Effect of different blood glucose target levels on the incidence of hypoglycemia during insulin therapy in the intensive care unit

Journal of Diabetes

Volumn 5, Issue 1, 2013, Pages 51-56

  Okawa, Makio ^a   Kunimoto, Fumio ^a   Kanamoto, Masafumi ^a   Narahara, Hajime ^a   Hinohara, Hiroshi ^a   Tobe, Masaru ^a   Yanagisawa, Akihiro ^a   Saito, Shigeru ^a  

^a GUNMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Glucose; Hypoglycemia; Insulin; Intensive insulin therapy; Mortality

Indexed keywords

GLUCOSE; HUMAN INSULIN;

ADULT; ARTICLE; ASSISTED VENTILATION; BLOOD GLUCOSE MONITORING; CONTINUOUS INFUSION; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; HOSPITAL ADMISSION; HUMAN; HYPOGLYCEMIA; INCIDENCE; INSULIN TREATMENT; INTENSIVE CARE UNIT; LENGTH OF STAY; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK FACTOR;

EID: 84873459263     PISSN: 17530393     EISSN: 17530407     Source Type: Journal    
DOI: 10.1111/1753-0407.12010     Document Type: Article

References (17)

1. Malmberg K, Rydén L, Hamsten A, Herlitz J, Waldenström A, Wedel H. Effects of insulin treatment on cause-specific one-year mortality and morbidity in diabetic patients with acute myocardial infarction. DIGAMI Study Group. Diabetes Insulin-Glucose in Acute Myocardial Infarction. Eur Heart J. 1996; 17: 1337-44.
2. van den Berghe G, Wouters P, Weekers F etal. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001; 345: 1359-67.
3. van den Berghe G, Wilmer A, Hermans G etal. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006; 354: 449-61.
4. Brunkhorst FM, Engel C, Bloos F etal. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008; 358: 125-39.
5. Preiser JC, Devos P, Ruiz-Santana S etal. A prospective randomised multi-centre controlled trial on tight glucose control by intensive insulin therapy in adult intensive care units: The Glucontrol study. Intensive Care Med. 2010; 36: 173-4.
6. Rady MY, Jonson DJ, Patel BM, Larson JS, Helmers RA. Influence of individual characteristics on outcome of glycemic control in intensive care unit patients with or without diabetes mellitus. Mayo Clin Proc. 2005; 80: 1558-67.
7. Gabbanelli V, Pantanetti S, Donati A, Principi T, Pelaila P. Correlation between hyperglycemia and mortality in a medical and surgical intensive care unit. Minerva Anestesiol. 2005; 71: 717-25.
8. Finney SJ, Zekveld C, Elia A, Evans TW. Glucose control and mortality in critically ill patients. JAMA. 2003; 290: 2041-7.
9. Mitrakou A, Ryan C, Veneman T etal. Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction. Am J Physiol. 1991; 260: E67-74.
10. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med. 1985; 13: 818-29.
11. Vincent JL, de Mendonça A, Cantraine F etal. Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: Results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine. Crit Care Med. 1998; 26: 1793-800.
12. Harris JA, Benedict FG. A biometric study of human basal metabolism. Proc Natl Acad Sci USA. 1918; 4: 370-3.
13. The NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009; 360: 1283-97.
14. Fischer KF, Lees JA, Newman JH. Hypoglycemia in hospitalized patients. Causes and outcomes. N Engl J Med. 1986; 315: 1245-50.
15. Vriesendorp TM, van Santen S, DeVries JH etal. Predisposing factors for hypoglycemia in the intensive care unit. Crit Care Med. 2006; 34: 96-101.
16. Egi M, Bellomo R, Stachowski E, French CJ, Hart G. Variability of blood glucose concentration and short-term morality in critically ill patients. Anesthesiology. 2006; 105: 244-52.
17. van den Berghe G, Wilmer A, Milants I etal. Intensive insulin therapy in mixed medical/surgical intensive care units: Benefit versus harm. Diabetes. 2006; 55: 3151-9.