Haploidentical transplantation in patients with acquired aplastic anemia

Bone Marrow Transplantation

Volumn 48, Issue 2, 2013, Pages 183-185

  Ciceri, F ^a   Lupo Stanghellini, M T ^a   Korthof, E T ^b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

aplastic anemia; ATG; haploidentical

Indexed keywords

ALEMTUZUMAB; BUSULFAN; CD19 ANTIGEN; CD3 ANTIGEN; CYCLOPHOSPHAMIDE; FLUDARABINE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; THYMOCYTE ANTIBODY;

ACQUIRED APLASTIC ANEMIA; ALLOGRAFT; APLASTIC ANEMIA; CD34 SELECTION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; GRAFT VERSUS HOST REACTION; HAPLOIDENTICAL STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNE RESPONSE; OVERALL SURVIVAL; PRIORITY JOURNAL; REVIEW; T CELL DEPLETION; WHOLE BODY RADIATION;

ANEMIA, APLASTIC; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS;

EID: 84873472226     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2012.231     Document Type: Review

References (25)

1. Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F et al. Treatment of high risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med 1998; 339: 1186-1193
2. Ciceri F, Labopin M, Aversa F, Rowe JM, Bunjes D, Lewalle P et al. Acute Leukemia Working Party (ALWP) of European Blood and Marrow Transplant (EBMT) Group A survey of fully haploidentical hematopoietic stem cell transplantation in adults with high-risk acute leukemia: A risk factor analysis of outcomes for patients in remission at transplantation. Blood 2008; 112: 3574-3581
3. Reisner Y, Hagin D, Martelli MF. Haploidentical hematopoietic transplantation: Current status and future perspectives. Blood 2011; 118: 6006-6017
4. Perruccio K, Tosti A, Burchielli E, Topini F, Ruggeri L, Carotti A et al. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood 2005; 106: 4397-4406
5. Di Ianni M, Falzetti F, Carotti A, Terenzi A, Castellino F, Bonifacio E et al. Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood 2011; 117: 3921-3928
6. Ciceri F, Bonini C, Stanghellini MT, Bondanza A, Traversari C, Salomoni M et al. Infusion of suicide-gene-engineered donor lymphocytes after family haploidentical haemopoietic stem-cell transplantation for leukaemia (the TK007 trial): A non-randomised phase I-II study. Lancet Oncol 2009; 10: 489-500
7. Bethge WA, Haegele M, Faul C, Lang P, Schumm M, Bornhauser M et al. Haploidentical allogeneic hematopoietic cell transplantation in adults with reduced-intensity conditioning and CD3/CD19 depletion: Fast engraftment and low toxicity. Exp Hematol 2006; 34: 1746-1752
8. Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. Haploidentical hematopoietic stem cell transplantation without in vitro T-cell depletion for the treatment of hematological malignancies. Bone Marrow Transplant 2006; 38: 291-297
9. Liu D, Huang X, Liu K, Xu L, Chen H, Han W et al. Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematological malignancies in children. Biol Blood Marrow Transplant 2008; 14: 469-477
10. Huang XJ, Liu DH, Liu KY, Xu LP, Chen H, Han W et al. Treatment of acute leukemia with unmanipulated HLA-mismatched/haploidentical blood and bone marrow transplantation. Biol Blood Marrow Transplant 2009; 15: 257-265
11. Luznik L, O'Donnell P, Symons H, Chen AR, Leffell MS, Zahurak M et al. HLA haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 2008; 14: 641-650
12. Tuve S, Gayoso J, Scheid C, Radke J, Kiani A, Serrano D et al. Haploidentical bone marrow transplantation with post-grafting cyclophosphamide: Multicenter experience with an alternative salvage strategy. Leukemia 2011; 25: 880-883
13. Peccatori J, Clerici D, Forcina A, Bernardi M, Crocchiolo R, Messina C et al. In-vivo T-regs generation by rapamycin-mycophenolate-ATG as a new platform for GVHD prophylaxis in T-cell repleted unmanipulated haploidentical peripheral stem cell transplantation: Results in 59 patients. Bone Marrow Transplant 2010; 45(Suppl 2): O88
14. Brunstein CG, Miller JS, Cao Q, McKenna DH, Hippen KL, Curtsinger J et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics. Blood 2011; 117: 1061-1070
15. Storb R, Thomas ED, Buckner CD, Clift RA, Deeg HJ, Fefer A et al. Marrow transplantation in thirty "untransfused" patients with severe aplastic anemia. Ann Intern Med 1980; 92: 30-36
16. Bacigalupo A, Hows J, Gordon-Simith EC, Gluckman E, Van Lint MT, Congiu M et al. Bone marrow transplantation for severe aplastic anemia from donors other than HLA identical siblings. A report of the EBMT Working Party. Bone Marrow Transplant 1988; 3: 531-535
17. Wagner JL, Deeg HJ, Seidel K, Anasetti C, Doney K, Sanders J et al. Bone marrow transplantation for severe aplastic anemia from genotypically HLA-nonidentical relatives. An update of the Seattle experience. Transplantation 1996; 61: 54-61
18. Passweg JR, Perez WS, Eapen M, Camitta BM, Gluckman E, Hinterberger W et al. Bone marrow transplants from mismatched related and unrelated donors for severe aplastic anemia. Bone Marrow Transplant 2006; 37: 641-649
19. Vassiliou GS, Webb DK, Pamphilon D, Knapper S, Veys PA. Improved outcome of alternative donor bone marrow transplantation in children with severe aplastic anaemia using a conditioning regimen containing low-dose total body irradiation, cyclophosphamide and Campath. Br J Haematol 2001; 114: 701-705
20. Tzeng CH, Chen PM, Fan S, Liu JH, Chiou TJ, Hsieh RK. CY/TBI-800 as a pretransplant regimen for allogeneic bone marrow transplantation for severe aplastic anemia using HLA-haploidentical family donors. Bone Marrow Transplant 1996; 18: 273-277
21. Xu LP, Liu KY, Liu DH, Han W, Chen H, Chen YH et al. A novel protocol for haploidentical hematopoietic SCT without in vitro T-cell depletion in the treatment of severe acquired aplastic anemia. Bone Marrow Transplant 2012; 47: 1507-1512
22. Woodard P, Cunningham JM, Benaim E, Chen X, Hale G, Horwitz E et al. Effective donor lymphohematopoietic reconstitution after haploidentical CD34-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia. Bone Marrow Transplant 2004; 33: 411-418
23. Lacerda JF, Martins C, Carmo JA, Lourenco F, Juncal C, Ismail S et al. Haploidentical stem cell transplantation with purified CD34 cells after a chemotherapy-alone conditioning regimen in heavily transfused severe aplastic anemia. Biol Blood Marrow Transplant 2005; 11: 399-400
24. Koh KN, Im HJ, Kim BE, Choi ES, Jang S, Kwon SW et al. Haploidentical haematopoietic stem cell transplantation using CD3 or CD3/CD19 depletion and conditioning with fludarabine, cyclophosphamide and antithymocyte globulin for acquired severe aplastic anaemia. Br J Haematol 2012; 157: 139-142
25. Fang B, Li N, Song Y, Li J, Zhao RC, Ma Y. Cotransplantation of haploidentical mesenchymal stem cells to enhance engraftment of hematopoietic stem cells and to reduce the risk of graft failure in two children with severe aplastic anemia. Pediatr Transplant 2009; 13: 499-502