Inducibility of atrial fibrillation after GP ablations and "autonomic blockade": Evidence for the pathophysiological role of the nonadrenergic and noncholinergic neurotransmitters

Journal of Cardiovascular Electrophysiology

Volumn 24, Issue 2, 2013, Pages 188-195

  Liu, Yu ^a   Scherlag, Benjamin J ^a   Fan, Youqi ^a   Varma, Vandana ^a   Male, Shailesh ^a   Chaudhry, Muhammad A ^b   Huang, Congxin ^a   Po, Sunny S ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

atrial fibrillation; autonomic nervous system; ganglionic plexus; neurotransmittors; sympathetic nervous system; vagus

Indexed keywords

NEUROTRANSMITTER;

ABLATION THERAPY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; EXPERIMENTAL DOG; GANGLIONATED PLEXI ABLATION; HEART ATRIUM FIBRILLATION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE REFRACTORY PERIOD; NONHUMAN; PRIORITY JOURNAL; VAGUS NERVE STIMULATION; WINDOW OF VULNERABILITY;

ADRENERGIC NEURONS; ANIMALS; ATRIAL FIBRILLATION; AUTONOMIC NERVOUS SYSTEM; CHOLINERGIC NEURONS; DOGS; GANGLION CYSTS; HEART CONDUCTION SYSTEM; NERVE NET; NEUROTRANSMITTER AGENTS;

EID: 84873409725     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2012.02449.x     Document Type: Article

References (36)

1. Scherlag BJ, Yamanashi W, Patel U, Lazzara R, Jackman WM,: Autonomically induced conversion of pulmonary vein focal firing into atrial fibrillation. J Am Coll Cardiol 2005; 45: 1878-1886.
2. Po SS, Scherlag BJ, Yamanashi WS, Edwards J, Zhou J, Wu R, Geng N, Lazzara R, Jackman WM,: Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm 2006; 3: 201-208.
3. Patterson E, Po SS, Scherlag BJ, Lazzara R,: Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm 2005; 2: 624-631.
4. Lemola K, Chartier D, Yeh YH, Dubuc M, Cartier R, Armour A, Ting M, Sakabe M, Shiroshita-Takeshita A, Comtois P, Nattel S,: Pulmonary vein region ablation in experimental vagal atrial fibrillation: Role of pulmonary veins versus autonomic ganglia. Circulation 2008; 117: 470-477.
5. Lu Z, Scherlag BJ, Lin J, Niu G, Fung KM, Zhao L, Ghias M, Jackman WM, Lazzara R, Jiang H, Po SS,: Atrial fibrillation begets atrial fibrillation: Autonomic mechanism for atrial electrical remodeling induced by short-term rapid atrial pacing. Circ Arrhythm Electrophysiol 2008; 1: 184-1892.
6. Niu G, Scherlag BJ, Lu Z, Ghias M, Zhang Y, Patterson E, Dasari TW, Zacharias S, Lazzara R, Jackman WM, Po SS,: An acute experimental model demonstrating 2 different forms of sustained atrial tachyarrhythmias. Circ Arrhythm Electrophysiol 2009; 2: 384-392.
7. Scherlag BJ, Nakagawa H, Jackman WM, Yamanashi WS, Patterson E, Po S, Lazzara R,: Electrical stimulation to identify neural elements on the heart: Their role in atrial fibrillation. J Interv Card Electrophysiol 2005; 13 (Suppl 1): 37-42.
8. Pappone C, Santinelli V, Manguso F, Vicedomini G, Gugliotta F, Augello G, Mazzone P, Tortoriello V, Landoni G, Zangrillo A, Lang C, Tomita T, Mesas C, Mastella E, Alfieri O,: Pulmonary vein denervation enhances long-term benefit after circumferential ablation for paroxysmal atrial fibrillation. Circulation 2004; 109: 327-334.
9. Lemery R, Birnie D, Tang AS, Green M, Gollob M,: Feasibility study of endocardial mapping of ganglionated plexuses during catheter ablation of atrial fibrillation. Heart Rhythm 2006; 3: 387-396.
10. Po SS, Nakagawa H, Jackman WM,: Localization of left atrial ganglionated plexi in patients with atrial fibrillation. J Cardiovasc Electrophysiol 2009; 20: 1186-1189.
11. Pokushalov E, Turov A, Shugayev P, Artyomenko S, Romanov A, Shirokova N,: Catheter ablation of left atrial ganglionated plexi for atrial fibrillation. Asian Cardiovasc Thorac Ann 2008; 16: 194-201.
12. Yuan BX, Ardell JL, Hopkins DA, Losier AM, Armour JA,: Gross and microscopic anatomy of the canine intrinsic cardiac nervous system. Anat Rec 1994; 239: 75-87.
13. Armour JA, Murphy DA, Yuan BX, Macdonald S, Hopkins DA,: Gross and microscopic anatomy of the human intrinsic cardiac nervous system. Anat Rec 1997; 247: 289-298.
14. Pauza DH, Skripka V, Pauziene N, Stropus R,: Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart. Anat Rec 2000; 259: 353-382.
15. Scherlag BJ, Hou YL, Lin J, Lu Z, Zacharias S, Dasari T, Niu G, Ghias M, Patterson E, Jackman WM, Lazzara R, Po SS,: An acute model for atrial fibrillation arising from a peripheral atrial site: Evidence for primary and secondary triggers. J Cardiovasc Electrophysiol 2008; 19: 519-527.
16. Nademanee K, McKenzie J, Kosar E, Schwab M, Sunsaneewitayakul B, Vasavakul T, Khunnawat C, Ngarmukos T,: A new approach for catheter ablation of atrial fibrillation: Mapping of the electrophysiologic substrate. J Am Coll Cardiol 2004; 43: 2044-2053.
17. Haïssaguerre M, Wright M, Hocini M, Jaïs P,: The substrate maintaining persistent atrial fibrillation. Circ Arrhythm Electrophysiol 2008; 1: 2-5.
18. Habel N, Müller JG, Znojkiewicz P, Thompson N, Calame J, Calame S, Noori A, Gallo A, Lustgarten DL, Sobel BE, Spector PS,: The impact of pharmacologic sympathetic and parasympathetic blockade on atrial electrogram characteristics in patients with atrial fibrillation. Pacing Clin Electrophysiol 2011; 34: 1460-1467.
19. Knecht S, Wright M, Matsuo S, Nault I, Lellouche N, Sacher F, Kim SJ, Morgan D, Afonso V, Shinzuke M, Hocini M, Clémenty J, Narayan SM, Ritter P, Jaïs P, Haïssaguerre M,: Impact of pharmacological autonomic blockade on complex fractionated atrial electrograms. J Cardiovasc Electrophysiol 2010; 21: 766-772.
20. Hill MR, Wallick DW, Mongeon LR, Martin PJ, Levy MN,: Vasoactive intestinal polypeptide antagonists attenuate vagally induced tachycardia in the anesthetized dog. Am J Physiol 1995; 269: H1467-H1472.
21. Singh S, Johnson PI, Javed A, Gray TS, Lonchyna VA, Wurster RD,: Monoamine- and histamine-synthesizing enzymes and neurotransmitters within neurons of adult human cardiac ganglia. Circulation 1999; 99: 411-419.
22. Hoover DB, Isaacs ER, Jacques F, Hoard JL, Pagé P, Armour JA,: Localization of multiple neurotransmitters in surgically derived specimens of human atrial ganglia. Neuroscience 2009; 164: 1170-1179.
23. Tan AY, Li H, Wachsmann-Hogiu S, Chen LS, Chen PS, Fishbein MC,: Autonomic innervation and segmental muscular disconnections at the human pulmonary vein-atrial junction: Implications for catheter ablation of atrial-pulmonary vein junction. J Am Coll Cardiol 2006; 48: 132-143.
24. Steele PA, Gibbins IL, Morris JL, Mayer B,: Multiple populations of neuropeptide-containing intrinsic neurons in the guinea pig heart. Neuroscience 1994; 62: 241-250.
25. Henning RJ, Sawmiller DR,: Vasoactive intestinal peptide: Cardiovascular effects. Cardiovasc Res 2001; 49: 27-37.
26. Yu L, Scherlag BJ, Li S, Sheng X, Lu Z, Nakagawa H, Zhang Y, Jackman WM, Lazzara R, Jiang H, Po SS,: Low-level vagosympathetic nerve stimulation inhibits atrial fibrillation inducibility: Direct evidence by neural recordings from intrinsic cardiac ganglia. J Cardiovasc Electrophysiol 2011; 22: 455-463.
27. Yu L, Scherlag BJ, Sha Y, Li S, Sharma T, Nakagawa H, Jackman WM, Lazzara R, Jiang H, Po SS,: Interactions between atrial electrical remodeling and autonomic remodeling: How to break the vicious cycle. Heart Rhythm 2012; 9: 804-809.
28. Takahashi Y, Jaïs P, Hocini M, Sanders P, Rotter M, Rostock T, Hsu LF, Sacher F, Clémenty J, Haïssaguerre M,: Shortening of fibrillatory cycle length in the pulmonary vein during vagal excitation. J Am Coll Cardiol 2006; 47: 774-780.
29. Scherlag BJ, Nakagawa H, Jackman WM, Lazzara R, Po SS,: Non-pharmacological, non-ablative approaches for the treatment of atrial fibrillation: Experimental evidence and potential clinical implications. J Cardiovasc Transl Res 2011; 4: 35-41.
30. Yang D, Xi Y, Ai T, Wu G, Sun J, Razavi M, Delapasse S, Shurail M, Gao L, Mathuria N, Elayda M, Cheng J,: Vagal stimulation promotes atrial electrical remodeling induced by rapid atrial pacing in dogs: Evidence of a noncholinergic effect. Pacing Clin Electrophysiol 2011; 34: 1092-1099.
31. Zhou J, Scherlag BJ, Edwards J, Jackman WM, Lazzara R, Po SS,: Gradients of atrial refractoriness and inducibility of atrial fibrillation due to stimulation of ganglionated plexi. J Cardiovasc Electrophysiol 2007; 18: 83-90.
32. Zhang Y, Scherlag BJ, Lu Z, Niu GD, Yamanashi WS, Hogan C, Fields J, Ghias M, Lazzara R, Jackman WM, Po S,: Comparison of atrial fibrillation inducibility by electrical stimulation of either the extrinsic or the intrinsic autonomic nervous systems. J Interv Card Electrophysiol 2009; 24: 5-10.
33. Doshi RN, Wu TJ, Yashima M, Kim YH, Ong JJ, Cao JM, Hwang C, Yashar P, Fishbein MC, Karagueuzian HS, Chen PS,: Relation between ligament of Marshall and adrenergic atrial tachyarrhythmia. Circulation 1999; 100: 876-83.
34. Lin J, Scherlag BJ, Lu Z, Zhang Y, Liu S, Patterson E, Jackman WM, Lazzara R, Po SS,: Inducibility of atrial and ventricular arrhythmias along the ligament of marshall: Role of autonomic factors. J Cardiovasc Electrophysiol 2008; 19: 955-962.
35. Lu Z, Scherlag BJ, Niu G, Lin J, Fung KM, Zhao L, Yu L, Jackman WM, Lazzara R, Jiang H, Po SS,: Functional properties of the superior vena cava (SVC)-aorta ganglionated plexus: Evidence suggesting an autonomic basis for rapid SVC firing. J Cardiovasc Electrophysiol 2010; 21: 1392-1399.
36. Stavrakis S, Scherlag BJ, Fan Y, Liu Y, Liu Q, Mao J, Cai H, Lazzara R, Po SS,: Antiarrhythmic effects of vasostatin-1 in a canine model of atrial fibrillation. J Cardiovasc Electrophysiol 2012; 23: 771-777.