Effect of mifepristone on COX-2 both in eutopic and ectopic endometrium in mouse endometriotic model

Archives of Gynecology and Obstetrics

Volumn 286, Issue 4, 2012, Pages 939-946

  Li, Xiujuan ^a   Bao, Yanyan ^a   Fang, Peng ^b   Chen, Yaping ^a   Qiao, Zhongdong ^b  

^a Shanghai Fifth Hospital   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Animal model; COX 2; ELISA; Endometriosis; RT PCR; Western Blot

Indexed keywords

CYCLOOXYGENASE 2; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MIFEPRISTONE; PROSTAGLANDIN E2; MENSTRUATION INDUCING AGENT; PTGS2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; COX 2 GENE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; ENDOMETRIOSIS; ENDOMETRIUM; ENZYME LINKED IMMUNOSORBENT ASSAY; EUTOPIC ENDOMETRIUM; FEMALE; FLUORESCENCE IMAGING; GENETIC TRANSCRIPTION; MOUSE; MOUSE MODEL; NONHUMAN; PAIN; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; DRUG SCREENING; FLUORESCENCE; METABOLISM; PATHOLOGY;

ANIMALS; CYCLOOXYGENASE 2; DINOPROSTONE; DRUG EVALUATION, PRECLINICAL; ENDOMETRIOSIS; ENDOMETRIUM; FEMALE; FLUORESCENCE; MENSTRUATION-INDUCING AGENTS; MICE; MICE, INBRED C57BL; MIFEPRISTONE; RNA, MESSENGER;

EID: 84873421714     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-012-2379-2     Document Type: Article

References (22)

1. Lampe L (2009) Endometriosis. Orv Hetil 150(6):245-250
2. Song JY, Peter R, Robert M, Frank M, Ian SF (1996) Uterus and endometrium: effect of high dose progestogens on white cells and necrosis in human endometrium. Hum Reprod 11(8):1713-1718
3. Benagiano G, Bastianelli C, Farris M (2008) Selective progesterone receptor modulators 2: use in reproductive medicine. Expert Opin Pharmacother 9(14):2473-2485
4. Kettel LM, Murphy AA, Morales AJ, Ulmann A, Baulieu EE, Yen SS (1996) Treatment of endometriosis with the antiprogesterone mifepristone (RU486). Fertil Steril 65(1):23-28
5. Baird DT, Brown A, Critchleym HOD, Williams AR, Lin S, Cheng L (2003) Effect of long-term treatment with low-dose mifepristone on the endometrium. Hum Reprod 18(1):61-68
6. Jiang J, Wu RF, Wang ZH, Sun HC, Xu Z, Xiu HM (2002) Effect of mifepristone on estrogen and progesterone receptors in human endometrial and endometriotic cells in vitro. Fertil Steril 77(5):995-1000
7. Hirata T, Osuga Y, Yoshino O, Hirota Y, Harada M, Takemura Y, Morimoto C, Koga K, Yano T, Tsutsumi O, Taketani Y (2005) Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent protein. Hum Reprod 20(8):2092-2096
8. Ota H, Igarashi S, Sasaki M, Tanaka T (2001) Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod 16(3):561-566
9. Wu MH, Wang CA, Lin CC, Chen LC, Chang WC, Tsai SJ (2005) Distinct regulation of cyclooxygenase-2 by interleukin-1beta in normal and endometriotic stromal cells. J Clin Endocrinol Metab 90(1):286-295
10. Tamura M, Deb S, Sebastian S, Okamura K, Bulun SE (2004) Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells. Fertil Steril 81(5):1351-1356
11. Li J, Lu Y, Ma D (2002) Cyclooxyenase-2 expression in endometrium carcinoma. Zhonghua Fu Chan Ke Za Zhi 37(7):408-410
12. Chishima F, Hayakawa S, Sugita K, Kinukawa N, Aleemuzzaman S, Nemoto N, Yamamoto T, Honda M (2002) Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients. Am J Reprod Immunol 48(1):50-56
13. Chishima F, Hayakawa S, Hirata Y, Nagai N, Kanaeda T, Tsubata K, Satoh K (2000) Peritoneal and peripheral B-1-cell populations in patients with endometriosis. J Obstet Gynaecol Res 26(2):141-149
14. Attar E, Bulun SE (2006) Aromatase and other steroidogenic genes in endometriosis: translational aspects. Hum Reprod Update 12(1):49-56
15. Bulun SE, Zeitoun KM, Takayama K, Sasano H (2000) Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance. J Mol Endocrinol 25(1):35-42
16. Zeitoun K, Takayama K, Sasano H, Suzuki T, Moghrabi N, Andersson S, Johns A, Meng L, Putman M, Carr B, Bulun SE (1998) Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol. J Clin Endocrinol Metab 83(12):4474-4480
17. Osteen KG, Bruner KL, Sharpe-Timms KL (1996) Steroid and growth factor regulation of matrix metalloproteinase expression and endometriosis. Semin Reprod Endocrinol 14(3):247-255
18. Dassen H, Punyadeera C, Kamps R, Delvoux B, Van Langendonckt A, Donnez J, Husen B, Thole H, Dunselman G, Groothuis P (2007) Estrogen metabolizing enzymes in endometrium and endometriosis. Hum Reprod 22(12):3148-3158
19. Wu Y, Guo SW (2006) Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780. Gynecol Obstet Invest 62(4):193-205
20. Mei L, Bao J, Tang L, Zhang C, Wang H, Sun L, Ma G, Huang L, Yang J, Zhang L, Liu K, Song C, Sun H (2010) A novel mifepristone-loaded implant for long-term treatment of endometriosis: in vitro and in vivo studies. Eur J Pharm Sci 39(5):421-427
21. Guo SW, Liu M, Shen F, Liu X (2011) Use of mifepristone to treat endometriosis: a review of clinical trials and trial-like studies conducted in China. Women Health (Lond Engl) 7(1):51-70
22. Kettel LM, Murphy AA, Morales AJ, Yen SS (1998) Preliminary report on the treatment of endometriosis with low-dose mifepristone (RU 486). Am J Obstet Gynecol 178(6):1151-1156