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Volumn 16, Issue 6, 2012, Pages 389-399

Genetic testing in combination with preventive donepezil treatment for patients with amnestic mild cognitive impairment: An exploratory economic evaluation of personalized medicine

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E4; DONEPEZIL;

EID: 84873452414     PISSN: 11771062     EISSN: 11792000     Source Type: Journal    
DOI: 10.1007/s40291-012-0010-7     Document Type: Article
Times cited : (19)

References (53)
  • 1
    • 84873434650 scopus 로고    scopus 로고
    • Alzheimer's Disease Education and Referral Centre, National Institute on Aging About Alzheimer's disease: Alzheimer's basics Accessed 25 Oct 2012
    • Alzheimer's Disease Education and Referral Centre, National Institute on Aging About Alzheimer's disease: Alzheimer's basics. http://www.nia.nih.gov/ alzheimers/topics/alzheimers-basics. Accessed 25 Oct 2012.
  • 2
    • 84873461945 scopus 로고    scopus 로고
    • Alzheimer Society Canada. Rising tide: the impact of dementia on Canadian society Accessed 25 Oct 2012
    • Alzheimer Society Canada. Rising tide: the impact of dementia on Canadian society. http://www.alzheimer.ca/en/Get-involved/Raise-your-voice/Rising-Tide/ Rising-tide-summary. Accessed 25 Oct 2012.
  • 4
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin e and donepezil for the treatment of mild cognitive impairment
    • 15829527 10.1056/NEJMoa050151 1:CAS:528:DC%2BD2MXltVCjsbg%3D
    • Petersen RC, Thomas RG, Grundman M, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. 2005;352(23):2379-88.
    • (2005) N Engl J Med , vol.352 , Issue.23 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 5
    • 0035317190 scopus 로고    scopus 로고
    • Genetic association between the apolipoprotein e (ApoE) gene alleles and various forms of Alzheimer's disease [in Russian]
    • 11421127 1:STN:280:DC%2BD38%2Fht12rtw%3D%3D
    • Korovaitseva GI, Shcherbatykh TV, Selezneva NV, et al. Genetic association between the apolipoprotein E (ApoE) gene alleles and various forms of Alzheimer's disease [in Russian]. Genetika. 2001;37(4):529-35.
    • (2001) Genetika , vol.37 , Issue.4 , pp. 529-535
    • Korovaitseva, G.I.1    Shcherbatykh, T.V.2    Selezneva, N.V.3
  • 6
    • 2942530314 scopus 로고    scopus 로고
    • Early-onset Alzheimer disease: When is genetic testing appropriate?
    • 15249849 10.1097/01.wad.0000126616.77653.71
    • Goldman JS, Hou CE. Early-onset Alzheimer disease: when is genetic testing appropriate? Alzheimer Dis Assoc Disord. 2004;18(2):65-7.
    • (2004) Alzheimer Dis Assoc Disord , vol.18 , Issue.2 , pp. 65-67
    • Goldman, J.S.1    Hou, C.E.2
  • 7
    • 0029931412 scopus 로고    scopus 로고
    • A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment
    • 8559365 10.1212/WNL.46.1.149 1:STN:280:DyaK287ktlWkuw%3D%3D
    • Tierney MC, Szalai JP, Snow WG, et al. A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment. Neurology. 1996;46(1):149-54.
    • (1996) Neurology , vol.46 , Issue.1 , pp. 149-154
    • Tierney, M.C.1    Szalai, J.P.2    Snow, W.G.3
  • 8
    • 5644241911 scopus 로고    scopus 로고
    • Apolipoprotein e epsilon4 genotype as a risk factor for cognitive decline and dementia: Data from the Canadian Study of Health and Aging
    • 15477624 10.1503/cmaj.1031789
    • Hsiung GY, Sadovnick AD, Feldman H. Apolipoprotein E epsilon4 genotype as a risk factor for cognitive decline and dementia: data from the Canadian Study of Health and Aging. CMAJ. 2004;171(8):863-7.
    • (2004) CMAJ , vol.171 , Issue.8 , pp. 863-867
    • Hsiung, G.Y.1    Sadovnick, A.D.2    Feldman, H.3
  • 9
    • 0030451283 scopus 로고    scopus 로고
    • Just caring: The moral and economic costs of APOE genotyping for Alzheimer's disease
    • 8993492 10.1111/j.1749-6632.1996.tb32606.x 1:STN:280:DyaK2s7ks1KgtA%3D%3D
    • Fleck LM. Just caring: the moral and economic costs of APOE genotyping for Alzheimer's disease. Ann NY Acad Sci. 1996;802:128-38.
    • (1996) Ann NY Acad Sci , vol.802 , pp. 128-138
    • Fleck, L.M.1
  • 10
    • 43549124541 scopus 로고    scopus 로고
    • Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia
    • 18458258 10.1503/cmaj.070797
    • Chertkow H, Massoud F, Nasreddine Z, et al. Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia. CMAJ. 2008;178(10):1273-85.
    • (2008) CMAJ , vol.178 , Issue.10 , pp. 1273-1285
    • Chertkow, H.1    Massoud, F.2    Nasreddine, Z.3
  • 11
    • 4143052423 scopus 로고    scopus 로고
    • Efficacy of donepezil in mild cognitive impairment: A randomized placebo-controlled trial
    • 15326237 10.1212/01.WNL.0000134664.80320.92 1:CAS:528: DC%2BD2cXmtlSjsbw%3D
    • Salloway S, Ferris S, Kluger A, et al. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology. 2004;63(4):651-7.
    • (2004) Neurology , vol.63 , Issue.4 , pp. 651-657
    • Salloway, S.1    Ferris, S.2    Kluger, A.3
  • 12
    • 0032918793 scopus 로고    scopus 로고
    • Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease
    • 10214734 10.1212/WNL.52.6.1138 1:STN:280:DyaK1M3ivFGntQ%3D%3D
    • Neumann PJ, Hermann RC, Kuntz KM, et al. Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease. Neurology. 1999;52(6):1138-45.
    • (1999) Neurology , vol.52 , Issue.6 , pp. 1138-1145
    • Neumann, P.J.1    Hermann, R.C.2    Kuntz, K.M.3
  • 13
    • 0032959931 scopus 로고    scopus 로고
    • Economic evaluation of donepezil for the treatment of Alzheimer's disease in Canada
    • 10323651
    • O'Brien BJ, Goeree R, Hux M, et al. Economic evaluation of donepezil for the treatment of Alzheimer's disease in Canada. J Am Geriatr Soc. 1999;47(5):570-8.
    • (1999) J Am Geriatr Soc , vol.47 , Issue.5 , pp. 570-578
    • O'Brien, B.J.1    Goeree, R.2    Hux, M.3
  • 14
    • 4143124385 scopus 로고    scopus 로고
    • Economic evaluation of donepezil in moderate to severe Alzheimer disease
    • 15326236 10.1212/01.WNL.0000134663.79663.6E 1:CAS:528: DC%2BD2cXmtlSjsb4%3D
    • Feldman N, Gauthier S, Hecker J, et al. Economic evaluation of donepezil in moderate to severe Alzheimer disease. Neurology. 2004;63:644-50.
    • (2004) Neurology , vol.63 , pp. 644-650
    • Feldman, N.1    Gauthier, S.2    Hecker, J.3
  • 15
    • 77649192580 scopus 로고    scopus 로고
    • Health economic effect of donepezil treatment for CDR 0.5 converters to Alzheimer's disease as shown by the Markov model
    • 19481822 10.1016/j.archger.2009.04.014 1:CAS:528:DC%2BC3cXivFels7s%3D
    • Kasuya M, Meguro K. Health economic effect of donepezil treatment for CDR 0.5 converters to Alzheimer's disease as shown by the Markov model. Arch Gerontol Geriatr. 2010;50(3):295-9.
    • (2010) Arch Gerontol Geriatr , vol.50 , Issue.3 , pp. 295-299
    • Kasuya, M.1    Meguro, K.2
  • 17
    • 3042651139 scopus 로고    scopus 로고
    • Grading quality of evidence and strength of recommendations
    • 15205295 10.1136/bmj.328.7454.1490
    • Atkins D, Best D, Briss PA, et al. Grading quality of evidence and strength of recommendations. BMJ. 2004;328(7454):1490.
    • (2004) BMJ , vol.328 , Issue.7454 , pp. 1490
    • Atkins, D.1    Best, D.2    Briss, P.A.3
  • 18
    • 1842789599 scopus 로고    scopus 로고
    • Conceptualization of mild cognitive impairment: A review
    • 15065223 10.1002/gps.1049
    • Davis HS, Rockwood K. Conceptualization of mild cognitive impairment: a review. Int J Geriatr Psychiatry. 2004;19(4):313-9.
    • (2004) Int J Geriatr Psychiatry , vol.19 , Issue.4 , pp. 313-319
    • Davis, H.S.1    Rockwood, K.2
  • 20
    • 80054863058 scopus 로고    scopus 로고
    • Regional differences in effects of APOE epsilon4 on cognitive impairment in non-demented subjects
    • 21952537 10.1159/000330492 1:CAS:528:DC%2BC3MXhtlagurfM
    • Norberg J, Graff C, Almkvist O, et al. Regional differences in effects of APOE epsilon4 on cognitive impairment in non-demented subjects. Dement Geriatr Cogn Disord. 2011;32(2):135-42.
    • (2011) Dement Geriatr Cogn Disord , vol.32 , Issue.2 , pp. 135-142
    • Norberg, J.1    Graff, C.2    Almkvist, O.3
  • 21
    • 84876171331 scopus 로고    scopus 로고
    • Statistics Canada Accessed 29 Oct 2012
    • Statistics Canada. Census: population and dwelling counts. http://www12.statcan.ca/census-recensement/2006/dp-pd/hlt/97-550/Index.cfm?TPL= P1C&Page=RETR&LANG=Eng&T=101. Accessed 29 Oct 2012.
    • Census: Population and Dwelling Counts
  • 22
    • 0037162382 scopus 로고    scopus 로고
    • Natural history of mild cognitive impairment in older persons
    • 12136057 10.1212/WNL.59.2.198 1:STN:280:DC%2BD38zptFSrtQ%3D%3D
    • Bennett DA, Wilson RS, Schneider JA, et al. Natural history of mild cognitive impairment in older persons. Neurology. 2002;59(2):198-205.
    • (2002) Neurology , vol.59 , Issue.2 , pp. 198-205
    • Bennett, D.A.1    Wilson, R.S.2    Schneider, J.A.3
  • 23
    • 0037318497 scopus 로고    scopus 로고
    • Functional transitions and active life expectancy associated with Alzheimer disease
    • 12580712 10.1001/archneur.60.2.253
    • Dodge HH, Shen C, Pandav R, et al. Functional transitions and active life expectancy associated with Alzheimer disease. Arch Neurol. 2003;60(2):253-9.
    • (2003) Arch Neurol , vol.60 , Issue.2 , pp. 253-259
    • Dodge, H.H.1    Shen, C.2    Pandav, R.3
  • 24
    • 61849113222 scopus 로고    scopus 로고
    • Rate of progression of mild cognitive impairment to dementia: Meta-analysis of 41 robust inception cohort studies
    • 19236314 10.1111/j.1600-0447.2008.01326.x 1:STN:280: DC%2BD1M3gtFGhsg%3D%3D
    • Mitchell AJ, Shiri-Feshki M. Rate of progression of mild cognitive impairment to dementia: meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand. 2009;119(4):252-65.
    • (2009) Acta Psychiatr Scand , vol.119 , Issue.4 , pp. 252-265
    • Mitchell, A.J.1    Shiri-Feshki, M.2
  • 25
    • 0033657481 scopus 로고    scopus 로고
    • A comparison of HUI2 and HUI3 utility scores in Alzheimer's disease
    • 11059474 10.1177/0272989X0002000405 1:STN:280:DC%2BD3crgslKnsA%3D%3D
    • Neumann PJ, Sandberg EA, Araki SS, et al. A comparison of HUI2 and HUI3 utility scores in Alzheimer's disease. Med Decis Making. 2000;20(4):413-22.
    • (2000) Med Decis Making , vol.20 , Issue.4 , pp. 413-422
    • Neumann, P.J.1    Sandberg, E.A.2    Araki, S.S.3
  • 26
    • 33745657911 scopus 로고    scopus 로고
    • Patient- and proxy-reported utility in Alzheimer disease using the EuroQoL
    • 16493236 10.1097/01.wad.0000201851.52707.c9
    • Jonsson L, Andreasen N, Kilander L, et al. Patient- and proxy-reported utility in Alzheimer disease using the EuroQoL. Alzheimer Dis Assoc Disord. 2006;20(1):49-55.
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , Issue.1 , pp. 49-55
    • Jonsson, L.1    Andreasen, N.2    Kilander, L.3
  • 27
    • 0031886125 scopus 로고    scopus 로고
    • Validity of the quality of well-being scale for patients with Alzheimer's disease
    • 10182417 10.1177/089826439801000103 1:STN:280:DyaK1cnhvVekuw%3D%3D
    • Kerner DN, Patterson TL, Grant I, Kaplan RM. Validity of the quality of well-being scale for patients with Alzheimer's disease. J Aging Health. 1998;10(1):44-61.
    • (1998) J Aging Health , vol.10 , Issue.1 , pp. 44-61
    • Kerner, D.N.1    Patterson, T.L.2    Grant, I.3    Kaplan, R.M.4
  • 28
    • 0027425211 scopus 로고
    • The clinical dementia rating (CDR): Current version and scoring rules
    • 8232972 10.1212/WNL.43.11.2412-a 1:STN:280:DyaK2c%2FltVKnuw%3D%3D
    • Morris JC. The clinical dementia rating (CDR): current version and scoring rules. Neurology. 1993;43(11):2412-4.
    • (1993) Neurology , vol.43 , Issue.11 , pp. 2412-2414
    • Morris, J.C.1
  • 29
    • 0345025166 scopus 로고    scopus 로고
    • Ministry of Health and Long-Term Care Accessed 25 Oct 2012
    • Ministry of Health and Long-Term Care. Ontario drug benefit formulary/comparative drug index no. 41. http://www.health.gov.on.ca/english/ providers/program/drugs/formulary/edition-41.pdf. Accessed 25 Oct 2012.
    • Ontario Drug Benefit Formulary/comparative Drug Index No. 41
  • 30
    • 34547109945 scopus 로고    scopus 로고
    • Ministry of Health and Long-Term Care Accessed 25 Oct 2012
    • Ministry of Health and Long-Term Care. Schedule of benefits for physician services under the Health Insurance Act. http://www.health.gov.on.ca/english/ providers/program/ohip/sob/physserv/physserv-mn.html. Accessed 25 Oct 2012.
    • Schedule of Benefits for Physician Services under the Health Insurance Act
  • 31
    • 84873455146 scopus 로고    scopus 로고
    • Ministry of Health and Long-Term Care. Schedule of benefits for laboratory services: April 1 Accessed 29 Oct 2012
    • Ministry of Health and Long-Term Care. Schedule of benefits for laboratory services: April 1, 1999. http://www.health.gov.on.ca/english/ providers/program/ohip/sob/lab/lab-services-sched-01-19990401.pdf. Accessed 29 Oct 2012.
    • (1999)
  • 33
    • 0004329564 scopus 로고    scopus 로고
    • final report prepared for the Ontario Ministry of Health and Long Term Care Accessed 25 Oct 2012
    • Miller F, Hurley J, Morgan S, et al. Predictive genetic tests and health care cost: final report prepared for the Ontario Ministry of Health and Long Term Care. http://www.health.gov.on.ca/fr/common/ministry/publications/reports/ geneticsrep02/chepa-rep.pdf. Accessed 25 Oct 2012.
    • Predictive Genetic Tests and Health Care Cost
    • Miller, F.1    Hurley, J.2    Morgan, S.3
  • 34
    • 70350303927 scopus 로고    scopus 로고
    • Cost-effectiveness: Cholinesterase inhibitors and memantine in vascular dementia
    • 19960752
    • Wong CL, Bansback N, Lee PE, Anis AH. Cost-effectiveness: cholinesterase inhibitors and memantine in vascular dementia. Can J Neurol Sci. 2009;36(6):735-9.
    • (2009) Can J Neurol Sci , vol.36 , Issue.6 , pp. 735-739
    • Wong, C.L.1    Bansback, N.2    Lee, P.E.3    Anis, A.H.4
  • 35
    • 0032497237 scopus 로고    scopus 로고
    • Relation between severity of Alzheimer's disease and costs of caring
    • 9757169 1:STN:280:DyaK1cvivFOhsg%3D%3D
    • Hux MJ, O'Brien BJ, Iskedjian M, et al. Relation between severity of Alzheimer's disease and costs of caring. CMAJ. 1998;159(5):457-65.
    • (1998) CMAJ , vol.159 , Issue.5 , pp. 457-465
    • Hux, M.J.1    O'Brien, B.J.2    Iskedjian, M.3
  • 36
    • 0028079887 scopus 로고
    • Progression and outcome of patients in a Canadian dementia clinic
    • 7874617 1:STN:280:DyaK2M7nvFKltQ%3D%3D
    • Hogan DB, Thierer DE, Ebly EM, Parhad IM. Progression and outcome of patients in a Canadian dementia clinic. Can J Neurol Sci. 1994;21(4):331-8.
    • (1994) Can J Neurol Sci , vol.21 , Issue.4 , pp. 331-338
    • Hogan, D.B.1    Thierer, D.E.2    Ebly, E.M.3    Parhad, I.M.4
  • 37
    • 0003617159 scopus 로고    scopus 로고
    • Statistics Canada health and personal care Accessed 25 Oct 2012
    • Statistics Canada. Consumer price index, health and personal care. http://www.statcan.gc.ca/tables-tableaux/sum-som/l01/cst01/cpis01a-eng.htm. Accessed 25 Oct 2012.
    • Consumer Price Index
  • 38
    • 53749092734 scopus 로고    scopus 로고
    • Expected value of perfect information: An empirical example of reducing decision uncertainty by conducting additional research
    • 19602213 10.1111/j.1524-4733.2008.00389.x
    • Oostenbrink JB, Al MJ, Oppe M, Rutten-van Molken MP. Expected value of perfect information: an empirical example of reducing decision uncertainty by conducting additional research. Value Health. 2008;11(7):1070-80.
    • (2008) Value Health , vol.11 , Issue.7 , pp. 1070-1080
    • Oostenbrink, J.B.1    Al, M.J.2    Oppe, M.3    Rutten-Van Molken, M.P.4
  • 39
    • 25444513776 scopus 로고    scopus 로고
    • Pharmacogenetic testing in the clinical management of schizophrenia: A decision-analytic model
    • 16160617 10.1097/01.jcp.0000177553.59455.24
    • Perlis RH, Ganz DA, Avorn J, et al. Pharmacogenetic testing in the clinical management of schizophrenia: a decision-analytic model. J Clin Psychopharmacol. 2005;25(5):427-34.
    • (2005) J Clin Psychopharmacol , vol.25 , Issue.5 , pp. 427-434
    • Perlis, R.H.1    Ganz, D.A.2    Avorn, J.3
  • 40
    • 31544458993 scopus 로고    scopus 로고
    • Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast cancer
    • 16267126 10.1093/annonc/mdj048 1:STN:280:DC%2BD28%2FjvVGmug%3D%3D
    • Lonning PE. Comparing cost/utility of giving an aromatase inhibitor as monotherapy for 5 years versus sequential administration following 2-3 or 5 years of tamoxifen as adjuvant treatment for postmenopausal breast cancer. Ann Oncol. 2006;17(2):217-25.
    • (2006) Ann Oncol , vol.17 , Issue.2 , pp. 217-225
    • Lonning, P.E.1
  • 41
    • 0027250294 scopus 로고
    • The economic burden of Alzheimer's disease care
    • 10.1377/hlthaff.12.2.164 1:STN:280:DyaK3szoslyksQ%3D%3D
    • Rice DP, Fox PJ, Max W, et al. The economic burden of Alzheimer's disease care. Health Aff (Millwood). 1993;12(2):164-76.
    • (1993) Health Aff (Millwood) , vol.12 , Issue.2 , pp. 164-176
    • Rice, D.P.1    Fox, P.J.2    Max, W.3
  • 42
    • 0345491530 scopus 로고    scopus 로고
    • Donepezil for the treatment of mild to moderate Alzheimer's disease in France: The economic implications
    • 14560059 10.1159/000074079 1:CAS:528:DC%2BD3sXpsVKrtLY%3D
    • Fagnani F, Lafuma A, Pechevis M, et al. Donepezil for the treatment of mild to moderate Alzheimer's disease in France: the economic implications. Dement Geriatr Cogn Disord. 2004;17(1-2):5-13.
    • (2004) Dement Geriatr Cogn Disord , vol.17 , Issue.1-2 , pp. 5-13
    • Fagnani, F.1    Lafuma, A.2    Pechevis, M.3
  • 43
    • 0032545939 scopus 로고    scopus 로고
    • Utility of the apolipoprotein e genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein e and Alzheimer's Disease
    • 9468467 10.1056/NEJM199802193380804 1:STN:280:DyaK1c7islCltA%3D%3D
    • Mayeux R, Saunders AM, Shea S, et al. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. N Engl J Med. 1998;338(8):506-11.
    • (1998) N Engl J Med , vol.338 , Issue.8 , pp. 506-511
    • Mayeux, R.1    Saunders, A.M.2    Shea, S.3
  • 44
    • 0036725818 scopus 로고    scopus 로고
    • Risk factors for Alzheimer's disease: A prospective analysis from the Canadian Study of Health and Aging
    • 12196314 10.1093/aje/kwf074
    • Lindsay J, Laurin D, Verreault R, et al. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol. 2002;156(5):445-53.
    • (2002) Am J Epidemiol , vol.156 , Issue.5 , pp. 445-453
    • Lindsay, J.1    Laurin, D.2    Verreault, R.3
  • 45
    • 80052639545 scopus 로고    scopus 로고
    • Predictive value of APOE-epsilon4 allele for progression from MCI to AD-type dementia: A meta-analysis
    • 21493755 10.1136/jnnp.2010.231555
    • Elias-Sonnenschein LS, Viechtbauer W, Ramakers IH, et al. Predictive value of APOE-epsilon4 allele for progression from MCI to AD-type dementia: a meta-analysis. J Neurol Neurosurg Psychiatry. 2011;82(10):1149-56.
    • (2011) J Neurol Neurosurg Psychiatry , vol.82 , Issue.10 , pp. 1149-1156
    • Elias-Sonnenschein, L.S.1    Viechtbauer, W.2    Ramakers, I.H.3
  • 47
    • 70349094526 scopus 로고    scopus 로고
    • Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts
    • 19752306 10.1001/archneurol.2009.106
    • Farias ST, Mungas D, Reed BR, et al. Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts. Arch Neurol. 2009;66(9):1151-7.
    • (2009) Arch Neurol , vol.66 , Issue.9 , pp. 1151-1157
    • Farias, S.T.1    Mungas, D.2    Reed, B.R.3
  • 48
    • 52649165209 scopus 로고    scopus 로고
    • Direct costs associated with mild cognitive impairment in primary care
    • 18416451 10.1002/gps.2018
    • Luppa M, Heinrich S, Matschinger H, et al. Direct costs associated with mild cognitive impairment in primary care. Int J Geriatr Psychiatry. 2008;23:963-71.
    • (2008) Int J Geriatr Psychiatry , vol.23 , pp. 963-971
    • Luppa, M.1    Heinrich, S.2    Matschinger, H.3
  • 49
    • 33845694258 scopus 로고    scopus 로고
    • Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease
    • 17159097 10.1212/01.wnl.0000247041.63081.98
    • Williams MM, Xiong C, Morris JC, Galvin JE. Survival and mortality differences between dementia with Lewy bodies vs Alzheimer disease. Neurology. 2006;67(11):1935-41.
    • (2006) Neurology , vol.67 , Issue.11 , pp. 1935-1941
    • Williams, M.M.1    Xiong, C.2    Morris, J.C.3    Galvin, J.E.4
  • 50
    • 36849078870 scopus 로고    scopus 로고
    • Cholinesterase inhibitors in mild cognitive impairment: A systematic review of randomized trials
    • 18044984 10.1371/journal.pmed.0040338
    • Raschetti R, Albanese E, Vanacore N, Maggini M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomized trials. PLoS Med. 2007;4(11):e338.
    • (2007) PLoS Med , vol.4 , Issue.11 , pp. 338
    • Raschetti, R.1    Albanese, E.2    Vanacore, N.3    Maggini, M.4
  • 51
    • 0141993614 scopus 로고    scopus 로고
    • Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study, part 1
    • 14568808 10.1001/archneur.60.10.1385
    • Lopez OL, Jagust WJ, DeKosky ST, et al. Prevalence and classification of mild cognitive impairment in the Cardiovascular Health Study Cognition Study, part 1. Arch Neurol. 2003;60:1385-9.
    • (2003) Arch Neurol , vol.60 , pp. 1385-1389
    • Lopez, O.L.1    Jagust, W.J.2    Dekosky, S.T.3
  • 52
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • 21460841 10.1038/ng.801 1:CAS:528:DC%2BC3MXktFahtrk%3D
    • Naj AC, Jun G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43(5):436-41.
    • (2011) Nat Genet , vol.43 , Issue.5 , pp. 436-441
    • Naj, A.C.1    Jun, G.2    Beecham, G.W.3
  • 53
    • 80053189259 scopus 로고    scopus 로고
    • Genomics and pharmacogenomics of dementia
    • 20718828 10.1111/j.1755-5949.2010.00189.x 1:CAS:528:DC%2BC3MXhtlOntLzO
    • Cacabelos R, Martinez-Bouza R. Genomics and pharmacogenomics of dementia. CNS Neurosci Ther. 2011;17(5):566-76.
    • (2011) CNS Neurosci Ther , vol.17 , Issue.5 , pp. 566-576
    • Cacabelos, R.1    Martinez-Bouza, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.