Pharmacokinetics of paracetamol and its metabolites in women at delivery and post-partum

British Journal of Clinical Pharmacology

Volumn 75, Issue 3, 2013, Pages 850-860

  Kulo, Aida ^a,b   Peeters, Mariska Y ^c   Allegaert, Karel ^a   Smits, Anne ^a   de Hoon, Jan ^a   Verbesselt, Rene ^a   Lewi, Liesbeth ^a   van de Velde, Marc ^a   Knibbe, Catherijne A J ^c  

^a UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^b UNIVERSITY OF SARAJEVO   (Bosnia and Herzegovina)

^c ST ANTONIUS HOSPITAL   (Netherlands)

Author keywords

Acetaminophen; Elimination routes; I.v. paracetamol; Population pharmacokinetics; Post partum; Pregnancy

Indexed keywords

DRUG METABOLITE; PARACETAMOL; PARACETAMOL GLUCURONIDE; PARACETAMOL SULFATE; PERFUSALGAN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; CESAREAN SECTION; DELIVERY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HUMAN; LOADING DRUG DOSE; NORMAL HUMAN; PRIORITY JOURNAL; PUERPERIUM; URINALYSIS;

ACETAMINOPHEN; ADMINISTRATION, INTRAVENOUS; ADULT; ANALGESICS, NON-NARCOTIC; DELIVERY, OBSTETRIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; METABOLIC CLEARANCE RATE; PAIN; PAIN MEASUREMENT; POSTPARTUM PERIOD; PREGNANCY;

EID: 84873433903     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2012.04402.x     Document Type: Article

References (29)

1. Anderson GD. Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach. Clin Pharmacokinet 2005; 44: 989-1008.
2. Chapman AB, Abraham WT, Zamudio S, Coffin C, Merouani A, Young D, Johnson A, Osorio F, Goldberg C, Moore LG, Dahms T, Schrier RW. Temporal relationships between hormonal and hemodynamic changes in early human pregnancy. Kidney Int 1998; 54: 2056-2063.
3. Roberts M, Lindheimer MD, Davison JM. Altered glomerular permselectivity to neutral dextrans and heteroporous membrane modeling in human pregnancy. Am J Physiol Renal Fluid Electrolyte Physiol 1996; 270: F338-343.
4. Milne JE, Lindheimer MD, Davison JM. Glomerular heteroporous membrane modeling in third trimester and postpartum before and during amino acid infusion. Am J Physiol Renal Physiol 2002; 282: F170-175.
5. Mattison D, Zajicek A. Gaps in knowledge in treating pregnant women. Gend Med 2006; 3: 169-182.
6. Conrad KP. Mechanisms of renal vasodilation and hyperfiltration during pregnancy. J Soc Gynecol Investig 2004; 11: 438-448.
7. Davies MH, Ngong JM, Yucesoy M, Acharya SK, Mills CO, Weaver JB, Waring RH, Elias E. The adverse influence of pregnancy upon sulphation: a clue to the pathogenesis of intrahepatic cholestasis of pregnancy? J Hepatol 1994; 21: 1127-1134.
8. Mastroianni AC, Faden R, Federman D. Women and health research: a report from the Institute of Medicine. Kennedy Inst Ethics J 1994; 4: 55-62.
9. Andrew MA, Easterling TR, Carr DB, Shen D, Buchanan ML, Rutherford T, Bennett R, Vicini P, Hebert MF. Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Clin Pharmacol Ther 2007; 81: 547-556.
10. Oscier CD, Milner QJ. Peri-operative use of paracetamol. Anaesthesia 2009; 64: 65-72.
11. Bock KW, Forster A, Gschaidmeier H, Brück M, Münzel P, Schareck W, Fournel-Gigleux S, Burchell B. Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronisyltransferase. Biochem Pharmacol 1993; 45: 1809-1814.
12. Burchell B, Brierley CH, Rance D. Specificity of human UDPglucuronosyltransferases and xenobiotic glucuronidation. Life Sci 1995; 57: 1819-1831.
13. Prescott LF, ed. Paracetamol: A Critical Bibliographic Review, Second edn. London: Taylor & Francis Publishers, 2001.
14. Reiter C, Weinshilboum R. Platelet phenol sulfotransferase activity: correlation with sulfate conjugation of paracetamol. Clin Pharmacol Ther 1982; 32: 612-621.
15. Pacifici GM. Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature. Int J Clin Pharmacol Ther 2004; 42: 488-495.
16. Gelotte CK, Auiler JF, Lynch JM, Temple AR, Slattery JT. Disposition of paracetamol at 4, 6, and 8g/day for 3 days in healthy young adults. Clin Pharmacol Ther 2007; 81: 840-848.
17. McNicol ED, Tzortzopoulou A, Cepeda MS, Francia MB, Farhat T, Schumann R. Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis. Br J Anaesth 2011; 106: 764-775.
18. Botting R, Ayoub SS. COX-3 and the mechanism of action of paracetamol/paracetamol. Prostaglandins Leukot Essent Fatty Acids 2005; 72: 85-87.
19. Gregoire N, Hovsepian L, Gualano V, Evene E, Dufour G, Gendron A. Safety and pharmacokinetics of paracetamol following intravenous administration of 5g during the first 24h with a 2-g starting dose. Clin Pharmacol Ther 2007; 81: 401-405.
20. Hahn TW, Mogensen T, Lund C, Jacobsen LS, Hjortsoe NC, Rasmussen SN, Rasmussen M. Analgesic effect of iv paracetamol: possible ceiling effect of paracetamol in postoperative pain. Acta Anaesthesiol Scand 2003; 47: 138-145.
21. Cornesse D, Senard M, Hans GA, Ledoux D, Kirsch M, Hick G, Hallet C, Joris J. Comparison between two intraoperative intravenous loading doses of paracetamol on pain after minor hand surgery: two grams vs one gram. Acta Chir Belg 2010; 110: 529-532.
22. Juhl GI, Norholt SE, Tonnesen E, Hiesse-Provost O, Jensen TS. Analgesic efficacy and safety of intravenous paracetamol (paracetamol) administered as a 2g starting dose following third molar surgery. Eur J Pain 2006; 10: 371-377.
23. Marcus HE, Fabian A, Dagtekin O, Schier R, Krep H, Böttiger BW, Teschendorf P, Spöhr F, Petzke F. Pain, postdural puncture headache, nausea, and pruritus after cesarean delivery: a survey of prophylaxis and treatment. Minerva Anestesiol 2011; 77: 1043-1049.
24. Miners JO, Robson RA, Birkett DJ. Paracetamol metabolism in pregnancy. Br J Clin Pharmacol 1986; 22: 359-362.
25. Kulo A, van de Velde M, de Hoon J, Verbesselt R, Devlieger R, Deprest J, Allegaert K. Pharmacokinetics of a loading dose of intravenous paracetamol post caesarean delivery. Int J Obstet Anesth 2012; 21: 125-128.
26. Allegaert K, Anderson BJ, Naulaers G, de Hoon J, Verbesselt R, Debeer A, Devlieger H, Tibboel D. Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates. Eur J Clin Pharmacol 2004; 60: 191-197.
27. Allegaert K, de Hoon J, Verbesselt R, Vanhole C, Devlieger H, Tibboel D. Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates. Acta Paediatr 2005; 94: 1273-1279.
28. Lowenthal DT, Oie S, Van Stone JC, Briggs WA, Levy G. Pharmacokinetics of paracetamol elimination by anephric patients. J Pharmacol Exp Ther 1976; 196: 570-578.
29. Matthew D. Pharmacokinetics in pregnancy. Best Pract Res Clin Obstet Gynaecol 2001; 15: 819-826.