Image-based 3D modeling study of the influence of vessel density and blood hemoglobin concentration on tumor oxygenation and response to irradiation

Medical Physics

Volumn 40, Issue 2, 2013, Pages

  Lagerlöf, Jakob H ^a   Kindblom, Jon ^b   Cortez, Eliane ^c   Pietras, Kristian ^c   Bernhardt, Peter ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

dosimetry; hypoxia; modeling; radiotherapy; tumor control probability

Indexed keywords

BLOOD; BLOOD VESSELS; DOSIMETRY; HEMOGLOBIN; IRRADIATION; ITERATIVE METHODS; MATRIX ALGEBRA; MODELS; OXYGEN; PROBABILITY DISTRIBUTIONS; RADIOTHERAPY; SURFACE TENSION; TUMORS;

HEMOGLOBIN CONCENTRATION; HISTOLOGICAL IMAGES; HYPOXIA; IMAGE THRESHOLDING; MICHAELIS-MENTEN MODEL; OXYGEN DISTRIBUTION; OXYGEN PARTIAL PRESSURE; TUMOR CONTROL PROBABILITY;

3D MODELING;

HEMOGLOBIN; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGEN TENSION; BLOOD OXYGENATION; BLOOD VESSEL DENSITY; BLOOD VESSEL PARAMETERS; CANCER CONTROL; CELL SURVIVAL; CONTROLLED STUDY; HEMOGLOBIN BLOOD LEVEL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULINOMA; IRRADIATION; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN DIFFUSION; OXYGEN ENHANCEMENT RATIO; OXYGEN TENSION; PANCREAS ISLET CELL CARCINOMA; PRIORITY JOURNAL; RADIATION RESPONSE; SIMULATION; STEADY STATE; THREE DIMENSIONAL IMAGING; TISSUE OXYGENATION; TISSUE PREPARATION; TUMOR OXYGENATION; ANIMAL; BIOLOGICAL MODEL; BLOOD; BLOOD VESSEL; METABOLISM; PANCREAS TUMOR; RADIATION EXPOSURE; TREATMENT OUTCOME; VASCULARIZATION;

ANIMALS; BLOOD VESSELS; HEMOGLOBINS; INSULINOMA; MICE; MODELS, BIOLOGICAL; OXYGEN; PANCREATIC NEOPLASMS; TREATMENT OUTCOME;

EID: 84873592570     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.4773886     Document Type: Article

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