-
1
-
-
0018348655
-
T antigen is bound to a host protein in SV40-transformed cells
-
Lane DP, Crawford LV. T antigen is bound to a host protein in SV40-transformed cells. Nature 1979: 278:261-3.
-
(1979)
Nature
, vol.278
, pp. 261-263
-
-
Lane, D.P.1
Crawford, L.V.2
-
2
-
-
0018760324
-
Characterization ofa54Kdalton cellular SV40tumorantigenpresentinSV40-transformed cells and uninfected embryonal carcinoma cells
-
Linzer DI, Levine AJ. Characterization ofa54Kdalton cellular SV40tumorantigenpresentinSV40-transformed cells and uninfected embryonal carcinoma cells. Cell 1979: 17:43-52.
-
(1979)
Cell
, vol.17
, pp. 43-52
-
-
Linzer, D.I.1
Levine, A.J.2
-
3
-
-
0018743916
-
Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse
-
DeLeo AB, Jay G, Appella E et al. Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse. Proc Natl Acad Sci USA 1979: 76:2420-4.
-
(1979)
Proc Natl Acad Sci USA
, vol.76
, pp. 2420-2424
-
-
Deleo, A.B.1
Jay, G.2
Appella, E.3
-
4
-
-
0024536654
-
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
-
Baker SJ, Fearon ER, Nigro JM et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989: 244:217-21.
-
(1989)
Science
, vol.244
, pp. 217-221
-
-
Baker, S.J.1
Fearon, E.R.2
Nigro, J.M.3
-
5
-
-
0024382760
-
The p53 proto-oncogene can act as a suppressor of transformation
-
Finlay CA, Hinds PW, Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell 1989: 57:1083-93.
-
(1989)
Cell
, vol.57
, pp. 1083-1093
-
-
Finlay, C.A.1
Hinds, P.W.2
Levine, A.J.3
-
7
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 2003: 13:49-58.
-
(2003)
Semin Cancer Biol
, vol.13
, pp. 49-58
-
-
Michael, D.1
Oren, M.2
-
8
-
-
0037325976
-
Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system
-
Scheffher M, Whitaker NJ. Human papillomavirus-induced carcinogenesis and the ubiquitin-proteasome system. Semin Cancer Biol 2003; 13:59-67.
-
(2003)
Semin Cancer Biol
, vol.13
, pp. 59-67
-
-
Scheffher, M.1
Whitaker, N.J.2
-
10
-
-
65549120715
-
GuW. Modes ofp53 regulation
-
Kruse JP, GuW. Modes ofp53 regulation. Cell 2009; 137:609-22.
-
(2009)
Cell
, vol.137
, pp. 609-622
-
-
Kruse, J.P.1
-
11
-
-
65349103899
-
Prives C. Blinded by the Light: The Growing Complexity ofp53
-
Vousden KH, Prives C. Blinded by the Light: The Growing Complexity ofp53. Cell 2009; 137:413-31.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
-
12
-
-
67749116091
-
Three birds with one stone
-
Toledo F, Bardot B. Cancer: Three birds with one stone. Nature 2009; 460:466-7.
-
(2009)
Nature
, vol.460
, pp. 466-467
-
-
Toledo, F.1
Cancer, B.B.2
-
13
-
-
67349086630
-
The mitochondrial p53 pathway
-
Vaseva AV, Moll UM. The mitochondrial p53 pathway. Biochim Biophys Acta 2009; 1787:414-20.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 414-420
-
-
Vaseva, A.1
Moll, A.2
-
14
-
-
0025858631
-
Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication
-
Bargonetti J, Friedman PN, Kern SE et al. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 1991; 65:1083-91.
-
(1991)
Cell
, vol.65
, pp. 1083-1091
-
-
Bargonetti, J.1
Friedman, P.N.2
Kern, S.E.3
-
15
-
-
0025815451
-
Identification of p53 as a sequence-specific DNA-binding protein
-
Kern SE, Kinzler KW, Bruskin A et al. Identification of p53 as a sequence-specific DNA-binding protein. Science 1991; 252:1708-11.
-
(1991)
Science
, vol.252
, pp. 1708-1711
-
-
Kern, S.E.1
Kinzler, K.W.2
Bruskin, A.3
-
16
-
-
0027771333
-
The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots
-
Pavletich NP, Chambers KA, Pabo CO. The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots. Genes Dev 1993; 7:2556-64.
-
(1993)
Genes Dev
, vol.7
, pp. 2556-2564
-
-
Pavletich, N.P.1
Chambers, K.A.2
Pabo, C.O.3
-
17
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenicmutations
-
Cho Y, Gorina S, Jeffrey PD et al. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenicmutations. Science 1994; 265:346-55.
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
-
18
-
-
0028979005
-
Human TAFII31 protein is a transcriptional coactivator of the p53 protein
-
Lu H, Levine AJ. Human TAFII31 protein is a transcriptional coactivator of the p53 protein. Proc Natl Acad Sci USA 1995; 92:5154-8.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5154-5158
-
-
Lu, H.1
Levine, A.J.2
-
19
-
-
0028922929
-
Klemm R et al. P53 transcriptional activation mediated by coactivators TAFII40 and TAFII60
-
Thut CJ, Chen JL, Klemm R et al. p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. Science 1995; 267:100-4.
-
(1995)
Science
, vol.267
, pp. 100-104
-
-
Thut, C.J.1
Chen, J.L.2
-
20
-
-
0027983521
-
Binding of basal transcription factor TFIIH to the acidic activation domains ofVP16 andp53
-
Xiao H, Pearson A, Coulombe B et al. Binding of basal transcription factor TFIIH to the acidic activation domains ofVP16 andp53. Mol Cell Biol 1994; 14:7013-24.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 7013-7024
-
-
Xiao, H.1
Pearson, A.2
Coulombe, B.3
-
21
-
-
0030797585
-
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
-
Gu W, Roeder RG. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 1997; 90:595-606.
-
(1997)
Cell
, vol.90
, pp. 595-606
-
-
Gu, W.1
Roeder, R.G.2
-
22
-
-
0030973238
-
Binding and modulation of p53 by p300/CBP coactivators
-
Lill NL, Grossman SR, Ginsberg D et al. Binding and modulation of p53 by p300/CBP coactivators. Nature 1997; 387:823-7.
-
(1997)
Nature
, vol.387
, pp. 823-827
-
-
Lill, N.L.1
Grossman, S.R.2
Ginsberg, D.3
-
23
-
-
0026448672
-
Regulation of the specific DNA binding function of p53
-
Hupp TR, Meek DW, Midgley CA et al. Regulation of the specific DNA binding function of p53. Cell 1992;71:875-86.
-
(1992)
Cell
, vol.71
, pp. 875-886
-
-
Hupp, T.R.1
Meek, D.W.2
Midgley, C.A.3
-
24
-
-
84970061891
-
Solution structure of the tetrameric minimum transforming domain of p53
-
Lee W, Harvey TS, Yin Y et al. Solution structure of the tetrameric minimum transforming domain of p53. Nat Struct Biol 1994; 1:877-90.
-
(1994)
Nat Struct Biol
, vol.1
, pp. 877-890
-
-
Lee, W.1
Harvey, T.S.2
Yin, Y.3
-
25
-
-
0028952841
-
Crystal structure of the tetramerization domain of the p53 tumor suppressorat 1.7 angstroms
-
Jeffrey PD, Gorina S, Pavletich NP. Crystal structure of the tetramerization domain of the p53 tumor suppressorat 1.7 angstroms. Science 1995; 267:1498-502.
-
(1995)
Science
, vol.267
, pp. 1498-1502
-
-
Jeffrey, P.D.1
Gorina, S.2
Pavletich, S.3
-
26
-
-
24344448786
-
P53 isoforms can regulate p53 transcriptional activity
-
Bourdon JC, Fernandes K, Murray-Zmijewski F et al. p53 isoforms can regulate p53 transcriptional activity. Genes Dev 2005; 19:2122-37.
-
(2005)
Genes Dev
, vol.19
, pp. 2122-2137
-
-
Bourdon, J.C.1
Fernandes, K.2
Murray-Zmijewski, F.3
-
27
-
-
0021616838
-
UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells
-
Maltzman W, Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cell Biol 1984; 4:1689-94.
-
(1984)
Mol Cell Biol
, vol.4
, pp. 1689-1694
-
-
Maltzman, W.1
Czyzyk, L.2
-
28
-
-
0026318356
-
Participation of p53 protein in the cellular response to DNA damage
-
Kastan MB, Onyekwere O, Sidransky D et al. Participation of p53 protein in the cellular response to DNA damage. CancerRes 1991; 51:6304-11.
-
(1991)
Cancerres
, vol.51
, pp. 6304-6311
-
-
Kastan, M.B.1
Onyekwere, O.2
Sidransky, D.3
-
29
-
-
0027500246
-
Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents
-
Fritsche M, Haessler C, Brandner G. Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 1993; 8:307-18.
-
(1993)
Oncogene
, vol.8
, pp. 307-318
-
-
Fritsche, M.1
Haessler, C.2
Brandner, G.3
-
30
-
-
0028110809
-
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
-
Graeber TG, Peterson JF, Tsai M et al. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Mol Cell Biol 1994; 14:6264-77.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 6264-6277
-
-
Graeber, T.G.1
Peterson, J.F.2
Tsai, M.3
-
31
-
-
0029964158
-
A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
-
Linke SP, Clarkin KC, Di Leonardo A et al. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev 1996; 10:934-47.
-
(1996)
Genes Dev
, vol.10
, pp. 934-947
-
-
Linke, S.P.1
Clarkin, K.C.2
Di Leonardo, A.3
-
32
-
-
0021004708
-
Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53
-
Reich NC, Oren M, Levine AJ. Two distinct mechanisms regulate the levels of a cellular tumor antigen, p53. Mol Cell Biol 1983; 3:2143-50.
-
(1983)
Mol Cell Biol
, vol.3
, pp. 2143-2150
-
-
Reich, N.C.1
Oren, M.2
Levine, A.J.3
-
33
-
-
0026660417
-
Human papillomavirus type 16 E6 increases the degradation rate of p53 inhumankeratinocytes
-
Hubbert NL, Sedman SA, Schiller JT. Human papillomavirus type 16 E6 increases the degradation rate of p53 inhumankeratinocytes. JVirol 1992; 66:6237-41.
-
(1992)
Jvirol
, vol.66
, pp. 6237-6241
-
-
Hubbert, N.1
Sedman, N.2
Schiller, J.T.3
-
34
-
-
0025639158
-
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
-
Scheffner M, Werness BA, Huibregtse JM et al. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990; 63:1129-36.
-
(1990)
Cell
, vol.63
, pp. 1129-1136
-
-
Scheffner, M.1
Werness, B.A.2
Huibregtse, J.M.3
-
35
-
-
0028205667
-
Accumulation of p53 in a mutant cell line defective in the ubiquitinpathway
-
Chowdary DR, Dermody JJ, Jha KK et al. Accumulation of p53 in a mutant cell line defective in the ubiquitinpathway. Mol CellBiol 1994; 14:1997-2003.
-
(1994)
Mol Cellbiol
, vol.14
, pp. 1997-2003
-
-
Chowdary, D.R.1
Dermody, J.J.2
Jha, K.K.3
-
36
-
-
0029952441
-
In vivo ubiquitination and proteasome-mediated degradation of p53(1)
-
Maki CG, Huibregtse JM, Howley PM. In vivo ubiquitination and proteasome-mediated degradation of p53(1). Cancer Res 1996; 56:2649-54.
-
(1996)
Cancer Res
, vol.56
, pp. 2649-2654
-
-
Maki, J.M.1
Huibregtse, J.M.2
Howley, P.M.3
-
37
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A et al. Mdm2 promotes the rapid degradation of p53. Nature 1997; 387:296-9.
-
(1997)
Nature
, vol.387
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
-
39
-
-
0031583962
-
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
-
Honda R, Tanaka H, Yasuda H. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett 1997; 420:25-7.
-
(1997)
FEBS Lett
, vol.420
, pp. 25-27
-
-
Honda, R.1
Tanaka, H.2
Yasuda, H.3
-
40
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
Fang S, Jensen JP, Ludwig RL et al. Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53. J Biol Chem 2000; 275:8945-51.
-
(2000)
J Biol Chem
, vol.275
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
-
41
-
-
0034624678
-
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
-
Honda R, Yasuda H. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 2000; 19:1473-6.
-
(2000)
Oncogene
, vol.19
, pp. 1473-1476
-
-
Honda, R.1
Yasuda, H.2
-
42
-
-
0028834902
-
Rescue of embryonic lethality in Mdm2-deficient mice by absence ofp53
-
Jones SN, Roe AE, Donehower LA et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence ofp53. Nature 1995; 378:206-8.
-
(1995)
Nature
, vol.378
, pp. 206-208
-
-
Jones, S.N.1
Roe, A.E.2
Donehower, L.A.3
-
43
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion ofp53
-
Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion ofp53. Nature 1995; 378:203-6.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes De Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
44
-
-
33644778697
-
Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo
-
Francoz S, Froment P, Bogaerts S et al. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. Proc Natl Acad Sci USA 2006; 103:3232-7.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3232-3237
-
-
Francoz, S.1
Froment, S.2
Bogaerts, P.S.3
-
45
-
-
33644772395
-
Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4
-
Grier JD, Xiong S, Elizondo-Fraire AC et al. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol 2006; 26:192-8.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 192-198
-
-
Grier, J.D.1
Xiong, S.2
Elizondo-Fraire, A.C.3
-
46
-
-
33646794425
-
Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
-
Marine JC, Francoz S, Maetens M et al. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ 2006; 13:927-34.
-
(2006)
Cell Death Differ
, vol.13
, pp. 927-934
-
-
Marine, J.C.1
Francoz, S.2
Maetens, M.3
-
47
-
-
33644757727
-
Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development
-
Xiong S, Van Pelt CS, Elizondo-Fraire AC et al. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci USA 2006; 103:3226-31.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3226-3231
-
-
Xiong, S.1
Van Pelt, C.S.2
Elizondo-Fraire, A.C.3
-
48
-
-
33845270990
-
Regulating the p53 pathway: In vitro hypotheses, in vivo veritas
-
Toledo F, Wahl GM. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas. Nat Rev Cancer 2006; 6:909-23.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 909-923
-
-
Toledo, F.1
Wahl, G.M.2
-
49
-
-
35148847384
-
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation
-
Itahana K, Mao H, Jin A et al. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell 2007; 12:355-66.
-
(2007)
Cancer Cell
, vol.12
, pp. 355-366
-
-
Itahana, K.1
Mao, H.2
Jin, A.3
-
50
-
-
0030575937
-
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressortransactivationdomain
-
Kussie PH, Gorina S, Marechal V et al. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressortransactivationdomain. Science 1996; 274:948-53.
-
(1996)
Science
, vol.274
, pp. 948-953
-
-
Kussie, P.H.1
Gorina, S.2
Marechal, V.3
-
51
-
-
0031588025
-
Molecular characterization of the hdm2-p53 interaction
-
Bottger A, Bottger V, Garcia-Echeverria C et al. Molecular characterization of the hdm2-p53 interaction. J Mol Biol 1997; 269:744-56.
-
(1997)
J Mol Biol
, vol.269
, pp. 744-756
-
-
Bottger, A.1
Bottger, V.2
Garcia-Echeverria, C.3
-
52
-
-
0031282325
-
Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo
-
Bottger A, Bottger V, Sparks A et al. Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo. Curr Biol 1997; 7:860-9.
-
(1997)
Curr Biol
, vol.7
, pp. 860-869
-
-
Bottger, A.1
Bottger, V.2
Sparks, A.3
-
53
-
-
10744221485
-
In vivo activation of the p53 pathway by small-molecule antagonists ofMDM2
-
Vassilev LT, Vu BT, Graves B et al. In vivo activation of the p53 pathway by small-molecule antagonists ofMDM2. Science 2004; 303:844-8.
-
(2004)
Science
, vol.303
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
-
54
-
-
33644673642
-
Structural details on mdm2-p53 interaction
-
Chi SW, Lee SH, Kim DH et al. Structural details on mdm2-p53 interaction. J Biol Chem 2005; 280:38795-802.
-
(2005)
J Biol Chem
, vol.280
, pp. 38795-38802
-
-
Chi, S.W.1
Lee, S.H.2
Kim, D.H.3
-
55
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 proteinandinhibits p53-mediatedtransactivation
-
Momand J, Zambetti GP, Olson DC et al. The mdm-2 oncogene product forms a complex with the p53 proteinandinhibits p53-mediatedtransactivation. Cell 1992; 69:1237-45.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
-
56
-
-
0027325132
-
Oncoprotein MDM2 conceals the activation domain of tumour suppressorp53
-
Oliner JD, Pietenpol JA, Thiagalingam S et al. Oncoprotein MDM2 conceals the activation domain of tumour suppressorp53. Nature 1993; 362:857-60.
-
(1993)
Nature
, vol.362
, pp. 857-860
-
-
Oliner, J.D.1
Pietenpol, J.A.2
Thiagalingam, S.3
-
57
-
-
4744350876
-
Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo
-
Saville MK, Sparks A, Xirodimas DP et al. Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. J Biol Chem 2004; 279:42169-81.
-
(2004)
J Biol Chem
, vol.279
, pp. 42169-42181
-
-
Saville, M.K.1
Sparks, A.2
Xirodimas, D.P.3
-
58
-
-
0142123127
-
HdmX stimulates Hdm2-mediated ubiquitination and degradation ofp53
-
Linares LK, Hengstermann A, Ciechanover A et al. HdmX stimulates Hdm2-mediated ubiquitination and degradation ofp53. Proc Natl Acad Sci USA 2003; 100:12009-14.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 12009-12014
-
-
Linares, L.K.1
Ciechanover, A.A.2
-
59
-
-
0037432773
-
Polyubiquitination of p53 by a ubiquitin ligase activity of p300
-
Grossman SR, Deato ME, Brignone C et al. Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science 2003; 300:342-4.
-
(2003)
Science
, vol.300
, pp. 342-344
-
-
Grossman, S.R.1
Deato, M.E.2
Brignone, C.3
-
60
-
-
0344629664
-
Involvement of the DNA repair protein hHR23 in p53 degradation
-
Glockzin S, Ogi FX, Hengstermann A et al. Involvement of the DNA repair protein hHR23 in p53 degradation. Mol Cell Biol 2003; 23:8960-9.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8960-8969
-
-
Glockzin, S.1
Ogi, F.X.2
Hengstermann, A.3
-
61
-
-
2942558344
-
A post-ubiquitination role for MDM2 andhHR23A in the p53 degradationpathway
-
Brignone C, Bradley KE, Kisselev AF et al. A post-ubiquitination role for MDM2 andhHR23A in the p53 degradationpathway. Oncogene 2004; 23:4121-9.
-
(2004)
Oncogene
, vol.23
, pp. 4121-4129
-
-
Brignone, C.1
Bradley, K.E.2
Kisselev, A.F.3
-
62
-
-
33847239087
-
Shi D et al. HHR23B is required for genotoxic-specific activation of p53 and apoptosis
-
Kaur M, Pop M, Shi D et al. hHR23B is required for genotoxic-specific activation of p53 and apoptosis. Oncogene 2006; 26:1231-7.
-
(2006)
Oncogene
, vol.26
, pp. 1231-1237
-
-
Kaur, M.1
Pop, M.2
-
63
-
-
0034458966
-
Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination
-
Nakamura S, Roth JA, Mukhopadhyay T. Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination. Mol Cell Biol 2000; 20:9391-8.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 9391-9398
-
-
Nakamura, S.1
Roth, J.A.2
Mukhopadhyay, T.3
-
64
-
-
0033767235
-
Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation
-
Rodriguez MS, Desterro JM, Lain S et al. Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation. Mol Cell Biol 2000; 20:8458-67.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 8458-8467
-
-
Rodriguez, M.S.1
Lain, J.M.S.2
-
65
-
-
20744448187
-
Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity
-
Feng L, Lin T, Uranishi H et al. Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity. Mol Cell Biol 2005; 25:5389-95.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5389-5395
-
-
Feng, L.1
Lin, T.2
Uranishi, H.3
-
66
-
-
22544484456
-
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation
-
Krummel KA, Lee CJ, Toledo F et al. The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation. Proc Natl Acad Sci USA 2005; 102:10188-93.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 10188-10193
-
-
Krummel, K.A.1
Lee, C.J.2
Toledo, F.3
-
67
-
-
32944458404
-
Ubiquitination of p53 at multiple sites in the DNA-binding domain
-
Chan WM, Mak MC, Fung TK et al. Ubiquitination of p53 at multiple sites in the DNA-binding domain. Mol Cancer Res 2006; 4:15-25.
-
(2006)
Mol Cancer Res
, vol.4
, pp. 15-25
-
-
Chan, W.M.1
Mak, M.C.2
Fung, T.K.3
-
68
-
-
33750834640
-
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation
-
Le Cam L, Linares LK, Paul C et al. E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell 2006; 127:775-88.
-
(2006)
Cell
, vol.127
, pp. 775-788
-
-
Le Cam, L.1
Linares, L.K.2
Paul, C.3
-
69
-
-
59149085299
-
MSL2 promotes Mdm2-independent cytoplasmic localization of p53
-
Kruse JP, Gu W. MSL2 promotes Mdm2-independent cytoplasmic localization of p53. J Biol Chem 2009; 284:3250-63.
-
(2009)
J Biol Chem
, vol.284
, pp. 3250-3263
-
-
Kruse, J.1
Gu, J.2
-
70
-
-
67651154117
-
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
-
Lee EW, Lee MS, Camus S et al. Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis. EMBO J 2009; 28:2100-13.
-
(2009)
EMBO J
, vol.28
, pp. 2100-2113
-
-
Lee, E.W.1
Lee, M.S.2
Camus, S.3
-
71
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu X, Bayle JH, Olson D et al. The p53-mdm-2 autoregulatory feedback loop. Genes Dev 1993; 7:1126-32.
-
(1993)
Genes Dev
, vol.7
, pp. 1126-1132
-
-
Wu, X.1
Bayle, J.H.2
Olson, D.3
-
72
-
-
0038788827
-
Critical contribution of the MDM2 acidic domain to p53 ubiquitination
-
Kawai H, Wiederschain D, Yuan ZM. Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Mol Cell Biol 2003; 23:4939-47.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4939-4947
-
-
Kawai, H.1
Wiederschain, D.2
Yuan, Z.M.3
-
73
-
-
0038451241
-
Critical role for a central part of Mdm2 in the ubiquitylation of p53
-
Meulmeester E, Frenk R, Stad R et al. Critical role for a central part of Mdm2 in the ubiquitylation of p53. Mol Cell Biol 2003; 23:4929-38.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 4929-4938
-
-
Meulmeester, E.1
Frenk, R.2
Stad, R.3
-
74
-
-
10144259344
-
MDMX: A novel p53-binding protein with some functional properties ofMDM2
-
Shvarts A, Steegenga WT, Riteco N et al. MDMX: a novel p53-binding protein with some functional properties ofMDM2. EMBO J 1996; 15:5349-57.
-
(1996)
EMBO J
, vol.15
, pp. 5349-5357
-
-
Shvarts, A.1
Steegenga, W.T.2
Riteco, N.3
-
75
-
-
13144249170
-
Mdmx and Mdm2: Brothers in arms?
-
Marine JC, Jochemsen AG. Mdmx and Mdm2: brothers in arms? Cell Cycle 2004; 3:900-4.
-
(2004)
Cell Cycle
, vol.3
, pp. 900-904
-
-
Marine, J.C.1
Jochemsen, A.G.2
-
76
-
-
0034623074
-
Hdmx stabilizes Mdm2 and p53
-
Stad R, Ramos YF, Little N et al. Hdmx stabilizes Mdm2 and p53. J Biol Chem 2000; 275:28039-44.
-
(2000)
J Biol Chem
, vol.275
, pp. 28039-28044
-
-
Stad, R.1
Ramos, Y.F.2
Little, N.3
-
77
-
-
0035958574
-
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63
-
Little NA, Jochemsen AG. Hdmx and Mdm2 can repress transcription activation by p53 but not by p63. Oncogene 2001; 20:4576-80.
-
(2001)
Oncogene
, vol.20
, pp. 4576-4580
-
-
Little, N.A.1
Jochemsen, A.G.2
-
78
-
-
0034863683
-
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
-
Parant J, Chavez-Reyes A, Little NA et al. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 2001; 29:92-5.
-
(2001)
Nat Genet
, vol.29
, pp. 92-95
-
-
Parant, J.A.1
Chavez-Reyes, J.A.2
Little, N.A.3
-
79
-
-
0036606416
-
Potter D et al. Mdmx is a negative regulator of p53 activity in vivo
-
Finch RA, Donoviel DB, Potter D et al. mdmx is a negative regulator of p53 activity in vivo. Cancer Res 2002; 62:3221-5.
-
(2002)
Cancer Res
, vol.62
, pp. 3221-3225
-
-
Finch, R.A.1
Donoviel, D.B.2
-
80
-
-
0036311067
-
Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development
-
Migliorini D, Lazzerini Denchi E, Danovi D et al. Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol Cell Biol 2002; 22:5527-38.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5527-5538
-
-
Migliorini, D.E.1
Lazzerini Denchi, D.E.2
Danovi, D.3
-
81
-
-
0037147143
-
MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination
-
Badciong JC, Haas AL. MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination. J Biol Chem 2002; 277:49668-75.
-
(2002)
J Biol Chem
, vol.277
, pp. 49668-49675
-
-
Badciong, J.C.1
Haas, A.L.2
-
82
-
-
0033621415
-
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
-
Sharp DA, Kratowicz SA, Sank MJ et al. Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein. J Biol Chem 1999; 274:38189-96.
-
(1999)
J Biol Chem
, vol.274
, pp. 38189-38196
-
-
Sharp, D.A.1
Kratowicz, S.A.2
Sank, M.J.3
-
83
-
-
0033051322
-
MDM2 interacts with MDMX through their RING finger domains
-
Tanimura S, Ohtsuka S, Mitsui K et al. MDM2 interacts with MDMX through their RING finger domains. FEBS Lett 1999; 447:5-9.
-
(1999)
FEBS Lett
, vol.447
, pp. 5-9
-
-
Tanimura, S.1
Ohtsuka, S.2
Mitsui, K.3
-
84
-
-
34249711818
-
Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity ofRING finger mutants ofMdm2
-
Singh RK, Iyappan S, Scheffner M. Hetero-oligomerization with MdmX rescues the ubiquitin/Nedd8 ligase activity ofRING finger mutants ofMdm2. J Biol Chem 2007; 282:10901-7.
-
(2007)
J Biol Chem
, vol.282
, pp. 10901-10907
-
-
Singh, R.K.1
Iyappan, S.2
Scheffner, M.3
-
85
-
-
0035203715
-
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
-
Stad R, Little NA, Xirodimas DP et al. Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms. EMBO Rep 2001; 2:1029-34.
-
(2001)
EMBO Rep
, vol.2
, pp. 1029-1034
-
-
Stad, R.1
Little, N.A.2
Xirodimas, D.P.3
-
86
-
-
0036510399
-
Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation
-
Migliorini D, Danovi D, Colombo E et al. Hdmx recruitment into the nucleus by Hdm2 is essential for its ability to regulate p53 stability and transactivation. J Biol Chem 2002; 277:7318-23.
-
(2002)
J Biol Chem
, vol.277
, pp. 7318-7323
-
-
Migliorini, D.D.1
Danovi, D.D.2
Colombo, E.3
-
87
-
-
0141866880
-
Hdmx protein stability is regulated by the ubiquitin ligase activity ofMdm2
-
de Graaf P, Little NA, Ramos YF et al. Hdmx protein stability is regulated by the ubiquitin ligase activity ofMdm2. J Biol Chem 2003; 278:38315-24.
-
(2003)
J Biol Chem
, vol.278
, pp. 38315-38324
-
-
De Graaf, P.1
Little, N.A.2
Ramos, Y.F.3
-
88
-
-
0042592947
-
MDM2 promotes ubiquitination and degradation of MDMX
-
Pan Y, Chen J. MDM2 promotes ubiquitination and degradation of MDMX. Mol Cell Biol 2003; 23:5113-21.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5113-5121
-
-
Pan, Y.1
Chen, J.2
-
89
-
-
0029587551
-
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
-
Quelle DE, Zindy F, Ashmun RA et al. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell 1995; 83:993-1000.
-
(1995)
Cell
, vol.83
, pp. 993-1000
-
-
Quelle, D.E.1
Zindy, F.2
Ashmun, R.A.3
-
90
-
-
0032549704
-
The Ink4a tumor suppressor gene product, p19Arf interacts with MDM2 and neutralizes MDM2's inhibition ofp53
-
Pomerantz J, Schreiber-Agus N, Liegeois NJ et al. The Ink4a tumor suppressor gene product, p19Arf interacts with MDM2 and neutralizes MDM2's inhibition ofp53. Cell 1998; 92:713-23.
-
(1998)
Cell
, vol.92
, pp. 713-723
-
-
Pomerantz, J.1
Schreiber-Agus, N.2
Liegeois, N.J.3
-
91
-
-
0032169516
-
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
-
Stott FJ, Bates S, James MC et al. The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J 1998; 17:5001-14.
-
(1998)
EMBO J
, vol.17
, pp. 5001-5014
-
-
Stott, F.J.1
Bates, S.2
James, M.C.3
-
92
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998; 92:725-34.
-
(1998)
Cell
, vol.92
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
93
-
-
0035899468
-
Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo
-
Xirodimas D, Saville MK, Edling C et al. Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo. Oncogene 2001; 20:4972-83.
-
(2001)
Oncogene
, vol.20
, pp. 4972-4983
-
-
Xirodimas, D.1
Saville, M.K.2
Edling, C.3
-
94
-
-
0033771948
-
Identification of a cryptic nucleolar-localization signal in MDM2
-
Lohrum MA, Ashcroft M, Kubbutat MH et al. Identification of a cryptic nucleolar-localization signal in MDM2. Nat Cell Biol 2000; 2:179-81.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 179-181
-
-
Lohrum, M.A.1
Ashcroft, M.2
Kubbutat, M.H.3
-
96
-
-
0033000482
-
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export ofMDM2 and p53
-
Zhang Y, Xiong Y. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export ofMDM2 and p53. Mol Cell 1999; 3:579-91.
-
(1999)
Mol Cell
, vol.3
, pp. 579-591
-
-
Zhang, Y.1
Xiong, Y.2
-
97
-
-
0033536063
-
P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2
-
Tao W, Levine AJ. P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2. Proc Natl Acad Sci USA 1999; 96:6937-41.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 6937-6941
-
-
Tao, W.1
Levine, W.2
-
98
-
-
0034744224
-
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
-
Llanos S, Clark PA, Rowe J et al. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat Cell Biol 2001; 3:445-52.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 445-452
-
-
Llanos, S.1
Clark, P.A.2
Rowe, J.3
-
99
-
-
0033521621
-
Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity ofMdm2 for tumor suppressorp53
-
Honda R, Yasuda H. Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity ofMdm2 for tumor suppressorp53. EMBO J 1999; 18:22-7.
-
(1999)
EMBO J
, vol.18
, pp. 22-27
-
-
Honda, R.1
Yasuda, H.2
-
100
-
-
0034603897
-
An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo
-
Midgley Ca, Desterro JM, Saville MK et al. An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene 2000; 19:2312-23.
-
(2000)
Oncogene
, vol.19
, pp. 2312-2323
-
-
Ca, M.1
Saville, J.2
-
101
-
-
33845185824
-
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
-
Ringshausen I, O'Shea CC, Finch AJ et al. Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 2006; 10:501-14.
-
(2006)
Cancer Cell
, vol.10
, pp. 501-514
-
-
Ringshausen, I.C.1
O'shea, I.C.2
Finch, A.J.3
-
102
-
-
0037459377
-
Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation
-
Leng RP, Lin Y, Ma W et al. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell2003; 112:779-91.
-
Cell2003
, vol.112
, pp. 779-791
-
-
Leng, R.P.1
Lin, Y.2
Ma, W.3
-
103
-
-
2342447397
-
The ubiquitin ligase COP1 is a critical negative regulator of p53
-
Dornan D, Wertz I, Shimizu H et al. The ubiquitin ligase COP1 is a critical negative regulator of p53. Nature 2004; 429:86-92.
-
(2004)
Nature
, vol.429
, pp. 86-92
-
-
Dornan, D.1
Wertz, I.2
Shimizu, H.3
-
104
-
-
0026740449
-
Amplification of a gene encoding a p53-associated protein in human sarcomas
-
Oliner JD, Kinzler KW, Meltzer PS et al. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature 1992; 358:80-3.
-
(1992)
Nature
, vol.358
, pp. 80-83
-
-
Oliner, J.D.1
Kinzler, K.W.2
Meltzer, P.S.3
-
105
-
-
0027232042
-
Meltzer P et al. P53 Mutation and MDM2 amplification inhuman soft tissue sarcomas
-
Leach FS, Tokino T, Meltzer P et al. p53 Mutation and MDM2 amplification inhuman soft tissue sarcomas. CancerRes 1993; 53:2231-4.
-
(1993)
Cancerres
, vol.53
, pp. 2231-2234
-
-
Leach, F.S.1
Tokino, T.2
-
106
-
-
5644302246
-
COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas
-
Dornan D, Bheddah S, Newton K et al. COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas. Cancer Res 2004; 64:7226-30.
-
(2004)
Cancer Res
, vol.64
, pp. 7226-7230
-
-
Dornan, D.1
Bheddah, S.2
Newton, K.3
-
107
-
-
9744227111
-
Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer
-
Duan W, Gao L, Druhan LJ et al. Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer. J Natl Cancer Inst 2004; 96:1718-21.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1718-1721
-
-
Duan, W.1
Gao, L.2
Druhan, L.J.3
-
108
-
-
0032524621
-
Characterization of human hect domain family members and their interactionwithUbcH5 andUbcH7
-
Schwarz SE, Rosa JL, Scheffner M. Characterization of human hect domain family members and their interactionwithUbcH5 andUbcH7. JBiolChem 1998; 273:12148-54.
-
(1998)
Jbiolchem
, vol.273
, pp. 12148-12154
-
-
Schwarz, S.E.1
Rosa, J.L.2
Scheffner, M.3
-
109
-
-
33745229246
-
ARF-BP1 as a potential therapeutic target
-
Chen D, Brooks CL, Gu W. ARF-BP1 as a potential therapeutic target. Br J Cancer 2006; 94:1555-8.
-
(2006)
Br J Cancer
, vol.94
, pp. 1555-1558
-
-
Chen, D.1
Brooks, C.L.2
Gu, W.3
-
110
-
-
21244451434
-
ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor
-
Chen D, Kon N, Li M et al. ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor. Cell 2005; 121:1071-83.
-
(2005)
Cell
, vol.121
, pp. 1071-1083
-
-
Chen, D.1
Li, N.M.2
-
111
-
-
21244472965
-
Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiq-uitination ofMcl-1 andregulates apoptosis
-
Zhong Q, Gao W, Du F et al. Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiq-uitination ofMcl-1 andregulates apoptosis. Cell2005; 121:1085-95.
-
Cell2005
, vol.121
, pp. 1085-1095
-
-
Zhong, Q.1
Gao, W.2
Du, F.3
-
112
-
-
27544473311
-
The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation
-
Adhikary S, Marinoni F, Hock A et al. The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 2005; 123:409-21.
-
(2005)
Cell
, vol.123
, pp. 409-421
-
-
Adhikary, S.1
Marinoni, F.2
Hock, A.3
-
113
-
-
4344563161
-
Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53
-
Rajendra R, Malegaonkar D, Pungaliya P et al. Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J Biol Chem 2004; 279:36440-4.
-
(2004)
J Biol Chem
, vol.279
, pp. 36440-36444
-
-
Rajendra, R.1
Malegaonkar, D.2
Pungaliya, P.3
-
114
-
-
24144483441
-
Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo
-
Weger S, Hammer E, Heilbronn R. Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. FEBS Lett 2005; 579:5007-12.
-
(2005)
FEBS Lett
, vol.579
, pp. 5007-5012
-
-
Weger, S.E.1
Hammer, S.E.2
Heilbronn, R.3
-
115
-
-
67650529837
-
Plk1-mediated phosphorylation of Topors regulates p53 stability
-
Yang X, Li H, Zhou Z et al. Plk1-mediated phosphorylation of Topors regulates p53 stability. J Biol Chem2009; 284:18588-92.
-
J Biol Chem2009
, vol.284
, pp. 18588-18592
-
-
Yang, X.H.1
Li, X.H.2
Zhou, Z.3
-
116
-
-
34047261783
-
CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation
-
Yang W, Rozan LM, McDonald ER, 3rd et al. CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation. J Biol Chem 2007; 282:3273-81.
-
(2007)
J Biol Chem
, vol.282
, pp. 3273-3281
-
-
Yang, W.1
Rozan, L.M.2
McDonald, E.R.3
-
117
-
-
33846219143
-
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'
-
Yamasaki S, Yagishita N, Sasaki T et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J 2007; 26:113-22.
-
(2007)
EMBO J
, vol.26
, pp. 113-122
-
-
Yamasaki, S.1
Yagishita, N.2
Sasaki, T.3
-
118
-
-
62449257012
-
Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP
-
Xia Y, Padre RC, De Mendoza TH et al. Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc Natl Acad Sci USA 2009; 106:2629-34.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2629-2634
-
-
Xia, Y.1
Padre, R.C.2
De Mendoza, T.H.3
-
119
-
-
67649852552
-
JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation
-
Sun L, Shi L, Li W et al. JFK, a Kelch domain-containing F-box protein, links the SCF complex to p53 regulation. Proc Natl Acad Sci USA 2009; 106:10195-200.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 10195-10200
-
-
Sun, L.1
Shi, L.2
Li, W.3
-
121
-
-
22844447871
-
The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation
-
Esser C, Scheffner M, Hohfeld J. The chaperone-associated ubiquitin ligase CHIP is able to target p53 for proteasomal degradation. J Biol Chem 2005; 280:27443-8.
-
(2005)
J Biol Chem
, vol.280
, pp. 27443-27448
-
-
Esser, C.1
Scheffner, M.2
Hohfeld, J.3
-
122
-
-
36849035345
-
Ubiquitination and degradation of mutant p53
-
Lukashchuk N, Vousden KH. Ubiquitination and degradation of mutant p53. Mol Cell Biol 2007; 27:8284-95.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8284-8295
-
-
Lukashchuk, N.1
Vousden, K.H.2
-
123
-
-
44149124776
-
Chaperone-dependent stabilization and degradation of p53 mutants
-
Muller P, Hrstka R, Coomber D et al. Chaperone-dependent stabilization and degradation of p53 mutants. Oncogene 2008; 27:3371-83.
-
(2008)
Oncogene
, vol.27
, pp. 3371-3383
-
-
Muller, P.1
Hrstka, R.2
Coomber, D.3
-
124
-
-
0027396829
-
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53
-
Huibregtse JM, Scheffner M, Howley PM. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol Cell Biol 1993; 13:775-84.
-
(1993)
Mol Cell Biol
, vol.13
, pp. 775-784
-
-
Huibregtse, J.M.1
Scheffner, M.2
Howley, P.M.3
-
125
-
-
0027358723
-
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
-
Scheffner M, Huibregtse JM, Vierstra RD et al. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993; 75:495-505.
-
(1993)
Cell
, vol.75
, pp. 495-505
-
-
Scheffner, M.1
Huibregtse, J.M.2
Vierstra, R.D.3
-
126
-
-
0028334011
-
Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: Implications for tumor suppressor gene function in development
-
Pan H, Griep AE. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 1994; 8:1285-99.
-
(1994)
Genes Dev
, vol.8
, pp. 1285-1299
-
-
Pan, H.1
Griep, A.E.2
-
127
-
-
24944485818
-
Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential
-
Simonson SJ, Difilippantonio MJ, Lambert PF. Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential. Cancer Res 2005; 65:8266-73.
-
(2005)
Cancer Res
, vol.65
, pp. 8266-8273
-
-
Simonson, S.J.1
Difilippantonio, M.J.2
Lambert, P.F.3
-
128
-
-
0036559896
-
Papillomaviruses and cancer: From basic studies to clinical application
-
zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2:342-50.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 342-350
-
-
Zur Hausen, H.1
-
129
-
-
0031058283
-
Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells
-
Beer-Romero P, Glass S, Rolfe M. Antisense targeting of E6AP elevates p53 in HPV-infected cells but not in normal cells. Oncogene 1997; 14:595-602.
-
(1997)
Oncogene
, vol.14
, pp. 595-602
-
-
Beer-Romero, P.1
Glass, S.2
Rolfe, M.3
-
130
-
-
0141676270
-
E6AP gene suppression and characterization with in vitro selected hammerheadribozymes
-
Kim Y, Cairns MJ, Marouga R et al. E6AP gene suppression and characterization with in vitro selected hammerheadribozymes. Cancer Gene Ther 2003; 10:707-16.
-
(2003)
Cancer Gene Ther
, vol.10
, pp. 707-716
-
-
Kim, Y.1
Cairns, M.J.2
Marouga, R.3
-
131
-
-
14744275857
-
The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase
-
Kelley ML, Keiger KE, Lee CJ et al. The global transcriptional effects of the human papillomavirus E6 protein in cervical carcinoma cell lines are mediated by the E6AP ubiquitin ligase. J Virol 2005; 79:3737-47.
-
(2005)
J Virol
, vol.79
, pp. 3737-3747
-
-
Kelley, M.L.1
Keiger, K.E.2
Lee, C.J.3
-
132
-
-
21644448222
-
Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53
-
Hengstermann A, D'Silva MA, Kuballa P et al. Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53. J Virol 2005; 79:9296-300.
-
(2005)
J Virol
, vol.79
, pp. 9296-9300
-
-
Hengstermann, A.M.1
D'silva, A.M.2
Kuballa, P.3
-
133
-
-
0035577765
-
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex
-
Querido E, Blanchette P, Yan Q et al. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev 2001; 15:3104-17.
-
(2001)
Genes Dev
, vol.15
, pp. 3104-3117
-
-
Querido, E.1
Blanchette, P.2
Yan, Q.3
-
134
-
-
42049098813
-
The adenovirus E1B-55K oncoprotein induces SUMO modification of p53
-
Muller S, Dobner T. The adenovirus E1B-55K oncoprotein induces SUMO modification of p53. Cell Cycle 2008; 7:754-58.
-
(2008)
Cell Cycle
, vol.7
, pp. 754-758
-
-
Muller, S.1
Dobner, T.2
-
135
-
-
0141704201
-
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53
-
Boutell C, Everett RD. The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53. J Biol Chem 2003; 278:36596-602.
-
(2003)
J Biol Chem
, vol.278
, pp. 36596-36602
-
-
Boutell, C.1
Everett, R.D.2
-
136
-
-
0041529593
-
Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7
-
Holowaty MN, Zeghouf M, Wu H et al. Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7. J Biol Chem 2003; 278:29987-94.
-
(2003)
J Biol Chem
, vol.278
, pp. 29987-29994
-
-
Holowaty, M.N.1
Zeghouf, M.2
Wu, H.3
-
137
-
-
70049110811
-
Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex
-
Sato Y, Kamura T, Shirata N et al. Degradation of phosphorylated p53 by viral protein-ECS E3 ligase complex. PLoS Pathog 2009; 5:e1000530.
-
(2009)
Plos Pathog
, vol.5
-
-
Sato, Y.1
Kamura, T.2
Shirata, N.3
-
138
-
-
33750464049
-
EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors
-
Cai QL, Knight JS, Verma SC et al. EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors. PLoS Pathog 2006; 2:e116.
-
(2006)
Plos Pathog
, vol.2
-
-
Cai, Q.1
Knight, Q.2
Verma, S.C.3
-
139
-
-
66149106996
-
Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2
-
Saha A, Murakami M, Kumar P et al. Epstein-Barr virus nuclear antigen 3C augments Mdm2-mediated p53 ubiquitination and degradation by deubiquitinating Mdm2. J Virol 2009; 83:4652-69.
-
(2009)
J Virol
, vol.83
, pp. 4652-4669
-
-
Saha, A.1
Murakami, M.2
Kumar, P.3
-
140
-
-
67449097025
-
TothZ, Shin YC et al. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway
-
Lee HR, TothZ, Shin YC et al. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway. J Virol 2009; 83:6739-47.
-
(2009)
J Virol
, vol.83
, pp. 6739-6747
-
-
Lee, H.R.1
-
141
-
-
0032518917
-
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
-
Roth J, Dobbelstein M, Freedman DA et al. Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J 1998; 17:554-64.
-
(1998)
EMBO J
, vol.17
, pp. 554-564
-
-
Roth, J.1
Dobbelstein, M.2
Freedman, D.A.3
-
142
-
-
0033559256
-
A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
-
Stommel JM, Marchenko ND, Jimenez GS et al. A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J 1999; 18:1660-72.
-
(1999)
EMBO J
, vol.18
, pp. 1660-1672
-
-
Stommel, J.M.1
Marchenko, N.D.2
Jimenez, G.S.3
-
143
-
-
0032980646
-
Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation ofp53
-
Tao W, Levine AJ. Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation ofp53. Proc Natl Acad Sci USA 1999; 96:3077-80.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3077-3080
-
-
Tao, W.1
Levine, W.2
-
144
-
-
0034282102
-
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
-
Boyd SD, Tsai KY, Jacks T. An intact HDM2 RING-finger domain is required for nuclear exclusion of p53. Nat Cell Biol 2000; 2:563-8.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 563-568
-
-
Boyd, S.D.1
Tsai, K.Y.2
Jacks, T.3
-
145
-
-
0348134742
-
Mono- versus polyubiquitination: Differential control of p53 fate by Mdm2
-
Li M, Brooks CL, Wu-Baer F et al. Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 2003; 302:1972-5.
-
(2003)
Science
, vol.302
, pp. 1972-1975
-
-
Li, M.1
Brooks, C.L.2
Wu-Baer, F.3
-
147
-
-
34047103990
-
C-terminal modifications regulate MDM2 dissociation and nuclear export ofp53
-
Carter S, Bischof O, Dejean A et al. C-terminal modifications regulate MDM2 dissociation and nuclear export ofp53. Nat Cell Biol 2007; 9:428-35.
-
(2007)
Nat Cell Biol
, vol.9
, pp. 428-435
-
-
Carter, S.1
Dejean, O.A.2
-
148
-
-
33847276654
-
Monoubiquitylation promotes mitochondrial p53 translocation
-
Marchenko ND, Wolff S, Erster S et al. Monoubiquitylation promotes mitochondrial p53 translocation. EMBO J 2007; 26:923-34.
-
(2007)
EMBO J
, vol.26
, pp. 923-934
-
-
Marchenko, N.D.1
Wolff, S.2
Erster, S.3
-
149
-
-
18644384283
-
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults
-
Zacchi P, Gostissa M, Uchida T et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults. Nature 2002; 419:853-7.
-
(2002)
Nature
, vol.419
, pp. 853-857
-
-
Zacchi, P.1
Gostissa, M.2
Uchida, M.3
-
150
-
-
18644384688
-
The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response
-
Zheng H, You H, Zhou XZ et al. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response. Nature 2002; 419:849-53.
-
(2002)
Nature
, vol.419
, pp. 849-853
-
-
Zheng, H.1
You, H.2
Zhou, X.Z.3
-
151
-
-
68249119759
-
Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation
-
Siepe D, Jentsch S. Prolyl isomerase Pin1 acts as a switch to control the degree of substrate ubiquitylation. Nat Cell Biol 2009; 11:967-72.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 967-972
-
-
Siepe, D.1
Jentsch, S.2
-
152
-
-
33845202484
-
Regulation of p53 localization and activity by Ubc13
-
Laine A, Topisirovic I, Zhai D et al. Regulation of p53 localization and activity by Ubc13. Mol Cell Biol 2006; 26:8901-13.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8901-8913
-
-
Laine, A.I.1
Topisirovic, A.I.2
Zhai, D.3
-
154
-
-
33847401446
-
RonaiZ. Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1
-
Laine A, RonaiZ. Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1. Oncogene 2007; 26:1477-83.
-
(2007)
Oncogene
, vol.26
, pp. 1477-1483
-
-
Laine, A.1
-
155
-
-
33847212425
-
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
-
Stevenson LF, Sparks A, Allende-Vega N et al. The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO J 2007; 26:976-86.
-
(2007)
EMBO J
, vol.26
, pp. 976-986
-
-
Stevenson, L.F.1
Sparks, A.2
Allende-Vega, N.3
-
156
-
-
64149087218
-
Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53
-
Dayal S, Sparks A, Jacob J et al. Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem 2009; 284:5030-41.
-
(2009)
J Biol Chem
, vol.284
, pp. 5030-5041
-
-
Dayal, S.1
Sparks, A.2
Jacob, J.3
-
157
-
-
0037061508
-
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
-
Li M, Chen D, Shiloh A et al. Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization. Nature 2002; 416:648-53.
-
(2002)
Nature
, vol.416
, pp. 648-653
-
-
Li, M.1
Chen, D.2
Shiloh, A.3
-
158
-
-
1842421376
-
A dynamic role ofHAUSP in the p53-Mdm2 pathway
-
Li M, Brooks CL, Kon N et al. A dynamic role ofHAUSP in the p53-Mdm2 pathway. Mol Cell 2004; 13:879-86.
-
(2004)
Mol Cell
, vol.13
, pp. 879-886
-
-
Li, M.1
Brooks, C.L.2
Kon, N.3
-
159
-
-
36348975260
-
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)
-
Yamaguchi T, Kimura J, Miki Y et al. The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha). J Biol Chem 2007; 282:33943-8.
-
(2007)
J Biol Chem
, vol.282
, pp. 33943-33948
-
-
Yamaguchi, T.1
Kimura, J.2
Miki, Y.3
-
160
-
-
33746766974
-
A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response
-
Zhang D, Zaugg K, Mak TW et al. A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Cell 2006; 126:529-42.
-
(2006)
Cell
, vol.126
, pp. 529-542
-
-
Zhang, D.1
Zaugg, K.2
Mak, T.W.3
-
161
-
-
1842431904
-
Tumour suppression: Disruption of HAUSP gene stabilizes p53
-
p following 486
-
Cummins JM, Rago C, Kohli M et al. Tumour suppression: disruption of HAUSP gene stabilizes p53. Nature 2004; 428:1 p following 486.
-
(2004)
Nature
, vol.428
, pp. 1
-
-
Cummins, J.M.1
Rago, C.2
Kohli, M.3
-
162
-
-
33746648187
-
Critical role for Daxx in regulating Mdm2
-
Tang J, Qu LK, Zhang J et al. Critical role for Daxx in regulating Mdm2. Nat Cell Biol 2006; 8:855-62.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 855-862
-
-
Tang, J.1
Zhang, L.K.J.2
-
163
-
-
46949093338
-
Kim SYet al. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
-
Song MS, Song SJ, Kim SYet al. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J 2008; 27:1863-74.
-
(2008)
EMBO J
, vol.27
, pp. 1863-1874
-
-
Song, M.S.1
Song, S.J.2
-
164
-
-
19444367393
-
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization ofHdmx and Hdm2
-
Meulmeester E, Maurice MM, Boutell C et al. Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization ofHdmx and Hdm2. Mol Cell 2005; 18:565-76.
-
(2005)
Mol Cell
, vol.18
, pp. 565-576
-
-
Meulmeester, E.1
Maurice, M.M.2
Boutell, C.3
-
165
-
-
25444478027
-
ATM-mediatedphosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor ofp53 activation
-
Meulmeester E, Pereg Y, Shiloh Y et al. ATM-mediatedphosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor ofp53 activation. Cell Cycle 2005; 4:1166-70.
-
(2005)
Cell Cycle
, vol.4
, pp. 1166-1170
-
-
Meulmeester, E.1
Pereg, Y.2
Shiloh, Y.3
-
166
-
-
2342567852
-
Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation
-
Stommel JM, Wahl GM. Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation. EMBO J 2004; 23:1547-56.
-
(2004)
EMBO J
, vol.23
, pp. 1547-1556
-
-
Stommel, J.M.1
Wahl, G.M.2
-
167
-
-
60549091914
-
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
-
Huang DT, Ayrault O, Hunt HW et al. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. Mol Cell 2009; 33:483-95.
-
(2009)
Mol Cell
, vol.33
, pp. 483-495
-
-
Huang, D.T.1
Ayrault, O.2
Hunt, H.W.3
-
168
-
-
1842591241
-
Nedd8 on cullin: Building an expressway to protein destruction
-
Pan ZQ, Kentsis A, Dias DC et al. Nedd8 on cullin: building an expressway to protein destruction. Oncogene 2004; 23:1985-97.
-
(2004)
Oncogene
, vol.23
, pp. 1985-1997
-
-
Pan, Z.Q.1
Kentsis, A.2
Dias, D.C.3
-
169
-
-
3142570737
-
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
-
Xirodimas DP, Saville MK, Bourdon JC et al. Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 2004; 118:83-97.
-
(2004)
Cell
, vol.118
, pp. 83-97
-
-
Xirodimas, D.P.1
Saville, M.K.2
Bourdon, J.C.3
-
170
-
-
0026460979
-
The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence ofintervening G2, M and G1
-
Handeli S, Weintraub H. The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence ofintervening G2, M and G1. Cell 1992; 71:599-611.
-
(1992)
Cell
, vol.71
, pp. 599-611
-
-
Handeli, S.1
Weintraub, H.2
-
171
-
-
33847328747
-
FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity
-
Abida WM, Nikolaev A, Zhao W et al. FBXO11 promotes the neddylation of p53 and inhibits its transcriptional activity. J Biol Chem 2006; 282:1797-804.
-
(2006)
J Biol Chem
, vol.282
, pp. 1797-1804
-
-
Abida, W.M.1
Nikolaev, A.2
Zhao, W.3
-
172
-
-
68049103216
-
An additional role for SUMO in ubiquitin-mediated proteolysis
-
Geoffroy MC, Hay RT. An additional role for SUMO in ubiquitin-mediated proteolysis. Nat Rev Mol CellBiol2009; 10:564-8.
-
Nat Rev Mol Cellbiol2009
, vol.10
, pp. 564-568
-
-
Geoffroy, M.C.1
Hay, R.T.2
-
173
-
-
0033570892
-
Fogal Vet al. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
-
Gostissa M, Hengstermann A, Fogal Vet al. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1. EMBO J 1999; 18:6462-71.
-
(1999)
EMBO J
, vol.18
, pp. 6462-6471
-
-
Gostissa, M.1
Hengstermann, A.2
-
174
-
-
0033571214
-
SUMO-1 modification activates the transcriptional response ofp53
-
Rodriguez MS, Desterro JM, Lain S et al. SUMO-1 modification activates the transcriptional response ofp53. EMBO J 1999; 18:6455-61.
-
(1999)
EMBO J
, vol.18
, pp. 6455-6461
-
-
Rodriguez, M.S.1
Desterro, J.M.2
Lain, S.3
-
175
-
-
0034789730
-
Involvement of PIAS1 in the sumoylation of tumor suppressor p53
-
Kahyo T, Nishida T, Yasuda H. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol Cell2001; 8:713-8.
-
Molcell2001
, vol.8
, pp. 713-718
-
-
Kahyo, T.1
Nishida, T.2
Yasuda, H.3
-
176
-
-
0035024007
-
A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis
-
Nelson V, Davis GE, Maxwell SA. A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis. Apoptosis 2001; 6:221-34.
-
(2001)
Apoptosis
, vol.6
, pp. 221-234
-
-
Nelson, V.1
Davis, G.E.2
Maxwell, S.A.3
-
177
-
-
0037022564
-
Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity
-
Schmidt D, Muller S. Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Proc Natl Acad Sci USA 2002; 99:2872-7.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2872-2877
-
-
Schmidt, D.1
Muller, S.2
-
178
-
-
33745210316
-
SchwambornK, MartinN et al. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis
-
Bischof O, SchwambornK, MartinN et al. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol Cell 2006; 22:783-94.
-
(2006)
Mol Cell
, vol.22
, pp. 783-794
-
-
Bischof, O.1
-
179
-
-
65649101212
-
Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
-
Wu SY, Chiang CM. Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J 2009; 28:1246-59.
-
(2009)
EMBO J
, vol.28
, pp. 1246-1259
-
-
Wu, S.Y.1
Chiang, C.M.2
-
180
-
-
33751549096
-
SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination
-
Lee MH, Lee SW, Lee EJ et al. SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. Nat Cell Biol 2006; 8:1424-31.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1424-1431
-
-
Lee, M.H.1
Lee, S.W.2
Lee, E.J.3
-
181
-
-
84930231419
-
Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish
-
Yuan H, Zhou J, Deng M et al. Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish. Cell Res 2009.
-
(2009)
Cell Res
-
-
Yuan, H.1
Zhou, J.2
Deng, M.3
-
182
-
-
0035827335
-
A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
-
Zhang Y, Xiong Y. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation. Science 2001; 292:1910-5.
-
(2001)
Science
, vol.292
, pp. 1910-1915
-
-
Zhang, Y.1
Xiong, Y.2
-
183
-
-
0037047345
-
The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo
-
Shimizu H, Burch LR, Smith AJ et al. The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem 2002; 277:28446-58.
-
(2002)
J Biol Chem
, vol.277
, pp. 28446-28458
-
-
Shimizu, H.1
Burch, L.R.2
Smith, A.J.3
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