOLOGICAL EXAMINATION; PREVENTION AND CONTROL;

CELL CULTURE TECHNIQUES; COLONY COUNT, MICROBIAL; DRUG CONTAMINATION; EQUIPMENT CONTAMINATION; HUMANS; LEPTOSPIRA; MICROBIOLOGICAL TECHNIQUES; REAL-TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT;

EID: 84873649040     PISSN: 10797440     EISSN: 19482124     Source Type: Journal    
DOI: 10.5731/pdajpst.2012.00892     Document Type: Article

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