Obstructive sleep apnoea syndrome is associated with relative hypocortisolemia and decreased hypothalamo-pituitary-adrenal axis response to 1 and 250μg ACTH and glucagon stimulation tests

Sleep Medicine

Volumn 14, Issue 2, 2013, Pages 160-164

  Karaca, Zuleyha ^a   Ismailogullari, Sevda ^a   Korkmaz, Selda ^a   Cakir, Ilkay ^a   Aksu, Murat ^a   Baydemir, Recep ^a   Tanriverdi, Fatih ^a   Bayram, Fahri ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

ACTH stimulation test; Cortisol; Dexamethasone suppression test; Glucagon stimulation test; HPA axis; OSAS

Indexed keywords

DEXAMETHASONE; GLUCAGEN HYPOKIT; GLUCAGON; TETRACOSACTIDE; UNCLASSIFIED DRUG;

ADULT; APNEA HYPOPNEA INDEX; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; COMPUTER PROGRAM; CONTROLLED STUDY; CORRELATION ANALYSIS; CORTICOTROPIN TEST; DEXAMETHASONE SUPPRESSION TEST; DISEASE ASSOCIATION; ENDOCRINE FUNCTION TEST; EVENING DOSAGE; FEMALE; GLUCAGON STIMULATION TEST; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SLEEP DISORDERED BREATHING;

ADRENOCORTICOTROPIC HORMONE; ADULT; BODY MASS INDEX; CIRCADIAN RHYTHM; CUSHING SYNDROME; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCAGON; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MIDDLE AGED; OBESITY; PITUITARY-ADRENAL SYSTEM; POLYSOMNOGRAPHY; REFERENCE VALUES; SLEEP APNEA, OBSTRUCTIVE;

EID: 84873524852     PISSN: 13899457     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2012.10.013     Document Type: Article

References (25)

1. Flemons W.W., Remmers J.E. The diagnosis of sleep apnea: questionnaires and home studies. Sleep 1996, 9:S243-S247.
2. Bixler E.O., Vgontzas A.N., Ten Have T., Tyson K., Kales A. Effects of age on sleep apnea in men: I. Prevalence and severity. Am J Respir Crit Care Med 1998, 157:144-148.
3. Henley D.E., Russell G.M., Douthwaite J.A., et al. Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy. J Clin Endocrinol Metab 2009, 94:4234-4242.
4. Nakamura T., Chin K., Shimizu K., et al. Acute effect of nasal continuous positive airway pressure therapy on the systemic immunity of patients with obstructive sleep apnea syndrome. Sleep 2001, 24:545-553.
5. Schmoller A., Eberhardt F., Jauch-Chara K., et al. Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea. Metabolism 2009, 58:848-853.
6. Tomfohr L.M., Edwards K.M., Dimsdale J.E. Is obstructive sleep apnea associated with cortisol levels? a systematic review of the research evidence. Sleep Med Rev 2012, 16:243-249.
7. Vgontzas A.N., Pejovic S., Zoumakis E., et al. Hypothalamic-pituitary-adrenal axis activity in obese men with and without sleep apnea: effects of continuous positive airway pressure therapy. J Clin Endocrinol Metab 2007, 92:4199-4207.
8. Barcelo A., Barbe F., De la P.M., et al. Insulin resistance and daytime sleepiness in patients with sleep apnoea. Thorax 2008, 63:946-950.
9. Carneiro G., Togeiro S.M., Hayashi L.F., et al. Effect of continuous positive airway pressure therapy on hypothalamic-pituitary-adrenal axis function and 24-h blood pressure profile in obese men with obstructive sleep apnea syndrome. Am J Physiol Endocrinol Metab 2008, 295:E380-E384.
10. Lam J.C., Yan C.S., Lai A.Y., et al. Determinants of daytime blood pressure in relation to obstructive sleep apnea in men. Lung 2009, 187:291-298.
11. Lanfranco F., Gianotti L., Pivetti S., et al. Obese patients with obstructive sleep apnoea syndrome show a peculiar alteration of the corticotroph but not of the thyrotroph and lactotroph function. Clin Endocrinol 2004, 60:41-48.
12. Panaree B., Chantana M., Wasana S., Chairat N. Effects of obstructive sleep apnea on serum brain-derived neurotrophic factor protein, cortisol, and lipid levels. Sleep Breath 2011, 15:649-656.
13. Dadoun F., Darmon P., Achard V., et al. Effect of sleep apnea syndrome on the circadian profile of cortisol in obese men. Am J Physiol Endocrinol Metab 2007, 293:E466-E474.
14. Sateia MJ, editor. International classification of sleep disorders: diagnostic and coding manual. Westchester (IL): American Academy of Sleep Medicine; 2005.
15. Iber C., Ancoli-Israel S., Chesson A., Quan S.F. American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications 2007, American Academy of Sleep Medicine, Westchester (IL). 1st ed.
16. Karaca Z., Lale A., Tanriverdi F., Kula M., Unluhizarci K., Kelestimur F. The comparison of low and standard dose ACTH and glucagon stimulation tests in the evaluation of hypothalamo-pituitary-adrenal axis in healthy adults. Pituitary 2011, 14:134-140.
17. Basu M., Sawhney R.C., Kumar S., Pal K., Prasad R., Selvamurthy W. Hypothalamic-pituitary-adrenal axis following glucocorticoid prophylaxis against acute mountain sickness. Horm Metab Res 2002, 34:318-324.
18. Follenius M., Brandenberger G., Bandesapt J.J., Libert J.P., Ehrhart J. Nocturnal cortisol release in relation to sleep structure. Sleep 1992, 15:21-27.
19. Raff H., Tzankoff S.P., Fitzgerald R.S. ACTH and cortisol responses to hypoxia in dogs. J Appl Physiol 1981, 51:1257-1260.
20. Ekstedt M., Akerstedt T., Soderstrom M. Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure. Psychosom Med 2004, 66:925-931.
21. Spath-Schwalbe E., Gofferje M., Kern W., Born J., Fehm H.L. Sleep disruption alters nocturnal ACTH and cortisol secretory patterns. Biol Psychiatr 1991, 29:575-584.
22. Otte C., Hart S., Neylan T.C., Marmar C.R., Yaffe K., Mohr D.C. A meta-analysis of cortisol response to challenge in human aging: importance of gender. Psychoneuroendocrinology 2005, 30:80-91.
23. Van Cauter E., Leproult R., Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA 2000, 284:861-868.
24. Lattova Z., Keckeis M., Maurovich-Horvat E., et al. The stress hormone system in various sleep disorders. J Psychiatr Res 2011, 45:1223-1228.
25. Buckley T.M., Schatzberg A.F. On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders. J Clin Endocrinol Metab 2005, 90:3106-3114.