The Inhibin B Response to a Motilin Receptor Agonist in Male Rats

Birth Defects Research Part B - Developmental and Reproductive Toxicology

Volumn 98, Issue 1, 2013, Pages 63-71

  Ziejewski, Mary K ^a   Vidal, Justin D ^a   Stanislaus, Dinesh ^a   Apostoli, April ^a   Chowdhury, Probash ^b   Laffan, Susan ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

circulating biomarker; Inhibin B; testis histopathology

Indexed keywords

ANDROSTANOLONE; FOLLITROPIN; GSK 1322888; HORMONE RECEPTOR STIMULATING AGENT; INHIBIN B; LUTEINIZING HORMONE; MOTILIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; DOSE RESPONSE; FOLLITROPIN BLOOD LEVEL; GERM LAYER; HISTOPATHOLOGY; LUTEINIZING HORMONE BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SEMINIFEROUS TUBULE; TESTIS INJURY; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; WEIGHT GAIN;

ADMINISTRATION, ORAL; ANIMALS; DIHYDROTESTOSTERONE; FOLLICLE STIMULATING HORMONE; INHIBINS; MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE;

EID: 84873448691     PISSN: 15429733     EISSN: 15429741     Source Type: Journal    
DOI: 10.1002/bdrb.21042     Document Type: Article

References (19)

1. Allenby G, Foster PMD, Sharpe RM. 1991. Evidence that secretion of immunoactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: correlation between in-vivo and in-vitro studies. Endocrinology 128(1):467-476.
2. Bartlett MS. 1937. Properties of sufficiency and statistical tests. Proc R Soc A 160:268-282.
3. Bassil AK, Dass NB, Murray CD, Muir A, Sanger GJ. 2005. Prokineticin-2, motilin, ghrelin and metoclopramide: prokinetic utility in mouse stomach and colon. Eur J Pharmacol 524:138-144.
4. Campbell G, Skillings JH. 1985. Nonparametric stepwise multiple comparison procedures. J Am Stat Assoc 80:998-1003.
5. Dunnett CW. 1955. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1095-1121.
6. Dunnett CW. 1964. New tables for multiple comparisons with a control. Biometrics 20:482-491.
7. Dunnett CW, Tamhance AC. 1991. Step-down multiple tests for comparing treatments with a control in unbalanced one-way layouts. Stat Med 10:939-946.
8. Fligner MA. 1984. A note on two-sided distribution-free treatment versus control multiple comparisons. J Am Stat Assoc 79:208-211.
9. Foley GL. 2001. Overview of male reproductive pathology. Toxicol Pathol 29:49-63.
10. Mann DR, Evans DC, Jacobs VL, Collins DC. 1986. Influence of acute intracerebroventricular (i.c.v.) administration of adrenocorticotropin (ACTH) on LH secretion in male rats: effect of pretreatment (i.c.v.) with ACTH antiserum on the serum LH response to an acute ether stress. J Endocrinol 108:275-532.
11. Rivier C, Rivest S. 1991. Effect of stress on the activity of the hypothalamic-pituitary-gonadal axis: peripheral and central mechanisms. Biol Reprod 45:523-532.
12. Sanger GJ, Holbrook JD, Andrews Paul LR. 2011. The translational value of rodent gastrointestinal functions: a cautionary tale. Trends Pharmacol Sci 32:402-409.
13. Shirley E. 1977. A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 33:386-389.
14. Steel RGD. 1959. A multiple comparison rank sum test: treatments versus control. Biometrics 15:560-572.
15. Tohei A, Tomabechi T, Mamada M, Akai M, Watanabe G, Taya K. 1997. Effects of repeated ether stress on the hypothalamic-pituitary-testes axis in adult rats with special reference to inhibin secretion. J Vet Med Sci 59(5):329-334.
16. Williams DA. 1971. A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27:103-117.
17. Williams DA. 1972. The comparison of several dose levels with a zero dose control. Biometrics 28:519-531.
18. Williams DA. 1977. Some inference procedures for monotonically ordered normal means. Biometrika 64:9-14.
19. Williams DA. 1986. A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control. Biometrics 42:183-186.