A link between glial Ca2+ signaling and hypoxia in aging?

Journal of Cerebral Blood Flow and Metabolism

Volumn 33, Issue 2, 2013, Pages 170-

  Iliff, Jeffrey J ^a   Nedergaard, Maiken ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; PURINERGIC RECEPTOR; CALCIUM; OXYGEN;

AGING; BLOOD FLOW; BREATHING; DEPOLARIZATION; EXCITATION; GLIA CELL; HOMEOSTASIS; HUMAN; HYPOXIA; NEUROMODULATION; NONHUMAN; NOTE; OXYGEN TISSUE LEVEL; PH; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION; ANIMAL; BRAIN HYPOXIA; CALCIUM SIGNALING; GLIA; IMMUNOLOGY; METABOLISM; PURKINJE CELL;

AGING; ANIMALS; CALCIUM; CALCIUM SIGNALING; HYPOXIA, BRAIN; NEUROGLIA; OXYGEN; PURKINJE CELLS;

MLCS; MLOWN;

EID: 84873409208     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2012.182     Document Type: Note

References (10)

1. Nedergaard M, Verkhratsky A. Artifact versus reality-how astrocytes contribute to synaptic events. Glia 2012; 60: 1013-1023.
2. Gourine AV, Kasymov V, Marina N, Tang F, Figueiredo MF, Lane S et al. Astrocytes control breathing through pH-dependent release of ATP. Science 2010; 329: 571-575.
3. Hoogland TM, Kuhn B, Gobel W, Huang W, Nakai J, Helmchen F et al. Radially expanding transglial calcium waves in the intact cerebellum. Proc Natl Acad Sci Usa 2009; 106: 3496-3501.
4. Nimmerjahn A, Mukamel EA, Schnitzer MJ. Motor behavior activates Bergmann glial networks. Neuron 2009; 62: 400-412.
5. Mathiesen C, Brazhe A, Thomsen K, Lauritzen M. Spontaneous calcium waves in Bergman glia increase with age and hypoxia and may reduce tissue oxygen. J Cereb Blood Flow Metab 2013; 33: 161-169 (this issue).
6. Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X et al. Astrocyte-mediated control of cerebral blood flow. Nat Neurosci 2006; 9: 260-267.
7. Wang F, Xu Q, Wang W, Takano T, Nedergaard M. Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2 +-dependent K + uptake. Proc Natl Acad Sci Usa 2012; 109: 7911-7916.
8. Schummers J, Yu H, Sur M. Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex. Science 2008; 320: 1638-1643.
9. Thrane AS, Rangroo Thrane V, Zeppenfeld D, Lou N, Xu Q, Nagelhus EA et al. General anesthesia selectively disrupts astrocyte calcium signaling in the awake mouse cortex. PNAS 2012; 109: 18974-18979.
10. Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat Neurosci 2007; 10: 1369-1376.