Fatty liver is a good indicator of subclinical atherosclerosis risk in obese children and adolescents regardless of liver enzyme elevation

Acta Paediatrica, International Journal of Paediatrics

Volumn 102, Issue 3, 2013, Pages

  Akin, Leyla ^a   Kurtoglu, Selim ^a   Yikilmaz, Ali ^a   Kendirci, Mustafa ^a   Elmali, Ferhan ^a   Mazicioglu, Mümtaz ^a  

^a ERCIYES UNIVERSITY   (Turkey)

Author keywords

Carotid intima media thickness; Children and adolescents; Elevated liver enzymes; Nonalcoholic fatty liver disease; Subclinical atherosclerosis

Indexed keywords

AMINOTRANSFERASE; GLUCOSE; LIPID; LIVER ENZYME;

ADOLESCENT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CHILD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SUBCLINICAL ATHEROSCLEROSIS;

ADOLESCENT; AGE FACTORS; ALANINE TRANSAMINASE; ASPARTATE AMINOTRANSFERASES; ATHEROSCLEROSIS; BODY MASS INDEX; CAROTID INTIMA-MEDIA THICKNESS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FATTY LIVER; FEMALE; HUMANS; LIVER FUNCTION TESTS; MALE; OBESITY; RISK FACTORS;

EID: 84873412907     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/apa.12099     Document Type: Article

References (31)

1. Vajro P, Lenta S, Socha P, Dhawan A, McKiernan P, Baumann U, et al. Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr 2012; 54: 700-13.
2. Loomba R, Sirlin CB, Schwimmer JB, Lavine JE,. Advances in pediatric nonalcoholic fatty liver disease. Hepatology 2009; 50: 1282-93.
3. Pacifico L, Cantisani V, Ricci P, Osborn JF, Schiavo E, Anania C, et al. Non-alcoholic fatty liver disease and carotid atherosclerosis in children. Pediatr Res 2008; 63: 423-7.
4. Meyer AA, Kundt G, Lenschow U, Schuff-Werner P, Kienast W,. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise program. J Am Coll Cardiol 2006; 48: 1865-70.
5. Volzke H, Robinson DM, Kleine V, Deutscher R, Hoffmann W, Ludemann J, et al. Hepatic steatosis is associated with an increased risk of carotid atherosclerosis. World J Gastroenterol 2005; 11: 1848-53.
6. Brea A, Mosquera D, Martin E, Arizti A, Cordero JL, Ros E,. Nonalcoholic fatty liver disease is associated with carotid atherosclerosis: a case control study. Arterioscler Thromb Vasc Biol 2005; 25: 1045-50.
7. Demircioglu F, Kocyigit A, Arslan N, Akmakci H, Hizli S, Sedat AT,. Intima-media thickness of carotid artery and susceptibility to atherosclerosis in obese children with non-alcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2008; 47: 68-75.
8. Manco M, Bedogni G, Monti L, Morino G, Natali G, Nobili V,. Intima-media thickness and liver histology in obese children and adolescents with non-alcoholic fatty liver disease. Atherosclerosis 2010; 209: 463-8.
9. Pacifico L, Anania C, Martino F, Cantisani V, Pascone R, Marcantonio A, et al. Functional and morphological vascular changes in pediatric nonalcoholic fatty liver disease. Hepatology 2010; 52: 1643-51.
10. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 2000; 85: 2402-10.
11. Matsuda M, DeFronzo RA,. Insulin sensitivity indices obtained from oral glucose tolerance testing. Comparison with the euglycemic insulin clamp. Diabetes Care 1999; 22: 1462-70.
12. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C,. Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 2005; 115: 500-3.
13. Pesce MA,. Reference ranges for laboratory tests and procedures. In:, Behrman K, Stanton J, editors. Nelson textbook of pediatrics. 18th ed. Philadelphia: Saunders, 2007.
14. Goran MI, Gower BA,. Longitudinal study on pubertal insulin resistance. Diabetes 2001; 50: 2444-50.
15. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R,. Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986; 74: 1399-406.
16. Celermajer DS, Sorensen KE, Gooch VM, Gooch VM, Spiegelhalter DJ, Miller OI, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5.
17. Jarvisalo MJ, Jartti L, Nanto-Salonen K, Irjala K, Rönnemaa T, Hartiala JJ, et al. Increased aortic intima-media thickness a marker of preclinical atherosclerosis in high-risk children. Circulation 2001; 104: 2943-7.
18. De Groot E, Hovingh GK, Wiegman A, Duriez P, Smit AJ, Fruchart JC, et al. Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation 2004; 109: 1133-8.
19. Atabek ME, Pirgon O, Kivrak AS,. Evidence for association between insulin resistance and premature carotid atherosclerosis in childhood obesity. Pediatr Res 2007; 61: 345-9.
20. Kelishadi R, Cook SR, Amra B, Adibi A,. Factors associated with insulin resistance and non-alcoholic fatty liver disease among youths. Atherosclerosis 2009; 204: 538-43.
21. Targher G, Bertolini L, Padovani R, Poli F, Scala L, Zenari L, et al. Non-alcoholic fatty liver disease is associated with carotid artery wall thickness in diet-controlled type 2 diabetic patients. J Endocrinol Invest 2006; 29: 55-60.
22. Fraser A, Longnecker MP, Lawlor DA,. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 2007; 133: 1814-20.
23. Manco M, Marcellini M, DeVito R, Comparcola D, Sartorelli MR, Nobili V,. Metabolic syndrome and liver histology in paediatric non-alcoholic steatohepatitis. Int J Obes 2008; 32: 381-7.
24. Patton HM, Sirlin C, Behling C, Middleton M, Schwimmer JB, Lavine JE,. Pediatric nonalcoholic fatty liver disease: a critical appraisal of current data and implications for future research. J Pediatr Gastroenterol Nutr 2006; 43: 413-27.
25. Guzzaloni G, Grugni G, Minocci A, Moro D, Morabito F,. Liver steatosis in juvenile obesity: correlations with lipid profile, hepatic biochemical parameters and glycemic and insulinemic responses to an oral glucose tolerance test. Int J Obes Relat Metab Disord 2000; 24: 772-6.
26. Chan DF, Li AM, Chu WC, Chan MH, Wong EM, Liu EK, et al. Hepatic steatosis in obese Chinese children. Int J Obes Relat Metab Disord 2004; 28: 1257-63.
27. Sagi R, Reif S, Neuman G, Webb M, Phillip M, Shalitin S,. Nonalcoholic fatty liver disease in overweight children and adolescents. Acta Paediatr 2007; 96: 1209-13.
28. Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE,. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics 2005; 115: 561-5.
29. Fracanzani AL, Burdick L, Raselli S, Pedotti P, Grigore L, Santorelli G, et al. Carotid artery intima-media thickness in nonalcoholic fatty liver disease. Am J Med 2008; 121: 72-8.
30. Gilmore IT, Burroughs A, Murray-Lyon IM, Williams R, Jenkins D, Hopkins A,. Indications, methods, and outcomes of percutaneous liver biopsy in England and Wales: an audit by the British Society of Gastroenterology and the Royal College of Physicians of London. Gut 1995; 36: 437-41.
31. Schwimmer JB,. Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Semin Liver Dis 2007; 27: 312-8.