Acetylcholine attenuates hypoxia/reoxygenation-induced mitochondrial and cytosolic ROS formation in H9c2 cells via M2 acetylcholine receptor

Cellular Physiology and Biochemistry

Volumn 31, Issue 2-3, 2013, Pages 189-198

  Miao, Yi ^a   Zhou, Jun ^a   Zhao, Mei ^a   Liu, Jinjun ^a   Sun, Lei ^a   Yu, Xiaojiang ^a   He, Xi ^a   Pan, Xiaoyue ^a   Zang, Weijin ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

Acetylcholine; Electronic transport chain; Hypoxia reoxygenation; M2 acetylcholine receptor; NADPH oxidase; Reactive oxygen species; Xanthine oxidase

Indexed keywords

ACETYLCHOLINE; ATROPINE; CASPASE 3; LACTATE DEHYDROGENASE; MITOCHONDRIAL DNA; MUSCARINIC M2 RECEPTOR; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SMALL INTERFERING RNA; XANTHINE OXIDASE; HEXAMETHONIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COPY NUMBER VARIATION; GENE SILENCING; HEART MITOCHONDRION; HEART MUSCLE CELL; HYPOXIA; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION INJURY; ANTIOXIDANT ACTIVITY; ENZYME ACTIVITY; ENZYME RELEASE; GENETIC TRANSFECTION; MITOCHONDRION; PROTEIN CLEAVAGE; RNA INTERFERENCE;

RATTUS;

EID: 84873587036     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000343360     Document Type: Article

References (26)

1. Eltzschig HK, Eckle T: Ischemia and reperfusion-from mechanism to translation. Nat Med 2011;17:1391-1401.
2. Murphy E, Steenbergen C: Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev 2008;88:581-609. (Pubitemid 351520088)
3. Minamino T: Cardioprotection from ischemia/reperfusion injury. Circ J 2012;76:1074-1082.
4. Radak Z, Zhao Z, Goto S, Koltai E: Age-associated neurodegeneration and oxidative damage to lipids, proteins and dna. Mol Aspects Med 2011;32:305-315.
5. Chen AF, Chen DD, Daiber A, Faraci FM, Li H, Rembold CM, Laher I: Free radical biology of the cardiovascular system. Clin Sci (Lond) 2012;123:73-91.
6. Zweier JL, Talukder MA: The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 2006;70:181-190.
7. Qin F, Simeone M, Patel R: Inhibition of NADPH oxidase reduces myocardial oxidative stress and apoptosis and improves cardiac function in heart failure after myocardial infarction. Free Radic Biol Med 2007;43:271-281. (Pubitemid 46977168)
8. Uemura K, Li M, Tsutsumi T, Yamazaki T, Kawada T, Kamiya A, Inagaki M, Sunagawa K, Sugimachi M: Efferent vagal nerve stimulation induces tissue inhibitor of metalloproteinase-1 in myocardial ischemia-reperfusion injury in rabbit. Am J Physiol Heart Circ Physiol 2007;293:H2254-H2261. (Pubitemid 47605869)
9. Calvillo L, Vanoli E, Andreoli E, Besana A, Omodeo E, Gnecchi M, Zerbi P, Vago G, Busca G, Schwartz PJ: Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. J Cardiovasc Pharmacol 2011;58:500-507.
10. Tsutsumi T, Ide T, Yamato M, Kudou W, Andou M, Hirooka Y, Utsumi H, Tsutsui H, Sunagawa K: Modulation of the myocardial redox state by vagal nerve stimulation after experimental myocardial infarction. Cardiovasc Res 2008;77:713-721. (Pubitemid 351301868)
11. Kim MH, Kim MO, Heo JS, Kim JS, Han HJ: Acetylcholine inhibits long-term hypoxia-induced apoptosis by suppressing the oxidative stress-mediated MAPKs activation as well as regulation of Bcl-2, c-IAPs, and caspase-3 in mouse embryonic stem cells. Apoptosis 2008;13:295-304.
12. Liu JJ, Li DL, Zhou J, Sun L, Zhao M, Kong SS, Wang YH, Yu XJ, Zhou J, Zang WJ: Acetylcholine prevents angiotensin II-induced oxidative stress and apoptosis in H9c2 cells. Apoptosis 2011;16:94-103.
13. Li DL, Liu JJ, Liu BH, Hu H, Sun L, Miao Y, Xu HF, Yu XJ, Ma X, Ren J, Zang WJ: Acetylcholine inhibits hypoxia-induced tumor necrosis factor-alpha production via regulation of MAPKs phosphorylation in cardiomyocytes. J Cell Physiol 2011;226:1052-1059.
14. Tsutsui H, Kinugawa S, Matsushima S: Oxidative stress and mitochondrial DNA damage in heart failure. Circ J 2008;72:A31-A37.
15. Li J, Zhu H, Shen E, Wan L, Arnold JM, Peng T: Deficiency of rac1 blocks NADPH oxidase activation, inhibits endoplasmic reticulum stress, and reduces myocardial remodeling in a mouse model of type 1 diabetes. Diabetes 2010;59:2033-2042.
16. Thayer JF, Yamamoto SS, Brosschot JF: The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol 2010;141:122-131.
17. Brack KE, Coote JH, Ng GA: Vagus nerve stimulation protects against ventricular fibrillation independent of muscarinic receptor activation. Cardiovasc Res 2011;91:437-446.
18. Sabbah HN: Electrical vagus nerve stimulation for the treatment of chronic heart failure. Cleve Clin J Med 2011;78:S24-S29.
19. Kong SS, Liu JJ, Hwang TC, Yu XJ, Lu Y, Zang WJ: Tumour necrosis factor-alpha and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. Clin Exp Pharmacol Physiol 2011;38:300-306.
20. Kakinuma Y, Ando M, Kuwabara M, Katare RG, Okudela K, Kobayashi M, Sato T: Acetylcholine from vagal stimulation protects cardiomyocytes against ischemia and hypoxia involving additive non-hypoxic induction of HIF-1alpha. Febs Lett 2005;579:2111-2118. (Pubitemid 40469679)
21. Chou HC, Chen YW, Lee TR, Wu FS, Chan HT, Lyu PC, Timms JF, Chan HL: Proteomics study of oxidative stress and Src kinase inhibition in H9c2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment. Free Radic Biol Med 2010;49:96-108.
22. Afanas'Ev I: ROS and RNS signaling in heart disorders: could antioxidant treatment be successful? Oxid Med Cell Longev 2011;2011:293769.
23. Harvey RD: Muscarinic receptor agonists and antagonists: effects on cardiovascular function. Handb Exp Pharmacol 2012;208:299-316.
24. Li DL, Liu BH, Sun L, Zhao M, He X, Yu XJ, Zang WJ: Alterations of muscarinic acetylcholine receptors-2, 4 and alpha7-nicotinic acetylcholine receptor expression after ischaemia/reperfusion in the rat isolated heart. Clin Exp Pharmacol Physiol 2010;37:1114-1119.
25. Harvey RD, Belevych AE: Muscarinic regulation of cardiac ion channels. Br J Pharmacol 2003;139:1074-1084. (Pubitemid 36920669)
26. Liu C, Su D: Nicotinic acetylcholine receptor alpha7 subunit: a novel therapeutic target for cardiovascular diseases. Front Med 2012;6:35-40.