Pectin-HPMC E15LV Vs pH sensitive polymer coating films for delayed drug delivery to the colon: A comparison of two dissolution models to assess colonic targeting performance in-vitro

International Journal of Applied Research in Natural Products

Volumn 5, Issue 3, 2012, Pages 1-16

  Newton, A M J ^a,b   Prabakaran, L ^c   Jayaveera, K N ^d  

^a Nirmala college of pharmacy   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^c RR College of Pharmacy   (India)

^d JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

Author keywords

Colon; Eudragit L 100; Inflammatory bowel disease; Mesalamine; Pectin

Indexed keywords

ANTIBIOTIC AGENT; BUFFER; CALCITONIN; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; INSULIN; MESALAZINE; PECTIN; POLYMER; POLYMETHACRYLIC ACID; POLYSACCHARIDE; VACCINE; VASOPRESSIN;

ANALYTICAL PARAMETERS; ARTICLE; CAPSULE FILLING; COLON; COLON CANCER; COLON FLORA; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; DRUG ABSORPTION; DRUG DELIVERY DEVICE; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG MANUFACTURE; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; DRUG TARGETING; ENTERITIS; FILM COATING; ILEUM; IN VITRO STUDY; PH MEASUREMENT; PH SENSITIVITY; TABLET FORMULATION; TOBACCO DEPENDENCE;

EID: 84873451525     PISSN: None     EISSN: 19406223     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Adkin DA, Kenyon CJ, Lerner EI, et al. The use of scintigraphy to provide "proof of concept" for novel polysaccharide preparations designed for colonic drug delivery. Pharm. Res. 1997: Jan; 14 (1): 103-7.
2. Ashford M, Fell JT. Attwood D, Sharma H, Woodhead P. An in vitro investigation into the suitability of pH- dependent polymers for colon targeting, Int. J. Pharm. 1993: 91: 241-245.
3. Ashford M, Fell JT. Targeting drugs to the colon: delivery systems for oral administration. J. Drug. Targeting. 1994: 2: 241-258.
4. Basit A, Bloor J, Perspective on colonic drug delivery. Business briefing: Pharma Tech. 2003: 185-190.
5. Brahma N. Singh. Modified release solid formulations for colonic delivery. Recent patents on drug delivery and formulations. 2007: 1: 53-63.
6. Chan LW, Ong KT, Heng PWS, Novel film modifier to alter the physical properties of composite ethyl cellulose films. Pharm Res. 2005: 22: 476-489.
7. Cremonini F, Talley NJ. Irritable bowel syndrome: epidemiology, natural history, health care seeking and emerging risk factors. Gastrenterol Clin North Am. 2005: 34, 189-204.
8. Daniel K, Podolsky MD. Inflammatory Bowel Disease. N. Engl. J. Med. 2002: 347: 417-429.
9. Drossman, DA, Li Z, Andruzzi E, US householder survey of functional gastrointestinal disorder: prevalence, sociodemography, and health impact. Dig. Dis. Sci. 1993: 38: 1569-1580.
10. Evans DF, Pye R, Bramely AG, Clark TJ, Dyson JD, Measurement of gastro intestinal pH profiles in normal ambulant human subjects, Gut. 1988: 29: 1035-1041.
11. Fallingborg J, Christensen LA, Jacobsen BA, Ramusen SN. Very low intraluminal colonic pH in patients with active ulcerative colitis. Dig. Dis. Sci. 1993: 38: 1989-1993.
12. Fernandez-Hervas MJ, Fell JT, pectin/chitosan mixture as coating for colon-specific drug delivery. An in vitro evaluation. Int. J.Pharm. 1998: 169: 115-119.
13. Follonier N, Cole ET, Evolution of hot melt extrusion as a new technique for the production of polymer based pellets for sustained release capsule containing high loadings freely soluble drugs. Drug Dev. Ind. Pharm. 1994; 20: 1323-1339.
14. Frohoff-Hulsmann MA, Schmitz A, Lippold BC, Aqueous ethyl cellulose dispersions containing containing plasticizers of different solubility and hydroxyl propyl methyl cellulose as coating material for diffusion pellets. I. drug release rate from coated pellets. Int. J. pharm. 1999: 177: 69-82.
15. Ibekwe VC, Fadda HM, Parsons GE, Basit AW. A comparative in vitro assessment of the drug release performance of pH- responsive polymers for ileo - colonic delivery. 2006: 308: 52-60.