Access to opioid analgesics and pain relief for patients with cancer

Nature Reviews Clinical Oncology

Volumn 10, Issue 2, 2013, Pages 108-116

  Dalal, Shalini ^a   Bruera, Eduardo ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CODEINE; FENTANYL; HYDROCODONE; MORPHINE; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; STEROID;

ANALGESIA; ATTITUDE TO HEALTH; AVASCULAR NECROSIS; AWARENESS; BONE DISEASE; CANCER CONTROL; CANCER PAIN; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CLINICAL FEATURE; COMPRESSION FRACTURE; DISEASE CLASSIFICATION; DRUG COST; DRUG EFFICACY; DRUG SAFETY; DRUG USE; DRUG UTILIZATION; HEALTH CARE AVAILABILITY; HEALTH CARE POLICY; HEALTH EDUCATION; HUMAN; NEUROPATHIC PAIN; NOCICEPTIVE PAIN; PAIN ASSESSMENT; PATIENT COMPLIANCE; PERIPHERAL NEUROPATHY; POSTOPERATIVE PAIN; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUALITY OF LIFE; RAYNAUD PHENOMENON; REVIEW; SPINE FRACTURE; TREATMENT OUTCOME; VISCERAL PAIN;

ANALGESICS, OPIOID; HEALTH SERVICES ACCESSIBILITY; HUMANS; NEOPLASMS; PAIN; PAIN MANAGEMENT; PALLIATIVE CARE;

EID: 84873407786     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2012.237     Document Type: Review

References (108)

1. Agency for Health Care Policy and Research, Acute Pain Management Panel. Acute pain management: Operative or medical procedures and trauma. Clinical Practice Guideline. (US Department of Health and Human Services, Washington DC, 1992).
2. Fortner, B. V. et al. Description and predictors of direct and indirect costs of pain reported by cancer patients. J. Pain Symptom Manage. 25, 9-18 (2003).
3. Mystakidou, K., Parpa, E., Katsouda, E., Galanos, A. & Vlahos, L. Pain and desire for hastened death in terminally ill cancer patients. Cancer Nurs. 28, 318-324 (2005).
4. O'Mahony, S. et al. Desire for hastened death, cancer pain and depression: report of a longitudinal observational study. J. Pain Symptom Manage. 29, 446-457 (2005).
5. Goudas, L. C., Bloch, R., Gialeli-Goudas, M., Lau, J. & Carr, D. B. The epidemiology of cancer pain. Cancer Invest. 23, 182-190 (2005).
6. Vuorinen, E. Pain as an early symptom in cancer. Clin. J. Pain 9, 272-278 (1993).
7. Ger, L. P., Ho, S. T., Wang, J. J. & Cherng, C. H. The prevalence and severity of cancer pain: a study of newly-diagnosed cancer patients in Taiwan. J. Pain Symptom Manage. 15, 285-293 (1998).
8. Daut, R. L. & Cleeland, C. S. The prevalence and severity of pain in cancer. Cancer 50, 1913-1918 (1982).
9. van den Beuken-van Everdingen, M. H. et al. Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann. Oncol. 18, 1437-1449 (2007).
10. International Agency for Research on Cancer. GLOBOCAN 2008: Cancer Incidence and Mortality Worldwide [online], http://www.iarc.fr/en/media-centre/ iarcnews/2010/globocan2008.php (2010).
11. WHO. Burden: mortality, morbidity and risk factors [online], http://www.who.int/nmh/publications/ncd-report-chapter1.pdf (2012).
12. van den Beuken-van Everdingen, M. H. et al. High prevalence of pain in patients with cancer in a large population-based study in The Netherlands. Pain 132, 312-320 (2007).
13. Apolone, G. et al. Pattern and quality of care of cancer pain management. Results from the Cancer Pain Outcome Research Study Group. Br. J. Cancer 100, 1566-1574 (2009).
14. WHO. WHO guidelines for cancer pain and palliative care reach health workers in 31 languages [online], http://www.whocancerpain.wisc.edu/?q=node/130 (2010).
15. Seya, M. J., Gelders, S. F., Achara, O. U., Milani, B. & Scholten, W. K. A first comparison between the consumption of and the need for opioid analgesics at country, regional, and global levels. J. Pain Palliat. Care Pharmacother. 25, 6-18 (2011).
16. WHO. Access to Controlled Medications Programme: briefing note. World Health Organization [online], http://www.who.int/medicines/areas/quality-safety/ access-to-controlled-medications-brnote-english.pdf (2007).
17. Worldwide Palliative Care Alliance. Mapping levels of palliative care development: a global update [online], http://www.thewpca.org/EasySiteWeb/ GatewayLink.aspx?alId=89788 (2011).
18. Foley, K. M. in Advances in Pain Research and Therapy Vol. 2 (eds Bonica, J. J. & Ventafridda, V.) 59-75 (Raven Press, New York, 1979).
19. Cleeland, C. S. et al. Pain and its treatment in outpatients with metastatic cancer. N. Engl. J. Med. 330, 592-596 (1994).
20. Ripamonti, C. et al. Pain experienced by patients hospitalized at the National Cancer Institute of Milan: research project "towards a pain-free hospital". Tumori 86, 412-418 (2000).
21. Beck, S. L. & Falkson, G. Prevalence and management of cancer pain in South Africa. Pain 94, 75-84 (2001).
22. Yun, Y. H. et al. Multicenter study of pain and its management in patients with advanced cancer in Korea. J. Pain Symptom Manage. 25, 430-437 (2003).
23. Deandrea, S., Montanari, M., Moja, L. & Apolone, G. Prevalence of undertreatment in cancer pain. A review of published literature. Ann. Oncol. 19, 1985-1991 (2008).
24. Grond, S., Zech, D., Diefenbach, C., Radbruch, L. & Lehmann, K. A. Assessment of cancer pain: a prospective evaluation in 2266 cancer patients referred to a pain service. Pain 64, 107-114 (1996).
25. Turk, D. C., Monarch, E. S., & Williams, A. D. Cancer patients in pain: considerations for assessing the whole person. Hematol. Oncol. Clin. North Am. 16, 511-525 (2002).
26. Ahles, T. A., Blanchard, E. B. & Ruckdeschel, J. C. The multidimensional nature of cancer-related pain. Pain 17, 277-288 (1983).
27. Bruera, E. & Kim, H. N. Cancer pain. JAMA 290, 2476-2479 (2003).
28. Portenoy, R. K. Treatment of cancer pain. Lancet 377, 2236-2247 (2011).
29. McGuire, D. B. in Cancer Pain Management (eds McGuire, D. B. & Yarbro, C. H.) 1-20 (Saunders, Philadelphia, 1987).
30. Mystakidou, K. et al. The relationship of subjective sleep quality, pain, and quality of life in advanced cancer patients. Sleep 30, 737-742 (2007).
31. Black, B. et al. The relationships among pain, nonpain symptoms, and quality of life measures in older adults with cancer receiving hospice care. Pain Med. 12, 880-889 (2011).
32. Paice, J. A. Assessment of symptom clusters in people with cancer. J. Natl Cancer Inst. Monogr. 98-102 (2004).
33. Anderson, K. O. et al. Minority cancer patients and their providers: pain management attitudes and practice. Cancer 88, 1929-1938 (2000).
34. Sloan, P. A., Donnelly, M. B., Schwartz, R. W. & Sloan, D. A. Cancer pain assessment and management by housestaff. Pain 67, 475-481 (1996).
35. Sloan, P. A., Vanderveer, B. L., Snapp, J. S., Johnson, M. & Sloan, D. A. Cancer pain assessment and management recommendations by hospice nurses. University of Kentucky, Lexington, Kentucky. J. Pain Symptom Manage. 18, 103-110 (1999).
36. Caraceni, A. et al. Pain measurement tools and methods in clinical research in palliative care: recommendations of an Expert Working Group of the European Association of Palliative Care. J. Pain Symptom Manage. 23, 239-255 (2002).
37. WHO. National cancer control programmes: policies and managerial guidelines 2nd edn (WHO, Geneva, 2002).
38. WHO & International Union Against Cancer. Global Action Against Cancer Now! (WHO, Geneva, 2005).
39. WHO. Cancer control: Knowledge into action. Palliative care (WHO, Geneva, 2007).
40. WHO. WHO Model Lists of Essential Medicines 15th edn (WHO, Geneva, 2007).
41. WHO. Cancer Pain Relief (WHO, Geneva, 1986).
42. WHO. Cancer pain relief: with a guide to opioid availability 2nd edn (WHO, Geneva, 1996).
43. Hanks, G. W. et al. Morphine and alternative opioids in cancer pain: the EAPC recommendations. Br. J. Cancer 84, 587-593 (2001).
44. Jacox, A. et al. Management of Cancer Pain. Clinical Practice Guideline No. 9 AHCPR Pub. No. 94-0592 (Agency for Health Care and Research, US Department of Health and Human Services, Public Health Service, Rockville, 1994).
45. Gordon, D. B. et al. American Pain Society recommendations for improving the quality of acute and cancer pain management: American Pain Society Quality of Care Task Force. Arch. Intern. Med. 165, 1574-1580 (2005).
46. National Comprehensive Cancer Network. AdultCancer Pain [online], http://www.nccn.org/professionals/physician-gls/PDF/pain.pdf (2012).
47. Ventafridda, V., Tamburini, M., Caraceni, A., De Conno, F. & Naldi, F. A validation study of the WHO method for cancer pain relief. Cancer 59, 850-856 (1987).
48. Zech, D. F., Grond, S., Lynch, J., Hertel, D. & Lehmann, K. A. Validation of World Health Organization Guidelines for cancer pain relief: a 10-year prospective study. Pain 63, 65-76 (1995).
49. International Narcotics Control Board. Report of the International Narcotics Control Board on Follow-up to the Twentieth Special Session of the General Assembly (UN, Vienna, 2009).
50. International Narcotics Control Board. Availability of opiates for medical needs (UN, New York, 1996).
51. UN. Single Convention on Narcotic Drugs, 1961 [online], http://www.unodc.org/unodc/en/treaties/single-convention.html (2012).
52. University of Wisconsin Pain & Policy Studies Group. Do international model drug control laws provide for drug availability? J. Pain Palliat. Care Pharmacother. 23, 145-152 (2009).
53. Gilson, A. M. et al. Ensuring patient access to essential medicines while minimizing harmful use: a revised World Health Organization tool to improve national drug control policy. J. Pain Palliat. Care Pharmacother. 25, 246-251 (2011).
54. Joranson, D. E., Ryan, K. M. & Maurer, M. A. in Bonica's Management of Pain 4th edn (eds Fishman, S. M., Ballantyne, J. C. & Rathmell, J. P.) 194-208 (Lippincott Williams & Wilkins, Baltimore, 2010).
55. Lamas, D. & Rosenbaum, L. Painful inequities-palliative care in developing countries. N. Engl. J. Med. 366, 199-201 (2012).
56. De Lima, L. Opioid availability in Latin America as a global problem: a new strategy with regional and national effects. J. Palliat. Med. 7, 97-103 (2004).
57. International Narcotics Control Board. Report of the International Narcotics Control Board on the Availability of Internationally Controlled Drugs: Ensuring Adequate Access for Medical and Scientific Purposes. United Nations, New York [online], http://www.unodc.org/documents/southerncone/noticias/2011/03- marco/Jife/Report-of-the-Board-on-the-availability-of-controlled-substances.pdf (2012).
58. International Narcotics Control Board. Narcotic Drugs: Estimated World Requirements for 2012-Statistics for 2010 [online], http://www.incb.org/ documents/Narcotic-Drugs/Technical-Publications/2011/Narcotic-Drugs-Report-2011. pdf (2012).
59. Sepúlveda, C., Marlin, A., Yoshida, T. & Ullrich, A. Palliative care: the World Health Organization's global perspective. J. Pain Symptom Manage. 24, 91-96 (2002).
60. Lynch, T., Connor, S. & Clark, D. Mapping levels of palliative care development: a global update. J. Pain Symptom Manage. http://dx.doi.org/10.1016/ j.jpainsymman.2012.05.011.
61. Webster, R., Lacey, J. & Quine, S. Palliative care: a public health priority in developing countries. J. Public Health Policy 28, 28-39 (2007).
62. Morrison, R. S., Augustin, R., Souvanna, P. & Meier, D. E. America's care of serious illness: a statebystate report card on access to palliative care in our nation's hospitals. J. Palliat. Med. 14, 1094-1096 (2011).
63. Hui, D. et al. Availability and integration of palliative care at US cancer centers. JAMA 303, 1054-1061 (2010).
64. Daugherty, C. K. Examining ethical dilemmas as obstacles to hospice and palliative care for advanced cancer patients. Cancer Invest. 22, 123-131 (2004).
65. Dalal, S. et al. Association between a name change from palliative to supportive care and the timing of patient referrals at a comprehensive cancer center. Oncologist 16, 105-111 (2011).
66. Johnson, C. E., Girgis, A., Paul, C. L. & Currow, D. C. Cancer specialists' palliative care referral practices and perceptions: results of a national survey. Palliat. Med. 22, 51-57 (2008).
67. Osta, B. E. et al. Interval between first palliative care consult and death in patients diagnosed with advanced cancer at a comprehensive cancer center. J. Palliat. Med. 11, 51-57 (2008).
68. Cheng, W. W., Willey, J., Palmer, J. L., Zhang, T. & Bruera, E. Interval between palliative care referral and death among patients treated at a comprehensive cancer center. J. Palliat. Med. 8, 1025-1032 (2005).
69. Stjernsward, J. et al. Jordan palliative care initiative: a WHO Demonstration Project. J. Pain Symptom Manage. 33, 628-633 (2007).
70. Rajagopal, M. R. & Joranson, D. E. India: opioid availability. An update. J. Pain Symptom Manage. 33, 615-622 (2007).
71. Joranson, D. E., Rajagopal, M. R. & Gilson, A. M. Improving access to opioid analgesics for palliative care in India. J. Pain Symptom Manage. 24, 152-159 (2002).
72. Livingstone, H. Pain relief in the developing world: the experience of hospice Africa-Uganda. J. Pain Palliat. Care Pharmacother. 17, 107-118 (2003).
73. Brennan, F., Carr, D. B. & Cousins, M. Pain management: a fundamental human right. Anesth. Analg. 105, 205-221 (2007).
74. De Lima, L., Sweeney, C., Palmer, J. L. & Bruera, E. Potent analgesics are more expensive for patients in developing countries: a comparative study. J. Pain Palliat. Care Pharmacother. 18, 59-70 (2004).
75. Paice, J. A., Toy, C. & Shott, S. Barriers to cancer pain relief: fear of tolerance and addiction. J. Pain Symptom Manage. 16, 1-9 (1998).
76. Oldenmenger, W. H., Sillevis Smitt, P. A., van Dooren, S., Stoter, G. & van der Rijt, C. C. A systematic review on barriers hindering adequate cancer pain management and interventions to reduce them: a critical appraisal. Eur. J. Cancer 45, 1370-1380 (2009).
77. Von Roenn, J. H., Cleeland, C. S., Gonin, R., Hatfield, A. K. & Pandya, K. J. Physician attitudes and practice in cancer pain management. A survey from the Eastern Cooperative Oncology Group. Ann. Intern. Med. 119, 121-126 (1993).
78. Pargeon, K. L. & Hailey, B. J. Barriers to effective cancer pain management: a review of the literature. J. Pain Symptom Manage. 18, 358-368 (1999).
79. Maltoni, M. Opioids, pain, and fear. Ann. Oncol. 19, 5-7 (2008).
80. Reid, C. M., Gooberman-Hill, R. & Hanks, G. W. Opioid analgesics for cancer pain: symptom control for the living or comfort for the dying? A qualitative study to investigate the factors influencing the decision to accept morphine for pain caused by cancer. Ann. Oncol. 19, 44-48 (2008).
81. Weissman, D. E., Joranson, D. E. & Hopwood, M. B. Wisconsin physicians' knowledge and attitudes about opioid analgesic regulations. Wis. Med. J. 90, 671-675 (1991).
82. Elliott, T. E. & Elliott, B. A. Physician attitudes and beliefs about use of morphine for cancer pain. J. Pain Symptom Manage. 7, 141-148 (1992).
83. Breuer, B., Fleishman, S. B., Cruciani, R. A. & Portenoy, R. K. Medical oncologists' attitudes and practice in cancer pain management: a national survey. J. Clin. Oncol. 29, 4769-4775 (2011).
84. Tierney, J. Trafficker or Healer? And Who's the Victim? New York Times (27 Mar 2007).
85. Fisher, W. POLITICS-US: Pain Drug Crackdown Hits "Nobodies" the Hardest [online], http://www.ipsnews.net/2006/05/politics-us-pain-drug- crackdown-hits-nobodies-the-hardest/ (2007).
86. Ward, S. E. et al. Patient-related barriers to management of cancer pain. Pain 52, 319-324 (1993).
87. Miaskowski, C. et al. Lack of adherence with the analgesic regimen: a significant barrier to effective cancer pain management. J. Clin. Oncol. 19, 4275-4279 (2001).
88. Oldenmenger, W. H. et al. Analgesic adherence measurement in cancer patients: comparison between electronic monitoring and diary. J. Pain Symptom Manage. 34, 639-647 (2007).
89. Boström, B., Sandh, M., Lundberg, D. & Fridlund, B. Cancer-related pain in palliative care: patients' perceptions of pain management. J. Adv. Nurs. 45, 410-419 (2004).
90. Yates, P. M. et al. Barriers to effective cancer pain management: a survey of hospitalized cancer patients in Australia. J. Pain Symptom Manage. 23, 393-405 (2002).
91. Saunders, C. in Scientific Foundations of Oncology (eds Symington, T. & Carter, R. L.) 673-679 (Heinemann, London, 1976).
92. Pain & Policy Studies Group. WHO Collaborating Center for Pain Policy and Palliative Care [online], http://www.painpolicy.wisc.edu/who-collaborating- center-pain-policy-and-palliative-care (2012).
93. WHO. Achieving balance in national opioids control policy: Guidelines for assessment (WHO, Geneva, 2000).
94. Blengini, C., Joranson, D. E. & Ryan, K. M. Italy reforms national policy for cancer pain relief and opioids. Eur. J. Cancer Care (Engl.) 12, 28-34 (2003).
95. Riley, J. & Ross, J. R. Reforming drug-control policy for palliative care in Romania. Lancet 367, 2040-2041 (2006).
96. Xu, J. Q., Kochanek, K. D., Murphy, S. L. & Tejada-Vera, B. Deaths: final data for 2007. Nat. Vital Stat. Rep. 58, 1-136 (2010).
97. Anderson, T. Cancer doctors pledge to widen access to pain relief in developing countries. BMJ 341, c4645 (2010).
98. Human Rights Watch. Unbearable pain: India's obligation to ensure palliative care (Human Rights Watch, New York, 2009).
99. Human Rights Watch. Needless pain: Government failure to provide palliative care for children in Kenya (Human Rights Watch, New York, 2010).
100. Human Rights Watch. Uncontrolled Pain: Ukraine's Obligation to Ensure Evidence-Based Palliative Care (Human Rights Watch, New York, 2011).
101. Human Rights Watch. "Please do not make us suffer any more..." Access To Treatment as a Human Right (Human Rights Watch, New York, 2009).
102. Cherny, N. I., Baselga, J., de Conno, F. & Radbruch, L. Formulary availability and regulatory barriers to accessibility of opioids for cancer pain in Europe: a report from the ESMO/EAPC Opioid Policy Initiative. Ann. Oncol. 21, 615-626 (2010).
103. Silbermann, M. et al. Palliative cancer care in Middle Eastern countries: accomplishments and challenges. Ann. Oncol. 23 (Suppl. 3), 15-28 (2012).
104. Dalal, S. & Bruera, E. Assessment and management of pain in the terminally ill. Prim. Care 38, 195-223 vii-viii (2011).
105. WHO. Cancer Pain Relief and Palliative Care: Report of a WHO Expert Committee (WHO, Geneva, 1990).
106. WHO. Cancer pain relief and palliative care in children (WHO, Geneva, 1998).
107. WHO. Symptom Relief in Terminal Illness (WHO, Geneva, 1998).
108. WHO. National cancer control programmes. Policies and managerial guidelines 2nd edn (WHO, Geneva, 2002).