Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia

Blood

Volumn 121, Issue 5, 2013, Pages 752-758

  Scaradavou, Andromachi ^a   Brunstein, Claudio G ^b   Eapen, Mary ^c   Le Rademacher, Jennifer ^c   Barker, Juliet N ^d   Chao, Nelson ^e   Cutler, Corey ^f   Delaney, Colleen ^g   Kan, Fangyu ^c   Isola, Luis ^h   Karanes, Chatchada ⁱ   Laughlin, Mary J ^j   Wagner, John E ^b   Shpall, Elizabeth J ^k  

^a NEW YORK BLOOD CENTER   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f DANA FARBER CANCER INSTITUTE   (United States)

^g Fred Hutchinson Cancer Research Center   (United States)

^h MOUNT SINAI MEDICAL CENTER   (United States)

ⁱ University of Virginia Health Systems ^*

^j UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^k UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

more..

Author keywords

Efficacy of transplanting adequately dosed 1 or 2 cord blood units

Indexed keywords

BUSULFAN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; FLUDARABINE; MELPHALAN; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; STEROID; TACROLIMUS; THYMOCYTE ANTIBODY;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER PATIENT; CORD BLOOD STEM CELL TRANSPLANTATION; GRAFT VERSUS HOST REACTION; HLA MATCHING; HUMAN; MAJOR CLINICAL STUDY; MORTALITY; NEUTROPHIL; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; RELAPSE; RISK ASSESSMENT; SAFETY; UMBILICAL CORD BLOOD;

EID: 84873542634     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-08-449108     Document Type: Article

References (30)

1. Rocha V, Gluckman E. Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft and transplantation-related factors. Br J Haematol. 2009;147(2):262-274.
2. Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE. Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning. Blood. 2003;102(5):1915-1919. (Pubitemid 37022593)
3. Barker JN, Weisdorf DJ, DeFor TE, et al. Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. Blood. 2005; 105(3):1343-1347. (Pubitemid 40170912)
4. Brunstein CB, Barker JN, Weisdorf DJ, et al. Umbilical cord blood transplantation after nonmyeloablative conditioning: Impact on transplantation outcomes in 110 adults with hematologic disease. Blood. 2007;110(8):3064-3070. (Pubitemid 350006962)
5. Cutler C, Stevenson K, Kim HT, et al. Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis. Bone Marrow Transplant. 2011; 46(5):659-667.
6. Avery S, Shi W, Lubin M, et al. Influence of infused cell dose and HLA-match on engraftment after double unit cord blood allografts. Blood. 2011;117(12):3277-3285.
7. Ponce DM, Zheng J, Gonzales AM, et al. Reduced late mortality risk contributes to similar survival after double-unit cord blood transplant compared with related and unrelated donor hematopoietic stem cell transplant. Biol Blood Marrow Transplant. 2011;17(9):1316-1326.
8. Brunstein CG, Gutman JA, Weisdorf DJ, et al. Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood. Blood. 2010; 116(22):4693-4696.
9. MacMillan ML, Weisdorf DJ, Brunstein CG, et al. Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors. Blood. 2009;113(11):2410-2415.
10. Verneris MR, Brunstein CG, Barker JN, et al. Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of two units. Blood. 2009;114(19):4293-4299.
11. Delaney C, Gutman JA, Appelbaum FR. Cord blood transplantation for haematoloigc malignancies: conditioning regimens, double cord blood transplants and infectious complications. Br J Haematol. 2009;147(2):207-216.
12. Barker JN, Byam C, Scaradavou A. How I treat: the selection and acquisition of unrelated cord blood grafts. Blood. 2011;117(8):2332-2339.
13. Gluckman E, Rocha V, Arcese W, et al. Factors associated with outcomes of unrelated cord blood transplant: guidelines for donor choice. Exp Hematol. 2004;32(4):397-407. (Pubitemid 38410917)
14. Przepiorka D, Weisdorf D, Martin P, et al. 1994 Consensus conference on acute GVHD grading. Bone Marrow Transplant. 1995;15(6):825-828.
15. Flowers ME, Kansu E, Sullivan KM. Pathophysiology and treatment of graft-versus-host disease. Hematol Oncol Clin North Am. 1999;13(5):1091-1112. (Pubitemid 29489294)
16. Klein JP, Moeschberger ML. Survival Analysis: Statistical Methods for Censored and Truncated Data. 2nd Ed. New York, NY: Springer-Verlag; 2003.
17. Cox DR. Regression model and life tables. J R Stat Soc B. 1972;34(2):187-200.
18. Klein JP, Andersen PK. Regression modeling of competing risks data based on pseudovalues of the cumulative incidence function. Biometrics. 2005;61(1):223-229. (Pubitemid 40380983)
19. Commenges D, Andersen PK. Score test of homogeneity for survival data. Life Time Data Analysis. 1995;1(2):145-160.
20. Lee EW, Wei LJ, Amato DA. Cox-type regression analysis for large numbers of small groups of correlated failure time observations. In: Survival Analysis: State of the Art. Klein JP, Goel PK, eds. Kluwer Academic Publishers: 1992;237-247.
21. Rubinstein P, Carrier C, Scaradavou A, et al. Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med. 1998;339(22):1565-1577. (Pubitemid 28536131)
22. Eapen M, Rubinstein P, Zhang M-J, et al. Outcomes of transplantation of unrelated umbilical cord blood and bone marrow in children with acute leukemia: a comparison study. Lancet. 2007;369(9577):1947-1954. (Pubitemid 46874578)
23. Brunstein CG, Fuchs EJ, Carter SL, et al. Alternative donor transplantation: results of parallel phase II trials using HLA-mismatched related bone marrow or unrelated umbilical cord blood grafts. Blood. 2011;118(2):282-286.
24. Rocha V, Labopin M, Mohty M, et al. Outcomes after double unit unrelated cord blood transplantation (UCBT) compared with single UCBT in adults with acute leukemia in remission. A Euorcord and ALWP Collaboration study [abstract]. Blood (ASH Annual Meeting Abstracts). 2010; 116(21):Abstract 910.
25. Gutman JA, Turtle CJ, Manley TJ, et al. Single unit dominance after double-unit umbilical cord blood transplant coincides with a specific CD8+ T-cell response against the non-engrafted unit. Blood. 2010;115(4):757-765.
26. Yahata T, Ando K, Miyatake H, et al. Competitive repopulation assay of two gene marked cord blood units in NOD/SCID/gammac (null) mice. Mol Ther. 2004;10(5):882-891. (Pubitemid 39419915)
27. Eldjerou LK, Chaudhury S, Baisre-de Leon A, et al. An in vivo model of double cord blood transplantation that correlates with clinical engraftment. Blood. 2010;116(19):3999-4006.
28. Delaney C, Hiemfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notchmediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010;16(2):232-236.
29. de Lima M, McNiece I, Robinson SN, et al. Cord blood engraftment with ex vivo mesenchymal-cell coculture. N Engl J Med. 2012;367(24):2305-2315.
30. Eapen M, Rocha V, Sanz G, et al. Effect of graft source on unrelated donor haematopoietic stem cell transplantation in adults with acute leukemia: a retrospective analysis. Lancet Oncol. 2010; 11(7):653-660.