Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement

Kidney International

Volumn 83, Issue 2, 2013, Pages 293-299

  Sethi, Sanjeev ^a   Fervenza, Fernando C ^a   Zhang, Yuzhou ^b   Zand, Ladan ^a   Meyer, Nicole C ^b   Borsa, Nicolò ^b   Nasr, Samih H ^a   Smith, Richard J H ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

alternative pathway of complement; C3 glomerulonephritis; membranoproliferative glomerulonephritis; persistent glomerulonephritis; postinfectious glomerulonephritis

Indexed keywords

ANGIOTENSIN II ANTAGONIST; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT MEMBRANE ATTACK COMPLEX; CORTICOSTEROID; CREATININE; CYCLOPHOSPHAMIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER;

ADOLESCENT; ADULT; AGED; ARTICLE; ATYPICAL POSTINFECTIOUS GLOMERULONEPHRITIS; CFH GENE; CFHR5 GENE; CLINICAL ARTICLE; CLINICAL EVALUATION; COMPLEMENT ALTERNATIVE PATHWAY; CREATININE BLOOD LEVEL; DIALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ELECTRON MICROSCOPY; FEMALE; GENE; GENE SEQUENCE; GENETIC VARIABILITY; GLOMERULONEPHRITIS; GLOMERULUS FILTRATION RATE; HEMATURIA; HUMAN; IMMUNOFLUORESCENCE MICROSCOPY; KIDNEY SCAR; MALE; MISSENSE MUTATION; MUTATIONAL ANALYSIS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS; TREATMENT DURATION;

EID: 84873405017     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.384     Document Type: Article

References (31)

1. Rodriguez-Iturbe B, Musser JM. The Current state of poststreptococcal glomerulonephritis. J Am Soc Nephrol 2008; 19: 1855-1864.
2. Rodriguez-Iturbe B, Batsford S. Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet. Kidney Int 2007; 71: 1094-1104.
3. Nadasdy T, Hebert LA. Infection-related glomerulonephritis: understanding mechanisms. Sem Nephrol 2011; 31: 369-375.
4. Eison T, Ault B, Jones D et al. Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis. Pediat Nephrol 2011; 26: 165-180.
5. Yousif Y, Okada K, Batsford S et al. Induction of glomerulonephritis in rats with staphylococcal phosphatase: new aspects in post-infectious ICGN. Kidney Int 1996; 50: 290-297.
6. Peake P, Pussell B, Karplus T et al. Post-streptococcal glomerulonephritis: studies on the interaction between nephritis strain-associated protein (NSAP), complement and the glomerulus. APMIS 1991; 99: 460-466.
7. Montseny J-J, Meyrier A, Kleinknecht D et al. The current spectrum of infectious glomerulonephritis: experience with 76 patients and review of the literature. Medicine (Baltimore) 1995; 74: 63-73.
8. Nasr SH, Markowitz GS, Stokes MB et al. Acute postinfectious glomerulonephritis in the modern era: experience with 86 adults and review of the literature. Medicine (Baltimore) 2008; 87: 21-32.
9. Hoy WE, White AV, Dowling A et al. Post-streptococcal glomerulonephritis is a strong risk factor for chronic kidney disease in later life. Kidney Int 2012; 81: 1026-1032.
10. Nasr SH, Fidler ME, Valeri AM et al. Postinfectious glomerulonephritis in the elderly. J Am Soc Nephrol 2011; 22: 187-195.
11. Ferreira VP, Pangburn MK, Cortés C. Complement control protein factor H: The good, the bad, and the inadequate. Mol Immunol 2010; 47: 2187-2197.
12. Skattum L, van Deuren M, van der Poll T et al. Complement deficiency states and associated infections. Mol Immunol 2011; 48: 1643-1655.
13. Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol 2009; 9: 729-740.
14. Moroni G, Pozzi C, Quaglini S et al. Long-term prognosis of diffuse proliferative glomerulonephritis associated with infection in adults. Nephrol Dialysis Transplant 2002; 17: 1204-1211.
15. Frémeaux-Bacchi V, Weiss L, Demouchy C et al. Hypocomplementaemia of poststreptococcal acute glomerulonephritis is associated with C3 nephritic factor (C3NeF) IgG autoantibody activity. Nephrol Dialysis Transplant 1994; 9: 1747-1750.
16. Meri S. Complement activation by circulating serum factors in human glomerulonephritis. Clin Exp Immunol 1985; 59: 276-284.
17. Hisano S, Matsushita M, Fujita T et al. Activation of the lectin complement pathway in post-streptococcal acute glomerulonephritis. Pathol Int 2007; 57: 351-357.
18. Sethi S, Fervenza FC, Zhang Y et al. C3 glomerulonephritis: clinicopathological findings, complement abnormalities, glomerular proteomic profile, treatment, and follow-up. Kidney Int 2012; 82: 465-473.
19. Payne D, Houtman P, Browning M. Acute post-streptococcal glomerulonephritis associated with prolonged hypocomplementaemia. J Clin Pathol 2008; 61: 1133-1135.
20. Dedeoglu I, Springate J, Waz W et al. Prolonged hypocomplementemia in poststreptococcal acute glomerulonephritis. Clin Nephrol 1996; 46: 302-305.
21. Zhang Y, Meyer NC, Wang K et al. Causes of alternative pathway dysregulation in dense deposit disease. Clin J Am Soc Nephrol 2012; 7: 265-274.
22. Tennessen JA, Bigham AW, O' Connor TD et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 2012; 337: 64-69.
23. Henikoff S, Henikoff JG. Amino acid substitution matrices from protein blocks. Proc Natl Acad Sci 1992; 89: 10915-10919.
24. Liu X, Jian X, Boerwinkle E. dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions. Hum Mutat 2011; 32: 894-899.
25. Vernon KA, Goicoechea de Jorge E, Hall AE et al. Acute presentation and persistent glomerulonephritis following streptococcal infection in a patient with heterozygous complement factor h-related protein 5 deficiency. Am J Kidney Dis 2012; 60: 121-125.
26. Sethi S, Nester CM, Smith RJH. Membranoproliferative glomerulonephritis and C3 glomerulopathy: resolving the confusion. Kidney Int 2012; 81: 434-441.
27. Servais A, Fremeaux-Bacchi V, Lequintrec M et al. Primary glomerulonephritis with isolated C3 deposits: a new entity which shares common genetic risk factors with haemolytic uraemic syndrome. J Med Genet 2007; 44: 193-199.
28. Sethi S, Fervenza FC, Zhang Y et al. Proliferative glomerulonephritis secondary to dysfunction of the alternative pathway of complement. Clin J Am Soc Nephrol 2011; 6: 1009-1017.
29. Sethi S, Fervenza FC. Membranoproliferative glomerulonephritis-a new look at an old entity. N Engl J Med 2012; 366: 1119-31.
30. Abrera-Abeleda MA, Nishimura C, Frees K et al. Allelic variants of complement genes associated with dense deposit disease. J Am Soc Nephrol 2011; 22: 1551-1559.
31. Maga TK, Meyer NC, Belsha C et al. A novel deletion in the RCA gene cluster causes atypical hemolytic uremic syndrome. Nephrol Dialysis Transplant 2011; 26: 739-741.