Acetate-free biofiltration reduces intradialytic hypotension: A European multicenter randomized controlled trial

Blood Purification

Volumn 34, Issue 3-4, 2013, Pages 354-363

  Tessitore, Nicola ^a   Santoro, Antonio ^c   Panzetta, Giovanni Oliviero ^d   Wizemann, Volker ^e   Perez Garcia, Rafael ^f   Martinez Ara, Jorge ^g   Perrone, Bruno ^h   Mantovani, William ^b   Poli, Albino ^b  

^a Division of Nephrology   (Italy)

^b UNIVERSITY HOSPITAL OF VERONA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d Nephrology and Dialysis Complex Structure   (Italy)

^e Georg Haas Dialysezentrum   (Germany)

^f HOSPITAL UNIVERSITARIO INFANTA LEONOR   (Spain)

^g HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^h Centre Hospitalier de Saintonge   (France)

Author keywords

Acetate free biofiltration; Bicarbonate hemodialysis; Cardiovascular morbidity; Cardiovascular mortality; Hemodiafiltration; Intradialytic hypotension; Systolic blood pressure

Indexed keywords

ACETIC ACID; BICARBONATE;

ADULT; AGED; ARTICLE; BIOFILTRATION; CARDIOVASCULAR MORTALITY; CHARLSON COMORBIDITY INDEX; CONTROLLED STUDY; DRY WEIGHT; FEMALE; FOLLOW UP; HEMODIAFILTRATION; HEMODIALYSIS PATIENT; HUMAN; HYPOTENSION; INCIDENCE; INTRADIALYTIC HYPOTENSION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SURVIVAL; SYSTOLIC BLOOD PRESSURE;

AGED; BICARBONATES; CARDIOVASCULAR DISEASES; EUROPE; FEMALE; HEMODIAFILTRATION; HEMODIALYSIS SOLUTIONS; HUMANS; HYPOTENSION; MALE; MIDDLE AGED; MORBIDITY; TREATMENT OUTCOME;

EID: 84873573060     PISSN: 02535068     EISSN: 14219735     Source Type: Journal    
DOI: 10.1159/000346293     Document Type: Article

References (50)

1. Foley RN, Parfrey PS, Harnett JD, Kent GM, Murray DC, Barre PE: Impact of hypertension on cardiomyopathy, morbidity and mortality in end-stage renal disease. Kidney Int 1996; 49: 1379-1385. (Pubitemid 26166411)
2. Tozawa M, Iseki K, Iseki C, Takishita S: Pulse pressure and risk of total mortality and cardiovascular events in patients on chronic hemodialysis. Kidney Int 2002; 61: 717-726. (Pubitemid 34102615)
3. Cheung AK, Sarnak MJ, Yan G, Berkoben M, Heika R, Kaufman A, Lewis J, Rocco M, Toto R, Windus D, Ornt D, Levey AS; HEMO Study Group: Cardiac diseases in maintenance hemodialysis patients: results of the HEMO study. Kidney Int 2004; 65: 2380-2389. (Pubitemid 38670024)
4. Charytan D, Kuntz RE, Mauri L, De Filippi C: Distribution of coronary artery disease and relation to mortality in asymptomatic hemodialysis patients. Am J Kidney Dis 2007; 49: 409-416.
5. Harnet JD, Foley RN, Kent GR, Barre PE, Murray D, Parfreys PS: Congestive heart failure in dialysis patients: prevalence, incidence, prognosis and risk factors. Kidney Int 1995; 47: 884-890.
6. London GM, Guerin AP, Marchais SJ, Pannier B, Safar ME, Day M, Metivier F: Cardiac and arterial interactions in end-stage renal disease. Kidney Int 1996; 50: 600-608. (Pubitemid 26274391)
7. Amann K, Ritz E: Microvascular disease-the Cinderella of uraemic heart disease. Nephrol Dial Transplant 2000; 15: 1493-1503.
8. Sigrist MK, McIntyre CW: Vascular calcification is associated with impaired microcirculatory function in chronic haemodialysis patients. Nephron Clin Pract 2008; 108:c121-c126. (Pubitemid 351346935)
9. Lindner A, Charra B, Sherrard DJ, Scribner BH: Accelerated atherosclerosis in prolonged maintenance hemodialysis. N Engl J Med 1974; 290: 697-701.
10. McIntyre CW: Effects of hemodialysis on cardiac function. Kidney Int 2009; 76: 371-375.
11. Davenport A, Cox C, Thuraisingham R: Achieving blood pressure targets during dialysis improve control but increases intradialytic hypotension. Kidney Int 2008; 75: 759-764. (Pubitemid 351323255)
12. McIntyre CW, Burton JO, Selby NM, Leccisotti L, Korsheed S, Baker CS, Camici PG: Hemodialysis- induced cardiac dysfunction is associated with an acute reduction in global and segmental myocardial blood flow. Clin J Am Soc Nephrol 2008; 3: 19-26.
13. Dasselaar JJ, Slart RHJA, Knip M, Pruim J, Tio RA, McIntyre CW, de Jong PE, Franssen CF: Hemodialysis is associated with a pronounced fall in myocardial perfusion. Nephrol Dial Transplant 2009; 24: 604-610.
14. Burton JO, Jefferies HJ, Selby NM, McIntyre CW: Hemodialysis-induced cardiac injury: determinants and associated outcomes. Clin J Am Soc Nephrol 2009; 4: 914-920.
15. Koch M, Thomas B, Tschope W, Ritz E: Survival and predictors of death in dialyzed diabetic patients. Diabetologia 1993; 36: 1113-1117. (Pubitemid 23288785)
16. Tisler A, Akocsi K, Borbas B, Fazakas L, Ferenczi S, Gorogh S, Culcsar I, Nagy L, Samik J, Szegedi J, Toth E, Wagner G, Kiss I: The effect of frequent or occasional dialysis-associated hypotension on survival of patients on maintenance haemodialysis. Nephrol Dial Transplant 2003; 18: 2601-2605. (Pubitemid 37483795)
17. Shoji T, Tsubakihara Y, Fujii M, Imai E: Hemodialysis- associated hypotension as an independent risk factor for two-year mortality in hemodialysis patients. Kidney Int 2004; 66: 1212-1220. (Pubitemid 39121031)
18. Bleyer AJ, Hartman J, Brannon PC, Reeves- Daniel A, Satko SG, Russell G: Characteristics of sudden death in hemodialysis patients. Kidney Int 2006; 69: 2268-2273. (Pubitemid 43882115)
19. Barnes E, Dutka DP, Khan M, Camici PG, Hall RJ: Effects of repeated episodes of reversible myocardial ischemia on myocardial blood flow and function in humans. Am J Physiol Heart Circ Physiol 2002; 282:H1603-H1608. (Pubitemid 34654825)
20. Wizemann V, Wabel P, Chamney P, Zaluska W, Moissl U, Rode C, Malecka-Masalska T, Marcelli D: The mortality risk of overhydration in haemodialysis patients. Nephrol Dial Transplant 2009; 24: 1574-1579.
21. McIntyre CW: Hemodialysis-induced myocardial stunning in chronic kidney disease - A new aspect of cardiovascular disease. Blood Purif 2010; 29: 105-110.
22. McIntyre CW: Recurrent circulatory stress: the dark side of dialysis. Semin Dial 2010; 5: 449-451.
23. Toyoda K, Fujii K, Fujimi S, Kumay J, Tsuchimochi H, Ibayashi S, Iida M: Stroke in patients on maintenance hemodialysis: a 22- year single-center study. Am J Kidney Dis 2005; 45: 1058-1066. (Pubitemid 40806519)
24. Santoro A, Mancini E, Basile C, Amoroso L, Di Giulio S, Usberti M, Colasanti G, Verzetti G, Rocco A, Mimbasciati E, Panzetta G, Bolzani R, Grandi F, Polacchini M: Blood volume controlled hemodialysis in hypotension-prone patients: a randomized, multicenter controlled trial. Kidney Int 2002; 62: 1034-1045. (Pubitemid 35316735)
25. Locatelli F, Altieri P, Andrulli S, Bolasco P, Sau G, Pedrini LA, Basile C, David S, Feriani M, Montagna G, Di Iorio BM, Memoli B, Cravero R, Battaglia G, Zoccali C: Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD. J Am Soc Nephrol 2010; 21: 1798-1807.
26. Selby NM, Lambie SH, Camici PG, Baker CS, McIntyre CW: Occurrence of regional left ventricular dysfunction in patients undergoing standard and biofeedback dialysis. Am J Kidney Dis 2006; 46: 830-841.
27. Selby NM, Burton JO, Chesterton LJ, Mc- Intyre CW: Dialysis-induced regional left ventricular dysfunction is ameliorated by cooling the dialysate. Clin J Am Soc Nephrol 2006; 1: 1216-1225.
28. Zucchelli P, Santoro A, Raggiotto G: Biofiltration in uremia: preliminary observations. Blood Purif 1984; 2: 187-195. (Pubitemid 15236064)
29. Santoro A, Guarnieri F, Ferramosca E, Grandi F: Acetate-free biofiltration; in Ronco C, Canaud P, Aljiama P (eds): Contributions to Nephrology. Basel, Karger, 2007, vol 158, pp 138-152.
30. Rabindranath KS, Strippoli GE, Roderick P, Wallace SA, MacLeod AM, Daly C: Comparison of hemodialysis, hemofiltration, and acetate- free biofiltration for ESDR: systematic review. Am J Kidney Dis 2005; 45: 437-447. (Pubitemid 40341323)
31. Santoro A, Panzetta G, Tessitore N, Atti M, Mancini E, Esteban J, London G, Martinez Ara J, Miguel JL, Neumann KH, Opatrny K, Perez R, Perrone B, Wizemann V, Zucchelli P: A prospective randomized European multicentre study of medium-long run mortality and morbidity comparing acetate-free biofiltration and bicarbonate dialysis. J Nephrol 1999; 12: 375-382. (Pubitemid 30014650)
32. Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383. (Pubitemid 17055592)
33. Daugirdas JT: Second-generation logarithmic estimates of single-pool variable volume Kt/V: an analysis of error. J Am Soc Nephrol 1993; 4: 1205-1213.
34. Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campo E, Sachs I, Reichek N: Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450-458. (Pubitemid 16119719)
35. Ergin A, Muntner P, Sherwin R, He J: Secular trends in cardiovascular disease mortality, incidence, and case fatality rates in adults in the United States. Am J Med 2004; 117: 219-227. (Pubitemid 39092714)
36. Sedwick P: Incidence rate ratio. BMJ 2010; 341:c4804.
37. Aiken LS, West SG: Multiple Regression: Testing and Interpreting Interactions. Thousand Oaks, Sage Publication Inc, 1991, pp 116-137.
38. Schrander-van der Meer AM, ter Wee PM, Kan G, Donker AJ, van Dorp WT: Improved cardiovascular variables during acetate-free biofiltration. Clin Nephrol 1999; 51: 304-309. (Pubitemid 29219298)
39. Cavalcanti S, Cianfrini A, Severi F, Badiali F, Bini S, Gattiani A, Cagnoli L, Santoro A: Model- based study on the effect of hemodialysis technique on the compensatory response to hypovolemia. Kidney Int 2004; 65: 1499-1510. (Pubitemid 38406993)
40. Selby NM, McIntyre CW: A systematic review of the clinical effects of reducing dialysate fluid temperature. Nephrol Dial Transplant 2006; 21: 1883-1189.
41. FHN Trial Group: In-center hemodialysis six times per week versus three times per week. N Engl J Med 2010; 363: 2287-2300.
42. Stidley CA, Hunt WC, Tentori F, Rohrscheib MR, Bedrick EJ, Meyer KB, Johnson HK, Zager PG: Changing relationship of blood pressure with mortality over time among hemodialysis patients. J Am Soc Nephrol 2006; 17: 513-520.
43. Agarwal R, Weir MR: Dry-weight: a concept revisited in an effort to avoid medication-directed approaches for blood pressure control in hemodialysis patients. Clin J Am Soc Nephrol 2010; 5: 1255-1260.
44. Landry DW, Oliver JA: Blood pressure instability during hemodialysis. Kidney Int 2006; 69: 1710-1711. (Pubitemid 43739193)
45. Chazot C, Vo-Van C, Deleaval P, Lorriaux C, Hurot JM, Mayor B, Jean G: Predialysis systolic blood pressure evolution in incident hemodialysis patients: effect of the dry weight method and prognostic value. Blood Purif 2012; 33: 275-283.
46. Chazot C, Charra B, Vo Van C, Jean G, Vanel T, Calemard E, Terrat JC, Ruffet M, Laurent G: The Janus-faced aspect of 'dry weight'. Nephrol Dial Transplant 1999; 14: 121-124.
47. Agarwal R, Andersen MJ, Bishu K, Saha C: Home blood pressure monitoring improves the diagnosis of hypertension in hemodialysis patients. Kidney Int 2006; 69: 900-906.
48. Zoccali C, Benedetto FA, Mallamaci F, Tripepi G, Giacone G, Stancanelli B, Cataliotti A, Malatino LS: Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression. Kidney Int 2004; 65: 1492-1498. (Pubitemid 38406992)
49. Herzog CA, Ma JZ, Collins AJ: Poor longterm survival after acute myocardial infarction among patients on long-term dialysis. N Engl J Med 1998; 339: 799-805. (Pubitemid 28447453)
50. Iseki K, Fukiyama K; Okawa Dialysis Study (OKIDS) Group: Clinical demographics and long-term prognosis after stroke in patients on chronic hemodialysis Nephrol Dial Transplant 2000; 15: 1808-1813.