Electrophysiological white matter dysfunction and association with neurobehavioral deficits following low-level primary blast trauma

Neurobiology of Disease

Volumn 52, Issue , 2013, Pages 150-159

  Park, Eugene ^a   Eisen, Rebecca ^a   Kinio, Anna ^a   Baker, Andrew J ^a,b  

^a ST MICHAEL'S HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

AlphaII spectrin; Blast injury; Electrophysiology; Mild traumatic brain injury; Primary blast; White matter injury

Indexed keywords

ANKYRIN; ANKYRIN G; CYTOSKELETON PROTEIN; NEUROFILAMENT PROTEIN; SPECTRIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BLAST INJURY; BRAIN DEPTH RECORDING; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; COGNITIVE DEFECT; CONTROLLED STUDY; CORPUS CALLOSUM; DISEASE ASSOCIATION; EVOKED RESPONSE; EXPLORATORY BEHAVIOR; IMMUNOPRECIPITATION; LATENT PERIOD; LUNG INJURY; MALE; NERVE CELL STIMULATION; NERVE POTENTIAL; NONHUMAN; OPEN FIELD BEHAVIOR; OPEN FIELD TEST; OUTCOME ASSESSMENT; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; ROTAROD TEST; SENSITIVITY ANALYSIS; WESTERN BLOTTING; WHITE MATTER INJURY;

ACTION POTENTIALS; ANIMALS; BLAST INJURIES; BRAIN INJURIES; CORPUS CALLOSUM; ELECTROPHYSIOLOGY; EXPLORATORY BEHAVIOR; MALE; MOTOR SKILLS; NERVE FIBERS, MYELINATED; RATS; RATS, SPRAGUE-DAWLEY; ROTAROD PERFORMANCE TEST;

EID: 84873523576     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.12.002     Document Type: Article

References (48)

1. Alford P.W., et al. Blast-induced phenotypic switching in cerebral vasospasm. Proc. Natl. Acad. Sci. U. S. A. 2011, 108:12705-12710.
2. Angelides K.J., et al. Distribution and lateral mobility of voltage-dependent sodium channels in neurons. J. Cell Biol. 1988, 106:1911-1925.
3. Baker A.J., et al. Attenuation of the electrophysiological function of the corpus callosum after fluid percussion injury in the rat. J. Neurotrauma 2002, 19:587-599.
4. Belanger H.G., et al. Symptom complaints following reports of blast versus non-blast mild TBI: does mechanism of injury matter?. Clin. Neuropsychol. 2011, 25:702-715.
5. Bogdanova Y., Verfaellie M. Cognitive sequelae of blast-induced traumatic brain injury: recovery and rehabilitation. Neuropsychol. Rev. 2012, 22:4-20.
6. Brachet A., et al. Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier. J. Cell Biol. 2010, 191:383-395.
7. Cernak I., et al. Cognitive deficits following blast injury-induced neurotrauma: possible involvement of nitric oxide. Brain Inj. 2001, 15:593-612.
8. Chen X.H., et al. Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig. J. Neuropathol. Exp. Neurol. 1999, 58:588-596.
9. Crawford D.K., et al. Functional recovery of callosal axons following demyelination: a critical window. Neuroscience 2009, 164:1407-1421.
10. Cullen D.K., et al. Blast-induced color change in photonic crystals corresponds with brain pathology. J. Neurotrauma 2011, 28:2307-2318.
11. Fann J.R., et al. Psychiatric illness following traumatic brain injury in an adult health maintenance organization population. Arch. Gen. Psychiatry 2004, 61:53-61.
12. Gentsch C., et al. Locomotor activity, defecation score and corticosterone levels during an open field exposure: a comparison among individually and group-housed rats, and genetically selected rat lines. Physiol. Behav. 1981, 27:183-186.
13. Hamberger A., et al. Redistribution of neurofilaments and accumulation of beta-amyloid protein after brain injury by rotational acceleration of the head. J. Neurotrauma 2003, 20:169-178.
14. Hoge C.W., et al. Mild traumatic brain injury in U.S. soldiers returning from Iraq. N. Engl. J. Med. 2008, 358:453-463.
15. Hu H., et al. Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression. Neuroscience 2010, 169:171-181.
16. Ibrahim M., et al. Relationship between myelin sheath diameter and internodal length in axons of the anterior medullary velum of the adult rat. J. Neurol. Sci. 1995, 133:119-127.
17. Kamnaksh A., et al. Factors affecting blast traumatic brain injury. J. Neurotrauma 2011, 28:2145-2153.
18. Kennedy J.E., et al. Symptoms in military service members after blast mTBI with and without associated injuries. NeuroRehabilitation 2010, 26:191-197.
19. Kennedy J.E., et al. Posttraumatic stress symptoms in OIF/OEF service members with blast-related and non-blast-related mild TBI. NeuroRehabilitation 2010, 26:223-231.
20. Koliatsos V.E., et al. A mouse model of blast injury to brain: initial pathological, neuropathological, and behavioral characterization. J. Neuropathol. Exp. Neurol. 2011, 70:399-416.
21. Komada M., Soriano P. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J. Cell Biol. 2002, 156:337-348.
22. Kordeli E., et al. AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J. Biol. Chem. 1995, 270:2352-2359.
23. Ling G., et al. Explosive blast neurotrauma. J. Neurotrauma 2009, 26:815-825.
24. Long J.B., et al. Blast Overpressure in Rats: Recreating a Battlefield Injury in the Laboratory. J. Neurotrauma 2009, 26(6):827-840. (Jun).
25. Mac Donald C.L., et al. Detection of blast-related traumatic brain injury in U.S. military personnel. N. Engl. J. Med. 2011, 364:2091-2100.
26. Matthews S.C., et al. A multimodal imaging study in U.S. veterans of Operations Iraqi and Enduring Freedom with and without major depression after blast-related concussion. Neuroimage 2011, 54(Suppl. 1):S69-S75.
27. Moore D.F., et al. Computational biology - modeling of primary blast effects on the central nervous system. Neuroimage 2009, 47(Suppl. 2):T10-T20.
28. Park E., et al. Heavy neurofilament accumulation and alpha-spectrin degradation accompany cerebellar white matter functional deficits following forebrain fluid percussion injury. Exp. Neurol. 2007, 204:49-57.
29. Park E., et al. A model of low-level primary blast brain trauma results in cytoskeletal proteolysis and chronic functional impairment in the absence of lung barotrauma. J. Neurotrauma 2011, 28:343-357.
30. Perrot R., et al. Review of the multiple aspects of neurofilament functions, and their possible contribution to neurodegeneration. Mol. Neurobiol. 2008, 38:27-65.
31. Peterson G.L. A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 1977, 83:346-356.
32. Posmantur R., et al. Neurofilament 68 and neurofilament 200 protein levels decrease after traumatic brain injury. J. Neurotrauma 1994, 11:533-545.
33. Posmantur R.M., et al. Light and confocal microscopic studies of evolutionary changes in neurofilament proteins following cortical impact injury in the rat. Exp. Neurol. 2000, 161:15-26.
34. Pun P.B., et al. Low level primary blast injury in rodent brain. Front. Neurol. 2011, 2:19.
35. Reeves T.M., et al. Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injury. Exp. Neurol. 2005, 196:126-137.
36. Reeves T.M., et al. Proteolysis of submembrane cytoskeletal proteins ankyrin-G and alphaII-spectrin following diffuse brain injury: a role in white matter vulnerability at Nodes of Ranvier. Brain Pathol. 2010, 20:1055-1068.
37. Rubovitch V., et al. A mouse model of blast-induced mild traumatic brain injury. Exp. Neurol. 2011, 232:280-289.
38. Rubtsov A.M., Lopina O.D. Ankyrins. FEBS Lett. 2000, 482:1-5.
39. Ruff R.L., et al. A case-control study examining whether neurological deficits and PTSD in combat veterans are related to episodes of mild TBI. BMJ Open 2012, 2:e000312.
40. Saljo A., et al. Blast exposure causes redistribution of phosphorylated neurofilament subunits in neurons of the adult rat brain. J. Neurotrauma 2000, 17:719-726.
41. Saljo A., et al. Low-level blasts raise intracranial pressure and impair cognitive function in rats. J. Neurotrauma 2009, 26:1345-1352.
42. Scheibel R.S., et al. Altered brain activation in military personnel with one or more traumatic brain injuries following blast. J. Int. Neuropsychol. Soc. 2012, 18:89-100.
43. Shea T.B., Chan W.K. Regulation of neurofilament dynamics by phosphorylation. Eur. J. Neurosci. 2008, 27:1893-1901.
44. Sponheim S.R., et al. Evidence of disrupted functional connectivity in the brain after combat-related blast injury. Neuroimage 2011, 54(Suppl. 1):S21-S29.
45. Srinivasan Y., et al. Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature 1988, 333:177-180.
46. Taber K.H., et al. Blast-related traumatic brain injury: what is known?. J. Neuropsychiatry Clin. Neurosci. 2006, 18:141-145.
47. Wang Y., et al. Tightly coupled repetitive blast-induced traumatic brain injury: development and characterization in mice. J. Neurotrauma 2011, 28:2171-2183.
48. Warden D. Military TBI during the Iraq and Afghanistan wars. J. Head Trauma Rehabil. 2006, 21:398-402.